Abstract：
:The widely occurring tetradecapeptide somatostatin (SRIF-14) has been variously implicated as a neurotransmitter, a neurohormone, a cybernin (local regulatory factor) and a hormone. In the first isolation of SRIF-14 from hypothalamic extracts and subsequent extracts of other tissues, peptides of higher molecular weight but with similar activity have been noted. Recently two such peptides have been characterized as the 28-amino acid SRIF-28 (from porcine gastro-intestinal tract and porcine and ovine hypothalamus and the 25-amino acid SRIF-25 (from ovine hypothalamus), each of which consists of an N-terminal extension of SRIF-14. We now report that SRIF-28 and SRIF-25 are more potent than SRIF-14 in the inhibition of insulin release, but that SRIF-14 preferentially inhibits glucagon release. This suggests that SRIF-28 and SRIF-25 are not mere biosynthetic precursors of SRIF-14 and that their differential release may be physiologically important.
journal_name
Naturejournal_title
Natureauthors
Mandarino L,Stenner D,Blanchard W,Nissen S,Gerich J,Ling N,Brazeau P,Bohlen P,Esch F,Guillemin Rdoi
10.1038/291076a0subject
Has Abstractpub_date
1981-05-07 00:00:00pages
76-7issue
5810eissn
0028-0836issn
1476-4687journal_volume
291pub_type
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