Targeted misexpression of a Drosophila opsin gene leads to altered visual function.

abstract：:The 20S cyclosome complex (also known as the anaphase-promoting complex) has ubiquitin ligase activity and is required for mitotic cyclin destruction and sister chromatid separation. The formation and activation of the 20S cyclosome complex is regulated by an unknown mechanism. Here we show that Cut4 (ref. 6) is an es...

journal_title：Nature

authors： Yamashita YM,Nakaseko Y,Samejima I,Kumada K,Yamada H,Michaelson D,Yanagida M

更新日期：1996-11-21 00:00:00

abstract：:Deception is common in nature and humans are no exception. Modern societies have created institutions to control cheating, but many situations remain where only intrinsic honesty keeps people from cheating and violating rules. Psychological, sociological and economic theories suggest causal pathways to explain how the...

journal_title：Nature

authors： Gächter S,Schulz JF

更新日期：2016-03-24 00:00:00

abstract：:Regulatory aspects of the Warnock Committee's report on reproductive technologies are summarized. A licensing authority with "substantial lay representation" would license practitioners and approve experimentation. Artificial insemination by donor would become a regulated service, and resulting children would be leg...

journal_title：Nature

authors：

更新日期：1984-07-26 00:00:00

abstract：:B LYMPHOCYTES are key participants in the immune response because of their specificity, their ability to take up and present antigens to T cells, and their capacity to differentiate into antibody-secreting cells. To limit reactivity to self antigens, autospecific B cells can be functionally inactivated or deleted. Dev...

journal_title：Nature

authors： Russell DM,Dembić Z,Morahan G,Miller JF,Bürki K,Nemazee D

更新日期：1991-11-28 00:00:00

abstract：:Microbialites, including biogenic stromatolites, thrombolites and dendrolites, were formed by various microbial mats that trapped and bound sediments or formed the locus of mineral precipitation. Microbialites were common and diverse during the Proterozoic, but declined in abundance and morphological diversity when mu...

journal_title：Nature

authors： Sheehan PM,Harris MT

更新日期：2004-07-01 00:00:00

abstract：:Antigenic variation in the haemagglutinin (HA) glycoprotein of influenza virus is associated with recurrent epidemics of respiratory disease in man (for review see ref. 1). We have examined the size of structural changes necessary to alter the antigenicity of HA by determining the three-dimensional structure of the HA...

journal_title：Nature

authors： Knossow M,Daniels RS,Douglas AR,Skehel JJ,Wiley DC

更新日期：1984-10-18 00:00:00

abstract：:Since the discovery of insulin nearly 70 years ago, there has been no problem more fundamental to diabetes research than understanding how insulin works at the cellular level. Insulin binds to the alpha subunit of the insulin receptor which activates the tyrosine kinase in the beta subunit, but the molecular events li...

journal_title：Nature

authors： Sun XJ,Rothenberg P,Kahn CR,Backer JM,Araki E,Wilden PA,Cahill DA,Goldstein BJ,White MF

更新日期：1991-07-04 00:00:00

abstract：:Although many animals use the Earth's magnetic field for orientation and navigation, the precise biophysical mechanisms underlying magnetic sensing have been elusive. One theoretical model proposes that geomagnetic fields are perceived by chemical reactions involving specialized photoreceptors. However, the specific p...

journal_title：Nature

authors： Gegear RJ,Casselman A,Waddell S,Reppert SM

更新日期：2008-08-21 00:00:00

abstract：:Change history: In Fig. 1c of this Letter, the two graphs were duplicates. The right panel of Fig. 1c has been corrected online. ...

journal_title：Nature

authors： Lai B,Gao W,Cui K,Xie W,Tang Q,Jin W,Hu G,Ni B,Zhao K

更新日期：2018-12-01 00:00:00

abstract：:In epithelial Madin-Darby canine kidney (MDCK) cells newly synthesized molecules are sorted in the trans-Golgi network and directly delivered to their apical and basolateral surface destinations. Sorting is mediated by signals in the cytoplasmic domains of basolateral transmembrane proteins whereas glycosylphosphatidy...

journal_title：Nature

authors： Scheiffele P,Peränen J,Simons K

更新日期：1995-11-02 00:00:00

abstract：:Many natural habitats exist on privately owned land outside protected areas, but few governments can afford to enforce or subsidize conservation of this biodiversity. Even in some developed countries, conservation subsidy schemes have only achieved limited success. Fortunately, some landowners may be willing to accept...

journal_title：Nature

authors： Oldfield TE,Smith RJ,Harrop SR,Leader-Williams N

更新日期：2003-05-29 00:00:00

abstract：:Self-assembled polyhedral structures are common in biology. The coats of many viruses, for example, have a structure based on icosahedral symmetry. The preparation of synthetic polyhedral molecular assemblies represents a challenging problem, but supramolecular chemistry has now advanced to the point where the task ma...

journal_title：Nature

authors： Olenyuk B,Whiteford JA,Fechtenkötter A,Stang PJ

更新日期：1999-04-29 00:00:00

abstract：:The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a ligand-dependent transcription factor that is important in adipocyte differentiation and glucose homeostasis and which depends on interactions with co-activators, including steroid receptor co-activating factor-1 (SRC-1). Here we present the X-ray ...

journal_title：Nature

authors： Nolte RT,Wisely GB,Westin S,Cobb JE,Lambert MH,Kurokawa R,Rosenfeld MG,Willson TM,Glass CK,Milburn MV

更新日期：1998-09-10 00:00:00

abstract：:Recently, a class of protein antigens of high relative molecular mass (Mt) which can induce protective immunity against blood-stage malaria has been identified. In Plasmodium falciparum the protein has a Mr of approximately 195,000 (P195). It is the precursor of three proteins of Mr 83,000 (83K), 42K and 19K which are...

journal_title：Nature

authors： Holder AA,Lockyer MJ,Odink KG,Sandhu JS,Riveros-Moreno V,Nicholls SC,Hillman Y,Davey LS,Tizard ML,Schwarz RT

更新日期：1985-09-19 00:00:00

abstract：:Neurons in the visual cortex are selectively responsive to light or dark bars presented at particular orientations. On the basis of physiological data, this orientation selectivity is hypothesized as being due at least partially to intracortical inhibitory mechanisms. But this hypothesis has been challenged by intrace...

journal_title：Nature

authors： Hata Y,Tsumoto T,Sato H,Hagihara K,Tamura H

更新日期：1988-10-27 00:00:00

abstract：:The origin of tetrapods from their fish antecedents, approximately 400 million years ago, was coupled with the origin of terrestrial locomotion and the evolution of supporting limbs. Polypterus is a member of the basal-most group of ray-finned fish (actinopterygians) and has many plesiomorphic morphologies that are co...

journal_title：Nature

authors： Standen EM,Du TY,Larsson HC

更新日期：2014-09-04 00:00:00

abstract：:In mammals, one of the most pronounced consequences of viral infection is the induction of type I interferons, cytokines with potent antiviral activity. Schlafen (Slfn) genes are a subset of interferon-stimulated early response genes (ISGs) that are also induced directly by pathogens via the interferon regulatory fact...

journal_title：Nature

authors： Li M,Kao E,Gao X,Sandig H,Limmer K,Pavon-Eternod M,Jones TE,Landry S,Pan T,Weitzman MD,David M

更新日期：2012-11-01 00:00:00

abstract：:Calcification of the aortic valve is the third leading cause of heart disease in adults. The incidence increases with age, and it is often associated with a bicuspid aortic valve present in 1-2% of the population. Despite the frequency, neither the mechanisms of valve calcification nor the developmental origin of a tw...

journal_title：Nature

authors： Garg V,Muth AN,Ransom JF,Schluterman MK,Barnes R,King IN,Grossfeld PD,Srivastava D

更新日期：2005-09-08 00:00:00

abstract：:A putative growth hormone receptor from rabbit liver and the growth hormone binding protein from rabbit serum have the same amino-terminal amino-acid sequence, indicating that the binding protein corresponds to the extracellular hormone-binding domain of the liver receptor. The complete amino-acid sequences derived fr...

journal_title：Nature

authors： Leung DW,Spencer SA,Cachianes G,Hammonds RG,Collins C,Henzel WJ,Barnard R,Waters MJ,Wood WI

更新日期：1987-12-10 00:00:00

abstract：:Cryptosporidium species cause acute gastroenteritis and diarrhoea worldwide. They are members of the Apicomplexa--protozoan pathogens that invade host cells by using a specialized apical complex and are usually transmitted by an invertebrate vector or intermediate host. In contrast to other Apicomplexans, Cryptosporid...

journal_title：Nature

authors： Xu P,Widmer G,Wang Y,Ozaki LS,Alves JM,Serrano MG,Puiu D,Manque P,Akiyoshi D,Mackey AJ,Pearson WR,Dear PH,Bankier AT,Peterson DL,Abrahamsen MS,Kapur V,Tzipori S,Buck GA

更新日期：2004-10-28 00:00:00

abstract：:The pathways that control insulin secretion and regulate pancreatic beta-cell mass are crucial in the development of diabetes mellitus. Maturity-onset diabetes of the young comprises a number of single-gene disorders affecting pancreatic beta-cell function, and the consequences of mutations in these genes are so serio...

journal_title：Nature

authors： Bell GI,Polonsky KS

更新日期：2001-12-13 00:00:00

abstract：:Post-transcriptional gene regulation frequently occurs through elements in mRNA 3' untranslated regions (UTRs). Although crucial roles for 3'UTR-mediated gene regulation have been found in Caenorhabditis elegans, most C. elegans genes have lacked annotated 3'UTRs. Here we describe a high-throughput method for reliable...

journal_title：Nature

authors： Jan CH,Friedman RC,Ruby JG,Bartel DP

更新日期：2011-01-06 00:00:00

abstract：:When simian virus 40 (SV40) infects host cells, the viral genes are expressed in two phases. Early in infection, the virus genome is transcribed and translated to yield two related proteins, 'large T' and 'small t' antigens. Later the rate of synthesis of the early messenger RNA falls and the viral genes coding for th...

journal_title：Nature

authors： McKay R,DiMaio D

更新日期：1981-02-26 00:00:00

abstract：:The theory of reinforcement learning provides a normative account, deeply rooted in psychological and neuroscientific perspectives on animal behaviour, of how agents may optimize their control of an environment. To use reinforcement learning successfully in situations approaching real-world complexity, however, agents...

journal_title：Nature

authors： Mnih V,Kavukcuoglu K,Silver D,Rusu AA,Veness J,Bellemare MG,Graves A,Riedmiller M,Fidjeland AK,Ostrovski G,Petersen S,Beattie C,Sadik A,Antonoglou I,King H,Kumaran D,Wierstra D,Legg S,Hassabis D

更新日期：2015-02-26 00:00:00

abstract：:Our current understanding of immunology was largely defined in laboratory mice, partly because they are inbred and genetically homogeneous, can be genetically manipulated, allow kinetic tissue analyses to be carried out from the onset of disease, and permit the use of tractable disease models. Comparably reductionist ...

journal_title：Nature

authors： Beura LK,Hamilton SE,Bi K,Schenkel JM,Odumade OA,Casey KA,Thompson EA,Fraser KA,Rosato PC,Filali-Mouhim A,Sekaly RP,Jenkins MK,Vezys V,Haining WN,Jameson SC,Masopust D

更新日期：2016-04-28 00:00:00

abstract：:Visible-light absorption and transport of the resultant electronic excitations to a reaction centre through Förster resonance energy transfer1-3 (FRET) are critical to the operation of biological light-harvesting systems4, and are used in various artificial systems made of synthetic dyes5, polymers6 or nanodots7,8. Th...

journal_title：Nature

authors： Lau JA,Chen L,Choudhury A,Schwarzer D,Verma VB,Wodtke AM

更新日期：2021-01-01 00:00:00

abstract：:Transition-metal perovskite oxides exhibit a wide range of extraordinary but imperfectly understood phenomena. The best known examples are high-temperature superconductivity in copper oxides, and colossal magnetoresistance in manganese oxides ('manganites'). All of these materials undergo a range of order-disorder tra...

journal_title：Nature

authors： Renner Ch,Aeppli G,Kim BG,Soh YA,Cheong SW

更新日期：2002-04-04 00:00:00

abstract：:Overexploitation of renewable resources today has a high cost on the welfare of future generations. Unlike in other public goods games, however, future generations cannot reciprocate actions made today. What mechanisms can maintain cooperation with the future? To answer this question, we devise a new experimental para...

journal_title：Nature

authors： Hauser OP,Rand DG,Peysakhovich A,Nowak MA

更新日期：2014-07-10 00:00:00

abstract：:Guided by brain-like 'spiking' computational frameworks, neuromorphic computing-brain-inspired computing for machine intelligence-promises to realize artificial intelligence while reducing the energy requirements of computing platforms. This interdisciplinary field began with the implementation of silicon circuits for...

journal_title：Nature

authors： Roy K,Jaiswal A,Panda P

更新日期：2019-11-01 00:00:00

abstract：:The inner ear is capable of highly selective frequency discrimination. This is achieved not only by the travelling wave of the basilar membrane in the cochlear partition, but also by the active participation of nonlinear and vulnerable elements that enhance frequency selectivity. It has been shown that isolated mammal...

journal_title：Nature

authors： Brundin L,Flock A,Canlon B

更新日期：1989-12-14 00:00:00