Crystal structure of a yeast TFIIA/TBP/DNA complex.

Abstract:

:The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 A resolution. TFIIA is composed of a beta-barrel and a four-helix bundle motif that together have a boot-like appearance. The beta-barrel extends the TBP beta-sheet and bridges over the DNA major groove immediately upstream of the TATA box. The four-helix bundle contributes substantially to the surface of the complex available for interaction with additional transcription factors.

journal_name

Nature

journal_title

Nature

authors

Tan S,Hunziker Y,Sargent DF,Richmond TJ

doi

10.1038/381127a0

subject

Has Abstract

pub_date

1996-05-09 00:00:00

pages

127-51

issue

6578

eissn

0028-0836

issn

1476-4687

journal_volume

381

pub_type

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