Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys.

abstract：:Recombination is the exchange of information between two homologous chromosomes during meiosis. The rate of recombination per nucleotide, which profoundly affects the evolution of chromosomal segments, is calculated by comparing genetic and physical maps. Human physical maps have been constructed using cytogenetics, o...

journal_title：Nature

authors： Yu A,Zhao C,Fan Y,Jang W,Mungall AJ,Deloukas P,Olsen A,Doggett NA,Ghebranious N,Broman KW,Weber JL

更新日期：2001-02-15 00:00:00

abstract：:MANY ferromanganese minerals have been found in marine manganese deposits. There have been terminological and intrinsic problems in accurately defining the constituents of manganese nodules(1), but 10-A manganite and delta-MnO(2) which are often compared with todorokite and birnessite seem to be the only major constit...

journal_title：Nature

authors： Usui A

更新日期：1979-05-31 00:00:00

abstract：:During fertilization, an egg and a sperm fuse to form a new embryo. Eggs develop from oocytes in a process called meiosis. Meiosis in human oocytes is highly error-prone, and defective eggs are the leading cause of pregnancy loss and several genetic disorders such as Down's syndrome. Which genes safeguard accurate pro...

journal_title：Nature

authors： Pfender S,Kuznetsov V,Pasternak M,Tischer T,Santhanam B,Schuh M

更新日期：2015-08-13 00:00:00

abstract：:Adenylyl cyclase is the prototypical second messenger generator. Nearly all of the eight cloned adenylyl cyclases are regulated by one or other arm of the phospholipase C pathway. Functional and ultrastructural investigations have shown that adenylyl cyclases are intimately associated with sites of calcium ion entry i...

journal_title：Nature

authors： Cooper DM,Mons N,Karpen JW

更新日期：1995-03-30 00:00:00

abstract：:The superposition principle is a fundamental tenet of quantum mechanics. It allows a quantum system to be 'in two places at the same time', because the quantum state of a physical system can simultaneously include measurably different physical states. The preparation and use of such superposed states forms the basis o...

journal_title：Nature

authors： Hofheinz M,Wang H,Ansmann M,Bialczak RC,Lucero E,Neeley M,O'Connell AD,Sank D,Wenner J,Martinis JM,Cleland AN

更新日期：2009-05-28 00:00:00

abstract：:Enhancers are DNA sequences that stimulate transcription from eukaryotic promoters. This stimulatory effect can be exerted over large distances and from a position either 5' or 3' of a promoter. Enhancers have been found in the genomes of many viruses, and in some cellular genes such as those encoding immunoglobulin h...

journal_title：Nature

authors： Garcia JV,Bich-Thuy LT,Stafford J,Queen C

更新日期：1986-07-24 00:00:00

abstract：:Environmental change has altered the phenology, morphological traits and population dynamics of many species. However, the links underlying these joint responses remain largely unknown owing to a paucity of long-term data and the lack of an appropriate analytical framework. Here we investigate the link between phenoty...

journal_title：Nature

authors： Ozgul A,Childs DZ,Oli MK,Armitage KB,Blumstein DT,Olson LE,Tuljapurkar S,Coulson T

更新日期：2010-07-22 00:00:00

abstract：:Leukaemia inhibitory factor (LIF) has a variety of effects on different cell types in vitro, inhibiting the differentiation of embryonic stem cells and promoting the survival and/or proliferation of primitive haematopoietic precursors and primordial germ cells. Here we show that LIF-deficient mice derived by gene targ...

journal_title：Nature

authors： Escary JL,Perreau J,Duménil D,Ezine S,Brûlet P

更新日期：1993-05-27 00:00:00

abstract：:Information from the human genome sequence will eventually alter many aspects of clinical practice. It will increase through our understanding of disease mechanisms, and guide the development of new drugs and therapeutic procedures. In the short term, however, knowledge of the genome will have a profound clinical impa...

journal_title：Nature

authors： Bell J

更新日期：2004-05-27 00:00:00

abstract：:Prized for their ability to rapidly generate chemical complexity by building new ring systems and stereocentres1, cycloaddition reactions have featured in numerous total syntheses2 and are a key component in the education of chemistry students3. Similarly, carbon-carbon (C-C) cross-coupling methods are integral to syn...

journal_title：Nature

authors： Chen TG,Barton LM,Lin Y,Tsien J,Kossler D,Bastida I,Asai S,Bi C,Chen JS,Shan M,Fang H,Fang FG,Choi HW,Hawkins L,Qin T,Baran PS

更新日期：2018-08-01 00:00:00

abstract：:Proteins are inherently plastic molecules, whose function often critically depends on excursions between different molecular conformations (conformers). However, a rigorous understanding of the relation between a protein's structure, dynamics and function remains elusive. This is because many of the conformers on its ...

journal_title：Nature

authors： Bouvignies G,Vallurupalli P,Hansen DF,Correia BE,Lange O,Bah A,Vernon RM,Dahlquist FW,Baker D,Kay LE

更新日期：2011-08-21 00:00:00

abstract：:The structure of the operator-binding domain of the lambda repressor has been determined at 3.2 A resolution. This domain contains an extended N-terminal arm and five alpha-helices. Model-building studies of the repressor-operator complex suggest that alpha-helices, especially the N-terminal parts of these helices, ma...

journal_title：Nature

authors： Pabo CO,Lewis M

更新日期：1982-07-29 00:00:00

abstract：:Birds can perceive the reflectance of ultraviolet light by biological structures. Here we show that the skin of the mouth and body of starling nestlings substantially reflects light in the ultraviolet range and that young in which this reflectance is reduced will gain less mass than controls, despite low background le...

journal_title：Nature

authors： Jourdie V,Moureau B,Bennett AT,Heeb P

更新日期：2004-09-16 00:00:00

abstract：:Major histocompatibility complex (MHC) class I and class II molecules bind immunogenic peptides and present them to lymphocytes bearing the alpha beta T-cell antigen receptor (TCR). An analogous antigen-presenting function also has been proposed for the non-MHC-encoded CD1 molecules, a family of non-polymorphic, beta ...

journal_title：Nature

authors： Beckman EM,Porcelli SA,Morita CT,Behar SM,Furlong ST,Brenner MB

更新日期：1994-12-15 00:00:00

abstract：:The Ras proto-oncogene is a central component of mitogenic signal-transduction pathways, and is essential for cells both to leave a quiescent state (G0) and to pass through the G1/S transition of the cell cycle. The mechanism by which Ras signalling regulates cell-cycle progression is unclear, however. Here we report ...

journal_title：Nature

authors： Peeper DS,Upton TM,Ladha MH,Neuman E,Zalvide J,Bernards R,DeCaprio JA,Ewen ME

更新日期：1997-03-13 00:00:00

abstract：:Jupiter's ring system has previously been described as being composed of a 'bright' narrow ring and an interior, vertically-extended halo. The one image which reveals this morphology most clearly is Voyager 2's parting shot of the Jupiter system, a wide-angle (WA) view of the ring ansa in forward-scattered light (FDS...

journal_title：Nature

authors： Showalter MR,Burns JA,Cuzzi JN,Pollack JB

更新日期：1985-08-08 00:00:00

abstract：:Hox genes are essential for growth and patterning of the tetrapod limb skeleton. Mice mutant for the Hoxd-13 gene have an important delay in morphogenesis owing to reduced proliferation. Based on the appearance of atavisms in such mice, we suggested that modifications of Hox gene regulation may have been a source of m...

journal_title：Nature

authors： Sordino P,van der Hoeven F,Duboule D

更新日期：1995-06-22 00:00:00

abstract：:A temperature sensitive mutant has been isolated for the first time from a replication defective acute leukaemia virus, AEV. In vivo, at 41 degrees C, the mutant shows a reduced leukaemogenic potential. In vitro, in erythroblasts transformed at 35 degrees C, haemoglobin synthesis can be induced by a shift to 41 degree...

journal_title：Nature

authors： Graf T,Ade N,Beug H

更新日期：1978-10-12 00:00:00

abstract：:Chronic electrical stimulation of the auditory nerve in patients with profound sensori-neural deafness is becoming increasingly routine. Therefore, it is important to understand more about the long-term consequences of this procedure. Hitherto, structural studies in animals after electrocochlear stimulation have conce...

journal_title：Nature

authors： Dodson HC,Walliker JR,Frampton S,Douek EE,Fourcin AJ,Bannister LH

更新日期：1986-03-06 00:00:00

abstract：:Chemical reactions inside single crystals are likely to be highly selective, but examples of single crystal to single crystal (SC-SC) transformations are uncommon, because crystallinity is difficult to retain following the rearrangement of atoms in the solid state. The most widely studied SC-SC transformations involve...

journal_title：Nature

authors： Huang Z,White PS,Brookhart M

更新日期：2010-06-03 00:00:00

abstract：:Graphene, or single-layered graphite, with its high crystallinity and interesting semimetal electronic properties, has emerged as an exciting two-dimensional material showing great promise for the fabrication of nanoscale devices. Thin, elongated strips of graphene that possess straight edges, termed graphene ribbons,...

journal_title：Nature

authors： Kosynkin DV,Higginbotham AL,Sinitskii A,Lomeda JR,Dimiev A,Price BK,Tour JM

更新日期：2009-04-16 00:00:00

abstract：:Increasing population and consumption are placing unprecedented demands on agriculture and natural resources. Today, approximately a billion people are chronically malnourished while our agricultural systems are concurrently degrading land, water, biodiversity and climate on a global scale. To meet the world's future ...

journal_title：Nature

authors： Foley JA,Ramankutty N,Brauman KA,Cassidy ES,Gerber JS,Johnston M,Mueller ND,O'Connell C,Ray DK,West PC,Balzer C,Bennett EM,Carpenter SR,Hill J,Monfreda C,Polasky S,Rockström J,Sheehan J,Siebert S,Tilman D,Zaks DP

更新日期：2011-10-12 00:00:00

abstract：:Transport of fermions, particles with half-integer spin, is central to many fields of physics. Electron transport runs modern technology, defining states of matter such as superconductors and insulators, and electron spin is being explored as a new carrier of information. Neutrino transport energizes supernova explosi...

journal_title：Nature

authors： Sommer A,Ku M,Roati G,Zwierlein MW

更新日期：2011-04-14 00:00:00

abstract：:One of the earliest computational principles attributed to the cerebellum was the measurement of time. This idea was originally suggested on anatomical grounds, and was taken up again to explain some of the deficits in cerebellar patients. The contribution of the cerebellum to eye movements, in contrast, has tradition...

journal_title：Nature

authors： Thier P,Dicke PW,Haas R,Barash S

更新日期：2000-05-04 00:00:00

abstract：:The role of magnetic domains (and the walls between domains) in determining the electrical properties of ferromagnetic materials has been investigated in great detail for many years, not least because control over domains offers a means of manipulating electron spin to control charge transport in 'spintronic' devices....

journal_title：Nature

authors： Kummamuru RK,Soh YA

更新日期：2008-04-17 00:00:00

abstract：:The products of six unidentified reading frames of human mitochondrial DNA are precipitated from a mitochondrial lysate by antibodies against highly purified native beef heart NADH-ubiquinone oxidoreductase (complex I). These products are enriched greatly in a human submitochondrial fraction enriched in NADH-Q1 and NA...

journal_title：Nature

authors： Chomyn A,Mariottini P,Cleeter MW,Ragan CI,Matsuno-Yagi A,Hatefi Y,Doolittle RF,Attardi G

更新日期：1985-04-18 00:00:00

abstract：:One way of accounting for lowered atmospheric carbon dioxide concentrations during Pleistocene glacial periods is by invoking the Antarctic stratification hypothesis, which links the reduction in CO2 to greater stratification of ocean surface waters around Antarctica. As discussed by Sigman and Boyle, this hypothesis ...

journal_title：Nature

authors： Keeling RF,Visbeck M

更新日期：2001-08-09 00:00:00

abstract：:Curare has long been regarded as a typical competitive antagonist of acetylcholine (ACh) at the vertebrate neuromuscular junction. Recently, however, it has been shown that curare can also block the channels opened by ACh at the frog neuromuscular junction as well as on rat and Aplysia neurones; moreover, curare is ab...

journal_title：Nature

authors： Trautmann A

更新日期：1982-07-15 00:00:00

abstract：:The hippocampus is an important part of the limbic system in the human brain that has essential roles in spatial navigation and the consolidation of information from short-term memory to long-term memory1,2. Here we use single-cell RNA sequencing and assay for transposase-accessible chromatin using sequencing (ATAC-se...

journal_title：Nature

authors： Zhong S,Ding W,Sun L,Lu Y,Dong H,Fan X,Liu Z,Chen R,Zhang S,Ma Q,Tang F,Wu Q,Wang X

更新日期：2020-01-01 00:00:00

abstract：:Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dimensional analysis of these molecular characteristics in human c...

journal_title：Nature

authors： Cancer Genome Atlas Research Network.

更新日期：2008-10-23 00:00:00