Directional guidance of neuronal migration in the olfactory system by the protein Slit.

Abstract:

:Although cell migration is crucial for neural development, molecular mechanisms guiding neuronal migration have remained unclear. Here we report that the secreted protein Slit repels neuronal precursors migrating from the anterior subventricular zone in the telencephalon to the olfactory bulb. Our results provide a direct demonstration of a molecular cue whose concentration gradient guides the direction of migrating neurons. They also support a common guidance mechanism for axon projection and neuronal migration and suggest that Slit may provide a molecular tool with potential therapeutic applications in controlling and directing cell migration.

journal_name

Nature

journal_title

Nature

authors

Wu W,Wong K,Chen J,Jiang Z,Dupuis S,Wu JY,Rao Y

doi

10.1038/22477

keywords:

subject

Has Abstract

pub_date

1999-07-22 00:00:00

pages

331-6

issue

6742

eissn

0028-0836

issn

1476-4687

journal_volume

400

pub_type

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