Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids.

Abstract:

:Anti-inflammatory glucocorticoids inhibit prostaglandin (PG) biosynthesis by preventing arachidonic acid release from phospholipids rather than inhibiting the cyclooxygenase. As in other cells, this steroid action depends on receptor occupation and de novo protein/RNA biosynthesis. We have previously shown in guinea pig perfused lungs and rat peritoneal leukocytes that the effect of steroids in PG generation is mediated by an uncharacterized 'second messenger'. Now, we report that this factor (which we have named 'macrocortin') is an intracellular polypeptide whose release and synthesis are stimulated by steroids. Macrocortin derived from rat peritoneal leukocytes is very similar to that released from guinea pig lungs.

journal_name

Nature

journal_title

Nature

authors

Blackwell GJ,Carnuccio R,Di Rosa M,Flower RJ,Parente L,Persico P

doi

10.1038/287147a0

subject

Has Abstract

pub_date

1980-09-11 00:00:00

pages

147-9

issue

5778

eissn

0028-0836

issn

1476-4687

journal_volume

287

pub_type

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