Nucleosome mobilization catalysed by the yeast SWI/SNF complex.

abstract：:About one-third of the carbon dioxide (CO(2)) released into the atmosphere as a result of human activity has been absorbed by the oceans, where it partitions into the constituent ions of carbonic acid. This leads to ocean acidification, one of the major threats to marine ecosystems and particularly to calcifying organ...

journal_title：Nature

authors： Beaufort L,Probert I,de Garidel-Thoron T,Bendif EM,Ruiz-Pino D,Metzl N,Goyet C,Buchet N,Coupel P,Grelaud M,Rost B,Rickaby RE,de Vargas C

更新日期：2011-08-03 00:00:00

abstract：:An Amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Segel M,Neumann B,Hill MFE,Weber IP,Viscomi C,Zhao C,Young A,Agley CC,Thompson AJ,Gonzalez GA,Sharma A,Holmqvist S,Rowitch DH,Franze K,Franklin RJM,Chalut KJ

更新日期：2019-09-01 00:00:00

abstract：:It is known that glucose-induced depolarization of pancreatic B-cells is due to reduced membrane K+-permeability and is coupled to an increase in the rate of glycolysis, but there has been no direct evidence linking specific metabolic processes or products to the closing of membrane K+ channels. During patch-clamp stu...

journal_title：Nature

authors： Cook DL,Hales CN

更新日期：1984-09-20 00:00:00

abstract：:When a portrait is coarsely quantized into blocks, the block structure hides the face, although lower spatial frequencies of the original image sufficient by themselves for recognition are preserved. Recognition can be recovered by blurring the image, or otherwise attenuating the spurious higher spatial frequency comp...

journal_title：Nature

authors： Morrone MC,Burr DC,Ross J

更新日期：1983-09-15 00:00:00

abstract：:In infected cells, the RNA genomes of RNA tumour viruses are copied into DNA by a virus-encoded reverse transcriptase enzyme. This transfer of information from RNA into DNA was thought to be a unique feature of RNA tumour viruses, but recent results suggest it may be a more general strategy. Hepatitis B virus (HBV) ha...

journal_title：Nature

authors： Toh H,Hayashida H,Miyata T

更新日期：1983-10-27 00:00:00

abstract：:Transcription factors recognize specific genomic sequences to regulate complex gene-expression programs. Although it is well-established that transcription factors bind to specific DNA sequences using a combination of base readout and shape recognition, some fundamental aspects of protein-DNA binding remain poorly und...

journal_title：Nature

authors： Afek A,Shi H,Rangadurai A,Sahay H,Senitzki A,Xhani S,Fang M,Salinas R,Mielko Z,Pufall MA,Poon GMK,Haran TE,Schumacher MA,Al-Hashimi HM,Gordân R

更新日期：2020-11-01 00:00:00

abstract：:Networks of interacting proteins orchestrate the responses of living cells to a variety of external stimuli, but how sensitive is the functioning of these protein networks to variations in their biochemical parameters? One possibility is that to achieve appropriate function, the reaction rate constants and enzyme conc...

journal_title：Nature

authors： Alon U,Surette MG,Barkai N,Leibler S

更新日期：1999-01-14 00:00:00

abstract：:Deviations from the universal genetic code have been reported for several microorganisms. Termination codons are used for coding some amino acids in Paramecium, Mycoplasma or Tetrahymena, and in Escherichia coli, the UGA termination codon is used to code for selenocysteine. In mitochondria, the changes of sense codons...

journal_title：Nature

authors： Kawaguchi Y,Honda H,Taniguchi-Morimura J,Iwasaki S

更新日期：1989-09-14 00:00:00

abstract：:DNA lesions interfere with DNA and RNA polymerase activity. Cyclobutane pyrimidine dimers and photoproducts generated by ultraviolet irradiation cause stalling of RNA polymerase II, activation of transcription-coupled repair enzymes, and inhibition of RNA synthesis. During the S phase of the cell cycle, collision of r...

journal_title：Nature

authors： Kruhlak M,Crouch EE,Orlov M,Montaño C,Gorski SA,Nussenzweig A,Misteli T,Phair RD,Casellas R

更新日期：2007-06-07 00:00:00

abstract：:The discovery of the structure of DNA transformed biology profoundly, catalysing the sequencing of the human genome and engendering a new view of biology as an information science. Two features of DNA structure account for much of its remarkable impact on science: its digital nature and its complementarity, whereby on...

journal_title：Nature

authors： Hood L,Galas D

更新日期：2003-01-23 00:00:00

abstract：:The ras proto-oncogene, found in all eukaryotes so far examined, encode s a protein with guanine nucleotide-binding and GTPase activity. Gene disruption experiments in yeast indicate that ras is essential for cell growth. Anit-sense mutagenesis approaches suggest that this is also true for Dictyostelium. Most mutation...

journal_title：Nature

authors： Reymond CD,Gomer RH,Nellen W,Theibert A,Devreotes P,Firtel RA

更新日期：1986-09-25 00:00:00

abstract：:Betelgeuse, a nearby red supergiant, is a fast-moving star with a powerful stellar wind that drives a bow shock into its surroundings. This picture has been challenged by the discovery of a dense and almost static shell that is three times closer to the star than the bow shock and has been decelerated by some external...

journal_title：Nature

authors： Mackey J,Mohamed S,Gvaramadze VV,Kotak R,Langer N,Meyer DM,Moriya TJ,Neilson HR

更新日期：2014-08-21 00:00:00

abstract：:The colonization of a new habitat is a fundamental process in metapopulation biology, but it is difficult to study. The emigration of colonists from established populations might be induced by resource competition owing to high local population density. Migration distances are also important because they determine the...

journal_title：Nature

authors： Gaggiotti OE,Jones F,Lee WM,Amos W,Harwood J,Nichols RA

更新日期：2002-03-28 00:00:00

abstract：:In response to adenosine 5'-diphosphate, the P2Y1 receptor (P2Y1R) facilitates platelet aggregation, and thus serves as an important antithrombotic drug target. Here we report the crystal structures of the human P2Y1R in complex with a nucleotide antagonist MRS2500 at 2.7 Å resolution, and with a non-nucleotide antago...

journal_title：Nature

authors： Zhang D,Gao ZG,Zhang K,Kiselev E,Crane S,Wang J,Paoletta S,Yi C,Ma L,Zhang W,Han GW,Liu H,Cherezov V,Katritch V,Jiang H,Stevens RC,Jacobson KA,Zhao Q,Wu B

更新日期：2015-04-16 00:00:00

abstract：:The distribution, accumulation and circulation of oxygen and hydrogen in Earth's interior dictate the geochemical evolution of the hydrosphere, atmosphere and biosphere. The oxygen-rich atmosphere and iron-rich core represent two end-members of the oxygen-iron (O-Fe) system, overlapping with the entire pressure-temper...

journal_title：Nature

authors： Hu Q,Kim DY,Yang W,Yang L,Meng Y,Zhang L,Mao HK

更新日期：2016-06-09 00:00:00

abstract：:Within the substantia nigra, the dendrites of dopaminergic neurons that project to the striatum appear to play an active and nonclassical role in the physiology of the neuron in that they release transmitter and protein, but little is known of the factors controlling release of substances from these dendrites. In this...

journal_title：Nature

authors： Nedergaard S,Bolam JP,Greenfield SA

更新日期：1988-05-12 00:00:00

abstract：:Excitation-contraction coupling in skeletal muscle involves a voltage sensor in the plasma membrane which, in response to depolarization, causes an intracellular calcium-release channel to open. The skeletal isoform of the ryanodine receptor (RyR-1) functions as the Ca2+-release channel and the dihydropyridine recepto...

journal_title：Nature

authors： Nakai J,Dirksen RT,Nguyen HT,Pessah IN,Beam KG,Allen PD

更新日期：1996-03-07 00:00:00

abstract：:Cosmological models in which dark matter consists of cold elementary particles predict that the dark halo population should extend to masses many orders of magnitude below those at which galaxies can form1-3. Here we report a cosmological simulation of the formation of present-day haloes over the full range of observe...

journal_title：Nature

authors： Wang J,Bose S,Frenk CS,Gao L,Jenkins A,Springel V,White SDM

更新日期：2020-09-01 00:00:00

abstract：:The restriction of intermingling between specific cell populations is crucial for the maintenance of organized patterns during development. A striking example is the restriction of cell mixing between segments in the insect epidermis and the vertebrate hindbrain that may enable each segment to maintain a distinct iden...

journal_title：Nature

authors： Xu Q,Mellitzer G,Robinson V,Wilkinson DG

更新日期：1999-05-20 00:00:00

abstract：:The pathways that control insulin secretion and regulate pancreatic beta-cell mass are crucial in the development of diabetes mellitus. Maturity-onset diabetes of the young comprises a number of single-gene disorders affecting pancreatic beta-cell function, and the consequences of mutations in these genes are so serio...

journal_title：Nature

authors： Bell GI,Polonsky KS

更新日期：2001-12-13 00:00:00

abstract：:The enzyme cytochrome c nitrite reductase catalyses the six-electron reduction of nitrite to ammonia as one of the key steps in the biological nitrogen cycle, where it participates in the anaerobic energy metabolism of dissimilatory nitrate ammonification. Here we report on the crystal structure of this enzyme from th...

journal_title：Nature

authors： Einsle O,Messerschmidt A,Stach P,Bourenkov GP,Bartunik HD,Huber R,Kroneck PM

更新日期：1999-07-29 00:00:00

abstract：:Rous sarcoma virus (RSV) is an acutely oncogenic avian retrovirus which induces sarcomas in animals and transforms fibroblasts in cell culture. Genetic analysis indicates that the viral src gene (v-src) mediates neoplastic transformation. The product of v-src is a 60,000 molecular weight (MW) phosphoprotein (pp60v-src...

journal_title：Nature

authors： Simon MA,Kornberg TB,Bishop JM

更新日期：1983-04-28 00:00:00

abstract：:Infection by the human immunodeficiency virus (HIV) is initiated by the binding of its extracellular envelope glycoprotein, gp120, to the CD4 antigen on target cells. To map the residues of the HIV-1 glycoprotein that are critical for binding and to analyse the effects of binding on viral infectivity, we created 15 mu...

journal_title：Nature

authors： Cordonnier A,Montagnier L,Emerman M

更新日期：1989-08-17 00:00:00

abstract：:Brood parasitism, where a brood of the parasitic species is fostered by the parents of another species, is well known among birds. In most cases, such offspring show a complete reliance upon their host parents for food, protection and warmth until their independence. In other vertebrate groups, however, such total dep...

journal_title：Nature

authors： Sato T

更新日期：1986-09-04 00:00:00

abstract：:Continuous turnover of epithelia is ensured by the extensive self-renewal capacity of tissue-specific stem cells. Similarly, epithelial tumour maintenance relies on cancer stem cells (CSCs), which co-opt stem cell properties. For most tumours, the cellular origin of these CSCs and regulatory pathways essential for sus...

journal_title：Nature

authors： Malanchi I,Peinado H,Kassen D,Hussenet T,Metzger D,Chambon P,Huber M,Hohl D,Cano A,Birchmeier W,Huelsken J

更新日期：2008-04-03 00:00:00

abstract：:The delivery of therapeutic drugs to solid tumours may be impaired by structural and functional abnormalities in blood and lymphatic vessels. Here we provide evidence that proliferating cancer cells cause intratumour vessels to compress and collapse. By reducing this compressive mechanical force and opening vessels, c...

journal_title：Nature

authors： Padera TP,Stoll BR,Tooredman JB,Capen D,di Tomaso E,Jain RK

更新日期：2004-02-19 00:00:00

abstract：:DNA methylation has a profound impact on genome stability, transcription and development. Although enzymes that catalyse DNA methylation have been well characterized, those that are involved in methyl group removal have remained elusive, until recently. The transformative discovery that ten-eleven translocation (TET) ...

journal_title：Nature

authors： Kohli RM,Zhang Y

更新日期：2013-10-24 00:00:00

abstract：: ...

journal_title：Nature

authors： Maitra A

更新日期：2019-03-01 00:00:00

abstract：:The effect of anthropogenic aerosols on cloud droplet concentrations and radiative properties is the source of one of the largest uncertainties in the radiative forcing of climate over the industrial period. This uncertainty affects our ability to estimate how sensitive the climate is to greenhouse gas emissions. Here...

journal_title：Nature

authors： Carslaw KS,Lee LA,Reddington CL,Pringle KJ,Rap A,Forster PM,Mann GW,Spracklen DV,Woodhouse MT,Regayre LA,Pierce JR

更新日期：2013-11-07 00:00:00

abstract：:High biodiversity has been shown to enhance ecological stability on small spatial scales and over intervals of weeks to decades. It remains unclear, however, whether this diversity-stability relationship can be scaled up to regional scales, or to longer timescales. Without empirical validation at larger scales, the im...

journal_title：Nature

authors： Kiessling W

更新日期：2005-01-27 00:00:00