Water capture by a desert beetle.

abstract：:During the evolution of sea urchins, a transfer RNA gene lost its tRNA function and became part of a protein-coding gene. This functional loss of a tRNA with specificity for one group of leucine codons (CUN, where N is any base) was accompanied by the gain of a new tRNA with that specificity. The new tRNA gene for CUN...

journal_title：Nature

authors： Cantatore P,Gadaleta MN,Roberti M,Saccone C,Wilson AC

更新日期：1987-10-29 00:00:00

abstract：:Positron emission tomography (PET) measurements of brain blood flow were used to monitor changes in the human primary and secondary somatosensory cortices during the period when somatosensory stimuli were expected. In anticipation of either focal or innocuous touching, or localized, painful shocks, blood flow decrease...

journal_title：Nature

authors： Drevets WC,Burton H,Videen TO,Snyder AZ,Simpson JR Jr,Raichle ME

更新日期：1995-01-19 00:00:00

abstract：:Cutaneous melanoma is a type of cancer with an inherent potential for lymph node colonization, which is generally preceded by neolymphangiogenesis. However, sentinel lymph node removal does not necessarily extend the overall survival of patients with melanoma. Moreover, lymphatic vessels collapse and become dysfunctio...

journal_title：Nature

authors： Olmeda D,Cerezo-Wallis D,Riveiro-Falkenbach E,Pennacchi PC,Contreras-Alcalde M,Ibarz N,Cifdaloz M,Catena X,Calvo TG,Cañón E,Alonso-Curbelo D,Suarez J,Osterloh L,Graña O,Mulero F,Megías D,Cañamero M,Martínez-Torrecuadrad

更新日期：2017-06-28 00:00:00

abstract：:A large impact by a comet or meteorite releases an enormous amount of energy, which evaporates, melts and fractures the surrounding rocks. Distinctive features of such impacts are 'shatter cones', deformed rocks characterized by hierarchical striated features. Although such features have been used for decades as unequ...

journal_title：Nature

authors： Sagy A,Reches Z,Fineberg J

更新日期：2002-07-18 00:00:00

abstract：:It is thought that immunity depends on naive CD4 T cells that proliferate in response to microbial antigens, differentiate into memory cells that produce anti-microbial lymphokines, and migrate to sites of infection. Here we use immunohistology to enumerate individual naive CD4 T cells, specific for a model antigen, i...

journal_title：Nature

authors： Reinhardt RL,Khoruts A,Merica R,Zell T,Jenkins MK

更新日期：2001-03-01 00:00:00

abstract：:Viruses are the most abundant biological organisms of the world's oceans. Viral infections are a substantial source of mortality in a range of organisms-including autotrophic and heterotrophic plankton-but their impact on the deep ocean and benthic biosphere is completely unknown. Here we report that viral production ...

journal_title：Nature

authors： Danovaro R,Dell'Anno A,Corinaldesi C,Magagnini M,Noble R,Tamburini C,Weinbauer M

更新日期：2008-08-28 00:00:00

abstract：:Stable maintenance of gene regulatory programs is essential for normal function in multicellular organisms. Epigenetic mechanisms, and DNA methylation in particular, are hypothesized to facilitate such maintenance by creating cellular memory that can be written during embryonic development and then guide cell-type-spe...

journal_title：Nature

authors： Shipony Z,Mukamel Z,Cohen NM,Landan G,Chomsky E,Zeliger SR,Fried YC,Ainbinder E,Friedman N,Tanay A

更新日期：2014-09-04 00:00:00

abstract：:The appendage primordia of Drosophila are subdivided into compartments by the localized expression of transcription factors. Interaction between cells in adjacent compartments establishes organizing centres responsible for generating spatial pattern and promoting cell proliferation in the developing appendages. Locali...

journal_title：Nature

authors： Diaz-Benjumea FJ,Cohen B,Cohen SM

更新日期：1994-11-10 00:00:00

abstract：:Ligand-gated ion channels are multi-subunit complexes where each subunit-type is encoded by several related genes. Heterologous expression of any one of the neuronal nicotinic acetylcholine receptors (nAChR) alpha-type subunits, either alone or with any beta-type subunit, typically yields functional nAChR channels. A ...

journal_title：Nature

authors： Ramirez-Latorre J,Yu CR,Qu X,Perin F,Karlin A,Role L

更新日期：1996-03-28 00:00:00

abstract：:Calcium permeability of basophil and mast cell membranes is stimulated on allergen binding to its specific membrane-bound IgE. This entry of Ca2+ ions into the cell triggers the degranulation and secretion process. Disodium cromoglycate (cromolyn DSCG), the disodium salt of 1,3-bis(-2-carboxychromon-5-yloxy)-2-hydroxy...

journal_title：Nature

authors： Mazurek N,Berger G,Pecht I

更新日期：1980-08-14 00:00:00

abstract：:SAMHD1, an analogue of the murine interferon (IFN)-γ-induced gene Mg11 (ref. 1), has recently been identified as a human immunodeficiency virus-1 (HIV-1) restriction factor that blocks early-stage virus replication in dendritic and other myeloid cells and is the target of the lentiviral protein Vpx, which can relieve ...

journal_title：Nature

authors： Goldstone DC,Ennis-Adeniran V,Hedden JJ,Groom HC,Rice GI,Christodoulou E,Walker PA,Kelly G,Haire LF,Yap MW,de Carvalho LP,Stoye JP,Crow YJ,Taylor IA,Webb M

更新日期：2011-11-06 00:00:00

abstract：:Apolipoprotein B (apo B) is crucial for the transport of cholesterol in humans. It is a large secretory protein that mediates the uptake of low-density lipoproteins and renders several forms of lipid droplets soluble in the blood. The binding of lipid by apo B also prevents this hydrophobic protein from precipitating ...

journal_title：Nature

authors： Chuck SL,Yao Z,Blackhart BD,McCarthy BJ,Lingappa VR

更新日期：1990-07-26 00:00:00

abstract：:Transmissible spongiform encephalopathies are associated with accumulation of PrP(Sc), a conformer of a cellular protein called PrP(C). PrP(Sc) is thought to replicate by imparting its conformation onto PrP(C) (ref. 1), yet conformational discrimination between PrP(C) and PrP(Sc) has remained elusive. Because depositi...

journal_title：Nature

authors： Fischer MB,Roeckl C,Parizek P,Schwarz HP,Aguzzi A

更新日期：2000-11-23 00:00:00

abstract：:N-methyl-d-aspartate (NMDA) receptors (NMDARs) are a major class of excitatory neurotransmitter receptors in the central nervous system. They form glutamate-gated ion channels that are highly permeable to calcium and mediate activity-dependent synaptic plasticity. NMDAR dysfunction is implicated in multiple brain diso...

journal_title：Nature

authors： Gielen M,Siegler Retchless B,Mony L,Johnson JW,Paoletti P

更新日期：2009-06-04 00:00:00

abstract：: ...

journal_title：Nature

authors： Cyranoski D

更新日期：2019-02-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Gewin V

更新日期：2018-10-01 00:00:00

abstract：:Cas9 is an RNA-guided DNA endonuclease that targets foreign DNA for destruction as part of a bacterial adaptive immune system mediated by clustered regularly interspaced short palindromic repeats (CRISPR). Together with single-guide RNAs, Cas9 also functions as a powerful genome engineering tool in plants and animals,...

journal_title：Nature

authors： Sternberg SH,LaFrance B,Kaplan M,Doudna JA

更新日期：2015-11-05 00:00:00

abstract：:At one time the synthetic chemist's last resort, reactions catalysed by transition metals are now the preferred method for synthesizing many types of organic molecule. A recent success in this type of catalysis is the discovery of reactions that form bonds between carbon and heteroatoms (such as nitrogen, oxygen, sulp...

journal_title：Nature

authors： Hartwig JF

更新日期：2008-09-18 00:00:00

abstract：:A putative growth hormone receptor from rabbit liver and the growth hormone binding protein from rabbit serum have the same amino-terminal amino-acid sequence, indicating that the binding protein corresponds to the extracellular hormone-binding domain of the liver receptor. The complete amino-acid sequences derived fr...

journal_title：Nature

authors： Leung DW,Spencer SA,Cachianes G,Hammonds RG,Collins C,Henzel WJ,Barnard R,Waters MJ,Wood WI

更新日期：1987-12-10 00:00:00

abstract：:The human gene for the hepatic enzyme phenylalanine hydroxylase has been cloned and used to analyse the phenylalanine hydroxylase locus in the human genome. The detection of polymorphisms in this locus by several restriction enzymes has allowed feasibility studies of prenatal diagnosis of classical phenylketonuria and...

journal_title：Nature

authors： Woo SL,Lidsky AS,Güttler F,Chandra T,Robson KJ

更新日期：1983-11-10 00:00:00

abstract：:The pseudogap is a partial gap in the electronic density of states that opens in the normal (non-superconducting) state of cuprate superconductors and whose origin is a long-standing puzzle. Its connection to the Mott insulator phase at low doping (hole concentration, p) remains ambiguous and its relation to the charg...

journal_title：Nature

authors： Badoux S,Tabis W,Laliberté F,Grissonnanche G,Vignolle B,Vignolles D,Béard J,Bonn DA,Hardy WN,Liang R,Doiron-Leyraud N,Taillefer L,Proust C

更新日期：2016-03-10 00:00:00

abstract：:Excitatory synaptic transmission in the central nervous system is mediated primarily by the release of glutamate from presynaptic terminals onto postsynaptic channels gated by N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors. The myriad intracellular responses arisi...

journal_title：Nature

authors： Wang Y,Small DL,Stanimirovic DB,Morley P,Durkin JP

更新日期：1997-10-02 00:00:00

abstract：:Low-resolution intensity spectra of Earth's atmosphere obtained from space reveal strong signatures of life ('biosignatures'), such as molecular oxygen and methane with abundances far from chemical equilibrium, as well as the presence of a 'red edge' (a sharp increase of albedo for wavelengths longer than 700 nm) caus...

journal_title：Nature

authors： Sterzik MF,Bagnulo S,Palle E

更新日期：2012-02-29 00:00:00

abstract：:The protein HLA-E is a non-classical major histocompatibility complex (MHC) molecule of limited sequence variability. Its expression on the cell surface is regulated by the binding of peptides derived from the signal sequence of some other MHC class I molecules. Here we report the identification of ligands for HLA-E. ...

journal_title：Nature

authors： Braud VM,Allan DS,O'Callaghan CA,Söderström K,D'Andrea A,Ogg GS,Lazetic S,Young NT,Bell JI,Phillips JH,Lanier LL,McMichael AJ

更新日期：1998-02-19 00:00:00

abstract：:The debate over human origins has focused on two competing theories. The single African origin model holds that anatomically modern Homo sapiens evolved in Africa 100,000-200,000 years ago. Members of this population migrated out of Africa, replacing archaic human groups through Asia and Europe, with racial differenti...

journal_title：Nature

authors： Waddle DM

更新日期：1994-03-31 00:00:00

abstract：:Retroviral integration is catalysed by a tetramer of integrase (IN) assembled on viral DNA ends in a stable complex, known as the intasome. How the intasome interfaces with chromosomal DNA, which exists in the form of nucleosomal arrays, is currently unknown. Here we show that the prototype foamy virus (PFV) intasome ...

journal_title：Nature

authors： Maskell DP,Renault L,Serrao E,Lesbats P,Matadeen R,Hare S,Lindemann D,Engelman AN,Costa A,Cherepanov P

更新日期：2015-07-16 00:00:00

abstract：:Endocytosis has long been thought of as simply a way for cells to internalize nutrients and membrane-associated molecules. But an explosive growth in knowledge has given a new dimension to our understanding of this process. It now seems that endocytosis is a master organizer of signalling circuits, with one of its mai...

journal_title：Nature

authors： Scita G,Di Fiore PP

更新日期：2010-01-28 00:00:00

abstract：:Mutations in the Schizosaccharomyces pombe cdc8 gene impair cytokinesis. Here we clone cdc8+ and find that it encodes a novel tropomyosin. Gene disruption results in lethal arrest of the cell cycle, but spore germination, cell growth, DNA replication and mitosis are all unaffected. Haploid cdc8 gene disruptants are re...

journal_title：Nature

authors： Balasubramanian MK,Helfman DM,Hemmingsen SM

更新日期：1992-11-05 00:00:00

abstract：:Collections in early Middle Miocene deposits at Pasalar in Turkey have yielded a very rich fauna. Included in this are two hominoid species referred here to Sivapithecus darwini (Abel) 1902 and Ramapithecus wickeri (Leakey) 1962. These are both more primitive morphologically and earlier in time than other species of t...

journal_title：Nature

authors： Andrews P,Tobien H

更新日期：1977-08-25 00:00:00

abstract：:The ability to pattern surfaces on a microscopic length scale is of importance for technological applications such as the fabrication of microelectronic circuits and digital storage media. Devices fabricated entirely from polymers are now available, opening up the possibility of adapting polymer processing technologie...

journal_title：Nature

authors： Higgins AM,Jones RA

更新日期：2000-03-30 00:00:00