Abstract:
:The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 A resolution. TFIIA is composed of a beta-barrel and a four-helix bundle motif that together have a boot-like appearance. The beta-barrel extends the TBP beta-sheet and bridges over the DNA major groove immediately upstream of the TATA box. The four-helix bundle contributes substantially to the surface of the complex available for interaction with additional transcription factors.
journal_name
Naturejournal_title
Natureauthors
Tan S,Hunziker Y,Sargent DF,Richmond TJdoi
10.1038/381127a0subject
Has Abstractpub_date
1996-05-09 00:00:00pages
127-51issue
6578eissn
0028-0836issn
1476-4687journal_volume
381pub_type
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