CD95's deadly mission in the immune system.

abstract：:The recent decades-long decline in East African rainfall suggests that multidecadal variability is an important component of the climate of this vulnerable region. Prior work based on analysing the instrumental record implicates both Indian and Pacific ocean sea surface temperatures (SSTs) as possible drivers of East ...

journal_title：Nature

authors： Tierney JE,Smerdon JE,Anchukaitis KJ,Seager R

更新日期：2013-01-17 00:00:00

abstract：:Quantum electrodynamics (resulting from the merger of quantum mechanics and relativity theory) has provided a clear understanding of phenomena ranging from particle physics to cosmology and from astrophysics to quantum chemistry. The ideas underlying quantum electrodynamics also influence the theory of condensed matte...

journal_title：Nature

authors： Novoselov KS,Geim AK,Morozov SV,Jiang D,Katsnelson MI,Grigorieva IV,Dubonos SV,Firsov AA

更新日期：2005-11-10 00:00:00

abstract：:AFTER exposure to secretagogues the small intestine changes from a tissue that absorbs fluid and electrolyte from lumen to blood into a tissue that secretes electrolyte and fluid into the lumen(1-4). It has been shown that this secretion results from an increase in the passive Cl(-) permeability of the mucosal border,...

journal_title：Nature

authors： Ilundain A,Naftalin RJ

更新日期：1979-05-31 00:00:00

abstract：:In this Letter, in Fig. 3c and f the Saccharomyces cerevisiae and Escherichia coli networks were subject to both weight loss and node deletion, a combination of two types of perturbation, as opposed to weight loss only (as the labelling incorrectly indicated). The collapse in Fig. 3h was also obtained from this combin...

journal_title：Nature

authors： Gao J,Barzel B,Barabási AL

更新日期：2019-04-01 00:00:00

abstract：:Touch and mechanical pain are first detected at our largest sensory surface, the skin. The cell bodies of sensory neurons that detect such stimuli are located in the dorsal root ganglia, and subtypes of these neurons are specialized to detect specific modalities of mechanical stimuli. Molecules have been identified th...

journal_title：Nature

authors： Wetzel C,Hu J,Riethmacher D,Benckendorff A,Harder L,Eilers A,Moshourab R,Kozlenkov A,Labuz D,Caspani O,Erdmann B,Machelska H,Heppenstall PA,Lewin GR

更新日期：2007-01-11 00:00:00

abstract：:The Redfield ratio of 106 carbon:16 nitrogen:1 phosphorus in marine phytoplankton is one of the foundations of ocean biogeochemistry, with applications in algal physiology, palaeoclimatology and global climate change. However, this ratio varies substantially in response to changes in algal nutrient status and taxonomi...

journal_title：Nature

authors： Sañudo-Wilhelmy SA,Tovar-Sanchez A,Fu FX,Capone DG,Carpenter EJ,Hutchins DA

更新日期：2004-12-16 00:00:00

abstract：:The epiblast (EPI) is the origin of all somatic and germ cells in mammals, and of pluripotent stem cells in vitro. To explore the ontogeny of human and primate pluripotency, here we perform comprehensive single-cell RNA sequencing for pre- and post-implantation EPI development in cynomolgus monkeys (Macaca fasciculari...

journal_title：Nature

authors： Nakamura T,Okamoto I,Sasaki K,Yabuta Y,Iwatani C,Tsuchiya H,Seita Y,Nakamura S,Yamamoto T,Saitou M

更新日期：2016-09-01 00:00:00

abstract：:The primary function of the adenovirus E1A-region genes is to activate other adenoviral genes during a permissive viral infection by modifying the host cell transcriptional apparatus. Host cell immortalization, or transformation by the whole adenoviral early region, presumably results as a consequence of these modific...

journal_title：Nature

authors： Webster KA,Muscat GE,Kedes L

更新日期：1988-04-07 00:00:00

abstract：:In the prehistoric green Sahara of Holocene North Africa-in contrast to the Neolithic of Europe and Eurasia-a reliance on cattle, sheep and goats emerged as a stable and widespread way of life, long before the first evidence for domesticated plants or settled village farming communities. The remarkable rock art found ...

journal_title：Nature

authors： Dunne J,Evershed RP,Salque M,Cramp L,Bruni S,Ryan K,Biagetti S,di Lernia S

更新日期：2012-06-20 00:00:00

abstract：:Jupiter's atmosphere is rotating differentially, with zones and belts rotating at speeds that differ by up to 100 metres per second. Whether this is also true of the gas giant's interior has been unknown, limiting our ability to probe the structure and composition of the planet. The discovery by the Juno spacecraft th...

journal_title：Nature

authors： Guillot T,Miguel Y,Militzer B,Hubbard WB,Kaspi Y,Galanti E,Cao H,Helled R,Wahl SM,Iess L,Folkner WM,Stevenson DJ,Lunine JI,Reese DR,Biekman A,Parisi M,Durante D,Connerney JEP,Levin SM,Bolton SJ

更新日期：2018-03-07 00:00:00

abstract：:The bithorax gene complex in Drosophila contains a minimum of eight genes that seem to code for substances controlling levels of thoracic and abdominal development. The state of repression of at least four of these genes is controlled by cis-regulatory elements and a separate locus (Polycomb) seems to code for a repre...

journal_title：Nature

authors： Lewis EB

更新日期：1978-12-07 00:00:00

abstract：:The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft between a domain structurally homologous to small GTPases and a helical domain unique to heterotrimeric G proteins. The structure, when combined with biochemical and genetic stud...

journal_title：Nature

authors： Noel JP,Hamm HE,Sigler PB

更新日期：1993-12-16 00:00:00

abstract：:Enhancers are cis-acting control elements which can stimulate at a distance the activity of a variety of eukaryotic promoters. First identified as a repeated 72 base pair (bp) sequence upstream of the simian virus 40 (SV40) early gene promoter, enhancers have since been shown to be associated with numerous other viral...

journal_title：Nature

authors： Herr W,Gluzman Y

更新日期：1985-02-21 00:00:00

abstract：:The sensitivity of soil carbon to warming is a major uncertainty in projections of carbon dioxide concentration and climate. Experimental studies overwhelmingly indicate increased soil organic carbon (SOC) decomposition at higher temperatures, resulting in increased carbon dioxide emissions from soils. However, recent...

journal_title：Nature

authors： Knorr W,Prentice IC,House JI,Holland EA

更新日期：2005-01-20 00:00:00

abstract：:The c-Myc oncoprotein promotes proliferation and apoptosis, such that mutations that disable apoptotic programmes often cooperate with MYC during tumorigenesis. Here we report that two common mutant MYC alleles derived from human Burkitt's lymphoma uncouple proliferation from apoptosis and, as a result, are more effec...

journal_title：Nature

authors： Hemann MT,Bric A,Teruya-Feldstein J,Herbst A,Nilsson JA,Cordon-Cardo C,Cleveland JL,Tansey WP,Lowe SW

更新日期：2005-08-11 00:00:00

abstract：:Neural mechanisms that mediate the ability to make value-guided decisions have received substantial attention in humans and animals1-6. Experiments in animals typically involve long training periods. By contrast, choices in the real world often need to be made between new options spontaneously. It is therefore possibl...

journal_title：Nature

authors： Bongioanni A,Folloni D,Verhagen L,Sallet J,Klein-Flügge MC,Rushworth MFS

更新日期：2021-01-06 00:00:00

abstract：:The ras-related low-molecular-mass GTPases participate in signal transduction involving a variety of cellular functions, including cell-cycle progression, cellular differentiation, cytoskeletal organization, protein transport and secretion. The cycling of these proteins between GTP-bound and GDP-bound states is partia...

journal_title：Nature

authors： Settleman J,Albright CF,Foster LC,Weinberg RA

更新日期：1992-09-10 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) are cell-surface molecules that transduce signals for cell growth and differentiation. The RTK encoded by the c-ret proto-oncogene is rearranged and constitutively activated in a large proportion of thyroid papillary carcinomas, and germ-line point mutations in c-ret seem to be respons...

journal_title：Nature

authors： Schuchardt A,D'Agati V,Larsson-Blomberg L,Costantini F,Pachnis V

更新日期：1994-01-27 00:00:00

abstract：:Although male parental care is rare among mammals, adult males of many cercopithecine primate species provide care for infants and juveniles. This care is often in the form of grooming, carrying, support in agonistic interactions, and protection against infanticide. For these behaviours to be interpreted as true paren...

journal_title：Nature

authors： Buchan JC,Alberts SC,Silk JB,Altmann J

更新日期：2003-09-11 00:00:00

abstract：:Establishment and maintenance of proper architecture is essential for endoplasmic reticulum (ER) function. Homotypic membrane fusion is required for ER biogenesis and maintenance, and has been shown to depend on GTP hydrolysis. Here we demonstrate that Drosophila Atlastin--the fly homologue of the mammalian GTPase atl...

journal_title：Nature

authors： Orso G,Pendin D,Liu S,Tosetto J,Moss TJ,Faust JE,Micaroni M,Egorova A,Martinuzzi A,McNew JA,Daga A

更新日期：2009-08-20 00:00:00

abstract：:Polymeric matrices can be used to grow new tissues and organs, and the delivery of growth factors from these matrices is one method to regenerate tissues. A problem with engineering tissues that exist in a mechanically dynamic environment, such as bone, muscle and blood vessels, is that most drug delivery systems have...

journal_title：Nature

authors： Lee KY,Peters MC,Anderson KW,Mooney DJ

更新日期：2000-12-21 00:00:00

abstract：:Protein modification by the conjugation of ubiquitin moieties--ubiquitination--plays a major part in many biological processes, including cell cycle and apoptosis. The enzymes that mediate ubiquitin-conjugation have been well-studied, but much less is known about the ubiquitin-specific proteases that mediate de-ubiqui...

journal_title：Nature

authors： Brummelkamp TR,Nijman SM,Dirac AM,Bernards R

更新日期：2003-08-14 00:00:00

abstract：:Intracellular responses recorded in vitro from the cochleas of anaesthetized mammals have shown that the mechanoreceptive inner and outer hair cells are sharply tuned, accounting for many of the properties of the afferent fibres in the auditory nerve. However, in vivo it has not been possible to measure directly the e...

journal_title：Nature

authors： Russell IJ,Richardson GP,Cody AR

更新日期：1986-05-29 00:00:00

abstract：:The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial com...

journal_title：Nature

authors： Mouse Genome Sequencing Consortium.,Waterston RH,Lindblad-Toh K,Birney E,Rogers J,Abril JF,Agarwal P,Agarwala R,Ainscough R,Alexandersson M,An P,Antonarakis SE,Attwood J,Baertsch R,Bailey J,Barlow K,Beck S,Berry E,Bir

更新日期：2002-12-05 00:00:00

abstract：:In the unactivated Limulus sperm, a 60- micro m-long bundle of actin filaments crosslinked by the protein scruin is bent and twisted into a coil around the base of the nucleus. At fertilization, the bundle uncoils and fully extends in five seconds to support a finger of membrane known as the acrosomal process. This bi...

journal_title：Nature

authors： Schmid MF,Sherman MB,Matsudaira P,Chiu W

更新日期：2004-09-02 00:00:00

abstract：:The widespread reorganization of cellular architecture in mitosis is achieved through extensive protein phosphorylation, driven by the coordinated activation of a mitotic kinase network and repression of counteracting phosphatases. Phosphatase activity must subsequently be restored to promote mitotic exit. Although Cd...

journal_title：Nature

authors： Grallert A,Boke E,Hagting A,Hodgson B,Connolly Y,Griffiths JR,Smith DL,Pines J,Hagan IM

更新日期：2015-01-01 00:00:00

abstract：:The metabolic basis of the autosomal recessive disease cystic fibrosis (CF) remains unidentified. Elevated levels of a serum protein in CF homozygotes and obligate heterozygotes have been described. As heterozygotes are clinically unaffected, any consistently observed abnormality in these individuals is a likely point...

journal_title：Nature

authors： Dorin JR,Novak M,Hill RE,Brock DJ,Secher DS,van Heyningen V

更新日期：1987-04-09 00:00:00

abstract：:Highly correlated electronic systems--such as transition-metal oxides that are doped Mott insulators--are complex systems which exhibit puzzling phenomena, including high-temperature superconductivity and colossal magnetoresistivity. Recent studies suggest that in such systems collective electronic phenomena are impor...

journal_title：Nature

authors： Yoo YK,Duewer F,Yang H,Yi D,Li JW,Xiang XD

更新日期：2000-08-17 00:00:00

abstract：:Hunger is a hard-wired motivational state essential for survival. Agouti-related peptide (AgRP)-expressing neurons in the arcuate nucleus (ARC) at the base of the hypothalamus are crucial to the control of hunger. They are activated by caloric deficiency and, when naturally or artificially stimulated, they potently in...

journal_title：Nature

authors： Krashes MJ,Shah BP,Madara JC,Olson DP,Strochlic DE,Garfield AS,Vong L,Pei H,Watabe-Uchida M,Uchida N,Liberles SD,Lowell BB

更新日期：2014-03-13 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Hsiang S,Allen D,Annan-Phan S,Bell K,Bolliger I,Chong T,Druckenmiller H,Huang LY,Hultgren A,Krasovich E,Lau P,Lee J,Rolf E,Tseng J,Wu T

更新日期：2020-09-01 00:00:00