Abstract:
:Although cell migration is crucial for neural development, molecular mechanisms guiding neuronal migration have remained unclear. Here we report that the secreted protein Slit repels neuronal precursors migrating from the anterior subventricular zone in the telencephalon to the olfactory bulb. Our results provide a direct demonstration of a molecular cue whose concentration gradient guides the direction of migrating neurons. They also support a common guidance mechanism for axon projection and neuronal migration and suggest that Slit may provide a molecular tool with potential therapeutic applications in controlling and directing cell migration.
journal_name
Naturejournal_title
Natureauthors
Wu W,Wong K,Chen J,Jiang Z,Dupuis S,Wu JY,Rao Ydoi
10.1038/22477keywords:
subject
Has Abstractpub_date
1999-07-22 00:00:00pages
331-6issue
6742eissn
0028-0836issn
1476-4687journal_volume
400pub_type
杂志文章相关文献
NATURE文献大全abstract::A basic requirement for quantum information processing systems is the ability to completely control the state of a single qubit. For qubits based on electron spin, a universal single-qubit gate is realized by a rotation of the spin by any angle about an arbitrary axis. Driven, coherent Rabi oscillations between two sp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07530
更新日期:2008-11-13 00:00:00
abstract::An important step towards understanding the molecular basis of the functional diversity of voltage-gated K+ channels in the mammalian brain has been the discovery of a family of genes encoding rat brain K+ channel-forming (RCK) proteins. All species of these RCK proteins form homomultimeric voltage-gated K+ channels w...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/345535a0
更新日期:1990-06-07 00:00:00
abstract::Lipoprotein(a) is an LDL-like lipoprotein whose concentration in plasma is correlated with atherosclerosis. The characteristic protein component of lipoprotein(a) is apolipoprotein(a) which is disulphide-linked to apolipoprotein B-100. Sequencing of cloned human apolipoprotein(a) complementary DNA shows that it is ver...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/330132a0
更新日期:1987-11-12 00:00:00
abstract::Time-of-flight mass spectrometry-most notably matrix-assisted laser-desorption-ionization time-of-flight (MALDI-TOF) spectrometry-is an important class of techniques for the study of proteins and other biomolecules. Although these techniques provide excellent performance for masses up to about 20,000 daltons, there ha...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35582
更新日期:1998-02-12 00:00:00
abstract::Some beetles in the Namib Desert collect drinking water from fog-laden wind on their backs. We show here that these large droplets form by virtue of the insect's bumpy surface, which consists of alternating hydrophobic, wax-coated and hydrophilic, non-waxy regions. The design of this fog-collecting structure can be re...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35102108
更新日期:2001-11-01 00:00:00
abstract::To mediate its survival and virulence, the malaria parasite Plasmodium falciparum exports hundreds of proteins into the host erythrocyte. To enter the host cell, exported proteins must cross the parasitophorous vacuolar membrane (PVM) within which the parasite resides, but the mechanism remains unclear. A putative Pla...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13574
更新日期:2014-07-31 00:00:00
abstract::Simple mathematical models of the transmission dynamics of human immunodeficiency virus help to clarify some of the essential relations between epidemiological factors, such as distributed incubation periods and heterogeneity in sexual activity, and the overall pattern of the AIDS epidemic. They also help to identify ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326137a0
更新日期:1987-03-12 00:00:00
abstract::Erythroid differentiation entails the biogenesis of a membrane skeleton, a network of proteins underlying and interacting with the plasma membrane, whose major constituent is the heterodimeric protein spectrin, composed of two structurally similar but distinct subunits, alpha (relative molecular mass (Mr) 240,000) and...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/321085a0
更新日期:1986-05-01 00:00:00
abstract::Histone post-translational modifications (PTMs) are associated with epigenetic states that form the basis for cell-type-specific gene expression1,2. Once established, histone PTMs can be maintained by positive feedback involving enzymes that recognize a pre-existing histone modification and catalyse the same modificat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0239-3
更新日期:2018-06-01 00:00:00
abstract::Toxoplasma gondii, an obligate intracellular parasite of the phylum Apicomplexa, can cause severe disease in humans with an immature or suppressed immune system. The outcome of Toxoplasma infection is highly dependent on the strain type, as are many of its in vitro growth properties. Here we use genetic crosses betwee...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05395
更新日期:2007-01-18 00:00:00
abstract::The evolution of snakes involved major changes in vertebrate body plan organization, but the developmental basis of those changes is unknown. The python axial skeleton consists of hundreds of similar vertebrae, forelimbs are absent and hindlimbs are severely reduced. Combined limb loss and trunk elongation is found in...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/20944
更新日期:1999-06-03 00:00:00
abstract::Lipoxygenase metabolites of arachidonic acid have recently been shown to modulate the activity of ion channels in nerve and muscle cells. The mechanism of action of these metabolites is, however, unknown. In sensory neurons of Aplysia, the S-K- channel is under the dual modulatory control of 5-hydroxytryptamine (5-HT)...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/342553a0
更新日期:1989-11-30 00:00:00
abstract::Occupancy of the T-cell antigen receptor is insufficient to induce T-cell activation optimally; a second co-stimulatory signal is required. Exposure of T-cell clones to complexes of antigen with major histocompatibility complex molecules in the absence of the co-stimulatory signal induces a state of clonal anergy. Thi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/356607a0
更新日期:1992-04-16 00:00:00
abstract::Quantum electrodynamics describes the interactions of electrons and photons. Electric charge (the gauge coupling constant) is energy dependent, and there is a previous claim that charge is affected by gravity (described by general relativity) with the implication that the charge is reduced at high energies. However, t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09506
更新日期:2010-11-04 00:00:00
abstract::Magnetic interactions and magnetic impurities are destructive to superconductivity in conventional superconductors. By contrast, in some unconventional macroscopic quantum systems (such as superfluid 3He and superconducting UGe2), the superconductivity (or superfluidity) is actually mediated by magnetic interactions. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35082019
更新日期:2001-06-21 00:00:00
abstract::In order to understand the dynamics of the India Asia collision zone, it is important to know the strain distribution in Central Asia, whose determination relies on the slip rates for active faults. Many previous slip-rate estimates of faults in Central Asia were based on the assumption that offset landforms are young...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/417428a
更新日期:2002-05-23 00:00:00
abstract::Many corals bleach as a result of increased seawater temperature, which causes them to lose their vital symbiotic algae (Symbiodinium spp.) - unless these symbioses are able to adapt to global warming, bleaching threatens coral reefs worldwide. Here I show that some corals have adapted to higher temperatures, at least...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/430742a
更新日期:2004-08-12 00:00:00
abstract::Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids1,2. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into non-toxic lipid alcohols3,4. Ferroptosis has previously been implica...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1705-2
更新日期:2019-11-01 00:00:00
abstract::The homotypic fusion of yeast vacuoles includes a 'docking' step, which we show here to consist of two sequential reactions: a reversible 'tethering' mediated by the GTPase Ypt7, and 'SNARE pairing', in which SNARE proteins from opposite membranes form a complex in trans. The function of this trans-SNARE complex must ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/25069
更新日期:1998-12-10 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) and other neurotrophins have a vital role in the development of the rat and mouse nervous system by influencing the expression of many specific genes that promote differentiation, cell survival, synapse formation and, later, synaptic plasticity. Although nitric oxide (NO) is kn...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07238
更新日期:2008-09-18 00:00:00
abstract::The assembly of microtubules has been investigated by time-resolved X-ray diffraction using synchrotron radiation. The small-angle scattering becomes visible within seconds and thus enables study of the structural transitions of the protein aggregates during assembly from their subunits in solution. The X-ray pattern ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/287595a0
更新日期:1980-10-16 00:00:00
abstract::Cancer control by adaptive immunity involves a number of defined death and clearance mechanisms. However, efficient inhibition of exponential cancer growth by T cells and interferon-γ (IFN-γ) requires additional undefined mechanisms that arrest cancer cell proliferation. Here we show that the combined action of the T-...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11824
更新日期:2013-02-21 00:00:00
abstract::The onsert of neuronal differentiation is characterised by intensive neurite growth; because microtubule formation is strictly required during this process, in vitro assembly of the tubulin present in the rat brain has been studied at different stages of development: the rate of assembly is very slow in the early stag...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/284353a0
更新日期:1980-03-27 00:00:00
abstract::A T-cell-mediated immune response is initiated by the T-cell receptor (TCR) interacting with peptide-bound major histocompatibility complex (pMHC) on an infected cell. The mechanism by which this interaction triggers intracellular phosphorylation of the TCR, which lacks a kinase domain, remains poorly understood. Here...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11220
更新日期:2012-07-05 00:00:00
abstract::Very large collisions in the asteroid belt could lead temporarily to a substantial increase in the rate of impacts of meteorites on Earth. Orbital simulations predict that fragments from such events may arrive considerably faster than the typical transit times of meteorites falling today, because in some large impacts...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02736
更新日期:2004-07-15 00:00:00
abstract::Systems of colour vision are normally identical in all members of a species, but a single design may not be adequate for species living in a diverse range of light environments. Here we show that in the mantis shrimp Haptosquilla trispinosa, which occupies a range of depths in the ocean, long-wavelength colour recepto...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35079184
更新日期:2001-05-31 00:00:00
abstract::The chemical induction of malignant transformation in BHK cells seems to result from a somatic mutation. Stable transformants, whose frequency is significantly increased by mutagenic carcinogens, can revert to normal and often display temperature-restricted phenotypes indicative of an altered gene product. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/264722a0
更新日期:1976-12-23 00:00:00
abstract::Most neurons of the mammalian central nervous system (CNS) lose the ability to regenerate severed axons in vivo after a certain point in development. At least part of this loss in regenerative potential is intrinsic to neurons. Although embryonic retinal ganglion cells (RGCs) can grow axons into tectum of any age, mos...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/385434a0
更新日期:1997-01-30 00:00:00
abstract::In Dictyostelium discoideum, carbohydrate binding proteins (CBPs) or lectins have been implicated in the molecular basis of cellular cohesion. To determine the role of these CBPs, we have attempted to isolate structural gene mutants in which the CBPs have a defective affinity for carbohydrate ligands. We now report th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/279215a0
更新日期:1979-05-17 00:00:00
abstract::Cancers emerge from an ongoing Darwinian evolutionary process, often leading to multiple competing subclones within a single primary tumour. This evolutionary process culminates in the formation of metastases, which is the cause of 90% of cancer-related deaths. However, despite its clinical importance, little is known...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14347
更新日期:2015-04-16 00:00:00