Abstract:
:Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous system. These cells have diverse roles in the maintenance of neurological function. In the embryo, the genetic mechanisms that underlie the specification of macroglial precursors in vivo appear strikingly similar to those that regulate the development of the diverse neuron types. The switch from producing neuronal to glial subtype-specific precursors can be modelled as an interplay between region-restricted components and temporal regulators that determine neurogenic or gliogenic phases of development, contributing to glial diversity. Gaining insight into the developmental genetics of macroglia has great potential to improve our understanding of a variety of neurological disorders in humans.
journal_name
Naturejournal_title
Natureauthors
Rowitch DH,Kriegstein ARdoi
10.1038/nature09611subject
Has Abstractpub_date
2010-11-11 00:00:00pages
214-22issue
7321eissn
0028-0836issn
1476-4687pii
nature09611journal_volume
468pub_type
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