Abstract:
:Anti-inflammatory glucocorticoids inhibit prostaglandin (PG) biosynthesis by preventing arachidonic acid release from phospholipids rather than inhibiting the cyclooxygenase. As in other cells, this steroid action depends on receptor occupation and de novo protein/RNA biosynthesis. We have previously shown in guinea pig perfused lungs and rat peritoneal leukocytes that the effect of steroids in PG generation is mediated by an uncharacterized 'second messenger'. Now, we report that this factor (which we have named 'macrocortin') is an intracellular polypeptide whose release and synthesis are stimulated by steroids. Macrocortin derived from rat peritoneal leukocytes is very similar to that released from guinea pig lungs.
journal_name
Naturejournal_title
Natureauthors
Blackwell GJ,Carnuccio R,Di Rosa M,Flower RJ,Parente L,Persico Pdoi
10.1038/287147a0subject
Has Abstractpub_date
1980-09-11 00:00:00pages
147-9issue
5778eissn
0028-0836issn
1476-4687journal_volume
287pub_type
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