Transmission dynamics of HIV infection.

Abstract:

:Simple mathematical models of the transmission dynamics of human immunodeficiency virus help to clarify some of the essential relations between epidemiological factors, such as distributed incubation periods and heterogeneity in sexual activity, and the overall pattern of the AIDS epidemic. They also help to identify what kinds of epidemiological data are needed to make predictions of future trends.

journal_name

Nature

journal_title

Nature

authors

May RM,Anderson RM

doi

10.1038/326137a0

subject

Has Abstract

pub_date

1987-03-12 00:00:00

pages

137-42

issue

6109

eissn

0028-0836

issn

1476-4687

journal_volume

326

pub_type

杂志文章

相关文献

NATURE文献大全
  • Imprisoned academics, China's Moon lander and AI moral code.

    abstract:: ...

    journal_title:Nature

    pub_type: 新闻

    doi:10.1038/d41586-018-07667-5

    authors:

    更新日期:2018-12-01 00:00:00

  • Neuroscience in the era of functional genomics and systems biology.

    abstract::Advances in genetics and genomics have fuelled a revolution in discovery-based, or hypothesis-generating, research that provides a powerful complement to the more directly hypothesis-driven molecular, cellular and systems neuroscience. Genetic and functional genomic studies have already yielded important insights into...

    journal_title:Nature

    pub_type: 杂志文章,评审

    doi:10.1038/nature08537

    authors: Geschwind DH,Konopka G

    更新日期:2009-10-15 00:00:00

  • Millisecond activation of transducin in the cyclic nucleotide cascade of vision.

    abstract::Cyclic GMP has been implicated as a messenger molecule involved in visual transduction. Photoexcited rhodopsin (R*) binds to a multisubunit membrane protein called transducin (T) and stimulates the exchange of a bound GDP molecule for GTP. This leads to the release of the alpha-subunit of T with bound GTP (T alpha-GTP...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/311659a0

    authors: Vuong TM,Chabre M,Stryer L

    更新日期:1984-10-18 00:00:00

  • Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13.

    abstract::The maintenance of genome stability during mitosis is coordinated by the spindle assembly checkpoint (SAC) through its effector the mitotic checkpoint complex (MCC), an inhibitor of the anaphase-promoting complex (APC/C, also known as the cyclosome)1,2. Unattached kinetochores control MCC assembly by catalysing a chan...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-018-0281-1

    authors: Alfieri C,Chang L,Barford D

    更新日期:2018-07-01 00:00:00

  • Photoelectrochemical cells.

    abstract::Until now, photovoltaics--the conversion of sunlight to electrical power--has been dominated by solid-state junction devices, often made of silicon. But this dominance is now being challenged by the emergence of a new generation of photovoltaic cells, based, for example, on nanocrystalline materials and conducting pol...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35104607

    authors: Grätzel M

    更新日期:2001-11-15 00:00:00

  • Two disparate ligand-binding sites in the human P2Y1 receptor.

    abstract::In response to adenosine 5'-diphosphate, the P2Y1 receptor (P2Y1R) facilitates platelet aggregation, and thus serves as an important antithrombotic drug target. Here we report the crystal structures of the human P2Y1R in complex with a nucleotide antagonist MRS2500 at 2.7 Å resolution, and with a non-nucleotide antago...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature14287

    authors: Zhang D,Gao ZG,Zhang K,Kiselev E,Crane S,Wang J,Paoletta S,Yi C,Ma L,Zhang W,Han GW,Liu H,Cherezov V,Katritch V,Jiang H,Stevens RC,Jacobson KA,Zhao Q,Wu B

    更新日期:2015-04-16 00:00:00

  • The impact and recovery of asteroid 2008 TC(3).

    abstract::In the absence of a firm link between individual meteorites and their asteroidal parent bodies, asteroids are typically characterized only by their light reflection properties, and grouped accordingly into classes. On 6 October 2008, a small asteroid was discovered with a flat reflectance spectrum in the 554-995 nm wa...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature07920

    authors: Jenniskens P,Shaddad MH,Numan D,Elsir S,Kudoda AM,Zolensky ME,Le L,Robinson GA,Friedrich JM,Rumble D,Steele A,Chesley SR,Fitzsimmons A,Duddy S,Hsieh HH,Ramsay G,Brown PG,Edwards WN,Tagliaferri E,Boslough MB,Spaldi

    更新日期:2009-03-26 00:00:00

  • Reversing histone methylation.

    abstract::Histones package DNA, and post-translational modifications of histones can regulate access to DNA. Until recently, histone methylation-unlike all other histone modifications-was considered a permanent mark. The discovery of enzymes that reverse the methylation of lysines and arginines challenges our current thinking o...

    journal_title:Nature

    pub_type: 杂志文章,评审

    doi:10.1038/nature04048

    authors: Bannister AJ,Kouzarides T

    更新日期:2005-08-25 00:00:00

  • Single-species models for many-species food webs.

    abstract::Most species live in species-rich food webs; yet, for a century, most mathematical models for population dynamics have included only one or two species. We ask whether such models are relevant to the real world. Two-species population models of an interacting consumer and resource collapse to one-species dynamics when...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/417541a

    authors: Murdoch WW,Kendall BE,Nisbet RM,Briggs CJ,McCauley E,Bolser R

    更新日期:2002-05-30 00:00:00

  • An unexpected specialization for horizontal disparity in primate primary visual cortex.

    abstract::The horizontal separation of the eyes means that objects nearer or farther than the fixation point project to different locations on the two retinae, differing principally in their horizontal coordinates (horizontal binocular disparity). Disparity-selective neurons have generally been studied with disparities applied ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature00909

    authors: Cumming BG

    更新日期:2002-08-08 00:00:00

  • A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity.

    abstract::Humoral immune responses to immunization and infection and susceptibilities to antibody-mediated autoimmunity are generally lower in males1-3. However, the mechanisms underlying such sexual dimorphism are not well understood. Here we show that there are intrinsic differences between the B cells that produce germinal c...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-019-1873-0

    authors: Zhao R,Chen X,Ma W,Zhang J,Guo J,Zhong X,Yao J,Sun J,Rubinfien J,Zhou X,Wang J,Qi H

    更新日期:2020-01-01 00:00:00

  • Synthesizing arbitrary quantum states in a superconducting resonator.

    abstract::The superposition principle is a fundamental tenet of quantum mechanics. It allows a quantum system to be 'in two places at the same time', because the quantum state of a physical system can simultaneously include measurably different physical states. The preparation and use of such superposed states forms the basis o...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature08005

    authors: Hofheinz M,Wang H,Ansmann M,Bialczak RC,Lucero E,Neeley M,O'Connell AD,Sank D,Wenner J,Martinis JM,Cleland AN

    更新日期:2009-05-28 00:00:00

  • Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.

    abstract::Cancer cells hijack and remodel existing metabolic pathways for their benefit. Argininosuccinate synthase (ASS1) is a urea cycle enzyme that is essential in the conversion of nitrogen from ammonia and aspartate to urea. A decrease in nitrogen flux through ASS1 in the liver causes the urea cycle disorder citrullinaemia...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature15529

    authors: Rabinovich S,Adler L,Yizhak K,Sarver A,Silberman A,Agron S,Stettner N,Sun Q,Brandis A,Helbling D,Korman S,Itzkovitz S,Dimmock D,Ulitsky I,Nagamani SC,Ruppin E,Erez A

    更新日期:2015-11-19 00:00:00

  • Elimination of action potentials blocks the structural development of retinogeniculate synapses.

    abstract::Although the influence of electrical activity on neural development has been studied extensively, experiments have only recently focused on the role of activity in the development of the mammalian central nervous system (CNS). Using tetrodotoxin (TTX) to abolish sodium-mediated action potentials, studies on the visual...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/323156a0

    authors: Kalil RE,Dubin MW,Scott G,Stark LA

    更新日期:1986-09-11 00:00:00

  • Tobacco smoking and somatic mutations in human bronchial epithelium.

    abstract::Tobacco smoking causes lung cancer1-3, a process that is driven by more than 60 carcinogens in cigarette smoke that directly damage and mutate DNA4,5. The profound effects of tobacco on the genome of lung cancer cells are well-documented6-10, but equivalent data for normal bronchial cells are lacking. Here we sequence...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-020-1961-1

    authors: Yoshida K,Gowers KHC,Lee-Six H,Chandrasekharan DP,Coorens T,Maughan EF,Beal K,Menzies A,Millar FR,Anderson E,Clarke SE,Pennycuick A,Thakrar RM,Butler CR,Kakiuchi N,Hirano T,Hynds RE,Stratton MR,Martincorena I,Janes

    更新日期:2020-02-01 00:00:00

  • Direct observation of a transverse periodicity in collagen fibrils.

    abstract::Collagen fibrils have been extensively studied by electron microscopy, but only scant evidence has yet been obtained about their transverse structure. A transverse pediodicity of about 40 or 80 A might be expected if the microfibril model (until recently the common preference) is correct, but little direct evidence fo...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/288410a0

    authors: Squire JM,Freundlich A

    更新日期:1980-11-27 00:00:00

  • Simple mathematical models with very complicated dynamics.

    abstract::First-order difference equations arise in many contexts in the biological, economic and social sciences. Such equations, even though simple and deterministic, can exhibit a surprising array of dynamical behaviour, from stable points, to a bifurcating hiearchy of stable cycles, to apparently random fluctuations. There ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/261459a0

    authors: May RM

    更新日期:1976-06-10 00:00:00

  • A per-cent-level determination of the nucleon axial coupling from quantum chromodynamics.

    abstract::The axial coupling of the nucleon, gA, is the strength of its coupling to the weak axial current of the standard model of particle physics, in much the same way as the electric charge is the strength of the coupling to the electromagnetic current. This axial coupling dictates the rate at which neutrons decay to proton...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-018-0161-8

    authors: Chang CC,Nicholson AN,Rinaldi E,Berkowitz E,Garron N,Brantley DA,Monge-Camacho H,Monahan CJ,Bouchard C,Clark MA,Joó B,Kurth T,Orginos K,Vranas P,Walker-Loud A

    更新日期:2018-06-01 00:00:00

  • Secretion requires a cytoplasmically disposed sulphydryl of the RER membrane.

    abstract::The capacity of the rough endoplasmic reticulum (RER) membrane of eukaryotic cells in translocate nascent presecretory proteins from the cytosol to the intracisternal space is preserved on cell fractionation and can be assayed in vitro. Two attempts to characterize this translocation activity have been reported. Warre...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/286174a0

    authors: Jackson RC,Walter P,Blobel G

    更新日期:1980-07-10 00:00:00

  • Piezoelectric and pyroelectric effects induced by interface polar symmetry.

    abstract::Interfaces in heterostructures have been a key point of interest in condensed-matter physics for decades owing to a plethora of distinctive phenomena-such as rectification1, the photovoltaic effect2, the quantum Hall effect3 and high-temperature superconductivity4-and their critical roles in present-day technical devi...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-020-2602-4

    authors: Yang MM,Luo ZD,Mi Z,Zhao J,E SP,Alexe M

    更新日期:2020-08-01 00:00:00

  • Firing patterns of motor units in normal rats.

    abstract::Skeletal muscles consist of motor units which may differ considerably in contractile properties and types of usage. Some units participate mainly in relatively rare, quick movements and contract rapidly and are easily fatigued (type FF); others contribute to the maintenance of posture and hence contract slowly and are...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/314164a0

    authors: Hennig R,Lømo T

    更新日期:1985-03-14 00:00:00

  • Elevated UV-B radiation reduces genome stability in plants.

    abstract::Long-term depletion of the stratospheric ozone layer contributes to an increase in terrestrial solar ultraviolet-B radiation. This has deleterious effects on living organisms, such as DNA damage. When exposed to elevated ultraviolet-B radiation (UV-B; 280-315 nm), plants display a wide variety of physiological and mor...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35017595

    authors: Ries G,Heller W,Puchta H,Sandermann H,Seidlitz HK,Hohn B

    更新日期:2000-07-06 00:00:00

  • Identification of a novel translation factor necessary for the incorporation of selenocysteine into protein.

    abstract::During the biosynthesis of selenoproteins in both prokaryotes and eukaryotes, selenocysteine is cotranslationally incorporated into the nascent polypeptide chain through a process directed by a UGA codon that normally functions as a stop codon. Recently, four genes have been identified whose products are required for ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/342453a0

    authors: Forchhammer K,Leinfelder W,Böck A

    更新日期:1989-11-23 00:00:00

  • Comments on the big-bang.

    abstract::Is the big-bang hot, warm or cold? And are galactic masses determined by the interplay of gravitational and strong interactions in the very early universe? ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/228258a0

    authors: Harrison ER

    更新日期:1970-10-17 00:00:00

  • Models for metal ion function in carbonic anhydrase.

    abstract::A model catalyst is described which has properties in common with carbonic anhydrase. The model demonstrates the availability of a mechanism, previously only hypothetical, for the action of the enzyme. It also shows, however, that this mechanism alone is not adequate to produce the high activity of the enzyme. ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/258677a0

    authors: Woolley P

    更新日期:1975-12-25 00:00:00

  • Inflammation in atherosclerosis.

    abstract::Abundant data link hypercholesterolaemia to atherogenesis. However, only recently have we appreciated that inflammatory mechanisms couple dyslipidaemia to atheroma formation. Leukocyte recruitment and expression of pro-inflammatory cytokines characterize early atherogenesis, and malfunction of inflammatory mediators m...

    journal_title:Nature

    pub_type: 杂志文章,评审

    doi:10.1038/nature01323

    authors: Libby P

    更新日期:2002-12-19 00:00:00

  • Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3' consensus sequence AAUAAA.

    abstract::A single U leads to G transversion in the 3' consensus sequence AAUAAA of the adenovirus early region 1A gene was constructed and the effect of this mutation on processing of the 3' end of the nuclear early region 1A RNAs was analysed. The results demonstrate that the intact AAUAAA is not required for RNA polyadenylat...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/305600a0

    authors: Montell C,Fisher EF,Caruthers MH,Berk AJ

    更新日期:1983-10-13 00:00:00

  • Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart.

    abstract::Understanding cellular response to environmental stress has broad implications for human disease. AMP-activated protein kinase (AMPK) orchestrates the regulation of energy-generating and -consuming pathways, and protects the heart against ischaemic injury and apoptosis. A role for circulating hormones such as adiponec...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature06504

    authors: Miller EJ,Li J,Leng L,McDonald C,Atsumi T,Bucala R,Young LH

    更新日期:2008-01-31 00:00:00

  • Practical quantum key distribution protocol without monitoring signal disturbance.

    abstract::Quantum cryptography exploits the fundamental laws of quantum mechanics to provide a secure way to exchange private information. Such an exchange requires a common random bit sequence, called a key, to be shared secretly between the sender and the receiver. The basic idea behind quantum key distribution (QKD) has wide...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature13303

    authors: Sasaki T,Yamamoto Y,Koashi M

    更新日期:2014-05-22 00:00:00

  • Density dependence explains tree species abundance and diversity in tropical forests.

    abstract::The recurrent patterns in the commonness and rarity of species in ecological communities--the relative species abundance--have puzzled ecologists for more than half a century. Here we show that the framework of the current neutral theory in ecology can easily be generalized to incorporate symmetric density dependence....

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature04030

    authors: Volkov I,Banavar JR,He F,Hubbell SP,Maritan A

    更新日期:2005-12-01 00:00:00