Landscape of transcription in human cells.

Abstract:

:Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations are also poorly understood. Because RNA represents the direct output of the genetic information encoded by genomes and a significant proportion of a cell's regulatory capabilities are focused on its synthesis, processing, transport, modification and translation, the generation of such a catalogue is crucial for understanding genome function. Here we report evidence that three-quarters of the human genome is capable of being transcribed, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs. These observations, taken together, prompt a redefinition of the concept of a gene.

journal_name

Nature

journal_title

Nature

authors

Djebali S,Davis CA,Merkel A,Dobin A,Lassmann T,Mortazavi A,Tanzer A,Lagarde J,Lin W,Schlesinger F,Xue C,Marinov GK,Khatun J,Williams BA,Zaleski C,Rozowsky J,Röder M,Kokocinski F,Abdelhamid RF,Alioto T,Antoshechkin

doi

10.1038/nature11233

subject

Has Abstract

pub_date

2012-09-06 00:00:00

pages

101-8

issue

7414

eissn

0028-0836

issn

1476-4687

pii

nature11233

journal_volume

489

pub_type

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