Crystal structure of a yeast TFIIA/TBP/DNA complex.

abstract：:The growth and differentiation of cytolytic T lymphocytes (CTL) is regulated by soluble growth hormones, of which interleukin-2 (IL-2) is considered to be of prime importance. Here we report that the lymphokine B-cell stimulatory factor (BSF-1 or interleukin-4) also has profound effects on the generation of these func...

journal_title：Nature

authors： Widmer MB,Grabstein KH

更新日期：1987-04-23 00:00:00

abstract：:During platelet activation there is a major reorganization in the platelet cytoskeleton that accompanies a rapid change in platelet shape. Many of the events associated with activation are attributed to a rise in calcium concentration within the platelet cytoplasm. One direct consequence of the elevated calcium is the...

journal_title：Nature

authors： O'Halloran T,Beckerle MC,Burridge K

更新日期：1985-10-03 00:00:00

abstract：:Macroscopic mechanical oscillators have been coaxed into a regime of quantum behaviour by direct refrigeration or a combination of refrigeration and laser-like cooling. This result supports the idea that mechanical oscillators may perform useful functions in the processing of quantum information with superconducting c...

journal_title：Nature

authors： Palomaki TA,Harlow JW,Teufel JD,Simmonds RW,Lehnert KW

更新日期：2013-03-14 00:00:00

abstract：:The Southern Ocean houses a diverse and productive community of organisms. Unicellular eukaryotic diatoms are the main primary producers in this environment, where photosynthesis is limited by low concentrations of dissolved iron and large seasonal fluctuations in light, temperature and the extent of sea ice. How diat...

journal_title：Nature

authors： Mock T,Otillar RP,Strauss J,McMullan M,Paajanen P,Schmutz J,Salamov A,Sanges R,Toseland A,Ward BJ,Allen AE,Dupont CL,Frickenhaus S,Maumus F,Veluchamy A,Wu T,Barry KW,Falciatore A,Ferrante MI,Fortunato AE,Glöckner

更新日期：2017-01-26 00:00:00

abstract：:High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein. In the cell nucleus it acts as an architectural chromatin-binding factor that bends DNA and promotes protein assembly on specific DNA targets. Outside the cell, it binds with high affinity to RAGE (the receptor for advanced glycatio...

journal_title：Nature

authors： Scaffidi P,Misteli T,Bianchi ME

更新日期：2002-07-11 00:00:00

abstract：:Tobacco smoking causes lung cancer1-3, a process that is driven by more than 60 carcinogens in cigarette smoke that directly damage and mutate DNA4,5. The profound effects of tobacco on the genome of lung cancer cells are well-documented6-10, but equivalent data for normal bronchial cells are lacking. Here we sequence...

journal_title：Nature

authors： Yoshida K,Gowers KHC,Lee-Six H,Chandrasekharan DP,Coorens T,Maughan EF,Beal K,Menzies A,Millar FR,Anderson E,Clarke SE,Pennycuick A,Thakrar RM,Butler CR,Kakiuchi N,Hirano T,Hynds RE,Stratton MR,Martincorena I,Janes

更新日期：2020-02-01 00:00:00

abstract：:It is currently debated whether segmentation in different animal phyla has a common origin and shares a common genetic mechanism. The apparent use of different genetic networks in arthropods and vertebrates has become a strong argument against a common origin of segmentation. Our knowledge of arthropod segmentation is...

journal_title：Nature

authors： Stollewerk A,Schoppmeier M,Damen WG

更新日期：2003-06-19 00:00:00

abstract：:Protein ubiquitination is a common form of post-translational modification that regulates a broad spectrum of protein substrates in diverse cellular pathways. Through a three-enzyme (E1-E2-E3) cascade, the attachment of ubiquitin to proteins is catalysed by the E3 ubiquitin ligase, which is best represented by the sup...

journal_title：Nature

authors： Angers S,Li T,Yi X,MacCoss MJ,Moon RT,Zheng N

更新日期：2006-10-05 00:00:00

abstract：:Escherichia coli RNA polymerase (RNAP) synthesizes RNA with remarkable fidelity in vivo. Its low error rate may be achieved by means of a 'proofreading' mechanism comprised of two sequential events. The first event (backtracking) involves a transcriptionally upstream motion of RNAP through several base pairs, which ca...

journal_title：Nature

authors： Shaevitz JW,Abbondanzieri EA,Landick R,Block SM

更新日期：2003-12-11 00:00:00

abstract：:Natural visual scenes are cluttered with multiple objects whose individual features must somehow be selectively linked (or 'bound') if perception is to coincide with reality. Recent neurophysiological evidence supports a 'binding-by-synchrony' hypothesis: neurons excited by features of the same object fire synchronous...

journal_title：Nature

authors： Thiele A,Stoner G

更新日期：2003-01-23 00:00:00

abstract：:Vertebrate limb formation is an evolutionarily conserved process programmed by an array of morphogenetic genes. As a result of transgene insertion, we previously identified a mutation at the mouse limb deformity (ld) locus that disrupts embryonic pattern formation, resulting in a reduction and fusion of the distal bon...

journal_title：Nature

authors： Woychik RP,Maas RL,Zeller R,Vogt TF,Leder P

更新日期：1990-08-30 00:00:00

abstract：:Knowledge of the composition of the Earth's core is important for understanding its melting point and therefore the temperature at the inner-core boundary and the temperature profile of the core and mantle. In addition, the partitioning of light elements between solid and liquid, as the outer core freezes at the inner...

journal_title：Nature

authors： Alfe D,Gillan MJ,Price GD

更新日期：2000-05-11 00:00:00

abstract：:Neurons in the visual cortex are selectively responsive to light or dark bars presented at particular orientations. On the basis of physiological data, this orientation selectivity is hypothesized as being due at least partially to intracortical inhibitory mechanisms. But this hypothesis has been challenged by intrace...

journal_title：Nature

authors： Hata Y,Tsumoto T,Sato H,Hagihara K,Tamura H

更新日期：1988-10-27 00:00:00

abstract：:Elucidation of the nature of the gene interactions that underly the sterility of interspecific hybrids is important in evolutionary biology. The interactions between the heterospecific X and Y (or Z and W) chromosomes are often used as an explanation for two reasons. First, the fertility of the hybrids of the heteroga...

journal_title：Nature

authors： Johnson NA,Perez DE,Cabot EL,Hollocher H,Wu CI

更新日期：1992-08-27 00:00:00

abstract：:Fluctuations in the counting rate of photons originating from uncorrelated point sources become, within the coherently illuminated area, slightly enhanced compared to a random sequence of classical particles. This phenomenon, known in astronomy as the Hanbury Brown-Twiss effect, is a consequence of quantum interferenc...

journal_title：Nature

authors： Kiesel H,Renz A,Hasselbach F

更新日期：2002-07-25 00:00:00

abstract：:Glutamate transporters are integral membrane proteins that catalyse neurotransmitter uptake from the synaptic cleft into the cytoplasm of glial cells and neurons. Their mechanism of action involves transitions between extracellular (outward)-facing and intracellular (inward)-facing conformations, whereby substrate bin...

journal_title：Nature

authors： Akyuz N,Altman RB,Blanchard SC,Boudker O

更新日期：2013-10-03 00:00:00

abstract：:To communicate, spacecraft and satellites rely on microwave devices, which at present are based on relatively inefficient thermionic electron sources that require heating and cannot be switched on instantaneously. Here we describe a microwave diode that uses a cold-cathode electron source consisting of carbon nanotube...

journal_title：Nature

authors： Teo KB,Minoux E,Hudanski L,Peauger F,Schnell JP,Gangloff L,Legagneux P,Dieumegard D,Amaratunga GA,Milne WI

更新日期：2005-10-13 00:00:00

abstract：:The protein TFIIB is a general transcription initiation factor that interacts with a promoter complex (D.DNA) containing the TATA-binding subunit (TFIID tau, or TBP) of TFIID to facilitate subsequent interaction with RNA polymerase II (ref. 2) through the associated TFIIF (ref. 3). The potential bridging function of T...

journal_title：Nature

authors： Hisatake K,Roeder RG,Horikoshi M

更新日期：1993-06-24 00:00:00

abstract：:Cutaneous malignant melanoma is a highly aggressive and frequently chemoresistant cancer, the incidence of which continues to rise. Epidemiological studies show that the major aetiological melanoma risk factor is ultraviolet (UV) solar radiation, with the highest risk associated with intermittent burning doses, especi...

journal_title：Nature

authors： Zaidi MR,Davis S,Noonan FP,Graff-Cherry C,Hawley TS,Walker RL,Feigenbaum L,Fuchs E,Lyakh L,Young HA,Hornyak TJ,Arnheiter H,Trinchieri G,Meltzer PS,De Fabo EC,Merlino G

更新日期：2011-01-27 00:00:00

abstract：:alpha-Neurotoxins bind to cholinergic receptor, block transmission, and induce sprouting of retinal terminals in the toad tectum. New connections retain an orderliness that suggests a selective affinity between presynaptic terminals. The results suggest that postsynaptic cells exert a control, associated with receptor...

journal_title：Nature

authors： Freeman JA

更新日期：1977-09-15 00:00:00

abstract：:A newly-constructed antibody-like molecule containing the gp120-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to block all HIV isolates, make it a good candidate for therapeutic u...

journal_title：Nature

authors： Capon DJ,Chamow SM,Mordenti J,Marsters SA,Gregory T,Mitsuya H,Byrn RA,Lucas C,Wurm FM,Groopman JE

更新日期：1989-02-09 00:00:00

abstract：:AFTER exposure to secretagogues the small intestine changes from a tissue that absorbs fluid and electrolyte from lumen to blood into a tissue that secretes electrolyte and fluid into the lumen(1-4). It has been shown that this secretion results from an increase in the passive Cl(-) permeability of the mucosal border,...

journal_title：Nature

authors： Ilundain A,Naftalin RJ

更新日期：1979-05-31 00:00:00

abstract：:In 1928, Dirac published an equation 1 that combined quantum mechanics and special relativity. Negative-energy solutions to this equation, rather than being unphysical as initially thought, represented a class of hitherto unobserved and unimagined particles-antimatter. The existence of particles of antimatter was conf...

journal_title：Nature

authors： Ahmadi M,Alves BXR,Baker CJ,Bertsche W,Capra A,Carruth C,Cesar CL,Charlton M,Cohen S,Collister R,Eriksson S,Evans A,Evetts N,Fajans J,Friesen T,Fujiwara MC,Gill DR,Hangst JS,Hardy WN,Hayden ME,Isaac CA,Johnson M

更新日期：2018-05-01 00:00:00

abstract：:Enzymes are the subset of proteins that catalyse the chemistry of life, transforming both macromolecular substrates and small molecules. The precise three-dimensional architecture of enzymes permits almost unerring selectivity in physical and chemical steps to impose remarkable rate accelerations and specificity in pr...

journal_title：Nature

authors： Walsh C

更新日期：2001-01-11 00:00:00

abstract：:The oxygen evolution reaction has an important role in many alternative-energy schemes because it supplies the protons and electrons required for converting renewable electricity into chemical fuels1-3. Electrocatalysts accelerate the reaction by facilitating the required electron transfer4, as well as the formation a...

journal_title：Nature

authors： Nong HN,Falling LJ,Bergmann A,Klingenhof M,Tran HP,Spöri C,Mom R,Timoshenko J,Zichittella G,Knop-Gericke A,Piccinin S,Pérez-Ramírez J,Cuenya BR,Schlögl R,Strasser P,Teschner D,Jones TE

更新日期：2020-11-01 00:00:00

abstract：:Alzheimer's disease (AD) affects more than 30% of people over 80 years of age. The aetiology and pathogenesis of this progressive dementia is poorly understood, but symptomatic disease is associated histopathologically with amyloid plaques, neurofibrillary tangles and neuronal loss primarily in the temporal lobe and n...

journal_title：Nature

authors： Kawabata S,Higgins GA,Gordon JW

更新日期：1991-12-12 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) is a disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in a pandemic1. The C5a complement factor and its receptor C5aR1 (also known as CD88) have a key role in the initiation and maintenance of several inflammatory respons...

journal_title：Nature

authors： Carvelli J,Demaria O,Vély F,Batista L,Chouaki Benmansour N,Fares J,Carpentier S,Thibult ML,Morel A,Remark R,André P,Represa A,Piperoglou C,Explore COVID-19 IPH group.,Explore COVID-19 Marseille Immunopole group.,Cordier PY

更新日期：2020-12-01 00:00:00

abstract：:Excitatory amino acids (EAAs) are important neurotransmitters in the vertebrate central nervous system. Electrophysiological and ligand-binding studies indicate that at least three different receptor subtypes for EAAs exist--N-methyl-D-aspartate, kainate and quisqualate receptor subtypes--on the basis of the preferred...

journal_title：Nature

authors： Wada K,Dechesne CJ,Shimasaki S,King RG,Kusano K,Buonanno A,Hampson DR,Banner C,Wenthold RJ,Nakatani Y

更新日期：1989-12-07 00:00:00

abstract：: ...

journal_title：Nature

authors： Ainsworth C

更新日期：2017-11-08 00:00:00

abstract：:Alternative splicing of eukaryotic messenger RNA precursors is now known to be of widespread importance in generating multiple transcripts from a single gene. This phenomenon has emphasized the problem of the way in which splice sites are selected; recent studies have discussed the role of secondary structure or affin...

journal_title：Nature

authors： Eperon LP,Estibeiro JP,Eperon IC

更新日期：1986-11-20 00:00:00