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Mutations in NOTCH1 cause aortic valve disease.

Abstract：

:Calcification of the aortic valve is the third leading cause of heart disease in adults. The incidence increases with age, and it is often associated with a bicuspid aortic valve present in 1-2% of the population. Despite the frequency, neither the mechanisms of valve calcification nor the developmental origin of a two, rather than three, leaflet aortic valve is known. Here, we show that mutations in the signalling and transcriptional regulator NOTCH1 cause a spectrum of developmental aortic valve anomalies and severe valve calcification in non-syndromic autosomal-dominant human pedigrees. Consistent with the valve calcification phenotype, Notch1 transcripts were most abundant in the developing aortic valve of mice, and Notch1 repressed the activity of Runx2, a central transcriptional regulator of osteoblast cell fate. The hairy-related family of transcriptional repressors (Hrt), which are activated by Notch1 signalling, physically interacted with Runx2 and repressed Runx2 transcriptional activity independent of histone deacetylase activity. These results suggest that NOTCH1 mutations cause an early developmental defect in the aortic valve and a later de-repression of calcium deposition that causes progressive aortic valve disease.

journal_name

Nature

journal_title

Nature

authors

Garg V,Muth AN,Ransom JF,Schluterman MK,Barnes R,King IN,Grossfeld PD,Srivastava D

doi

10.1038/nature03940

keywords:

subject

Has Abstract

pub_date

2005-09-08 00:00:00

pages

270-4

issue

7056

eissn

0028-0836

issn

1476-4687

pii

nature03940

journal_volume

437

pub_type

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