Predominant use of a V alpha gene segment in mouse T-cell receptors for cytochrome c.

Abstract:

:The T-cell receptor is a cell surface heterodimer consisting of an alpha and a beta chain that binds foreign antigen in the context of a cell surface molecule encoded by the major histocompatibility complex (MHC), thus restricting the T-cell response to the surface of antigen presenting cells. The variable (V) domain of the receptor binds antigen and MHC molecules and is composed of distinct regions encoded by separate gene elements--variable (V alpha and V beta), diversity (D beta) and joining (J alpha and J beta)--rearranged and joined during T-cell differentiation to generate contiguous V alpha and V beta genes. T-helper cells, which facilitate T and B cell responses, bind antigen in the context of a class II MHC molecule. The helper T-cell response to cytochrome c in mice is a well-defined model for studying the T-cell response to restricted antigen and MHC determinants. Only mice expressing certain class II molecules can respond to this antigen (Ek alpha Ek beta, Ek alpha Eb beta, Ev alpha Ev beta and Ek alpha Es beta). Most T cells appear to recognize the C-terminal peptide of cytochrome c (residues 81-104 in pigeon cytochrome c). We have raised helper T cells to pigeon cytochrome c or its C-terminal peptide analogues in four different MHC congenic strains of mice encoding each of the four responding class II molecules. We have isolated and sequenced seven V alpha genes and six V beta genes and analysed seven additional helper T cells by Northern blot to compare the structure of the V alpha and V beta gene segments with their antigen and MHC specificities. We have added five examples taken from the literature. These data show that a single V alpha gene segment is responsible for a large part of the response of mice to cytochrome c but there is no simple correlation of MHC restriction with gene segment use.

journal_name

Nature

journal_title

Nature

authors

Winoto A,Urban JL,Lan NC,Goverman J,Hood L,Hansburg D

doi

10.1038/324679a0

subject

Has Abstract

pub_date

1986-12-18 00:00:00

pages

679-82

issue

6098

eissn

0028-0836

issn

1476-4687

journal_volume

324

pub_type

杂志文章

相关文献

NATURE文献大全
  • Visual synchrony affects binding and segmentation in perception.

    abstract::The visual system analyses information by decomposing complex objects into simple components (visual features) that are widely distributed across the cortex. When several objects are present simultaneously in the visual field, a mechanism is required to group (bind) together visual features that belong to each object ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/28166

    authors: Usher M,Donnelly N

    更新日期:1998-07-09 00:00:00

  • Proliferation of mature oligodendrocytes after trauma to the central nervous system.

    abstract::It has long been thought that mature oligodendrocytes in the adult mammalian central nervous system (CNS) are post-mitotic and are unable to proliferate in response to injury. The implications of this have been profound, because it has been suggested that this failure of oligodendrocytes to undergo mitosis is perhaps ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/308274a0

    authors: Ludwin SK

    更新日期:1984-03-15 00:00:00

  • Hybrid formation between African trypanosomes during cyclical transmission.

    abstract::Trypanosomes of the species Trypanosoma brucei reproduce primarily by binary fission, but the frequency of enzyme electrophoretic variants in natural populations of T. brucei has provided indirect evidence for the existence of a sexual cycle. These studies, coupled with studies of restriction fragment length polymorph...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/322173a0

    authors: Jenni L,Marti S,Schweizer J,Betschart B,Le Page RW,Wells JM,Tait A,Paindavoine P,Pays E,Steinert M

    更新日期:1986-07-10 00:00:00

  • A Mott insulator of fermionic atoms in an optical lattice.

    abstract::Strong interactions between electrons in a solid material can lead to surprising properties. A prime example is the Mott insulator, in which suppression of conductivity occurs as a result of interactions rather than a filled Bloch band. Proximity to the Mott insulating phase in fermionic systems is the origin of many ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature07244

    authors: Jördens R,Strohmaier N,Günter K,Moritz H,Esslinger T

    更新日期:2008-09-11 00:00:00

  • Molecular components of the B-cell antigen receptor complex of the IgM class.

    abstract::The antigen receptors on mature B lymphocytes are membrane-bound immunoglobulins of the IgM and IgD classes whose cross-linking by polyvalent antigens results in B-cell proliferation and differentiation. How these membrane-bound immunoglobulin chains, which lack a cytoplasmic tail, generate a cell activation signal is...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/343760a0

    authors: Hombach J,Tsubata T,Leclercq L,Stappert H,Reth M

    更新日期:1990-02-22 00:00:00

  • Author Correction: The wide-binary origin of (2014) MU69-like Kuiper belt contact binaries.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature

    pub_type: 已发布勘误

    doi:10.1038/s41586-020-2351-4

    authors: Grishin E,Malamud U,Perets HB,Wandel O,Schäfer CM

    更新日期:2020-06-01 00:00:00

  • Adenovirus E1A products suppress myogenic differentiation and inhibit transcription from muscle-specific promoters.

    abstract::The primary function of the adenovirus E1A-region genes is to activate other adenoviral genes during a permissive viral infection by modifying the host cell transcriptional apparatus. Host cell immortalization, or transformation by the whole adenoviral early region, presumably results as a consequence of these modific...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/332553a0

    authors: Webster KA,Muscat GE,Kedes L

    更新日期:1988-04-07 00:00:00

  • Vaccine protection against Zika virus from Brazil.

    abstract::Zika virus (ZIKV) is a flavivirus that is responsible for the current epidemic in Brazil and the Americas. ZIKV has been causally associated with fetal microcephaly, intrauterine growth restriction, and other birth defects in both humans and mice. The rapid development of a safe and effective ZIKV vaccine is a global ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature18952

    authors: Larocca RA,Abbink P,Peron JP,Zanotto PM,Iampietro MJ,Badamchi-Zadeh A,Boyd M,Ng'ang'a D,Kirilova M,Nityanandam R,Mercado NB,Li Z,Moseley ET,Bricault CA,Borducchi EN,Giglio PB,Jetton D,Neubauer G,Nkolola JP,Maxfield

    更新日期:2016-08-25 00:00:00

  • Correlative genetic variation in natural populations of cats, mice and men.

    abstract::The study of the extent and basis of gene-enzyme variation has long been a principal concern of population genetics. Numerous surveys have indicated considerable amounts of genetic variation detectable in natural populations, with few exceptions. The variances of average heterozygosities (H) between species and among ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/288580a0

    authors: O'Brien SJ,Gail MH,Levin DL

    更新日期:1980-12-11 00:00:00

  • Do animal personalities emerge?

    abstract::The evolution of animal personalities is a topic of primary importance in behavioural ecology. An intriguing empirical fact is the consistency of animal responses to repeated stresses or threats. Wolf et al. propose an evolutionary model to explain the emergence of consistent personalities. They show that a population...

    journal_title:Nature

    pub_type: 评论,杂志文章

    doi:10.1038/nature06743

    authors: Massol F,Crochet PA

    更新日期:2008-02-28 00:00:00

  • Observation of half-integer thermal Hall conductance.

    abstract::Topological states of matter are characterized by topological invariants, which are physical quantities whose values are quantized and do not depend on the details of the system (such as its shape, size and impurities). Of these quantities, the easiest to probe is the electrical Hall conductance, and fractional values...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-018-0184-1

    authors: Banerjee M,Heiblum M,Umansky V,Feldman DE,Oreg Y,Stern A

    更新日期:2018-07-01 00:00:00

  • Sub-piconewton force fluctuations of actomyosin in vitro.

    abstract::A new system has been developed for measuring the forces produced by a small number (less than 5-150) of myosin molecules interacting with a single actin filament in vitro. The technique can resolve forces of less than a piconewton and has a time resolution in the submillisecond range. It can thus detect fluctuations ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/352301a0

    authors: Ishijima A,Doi T,Sakurada K,Yanagida T

    更新日期:1991-07-25 00:00:00

  • Cloning and expression of apical membrane water channel of rat kidney collecting tubule.

    abstract::Concentrating urine is mandatory for most mammals to prevent water loss from the body. Concentrated urine is produced in response to vasopressin by the transepithelial recovery of water from the lumen of the kidney collecting tubule through highly water-permeable membranes. In this nephron segment, vasopressin regulat...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/361549a0

    authors: Fushimi K,Uchida S,Hara Y,Hirata Y,Marumo F,Sasaki S

    更新日期:1993-02-11 00:00:00

  • Identification of talin as a major cytoplasmic protein implicated in platelet activation.

    abstract::During platelet activation there is a major reorganization in the platelet cytoskeleton that accompanies a rapid change in platelet shape. Many of the events associated with activation are attributed to a rise in calcium concentration within the platelet cytoplasm. One direct consequence of the elevated calcium is the...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/317449a0

    authors: O'Halloran T,Beckerle MC,Burridge K

    更新日期:1985-10-03 00:00:00

  • TET2 promotes histone O-GlcNAcylation during gene transcription.

    abstract::Ten eleven translocation (TET) enzymes, including TET1, TET2 and TET3, convert 5-methylcytosine to 5-hydroxymethylcytosine and regulate gene transcription. However, the molecular mechanism by which TET family enzymes regulate gene transcription remains elusive. Using protein affinity purification, here we search for f...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11742

    authors: Chen Q,Chen Y,Bian C,Fujiki R,Yu X

    更新日期:2013-01-24 00:00:00

  • An intrinsic velocity-independent criterion for superfluid turbulence.

    abstract::Hydrodynamic flow in classical and quantum fluids can be either laminar or turbulent. Vorticity in turbulent flow is often modelled with vortex filaments. While this represents an idealization in classical fluids, vortices are topologically stable quantized objects in superfluids. Superfluid turbulence is therefore th...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature01880

    authors: Finne AP,Araki T,Blaauwgeers R,Eltsov VB,Kopnin NB,Krusius M,Skrbek L,Tsubota M,Volovik GE

    更新日期:2003-08-28 00:00:00

  • DNA interrogation by the CRISPR RNA-guided endonuclease Cas9.

    abstract::The clustered regularly interspaced short palindromic repeats (CRISPR)-associated enzyme Cas9 is an RNA-guided endonuclease that uses RNA-DNA base-pairing to target foreign DNA in bacteria. Cas9-guide RNA complexes are also effective genome engineering agents in animals and plants. Here we use single-molecule and bulk...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature13011

    authors: Sternberg SH,Redding S,Jinek M,Greene EC,Doudna JA

    更新日期:2014-03-06 00:00:00

  • Catalytic activation of β-arrestin by GPCRs.

    abstract::β-arrestins are critical regulator and transducer proteins for G-protein-coupled receptors (GPCRs). β-arrestin is widely believed to be activated by forming a stable and stoichiometric GPCR-β-arrestin scaffold complex, which requires and is driven by the phosphorylated tail of the GPCR. Here we demonstrate a distinct ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-018-0079-1

    authors: Eichel K,Jullié D,Barsi-Rhyne B,Latorraca NR,Masureel M,Sibarita JB,Dror RO,von Zastrow M

    更新日期:2018-05-01 00:00:00

  • Relationship between receptor and mammary tumour virus production after stimulation by glucocorticoid.

    abstract::A short exposure of primary cultures of mouse mammary tumour cells to glucocorticoids results in at least a three-fold stimulation of mammary tumour virus (MTV) production. Specific interaction of glucocorticoids with the cytoplasmic and nuclear receptors can also be demonstrated. The biological potency of various ste...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/262107a0

    authors: Shyamala G,Dickson C

    更新日期:1976-07-08 00:00:00

  • Ghrelin is a growth-hormone-releasing acylated peptide from stomach.

    abstract::Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary. They act through GHS-R, a G-protein-coupled receptor for which the ligand is unknown. Recent cloning of GHS-R strongly suggests that an endogenous ligand for the receptor does exist and...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/45230

    authors: Kojima M,Hosoda H,Date Y,Nakazato M,Matsuo H,Kangawa K

    更新日期:1999-12-09 00:00:00

  • Author Correction: Global land change from 1982 to 2016.

    abstract::In this Letter, errors in Supplementary Table 1 have been corrected. ...

    journal_title:Nature

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/s41586-018-0573-5

    authors: Song XP,Hansen MC,Stehman SV,Potapov PV,Tyukavina A,Vermote EF,Townshend JR

    更新日期:2018-11-01 00:00:00

  • Ant navigation: priming of visual route memories.

    abstract::Ants travelling to and fro between their nest and a foraging area may follow stereotyped foodward and homeward routes that are guided by different visual and directional memory sequences. Honeybees are known to fly a feeder-to-hive or hive-to-feeder vector according to whether or not they have recently fed--their feed...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/438302a

    authors: Harris RA,Hempel de Ibarra N,Graham P,Collett TS

    更新日期:2005-11-17 00:00:00

  • The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry.

    abstract::Chemokines are chemotactic cytokines that activate and direct the migration of leukocytes. There are two subfamilies, the CXC and the CC chemokines. We recently found that the CXC-chemokine stromal cell-derived factor-1 (SDF-1) is a highly efficacious lymphocyte chemoattractant. Chemokines act on responsive leukocyte ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/382829a0

    authors: Bleul CC,Farzan M,Choe H,Parolin C,Clark-Lewis I,Sodroski J,Springer TA

    更新日期:1996-08-29 00:00:00

  • Role of spectral detail in sound-source localization.

    abstract::Sounds heard over headphones are typically perceived inside the head (internalized), unlike real sound sources which are perceived outside the head (externalized). If the acoustical waveforms from a real sound source are reproduced precisely using headphones, auditory images are appropriately externalized and localize...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/25526

    authors: Kulkarni A,Colburn HS

    更新日期:1998-12-24 00:00:00

  • Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester.

    abstract::Although it has been proposed that the activation of T lymphocytes is mediated by an early rise in cytosolic calcium concentration, it has not been possible to mimic antigen- or mitogen-induced mouse lymphocyte activation by calcium ionophores that bypass receptor-mediated processes. There is now evidence from other s...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/313318a0

    authors: Truneh A,Albert F,Golstein P,Schmitt-Verhulst AM

    更新日期:1985-01-24 00:00:00

  • Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.

    abstract::Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of the disease. It may be possible to overcome these challenges by reprogramming primary cells from patients into induced pluripotent stem cell...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature10821

    authors: Israel MA,Yuan SH,Bardy C,Reyna SM,Mu Y,Herrera C,Hefferan MP,Van Gorp S,Nazor KL,Boscolo FS,Carson CT,Laurent LC,Marsala M,Gage FH,Remes AM,Koo EH,Goldstein LS

    更新日期:2012-01-25 00:00:00

  • Calcium signalling in the guidance of nerve growth by netrin-1.

    abstract::Pathfinding by growing axons in the developing nervous system is guided by diffusible or bound factors that attract or repel the axonal growth cone. The cytoplasmic signalling mechanisms that trigger the responses of the growth cone to guidance factors are mostly unknown. Previous studies have shown that the level and...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/47507

    authors: Hong K,Nishiyama M,Henley J,Tessier-Lavigne M,Poo M

    更新日期:2000-01-06 00:00:00

  • Are vertebrate exons scanned during splice-site selection?

    abstract::Pairwise recognition of splice sites as a result of a scanning mechanism is an attractive model to explain the coordination of vertebrate splicing. Such a mechanism would predict a polarity-of-site recognition in the scanned unit, but no evidence for a polarity gradient across introns has been found. We have suggested...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/360277a0

    authors: Niwa M,MacDonald CC,Berget SM

    更新日期:1992-11-19 00:00:00

  • Microconversion between murine H-2 genes integrated into yeast.

    abstract::Patchwork homology observed between divergent members of polymorphic multigene families is thought to reflect evolution by short-tract gene conversion (nonreciprocal recombination), although this mechanism cannot usually be confirmed in higher organisms. In contrast to meiotic conversions observed in laboratory yeast ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/347192a0

    authors: Wheeler CJ,Maloney D,Fogel S,Goodenow RS

    更新日期:1990-09-13 00:00:00

  • A global resource allocation strategy governs growth transition kinetics of Escherichia coli.

    abstract::A grand challenge of systems biology is to predict the kinetic responses of living systems to perturbations starting from the underlying molecular interactions. Changes in the nutrient environment have long been used to study regulation and adaptation phenomena in microorganisms and they remain a topic of active inves...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature24299

    authors: Erickson DW,Schink SJ,Patsalo V,Williamson JR,Gerland U,Hwa T

    更新日期:2017-11-02 00:00:00