Abstract:
:The CTF/NF-I group of cellular DNA binding proteins recognizes the sequence GCCAAT and is implicated in eukaryotic transcription as well as DNA replication. Molecular analysis of human CTF/NF-I complementary DNA clones reveals multiple messenger RNA species containing alternative coding regions, apparently as a result of differential splicing. Expression and functional analysis establish that individual gene products can bind to GCCAAT recognition sites and serve both as promoter-selective transcriptional activators and as initiation factors for DNA replication.
journal_name
Naturejournal_title
Natureauthors
Santoro C,Mermod N,Andrews PC,Tjian Rdoi
10.1038/334218a0subject
Has Abstractpub_date
1988-07-21 00:00:00pages
218-24issue
6179eissn
0028-0836issn
1476-4687journal_volume
334pub_type
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