Tissue ablation by a free-electron laser tuned to the amide II band.

abstract：:The ability to repair or promote regeneration within the adult human brain has been envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors and cell transplants designed to rescue or replace a specific population of neurons, and the results have largely been disappointing. New a...

journal_title：Nature

authors： Barker RA,Götz M,Parmar M

更新日期：2018-05-01 00:00:00

abstract：:Cosmological models in which dark matter consists of cold elementary particles predict that the dark halo population should extend to masses many orders of magnitude below those at which galaxies can form1-3. Here we report a cosmological simulation of the formation of present-day haloes over the full range of observe...

journal_title：Nature

authors： Wang J,Bose S,Frenk CS,Gao L,Jenkins A,Springel V,White SDM

更新日期：2020-09-01 00:00:00

abstract：:The respiratory organs of terrestrial insects consist of tracheal tubes with external spiracular valves that control gas exchange. Despite their relatively high metabolic rate, many insects have highly discontinuous patterns of gas exchange, including long periods when the spiracles are fully closed. Two explanations ...

journal_title：Nature

authors： Hetz SK,Bradley TJ

更新日期：2005-02-03 00:00:00

abstract：:Individual mammals have the capacity to express at least one million distinct antigen binding specificities, implying a high degree of structural heterogeneity in the variable heavy and light chain (VH and VL) portions of the antibody molecules. Studies of higher vertebrate species suggest that this heterogeneity is c...

journal_title：Nature

authors： Mäkelä O,Litman GW

更新日期：1980-10-16 00:00:00

abstract：:State-of-the-art optical clocks1 achieve precisions of 10-18 or better using ensembles of atoms in optical lattices2,3 or individual ions in radio-frequency traps4,5. Promising candidates for use in atomic clocks are highly charged ions6 (HCIs) and nuclear transitions7, which are largely insensitive to external pertur...

journal_title：Nature

authors： Schüssler RX,Bekker H,Braß M,Cakir H,Crespo López-Urrutia JR,Door M,Filianin P,Harman Z,Haverkort MW,Huang WJ,Indelicato P,Keitel CH,König CM,Kromer K,Müller M,Novikov YN,Rischka A,Schweiger C,Sturm S,Ulmer S,Elis

更新日期：2020-05-01 00:00:00

abstract：:Using numerical simulation, Holmström et al. proposed a plausible alternative explanation of the observed Lyman-alpha absorption that was seen during the transit of HD 209458b (ref. 2). They conclude that radiation pressure alone cannot explain the observations and that a peculiar stellar wind is needed. Here we show ...

journal_title：Nature

authors： Lecavelier des Etangs A,Vidal-Madjar A,Désert JM

更新日期：2008-11-13 00:00:00

abstract：:Retroviral integration is catalysed by a tetramer of integrase (IN) assembled on viral DNA ends in a stable complex, known as the intasome. How the intasome interfaces with chromosomal DNA, which exists in the form of nucleosomal arrays, is currently unknown. Here we show that the prototype foamy virus (PFV) intasome ...

journal_title：Nature

authors： Maskell DP,Renault L,Serrao E,Lesbats P,Matadeen R,Hare S,Lindemann D,Engelman AN,Costa A,Cherepanov P

更新日期：2015-07-16 00:00:00

abstract：:Non-small-cell lung cancer is the leading cause of cancer-related death worldwide. Chemotherapies such as the topoisomerase II (TopoII) inhibitor etoposide effectively reduce disease in a minority of patients with this cancer; therefore, alternative drug targets, including epigenetic enzymes, are under consideration f...

journal_title：Nature

authors： Fillmore CM,Xu C,Desai PT,Berry JM,Rowbotham SP,Lin YJ,Zhang H,Marquez VE,Hammerman PS,Wong KK,Kim CF

更新日期：2015-04-09 00:00:00

abstract：:In the Methods section of this Article, 'greater than' should have been 'less than' in the sentence 'Putative regions of clustered rearrangements were identified as having an average inter-rearrangement distance that was at least 10 times greater than the whole-genome average for the individual sample. '. The Article ...

journal_title：Nature

authors： Nik-Zainal S,Davies H,Staaf J,Ramakrishna M,Glodzik D,Zou X,Martincorena I,Alexandrov LB,Martin S,Wedge DC,Van Loo P,Ju YS,Smid M,Brinkman AB,Morganella S,Aure MR,Lingjærde OC,Langerød A,Ringnér M,Ahn SM,Boyault S

更新日期：2019-02-01 00:00:00

abstract：:Analytical tools that have spatial resolution at the nanometre scale are indispensable for the life and physical sciences. It is desirable that these tools also permit elemental and chemical identification on a scale of 10 nm or less, with large penetration depths. A variety of techniques in X-ray imaging are currentl...

journal_title：Nature

authors： Chao W,Harteneck BD,Liddle JA,Anderson EH,Attwood DT

更新日期：2005-06-30 00:00:00

abstract：:Homologous recombination is a molecular process that has multiple important roles in DNA metabolism, both for DNA repair and genetic variation in all forms of life. Generally, homologous recombination involves the exchange of genetic information between two identical or nearly identical DNA molecules; however, homolog...

journal_title：Nature

authors： Keskin H,Shen Y,Huang F,Patel M,Yang T,Ashley K,Mazin AV,Storici F

更新日期：2014-11-20 00:00:00

abstract：:For hundreds of years, scientists have tracked the changing appearance of Mars, first by hand drawings and later by photographs. Because of this historical record, many classical albedo patterns have long been known to shift in appearance over time. Decadal variations of the martian surface albedo are generally attrib...

journal_title：Nature

authors： Fenton LK,Geissler PE,Haberle RM

更新日期：2007-04-05 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV, also known as human herpesvirus 8, or HHV 8) is a virus that is consistently present in Kaposi's sarcoma and in primary-effusion (body-cavity-based) lymphomas, malignancies that occur frequently, but not exclusively, in AIDS patients. KSHV is a gamma herpesvirus with homo...

journal_title：Nature

authors： Arvanitakis L,Geras-Raaka E,Varma A,Gershengorn MC,Cesarman E

更新日期：1997-01-23 00:00:00

abstract：:Foreign protein antigens must be broken down within endosomes or lysosomes to generate suitable peptides that will form complexes with class II major histocompatibility complex molecules for presentation to T cells. However, it is not known which proteases are required for antigen processing. To investigate this, we e...

journal_title：Nature

authors： Manoury B,Hewitt EW,Morrice N,Dando PM,Barrett AJ,Watts C

更新日期：1998-12-17 00:00:00

abstract：:Obesity has become more prevalent in most developed countries over the past few decades, and is increasingly recognized as a major risk factor for several common types of cancer. As the worldwide obesity epidemic has shown no signs of abating, better understanding of the mechanisms underlying obesity-associated cancer...

journal_title：Nature

authors： Yoshimoto S,Loo TM,Atarashi K,Kanda H,Sato S,Oyadomari S,Iwakura Y,Oshima K,Morita H,Hattori M,Honda K,Ishikawa Y,Hara E,Ohtani N

更新日期：2013-07-04 00:00:00

abstract：:Anti-inflammatory glucocorticoids inhibit prostaglandin (PG) biosynthesis by preventing arachidonic acid release from phospholipids rather than inhibiting the cyclooxygenase. As in other cells, this steroid action depends on receptor occupation and de novo protein/RNA biosynthesis. We have previously shown in guinea p...

journal_title：Nature

authors： Blackwell GJ,Carnuccio R,Di Rosa M,Flower RJ,Parente L,Persico P

更新日期：1980-09-11 00:00:00

abstract：:Certain bacteria promote the formation of ice in super-cooled water by means of ice nucleators which contain a unique protein associated with the cell membrane. Ice nucleators in general are believed to act by mimicking the structure of an ice crystal surface, thus imposing an ice-like arrangement on the water molecul...

journal_title：Nature

authors： Parody-Morreale A,Murphy KP,Di Cera E,Fall R,DeVries AL,Gill SJ

更新日期：1988-06-23 00:00:00

abstract：:In Fig. 1b of this Article, a U was inadvertently inserted after G15 in the D loop. The original Article has not been corrected. ...

journal_title：Nature

authors： Naganuma M,Sekine SI,Chong YE,Guo M,Yang XL,Gamper H,Hou YM,Schimmel P,Yokoyama S

更新日期：2018-12-01 00:00:00

abstract：:In Fig. 6a of this Article, the two dots corresponding to Cidea and S100b were erroneously moved to the top left of the volcano plot; this figure has been corrected online.An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Zeng X,Ye M,Resch JM,Jedrychowski MP,Hu B,Lowell BB,Ginty DD,Spiegelman BM

更新日期：2019-06-01 00:00:00

abstract：:XX female mammals undergo transcriptional silencing of most genes on one of their two X chromosomes to equalize X-linked gene dosage with XY males in a process referred to as X-chromosome inactivation (XCI). XCI is an example of epigenetic regulation. Once enacted in individual cells of the early female embryo, XCI is...

journal_title：Nature

authors： Kalantry S,Purushothaman S,Bowen RB,Starmer J,Magnuson T

更新日期：2009-07-30 00:00:00

abstract：:Neutralizing antibody function provides a foundation for the efficacy of vaccines and therapies1-3. Here, using a robust in vitro Ebola virus (EBOV) pseudo-particle infection assay and a well-defined set of solid-phase assays, we describe a wide spectrum of antibody responses in a cohort of healthy survivors of the Si...

journal_title：Nature

authors： Adaken C,Scott JT,Sharma R,Gopal R,Dicks S,Niazi S,Ijaz S,Edwards T,Smith CC,Cole CP,Kamara P,Kargbo O,Doughty HA,van Griensven J,Horby PW,Gevao SM,Sahr F,Ebola-CP Consortium.,Dimelow RJ,Tedder RS,Semple MG,Paxt

更新日期：2021-01-27 00:00:00

abstract：:Lung epithelial cells can influence immune responses to airway allergens. Airway epithelial cells also undergo apoptosis after encountering environmental allergens; yet, relatively little is known about how these are cleared, and their effect on airway inflammation. Here we show that airway epithelial cells efficientl...

journal_title：Nature

authors： Juncadella IJ,Kadl A,Sharma AK,Shim YM,Hochreiter-Hufford A,Borish L,Ravichandran KS

更新日期：2013-01-24 00:00:00

abstract：:The recently emerged fields of metamaterials and transformation optics promise a family of exciting applications such as invisibility, optical imaging with deeply subwavelength resolution and nanophotonics with the potential for much faster information processing. The possibility of creating optical negative-index met...

journal_title：Nature

authors： Xiao S,Drachev VP,Kildishev AV,Ni X,Chettiar UK,Yuan HK,Shalaev VM

更新日期：2010-08-05 00:00:00

abstract：:The collagens represent an interesting example of a structurally related but genetically distinct family of proteins. Type I, the most abundant of the vertebrate collagens, comprises two pro alpha 1(I) chains and one pro alpha 2(I) chain, each containing terminal propeptides and a central domain of 338 (Gly, X, Y) rep...

journal_title：Nature

authors： Chu ML,de Wet W,Bernard M,Ding JF,Morabito M,Myers J,Williams C,Ramirez F

更新日期：1984-07-26 00:00:00

abstract：:The carbothermal reduction of silica into silicon requires the use of temperatures well above the silicon melting point (> or =2,000 degrees C). Solid silicon has recently been generated directly from silica at much lower temperatures (< or =850 degrees C) via electrochemical reduction in molten salts. However, the si...

journal_title：Nature

authors： Bao Z,Weatherspoon MR,Shian S,Cai Y,Graham PD,Allan SM,Ahmad G,Dickerson MB,Church BC,Kang Z,Abernathy HW 3rd,Summers CJ,Liu M,Sandhage KH

更新日期：2007-03-08 00:00:00

abstract：:Understanding the capacity of natural populations to adapt to their local environment is a central topic in evolutionary biology. Phenotypic differences between populations may have a genetic basis, but showing that they reflect different adaptive optima requires the quantification of both gene flow and selection. Goo...

journal_title：Nature

authors： Postma E,van Noordwijk AJ

更新日期：2005-01-06 00:00:00

abstract：:The products of six unidentified reading frames of human mitochondrial DNA are precipitated from a mitochondrial lysate by antibodies against highly purified native beef heart NADH-ubiquinone oxidoreductase (complex I). These products are enriched greatly in a human submitochondrial fraction enriched in NADH-Q1 and NA...

journal_title：Nature

authors： Chomyn A,Mariottini P,Cleeter MW,Ragan CI,Matsuno-Yagi A,Hatefi Y,Doolittle RF,Attardi G

更新日期：1985-04-18 00:00:00

abstract：:High-energy cosmic-ray electrons and positrons (CREs), which lose energy quickly during their propagation, provide a probe of Galactic high-energy processes and may enable the observation of phenomena such as dark-matter particle annihilation or decay. The CRE spectrum has been measured directly up to approximately 2 ...

journal_title：Nature

authors： DAMPE Collaboration.

更新日期：2017-12-07 00:00:00

abstract：:The regular occurrence of a peak due to an unidentified substance (X) in the gas chromatographic traces obtained from phenolic extracts of urine from human pregnant and non-pregnant females has been reported. The biphasic excretion of X with maxima in the luteal phase of the ovulatory cycle and relatively high levels ...

journal_title：Nature

authors： Stitch SR,Toumba JK,Groen MB,Funke CW,Leemhuis J,Vink J,Woods GF

更新日期：1980-10-23 00:00:00

abstract：:Cytosine DNA methylation is important in regulating gene expression and in silencing transposons and other repetitive sequences. Recent genomic studies in Arabidopsis thaliana have revealed that many endogenous genes are methylated either within their promoters or within their transcribed regions, and that gene methyl...

journal_title：Nature

authors： Cokus SJ,Feng S,Zhang X,Chen Z,Merriman B,Haudenschild CD,Pradhan S,Nelson SF,Pellegrini M,Jacobsen SE

更新日期：2008-03-13 00:00:00