20S cyclosome complex formation and proteolytic activity inhibited by the cAMP/PKA pathway.

abstract：:The tropical forests of Borneo and Amazonia may each contain more tree species diversity in half a square kilometre than do all the temperate forests of Europe, North America, and Asia combined. Biologists have long been fascinated by this disparity, using it to investigate potential drivers of biodiversity. Latitudin...

journal_title：Nature

authors： Usinowicz J,Chang-Yang CH,Chen YY,Clark JS,Fletcher C,Garwood NC,Hao Z,Johnstone J,Lin Y,Metz MR,Masaki T,Nakashizuka T,Sun IF,Valencia R,Wang Y,Zimmerman JK,Ives AR,Wright SJ

更新日期：2017-10-05 00:00:00

abstract：:Systems of colour vision are normally identical in all members of a species, but a single design may not be adequate for species living in a diverse range of light environments. Here we show that in the mantis shrimp Haptosquilla trispinosa, which occupies a range of depths in the ocean, long-wavelength colour recepto...

journal_title：Nature

authors： Cronin TW,Caldwell RL,Marshall J

更新日期：2001-05-31 00:00:00

abstract：:As key executers of biological functions, the activity and abundance of proteins are subjected to extensive regulation. Deciphering the genetic architecture underlying this regulation is critical for understanding cellular signalling events and responses to environmental cues. Using random mutagenesis in haploid human...

journal_title：Nature

authors： Brockmann M,Blomen VA,Nieuwenhuis J,Stickel E,Raaben M,Bleijerveld OB,Altelaar AFM,Jae LT,Brummelkamp TR

更新日期：2017-06-08 00:00:00

abstract：:Phenylketonuria (PKU) is an autosomal recessive human genetic disorder caused by a deficiency of hepatic phenylalanine hydroxylase (PAH, phenylalanine 4-monooxygenase, EC 1.14.16.1). PKU is a common inborn error of amino-acid metabolism in caucasian populations and approximately 1 in 50 individuals are carriers of a P...

journal_title：Nature

authors： DiLella AG,Marvit J,Brayton K,Woo SL

更新日期：1987-05-28 00:00:00

abstract：:Initial studies of somatically acquired mutations in immunoglobulin V regions from hybridomas and myelomas that are not derived from joining aberrations, suggested a controlled and specific hypermutation process, because spontaneous mutation rates observed for other genes are extremely low. Some evidence for the idea ...

journal_title：Nature

authors： O'Brien RL,Brinster RL,Storb U

更新日期：1987-03-26 00:00:00

abstract：:The CTF/NF-I group of cellular DNA binding proteins recognizes the sequence GCCAAT and is implicated in eukaryotic transcription as well as DNA replication. Molecular analysis of human CTF/NF-I complementary DNA clones reveals multiple messenger RNA species containing alternative coding regions, apparently as a result...

journal_title：Nature

authors： Santoro C,Mermod N,Andrews PC,Tjian R

更新日期：1988-07-21 00:00:00

abstract：:On infection of their host, temperate viruses that infect bacteria (bacteriophages; hereafter referred to as phages) enter either a lytic or a lysogenic cycle. The former results in lysis of bacterial cells and phage release (resulting in horizontal transmission), whereas lysogeny is characterized by the integration o...

journal_title：Nature

authors： Rollie C,Chevallereau A,Watson BNJ,Chyou TY,Fradet O,McLeod I,Fineran PC,Brown CM,Gandon S,Westra ER

更新日期：2020-02-01 00:00:00

abstract：:Lignin is a complex polymer of phenylpropanoid subunits. It is an essential component of woody tissue, to which it imparts structural rigidity. Lignin is remarkably resistant to degradation by most microbes; nevertheless, a few species of white-rot fungi are able to catalyse its oxidation to CO2. Its biodegradation is...

journal_title：Nature

authors： Tien M,Tu CP

更新日期：1987-04-02 00:00:00

abstract：:Yeasts, which have been a component of the human diet for at least 7,000 years, possess an elaborate cell wall α-mannan. The influence of yeast mannan on the ecology of the human microbiota is unknown. Here we show that yeast α-mannan is a viable food source for the Gram-negative bacterium Bacteroides thetaiotaomicron...

journal_title：Nature

authors： Cuskin F,Lowe EC,Temple MJ,Zhu Y,Cameron E,Pudlo NA,Porter NT,Urs K,Thompson AJ,Cartmell A,Rogowski A,Hamilton BS,Chen R,Tolbert TJ,Piens K,Bracke D,Vervecken W,Hakki Z,Speciale G,Munōz-Munōz JL,Day A,Peña MJ,

更新日期：2015-01-08 00:00:00

abstract：:Secretory-protein translocation into the endoplasmic reticulum (ER) is thought to be catalysed by integral membrane proteins. Genetic selections uncovered three Saccharomyces cerevisiae genes (SEC61, SEC62 and SEC63), mutations in which block import of precursor proteins into the ER lumen in vivo and in vitro. The DNA...

journal_title：Nature

authors： Deshaies RJ,Sanders SL,Feldheim DA,Schekman R

更新日期：1991-02-28 00:00:00

abstract：:Pluto's tenuous nitrogen atmosphere was first detected by the imprint left on the light curve of a star that was occulted by the planet in 1985 (ref. 1), and studied more extensively during a second occultation event in 1988 (refs 2-6). These events are, however, quite rare and Pluto's atmosphere remains poorly unders...

journal_title：Nature

authors： Sicardy B,Widemann T,Lellouch E,Veillet C,Cuillandre JC,Colas F,Roques F,Beisker W,Kretlow M,Lagrange AM,Gendron E,Lacombe F,Lecacheux J,Birnbaum C,Fienga A,Leyrat C,Maury A,Raynaud E,Renner S,Schultheis M,Brooks

更新日期：2003-07-10 00:00:00

abstract：:An evolutionary view of ageing suggests that mortality may be due to an energy-saving strategy of reduced error regulation in somatic cells. This supports Orgel's 'error catastrophe' hypothesis and offers a new basis for the study of normal and abnormal ageing syndromes and of apparently immortal transformed cell line...

journal_title：Nature

authors： Kirkwood TB

更新日期：1977-11-24 00:00:00

abstract：:Many voltage-dependent K+ channels open when the membrane is depolarized and then rapidly close by a process called inactivation. Neurons use inactivating K+ channels to modulate their firing frequency. In Shaker-type K+ channels, the inactivation gate, which is responsible for the closing of the channel, is formed by...

journal_title：Nature

authors： Zhou M,Morais-Cabral JH,Mann S,MacKinnon R

更新日期：2001-06-07 00:00:00

abstract：:A long-standing goal of artificial intelligence is an algorithm that learns, tabula rasa, superhuman proficiency in challenging domains. Recently, AlphaGo became the first program to defeat a world champion in the game of Go. The tree search in AlphaGo evaluated positions and selected moves using deep neural networks....

journal_title：Nature

authors： Silver D,Schrittwieser J,Simonyan K,Antonoglou I,Huang A,Guez A,Hubert T,Baker L,Lai M,Bolton A,Chen Y,Lillicrap T,Hui F,Sifre L,van den Driessche G,Graepel T,Hassabis D

更新日期：2017-10-18 00:00:00

abstract：:Although individuals age and die with time, an animal species can continue indefinitely, because of its immortal germ-cell lineage. How the germline avoids transmitting damage from one generation to the next remains a fundamental question in biology. Here we identify a lysosomal switch that enhances germline proteosta...

journal_title：Nature

authors： Bohnert KA,Kenyon C

更新日期：2017-11-30 00:00:00

abstract：:Some beetles in the Namib Desert collect drinking water from fog-laden wind on their backs. We show here that these large droplets form by virtue of the insect's bumpy surface, which consists of alternating hydrophobic, wax-coated and hydrophilic, non-waxy regions. The design of this fog-collecting structure can be re...

journal_title：Nature

authors： Parker AR,Lawrence CR

更新日期：2001-11-01 00:00:00

abstract：:The gut of healthy human neonates is usually devoid of viruses at birth, but quickly becomes colonized, which-in some cases-leads to gastrointestinal disorders1-4. Here we show that the assembly of the viral community in neonates takes place in distinct steps. Fluorescent staining of virus-like particles purified from...

journal_title：Nature

authors： Liang G,Zhao C,Zhang H,Mattei L,Sherrill-Mix S,Bittinger K,Kessler LR,Wu GD,Baldassano RN,DeRusso P,Ford E,Elovitz MA,Kelly MS,Patel MZ,Mazhani T,Gerber JS,Kelly A,Zemel BS,Bushman FD

更新日期：2020-05-01 00:00:00

abstract：:The extreme resistance of bacterial endospores to heat may result from dehydration of the central protoplast brought about and maintained by osmotic activity of expanded electronegative peptidoglycan polymer, and positively charged counterions associated with it, in the surrounding cortex. The cortex may thus act as a...

journal_title：Nature

authors： Gould GW,Dring GJ

更新日期：1975-12-04 00:00:00

abstract：:Cyclin-dependent kinase 5 (Cdk5) and its neuron-specific regulator p35 are essential for neuronal migration and for the laminar configuration of the cerebral cortex. In addition, p35/Cdk5 kinase concentrates at the leading edges of axonal growth cones and regulates neurite outgrowth in cortical neurons in culture. The...

journal_title：Nature

authors： Nikolic M,Chou MM,Lu W,Mayer BJ,Tsai LH

更新日期：1998-09-10 00:00:00

abstract：:Galactic cosmic rays (CRs) are widely believed to be accelerated by shock waves associated with the expansion of supernova ejecta into the interstellar medium. A key issue in this long-standing conjecture is a theoretical prediction that the interstellar magnetic field can be substantially amplified at the shock of a ...

journal_title：Nature

authors： Uchiyama Y,Aharonian FA,Tanaka T,Takahashi T,Maeda Y

更新日期：2007-10-04 00:00:00

abstract：:For unknown reasons, autoimmune diseases such as type 1 diabetes develop after prolonged periods of inflammation of mononuclear cells in target tissues. Here we show that progression of pancreatic islet inflammation to overt diabetes in nonobese diabetic (NOD) mice is driven by the 'avidity maturation' of a prevailing...

journal_title：Nature

authors： Amrani A,Verdaguer J,Serra P,Tafuro S,Tan R,Santamaria P

更新日期：2000-08-17 00:00:00

abstract：:Numerous post-translational modifications of histones have been described in organisms ranging from yeast to humans. Growing evidence for dynamic regulation of these modifications, position- and modification-specific protein interactions, and biochemical crosstalk between modifications has strengthened the 'histone co...

journal_title：Nature

authors： McGinty RK,Kim J,Chatterjee C,Roeder RG,Muir TW

更新日期：2008-06-05 00:00:00

abstract：:Perfusion chromatography is a technique based on fluid dynamics for reducing stagnant mobile phase mass transfer in liquid chromatography. This is achieved by using supports with large pores that allow mobile phase to flow through particles. ...

journal_title：Nature

authors： Regnier FE

更新日期：1991-04-18 00:00:00

abstract：:Animal microRNAs (miRNAs) regulate gene expression by inhibiting translation and/or by inducing degradation of target messenger RNAs. It is unknown how much translational control is exerted by miRNAs on a genome-wide scale. We used a new proteomic approach to measure changes in synthesis of several thousand proteins i...

journal_title：Nature

authors： Selbach M,Schwanhäusser B,Thierfelder N,Fang Z,Khanin R,Rajewsky N

更新日期：2008-09-04 00:00:00

abstract：:Growth of basal cell carcinomas (BCCs) requires high levels of hedgehog (HH) signalling through the transcription factor GLI. Although inhibitors of membrane protein smoothened (SMO) effectively suppress HH signalling, early tumour resistance illustrates the need for additional downstream targets for therapy. Here we ...

journal_title：Nature

authors： Atwood SX,Li M,Lee A,Tang JY,Oro AE

更新日期：2013-02-28 00:00:00

abstract：:Adenylyl cyclase is the prototypical second messenger generator. Nearly all of the eight cloned adenylyl cyclases are regulated by one or other arm of the phospholipase C pathway. Functional and ultrastructural investigations have shown that adenylyl cyclases are intimately associated with sites of calcium ion entry i...

journal_title：Nature

authors： Cooper DM,Mons N,Karpen JW

更新日期：1995-03-30 00:00:00

abstract：:The inhibitory activity associated with myelin is a major obstacle for successful axon regeneration in the adult mammalian central nervous system (CNS). In addition to myelin-associated glycoprotein (MAG) and Nogo-A, available evidence suggests the existence of additional inhibitors in CNS myelin. We show here that a ...

journal_title：Nature

authors： Wang KC,Koprivica V,Kim JA,Sivasankaran R,Guo Y,Neve RL,He Z

更新日期：2002-06-27 00:00:00

abstract：:Heat is fundamental to power generation and many industrial processes, and is most useful at high temperatures because it can be converted more efficiently to other types of energy. However, efficient transportation, storage and conversion of heat at extreme temperatures (more than about 1,300 kelvin) is impractical f...

journal_title：Nature

authors： Amy C,Budenstein D,Bagepalli M,England D,DeAngelis F,Wilk G,Jarrett C,Kelsall C,Hirschey J,Wen H,Chavan A,Gilleland B,Yuan C,Chueh WC,Sandhage KH,Kawajiri Y,Henry A

更新日期：2017-10-11 00:00:00

abstract：:Histamine secretion from mast cells may be inhibited by elevated intracellular levels of cyclic AMP and by several anti-allergic drugs. These compounds are claimed to act directly on the calcium-gating mechanism activated by the anaphylactic reaction, preventing influx of Ca2+ from the external environment and so bloc...

journal_title：Nature

authors： Ennis M,Truneh A,White JR,Pearce FL

更新日期：1981-01-15 00:00:00

abstract：:The idea that natural selection on genes might be detected using only a single genome has been put forward by Plotkin and colleagues, who present a method that they claim can detect selection without the need for comparative data and which, if correct, would confer greater power of analysis with less information. Here...

journal_title：Nature

authors： Hahn MW,Mezey JG,Begun DJ,Gillespie JH,Kern AD,Langley CH,Moyle LC

更新日期：2005-01-20 00:00:00