A suppression of differential rotation in Jupiter's deep interior.

abstract：:The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. Here we have determined three different crystal structures of the extracellular ligand-binding region of mGluR1--in a complex with glutamate and in two unliganded forms. ...

journal_title：Nature

authors： Kunishima N,Shimada Y,Tsuji Y,Sato T,Yamamoto M,Kumasaka T,Nakanishi S,Jingami H,Morikawa K

更新日期：2000-10-26 00:00:00

abstract：:Groundwater is a primary source of fresh water in many parts of the world. Some regions are becoming overly dependent on it, consuming groundwater faster than it is naturally replenished and causing water tables to decline unremittingly. Indirect evidence suggests that this is the case in northwest India, but there ha...

journal_title：Nature

authors： Rodell M,Velicogna I,Famiglietti JS

更新日期：2009-08-20 00:00:00

abstract：:The neural crest, a source of many different cell types in vertebrate embryos, has not been identified in other chordates. Current opinion therefore holds that neural crest cells were a vertebrate innovation. Here we describe a migratory cell population resembling neural crest cells in the ascidian urochordate Ecteina...

journal_title：Nature

authors： Jeffery WR,Strickler AG,Yamamoto Y

更新日期：2004-10-07 00:00:00

abstract：:Particle physicists see neutrons as tiny massive particles with a confinement radius of about 0.7 fm and a distinct internal quark gluon structure. In quantum mechanics, neutrons are described by wave packets whose spatial extent may become ten orders of magnitude larger than the confinement radius, and can even reach...

journal_title：Nature

authors： Rauch H,Lemmel H,Baron M,Loidl R

更新日期：2002-06-06 00:00:00

abstract：:Dense plexuses of neurones containing immunoreactive vasoactive intestinal peptide (VIP) have been found in discrete areas of the central nervous system and in peripheral organs, including the gastrointestinal tract, pancreas and urogenital system. In many of these locations VIP is concentrated in nerve endings, where...

journal_title：Nature

authors： Giachetti A,Said SI

更新日期：1979-10-18 00:00:00

abstract：: ...

journal_title：Nature

authors： Reardon S

更新日期：2018-12-01 00:00:00

abstract：:Spontaneous type 1 diabetes occurs when the autoimmune destruction of pancreatic beta-islet cells prevents production of the hormone insulin. This causes an inability to regulate glucose metabolism, which results in dangerously raised blood glucose concentrations. It is generally accepted that thymus-derived lymphocyt...

journal_title：Nature

authors： Wilson DB

更新日期：2005-11-24 00:00:00

abstract：:Protein engineering is being developed for mapping the energetics and pathway of protein folding. From kinetic studies on wild-type and mutant proteins, the sequence and energetics of formation of tertiary interactions of side chains can be mapped and the formation of secondary structure inferred. Here we cross-check ...

journal_title：Nature

authors： Bycroft M,Matouschek A,Kellis JT Jr,Serrano L,Fersht AR

更新日期：1990-08-02 00:00:00

abstract：:Aneuploidy, referring here to genome contents characterized by abnormal numbers of chromosomes, has been associated with developmental defects, cancer and adaptive evolution in experimental organisms. However, it remains unresolved how aneuploidy impacts gene expression and whether aneuploidy could directly bring abou...

journal_title：Nature

authors： Pavelka N,Rancati G,Zhu J,Bradford WD,Saraf A,Florens L,Sanderson BW,Hattem GL,Li R

更新日期：2010-11-11 00:00:00

abstract：:Microcrystals of the lipoprotein-phosphoprotein complex which are found in the oocytes of Xenopus laevis were examined using electron microscopy. Analysis of Fourier transforms of the images of the (010) and (001) projections showed the space group to be P2(1)22(1). Ten projections were combined to produce a map of th...

journal_title：Nature

authors： Ohlendorf DH,Wrenn RF,Banaszak LJ

更新日期：1978-03-02 00:00:00

abstract：:In the absence of extraneously added template, standard preparations of Q beta replicase spontaneously synthesize RNA in vitro, possibly as a result of RNA contamination. Using special enzyme purifications, Sumper and Luce presented evidence that self-replicating RNA not present ab initio can grow out of 'template-fre...

journal_title：Nature

authors： Biebricher CK,Eigen M,Luce R

更新日期：1986-05-01 00:00:00

abstract：:Self-reproduction is central to biological life for long-term sustainability and evolutionary adaptation. Although these traits would also be desirable in many engineered systems, the principles of self-reproduction have not been exploited in machine design. Here we create simple machines that act as autonomous modula...

journal_title：Nature

authors： Zykov V,Mytilinaios E,Adams B,Lipson H

更新日期：2005-05-12 00:00:00

abstract：:During the subduction of oceanic lithosphere, water is liberated from minerals by progressive dehydration reactions and is thought to be critical to several geologically important processes such as island-arc volcanism, intermediate-depth seismicity and chemical exchange between the subducting lithosphere and mantle. ...

journal_title：Nature

authors： Bina CR,Navrotsky A

更新日期：2000-12-14 00:00:00

abstract：:Ice flow along land-terminating margins of the Greenland Ice Sheet (GIS) varies considerably in response to fluctuating inputs of surface meltwater to the bed of the ice sheet. Such inputs lubricate the ice-bed interface, transiently speeding up the flow of ice. Greater melting results in faster ice motion during summ...

journal_title：Nature

authors： Tedstone AJ,Nienow PW,Gourmelen N,Dehecq A,Goldberg D,Hanna E

更新日期：2015-10-29 00:00:00

abstract：:We report the first atomic resolution structure of an animal virus, human rhinovirus 14. It is strikingly similar to known icosahedral plant RNA viruses. Four neutralizing immunogenic regions have been identified. These, and corresponding antigenic sequences of polio and foot-and-mouth disease viruses, reside on exter...

journal_title：Nature

authors： Rossmann MG,Arnold E,Erickson JW,Frankenberger EA,Griffith JP,Hecht HJ,Johnson JE,Kamer G,Luo M,Mosser AG

更新日期：1985-09-12 00:00:00

abstract：:Although cell adhesion to substrate must ultimately depend on 'sticking' by physical forces at the outer surface, we suggest that control is exercised through the 'grip' of the cytoskeleton. Our experiments indicate that grip can be relaxed by agents which release surface glycoproteins from some form of side-to-side o...

journal_title：Nature

authors： Rees DA,Lloyd CW,Thom D

更新日期：1977-05-12 00:00:00

abstract：:RNAs that contain specific high-affinity binding sites for small molecule ligands immobilized on a solid support are present at a frequency of roughly one in 10(10)-10(11) in pools of random sequence RNA molecules. Here we describe a new in vitro selection procedure designed to ensure the isolation of RNAs that bind t...

journal_title：Nature

authors： Sassanfar M,Szostak JW

更新日期：1993-08-05 00:00:00

abstract：:A list of authors and their affiliations appears at the end of the paper New-particle formation is a major contributor to urban smog1,2, but how it occurs in cities is often puzzling3. If the growth rates of urban particles are similar to those found in cleaner environments (1-10 nanometres per hour), then existing un...

journal_title：Nature

authors： Wang M,Kong W,Marten R,He XC,Chen D,Pfeifer J,Heitto A,Kontkanen J,Dada L,Kürten A,Yli-Juuti T,Manninen HE,Amanatidis S,Amorim A,Baalbaki R,Baccarini A,Bell DM,Bertozzi B,Bräkling S,Brilke S,Murillo LC,Chiu R,

更新日期：2020-05-01 00:00:00

abstract：:In the initiation of translation in eukaryotes, binding of the small ribosomal subunit to the messenger RNA results from recognition of the 5' cap structure (m7GpppX) of the mRNA by the cap-binding complex eIF4F. eIF4F is itself a three-subunit complex comprising the cap-binding protein eIF4E, eIF4A, an ATP-dependent ...

journal_title：Nature

authors： Craig AW,Haghighat A,Yu AT,Sonenberg N

更新日期：1998-04-02 00:00:00

abstract：:By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microe...

journal_title：Nature

authors： Minn AJ,Gupta GP,Siegel PM,Bos PD,Shu W,Giri DD,Viale A,Olshen AB,Gerald WL,Massagué J

更新日期：2005-07-28 00:00:00

abstract：:Current ideas about the dependence of neurons on target-derived growth factors were formulated on the basis of experiments involving neurons with projections to the periphery. Nerve growth factor (NGF) and recently identified members of the NGF family of neuronal growth factors, known as neurotrophins, are thought to ...

journal_title：Nature

authors： Yan Q,Elliott J,Snider WD

更新日期：1992-12-24 00:00:00

abstract：:Mammals owe part of their evolutionary success to the harmonious exchanges of information, energy and immunity between females and their offspring. This functional reciprocity is vital for the survival and normal development of infants, and for the inclusive fitness of parents. It is best seen in the intense exchanges...

journal_title：Nature

authors： Schaal B,Coureaud G,Langlois D,Giniès C,Sémon E,Perrier G

更新日期：2003-07-03 00:00:00

abstract：:Fas is a type-I membrane protein that transduces an apoptotic signal. Binding of Fas ligand or agonistic anti-Fas antibody to Fas kills the cells by apoptosis. Studies in the nematode Caenorhabditis elegans have suggested that proteases such as interleukin-1 beta-converting enzyme (ICE) or the product of the C. elegan...

journal_title：Nature

authors： Enari M,Hug H,Nagata S

更新日期：1995-05-04 00:00:00

abstract：:The ability to control the quantum state of a single electron spin in a quantum dot is at the heart of recent developments towards a scalable spin-based quantum computer. In combination with the recently demonstrated controlled exchange gate between two neighbouring spins, driven coherent single spin rotations would p...

journal_title：Nature

authors： Koppens FH,Buizert C,Tielrooij KJ,Vink IT,Nowack KC,Meunier T,Kouwenhoven LP,Vandersypen LM

更新日期：2006-08-17 00:00:00

abstract：:Three Hipparion trails, two from adults and one from a juvenile dating from about 3.5 Myr ago, have now been found in Laetoli. Comparison of the Hipparion footprints with a variety of imprints made by domestic horses showed that the animals moved with a running walk over the soft and slippery soil of Laetoli: in the a...

journal_title：Nature

authors： Renders E

更新日期：1984-03-08 00:00:00

abstract：:Haematopoietic stem cells drive blood production, but their population size and lifetime dynamics have not been quantified directly in humans. Here we identified 129,582 spontaneous, genome-wide somatic mutations in 140 single-cell-derived haematopoietic stem and progenitor colonies from a healthy 59-year-old man and ...

journal_title：Nature

authors： Lee-Six H,Øbro NF,Shepherd MS,Grossmann S,Dawson K,Belmonte M,Osborne RJ,Huntly BJP,Martincorena I,Anderson E,O'Neill L,Stratton MR,Laurenti E,Green AR,Kent DG,Campbell PJ

更新日期：2018-09-01 00:00:00

abstract：:Activity-induced changes in the efficacy of synaptic transmission between neurones are central to several prominent theories of learning. In both in vivo and in vitro preparations of the hippocampus, a conditioning high-frequency stimulus delivered to afferent fibres results in a long-term potentiation of synaptic tra...

journal_title：Nature

authors： Malinow R,Miller JP

更新日期：1986-04-10 00:00:00

abstract：:Histone post-translational modifications (PTMs) are associated with epigenetic states that form the basis for cell-type-specific gene expression1,2. Once established, histone PTMs can be maintained by positive feedback involving enzymes that recognize a pre-existing histone modification and catalyse the same modificat...

journal_title：Nature

authors： Yu R,Wang X,Moazed D

更新日期：2018-06-01 00:00:00

abstract：:Since the discovery of superconductivity in the high-transition-temperature (high-T(c)) copper oxides two decades ago, it has been firmly established that the CuO(2) plane is essential for superconductivity and gives rise to a host of other very unusual properties. A new family of superconductors with the general comp...

journal_title：Nature

authors： Chen TY,Tesanovic Z,Liu RH,Chen XH,Chien CL

更新日期：2008-06-26 00:00:00

abstract：:Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations are also poorly understood. Because RNA represents the direct out...

journal_title：Nature

authors： Djebali S,Davis CA,Merkel A,Dobin A,Lassmann T,Mortazavi A,Tanzer A,Lagarde J,Lin W,Schlesinger F,Xue C,Marinov GK,Khatun J,Williams BA,Zaleski C,Rozowsky J,Röder M,Kokocinski F,Abdelhamid RF,Alioto T,Antoshechkin

更新日期：2012-09-06 00:00:00