Abstract:
:A combination of biochemistry in animal cell-free systems and genetics in yeast is revealing the molecular machinery of the secretory pathway of eukaryotes. Transporting vesicles have a simple coat structure and employ a general mechanism for fusion that is conserved in evolution.
journal_name
Naturejournal_title
Natureauthors
Rothman JE,Orci Ldoi
10.1038/355409a0subject
Has Abstractpub_date
1992-01-30 00:00:00pages
409-15issue
6359eissn
0028-0836issn
1476-4687journal_volume
355pub_type
杂志文章,评审相关文献
NATURE文献大全abstract::Dynamic access to genetic information is central to organismal development and environmental response. Consequently, genomic processes must be regulated by mechanisms that alter genome function relatively rapidly. Conventional chromatin immunoprecipitation (ChIP) experiments measure transcription factor occupancy, but...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10985
更新日期:2012-04-11 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/d41586-019-00673-1
更新日期:2019-02-01 00:00:00
abstract::Alternative splicing of pre-messenger RNAs diversifies gene products in eukaryotes and is guided by factors that enable spliceosomes to recognize particular splice sites. Here we report that alternative splicing of Saccharomyces cerevisiae SRC1 pre-mRNA is promoted by the conserved ubiquitin-like protein Hub1. Structu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10143
更新日期:2011-05-25 00:00:00
abstract::The presence of large Northern Hemisphere ice sheets and reduced greenhouse gas concentrations during the Last Glacial Maximum fundamentally altered global ocean-atmosphere climate dynamics. Model simulations and palaeoclimate records suggest that glacial boundary conditions affected the El Niño-Southern Oscillation, ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature24669
更新日期:2018-02-15 00:00:00
abstract::The interrelationships between major living vertebrate, and even chordate, groups are now reasonably well resolved thanks to a large amount of generally congruent data derived from molecular sequences, anatomy and physiology. But fossils provide unexpected combinations of characters that help us to understand how the ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature14437
更新日期:2015-04-23 00:00:00
abstract::Interfaces in heterostructures have been a key point of interest in condensed-matter physics for decades owing to a plethora of distinctive phenomena-such as rectification1, the photovoltaic effect2, the quantum Hall effect3 and high-temperature superconductivity4-and their critical roles in present-day technical devi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2602-4
更新日期:2020-08-01 00:00:00
abstract::Extracellular signalling by the purine nucleotide ATP has long been associated with sensory function. In the periphery, ATP mediates nociception, mechanosensitivity, thermal sensitivity and O2 chemosensitivity. These processes share a common mechanism that involves the release of ATP to excite afferent fibres via acti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03690
更新日期:2005-07-07 00:00:00
abstract::A hybrid gene was constructed between the beta-lactamase gene of plasmid pBR322 and the cloned coding sequence for rat growth hormone. This gene is expressed in bacteria and growth hormone sequences are detectable by immunological methods. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/276795a0
更新日期:1978-12-21 00:00:00
abstract::RecBCD enzyme is a processive DNA helicase and nuclease that participates in the repair of chromosomal DNA through homologous recombination. We have visualized directly the movement of individual RecBCD enzymes on single molecules of double-stranded DNA (dsDNA). Detection involves the optical trapping of solitary, flu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35053131
更新日期:2001-01-18 00:00:00
abstract::Scrapie and related animal and human disorders are neurodegenerative diseases characterized by the formation of a modified, partly proteinase-resistant protein (PrP) of the host, which tends to aggregate as amyloid fibrils and accumulate in the brain of infected individuals. There is a general consensus that the patho...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/356598a0
更新日期:1992-04-16 00:00:00
abstract::During lymphocyte development, cellular proliferation and positive and negative selection events ensure the production of T and B lymphocytes bearing highly diverse, but self-tolerant, repertoires of antigen receptors. These processes are initiated when engagement of growth-factor receptors, or the T and B lymphocyte ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/374474a0
更新日期:1995-03-30 00:00:00
abstract::Tumour suppressor genes (TSGs) inhibiting normal cellular growth are frequently silenced epigenetically in cancer. DNA methylation is commonly associated with TSG silencing, yet mutations in the DNA methylation initiation and recognition machinery in carcinogenesis are unknown. An intriguing possible mechanism for gen...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06468
更新日期:2008-01-10 00:00:00
abstract::We describe here a new view of primary visual cortex (V1) based on measurements of neural responses in V1 to patterns called 'illusory contours' (Fig. 1a, b). Detection of an object's boundary contours is a fundamental visual task. Boundary contours are defined by discontinuities not only in luminance and colour, but ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/365550a0
更新日期:1993-10-07 00:00:00
abstract::The well known trade-off between hardness and toughness (resistance to fracture) makes simultaneous improvement of both properties challenging, especially in diamond. The hardness of diamond can be increased through nanostructuring strategies1,2, among which the formation of high-density nanoscale twins - crystalline ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2361-2
更新日期:2020-06-01 00:00:00
abstract::Fusion of myeloma cells and B lymphocytes to form hybridomas which produce monoclonal antibodies has been a major advance, but the poor efficiency and randomness of viral or polyethylene glycol fusion techniques generally gives poor yields of specific, high affinity antibodies. High voltage electrical fields with diel...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/310792a0
更新日期:1984-08-30 00:00:00
abstract::Cation-selective P2X receptor channels were first described in sensory neurons where they are important for primary afferent neurotransmission and nociception. Here we report the cloning of a complementary DNA (P2X3) from rat dorsal root ganglia that had properties dissimilar to those of sensory neurons. We also found...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/377432a0
更新日期:1995-10-05 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 面试
doi:10.1038/d41586-018-07047-z
更新日期:2018-10-01 00:00:00
abstract::The exceptionally broad species diversity of vascular plant genera in east Asian temperate forests, compared with their sister taxa in North America, has been attributed to the greater climatic diversity of east Asia, combined with opportunities for allopatric speciation afforded by repeated fragmentation and coalesce...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35093166
更新日期:2001-09-13 00:00:00
abstract::On infection of their host, temperate viruses that infect bacteria (bacteriophages; hereafter referred to as phages) enter either a lytic or a lysogenic cycle. The former results in lysis of bacterial cells and phage release (resulting in horizontal transmission), whereas lysogeny is characterized by the integration o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-1936-2
更新日期:2020-02-01 00:00:00
abstract::T cells recognize foreign proteins as peptides bound to self molecules encoded by the major histocompatibility complex (MHC). The kinetics of interaction between purified class II MHC molecules and peptides is unusual, in that the rate of association is very slow, but once formed, the complexes are extremely stable. T...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/342800a0
更新日期:1989-12-14 00:00:00
abstract::It has been established that many eukaryotic mRNAs contain poly(adenylic acid) tracts at their 3'-termini. The polyadenylation of mRNA occurs post-transcriptionally in the nucleus as a rapid, initial addition of 100-200 adenylate residues to the pre-mRNA (ref. 1). Subsequently, a slower chain extension (6-8 bases) of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/267178a0
更新日期:1977-05-12 00:00:00
abstract::DNA replication in eukaryotes is strictly regulated by several mechanisms. A central step in this replication is the assembly of the heterohexameric minichromosome maintenance (MCM2-7) helicase complex at replication origins during G1 phase as an inactive double hexamer. Here, using cryo-electron microscopy, we report...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14685
更新日期:2015-08-13 00:00:00
abstract::Thrombosis--localized clotting of the blood--can occur in the arterial or the venous circulation and has a major medical impact. Acute arterial thrombosis is the proximal cause of most cases of myocardial infarction (heart attack) and of about 80% of strokes, collectively the most common cause of death in the develope...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature06797
更新日期:2008-02-21 00:00:00
abstract::Lymphocyte-specific tyrosine protein kinase p56lck is physically associated with CD4 and CD8 T-cell surface molecules, suggesting that it may transduce CD4/CD8-triggered tyrosine phosphorylation signals during antigen stimulation. Indeed, antibody-mediated aggregation of CD4 (to mimic interaction with its ligand, majo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/350062a0
更新日期:1991-03-07 00:00:00
abstract::IgE and its receptors are believed to have evolved as a mechanism to protect mammals against parasites. But other and intrinsically innocuous antigens can subvert this system to provoke an allergic response. For human populations in industrialized countries, allergy and asthma now represent a far greater threat than p...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/366421a0
更新日期:1993-12-02 00:00:00
abstract::Through their functional diversification, distinct lineages of CD4(+) T cells can act to either drive or constrain immune-mediated pathology. Transcription factors are critical in the generation of cellular diversity, and negative regulators antagonistic to alternate fates often act in conjunction with positive regula...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12199
更新日期:2013-06-27 00:00:00
abstract::Evolutionary relationships among the eight major lineages of Mollusca have remained unresolved despite their diversity and importance. Previous investigations of molluscan phylogeny, based primarily on nuclear ribosomal gene sequences or morphological data, have been unsuccessful at elucidating these relationships. Re...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10382
更新日期:2011-09-04 00:00:00
abstract::Cell adhesions to the extracellular matrix (ECM) are necessary for morphogenesis, immunity and wound healing. Focal adhesions are multifunctional organelles that mediate cell-ECM adhesion, force transmission, cytoskeletal regulation and signalling. Focal adhesions consist of a complex network of trans-plasma-membrane ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09621
更新日期:2010-11-25 00:00:00
abstract::In this Article, in Fig. 1a, the 5' and 3' labels were reversed in the DNA sequence, and Fig. 4 was missing panel labels a-e. These errors have been corrected online. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1343-8
更新日期:2019-07-01 00:00:00
abstract::Rac signalling to actin -- a pathway that is thought to be mediated by the protein Scar/WAVE (WASP (Wiskott-Aldrich syndrome protein)-family verprolin homologous protein -- has a principal role in cell motility. In an analogous pathway, direct interaction of Cdc42 with the related protein N-WASP stimulates actin polym...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00859
更新日期:2002-08-15 00:00:00