Laser-plasma acceleration of quasi-monoenergetic protons from microstructured targets.

Abstract:

:Particle acceleration based on high intensity laser systems (a process known as laser-plasma acceleration) has achieved high quality particle beams that compare favourably with conventional acceleration techniques in terms of emittance, brightness and pulse duration. A long-term difficulty associated with laser-plasma acceleration--the very broad, exponential energy spectrum of the emitted particles--has been overcome recently for electron beams. Here we report analogous results for ions, specifically the production of quasi-monoenergetic proton beams using laser-plasma accelerators. Reliable and reproducible laser-accelerated ion beams were achieved by intense laser irradiation of solid microstructured targets. This proof-of-principle experiment serves to illuminate the role of laser-generated plasmas as feasible particle sources. Scalability studies show that, owing to their compact size and reasonable cost, such table-top laser systems with high repetition rates could contribute to the development of new generations of particle injectors that may be suitable for medical proton therapy.

journal_name

Nature

journal_title

Nature

authors

Schwoerer H,Pfotenhauer S,Jäckel O,Amthor KU,Liesfeld B,Ziegler W,Sauerbrey R,Ledingham KW,Esirkepov T

doi

10.1038/nature04492

keywords:

subject

Has Abstract

pub_date

2006-01-26 00:00:00

pages

445-8

issue

7075

eissn

0028-0836

issn

1476-4687

pii

nature04492

journal_volume

439

pub_type

杂志文章

相关文献

NATURE文献大全
  • Exciton-polariton topological insulator.

    abstract::Topological insulators-materials that are insulating in the bulk but allow electrons to flow on their surface-are striking examples of materials in which topological invariants are manifested in robustness against perturbations such as defects and disorder1. Their most prominent feature is the emergence of edge states...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-018-0601-5

    authors: Klembt S,Harder TH,Egorov OA,Winkler K,Ge R,Bandres MA,Emmerling M,Worschech L,Liew TCH,Segev M,Schneider C,Höfling S

    更新日期:2018-10-01 00:00:00

  • Initial radiation of jaws demonstrated stability despite faunal and environmental change.

    abstract::More than 99 per cent of the roughly 58,000 living vertebrate species have jaws. This major clade, whose members are collectively known as gnathostomes ('jawed mouths'), made its earliest definitive appearance in the Silurian period, 444-416 million years (Myr) ago, with both the origin of the modern (crown-group) rad...

    journal_title:Nature

    pub_type: 历史文章,杂志文章

    doi:10.1038/nature10207

    authors: Anderson PS,Friedman M,Brazeau MD,Rayfield EJ

    更新日期:2011-07-06 00:00:00

  • The Xenopus localized messenger RNA An3 may encode an ATP-dependent RNA helicase.

    abstract::The maternal messenger RNA An3 was originally identified localized to the animal hemisphere of Xenopus laevis oocytes, eggs and early embryos. Xenopus embryos depend on mRNA and protein present in the egg before fertilization (maternal molecules) to provide the information needed for early development. Localization of...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/349717a0

    authors: Gururajan R,Perry-O'Keefe H,Melton DA,Weeks DL

    更新日期:1991-02-21 00:00:00

  • The contribution of China's emissions to global climate forcing.

    abstract::Knowledge of the contribution that individual countries have made to global radiative forcing is important to the implementation of the agreement on "common but differentiated responsibilities" reached by the United Nations Framework Convention on Climate Change. Over the past three decades, China has experienced rapi...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature17165

    authors: Li B,Gasser T,Ciais P,Piao S,Tao S,Balkanski Y,Hauglustaine D,Boisier JP,Chen Z,Huang M,Li LZ,Li Y,Liu H,Liu J,Peng S,Shen Z,Sun Z,Wang R,Wang T,Yin G,Yin Y,Zeng H,Zeng Z,Zhou F

    更新日期:2016-03-17 00:00:00

  • Genetic information and life insurance.

    abstract::Genetic testing will become the future standard of medical care. Life insurers will also need access to genetic information if the insurance industry is to survive intact and if cover is to remain affordable. ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/376013a0

    authors: Pokorski RJ

    更新日期:1995-07-06 00:00:00

  • Patterns and trends of Northern Hemisphere snow mass from 1980 to 2018.

    abstract::Warming surface temperatures have driven a substantial reduction in the extent and duration of Northern Hemisphere snow cover1-3. These changes in snow cover affect Earth's climate system via the surface energy budget, and influence freshwater resources across a large proportion of the Northern Hemisphere4-6. In contr...

    journal_title:Nature

    pub_type: 历史文章,杂志文章

    doi:10.1038/s41586-020-2258-0

    authors: Pulliainen J,Luojus K,Derksen C,Mudryk L,Lemmetyinen J,Salminen M,Ikonen J,Takala M,Cohen J,Smolander T,Norberg J

    更新日期:2020-05-01 00:00:00

  • Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding.

    abstract::Interactions of CD4 with the class II major histocompatibility complex (MHC) are crucial during thymic ontogeny and subsequently for helper and cytotoxic functions of CD4+CD8- T lymphocytes. CD4 is the receptor for the T-lymphotropic human immunodeficiency virus and binds its envelope glycoprotein, gp120. The residues...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/339548a0

    authors: Clayton LK,Sieh M,Pious DA,Reinherz EL

    更新日期:1989-06-15 00:00:00

  • Synthetic peptides as nuclear localization signals.

    abstract::The nuclear envelope defines a compartment boundary which is penetrated by pores that mediate a remarkable transport process. Precursor RNAs are retained in the nucleus, while processed messenger RNA, transfer RNA and ribosomal subunits are transported to the cytoplasm. Proteins destined for the nucleus become localiz...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/322641a0

    authors: Goldfarb DS,Gariépy J,Schoolnik G,Kornberg RD

    更新日期:1986-08-14 00:00:00

  • Regulation of cytolytic T-lymphocyte generation by B-cell stimulatory factor.

    abstract::The growth and differentiation of cytolytic T lymphocytes (CTL) is regulated by soluble growth hormones, of which interleukin-2 (IL-2) is considered to be of prime importance. Here we report that the lymphokine B-cell stimulatory factor (BSF-1 or interleukin-4) also has profound effects on the generation of these func...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/326795a0

    authors: Widmer MB,Grabstein KH

    更新日期:1987-04-23 00:00:00

  • Functional contributions of alpha5 subunit to neuronal acetylcholine receptor channels.

    abstract::Ligand-gated ion channels are multi-subunit complexes where each subunit-type is encoded by several related genes. Heterologous expression of any one of the neuronal nicotinic acetylcholine receptors (nAChR) alpha-type subunits, either alone or with any beta-type subunit, typically yields functional nAChR channels. A ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/380347a0

    authors: Ramirez-Latorre J,Yu CR,Qu X,Perin F,Karlin A,Role L

    更新日期:1996-03-28 00:00:00

  • The ultimate speed of magnetic switching in granular recording media.

    abstract::In magnetic memory devices, logical bits are recorded by selectively setting the magnetization vector of individual magnetic domains either 'up' or 'down'. In such devices, the fastest and most efficient recording method involves precessional switching: when a magnetic field B(p) is applied as a write pulse over a per...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature02438

    authors: Tudosa I,Stamm C,Kashuba AB,King F,Siegmann HC,Stöhr J,Ju G,Lu B,Weller D

    更新日期:2004-04-22 00:00:00

  • Bee foraging in uncertain environments using predictive hebbian learning.

    abstract::Recent work has identified a neuron with widespread projections to odour processing regions of the honeybee brain whose activity represents the reward value of gustatory stimuli. We have constructed a model of bee foraging in uncertain environments based on this type of neuron and a predictive form of hebbian synaptic...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/377725a0

    authors: Montague PR,Dayan P,Person C,Sejnowski TJ

    更新日期:1995-10-26 00:00:00

  • The structure of Venus' middle atmosphere and ionosphere.

    abstract::The atmosphere and ionosphere of Venus have been studied in the past by spacecraft with remote sensing or in situ techniques. These early missions, however, have left us with questions about, for example, the atmospheric structure in the transition region from the upper troposphere to the lower mesosphere (50-90 km) a...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature06239

    authors: Pätzold M,Häusler B,Bird MK,Tellmann S,Mattei R,Asmar SW,Dehant V,Eidel W,Imamura T,Simpson RA,Tyler GL

    更新日期:2007-11-29 00:00:00

  • One rogue agent suffices for genomic chaos.

    abstract:: ...

    journal_title:Nature

    pub_type: 评论,新闻

    doi:10.1038/d41586-019-00260-4

    authors: Larrimore KE,Rancati G

    更新日期:2019-02-01 00:00:00

  • A new metabolic cell-wall labelling method reveals peptidoglycan in Chlamydia trachomatis.

    abstract::Peptidoglycan (PG), an essential structure in the cell walls of the vast majority of bacteria, is critical for division and maintaining cell shape and hydrostatic pressure. Bacteria comprising the Chlamydiales were thought to be one of the few exceptions. Chlamydia harbour genes for PG biosynthesis and exhibit suscept...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature12892

    authors: Liechti GW,Kuru E,Hall E,Kalinda A,Brun YV,VanNieuwenhze M,Maurelli AT

    更新日期:2014-02-27 00:00:00

  • Crystal structure of a yeast TFIIA/TBP/DNA complex.

    abstract::The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 A resolution. TFIIA is composed of a beta-barrel and a four-helix bundle motif that together have a boot-like appearance. The beta-barrel extends the TBP beta-...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/381127a0

    authors: Tan S,Hunziker Y,Sargent DF,Richmond TJ

    更新日期:1996-05-09 00:00:00

  • Conserved factors regulate signalling in Arabidopsis thaliana shoot and root stem cell organizers.

    abstract::Throughout the lifespan of a plant, which in some cases can last more than one thousand years, the stem cell niches in the root and shoot apical meristems provide cells for the formation of complete root and shoot systems, respectively. Both niches are superficially different and it has remained unclear whether common...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature05703

    authors: Sarkar AK,Luijten M,Miyashima S,Lenhard M,Hashimoto T,Nakajima K,Scheres B,Heidstra R,Laux T

    更新日期:2007-04-12 00:00:00

  • Science without borders: 4 big questions.

    abstract:: ...

    journal_title:Nature

    pub_type: 社论

    doi:10.1038/d41586-018-06975-0

    authors: Hodson R

    更新日期:2018-10-01 00:00:00

  • Chimpanzees and AIDS research.

    abstract::Pressure is mounting to relax the regulations on importation of chimpanzees for research. Such a policy is unnecessary and would deepen the plight of an already endangered species. ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/333513a0

    authors: Prince AM,Moor-Jankowski J,Eichberg JW,Schellekens H,Mauler RF,Girard M,Goodall J

    更新日期:1988-06-09 00:00:00

  • Short alanine-based peptides may form 3(10)-helices and not alpha-helices in aqueous solution.

    abstract::Short alanine peptides, containing 16 or 17 residues, appear to form alpha-helices in aqueous solution. But the main spectroscopic analyses used on helical peptides (circular dichroism and nuclear magnetic resonance) cannot distinguish between an alpha-helix (in which the ith residue is hydrogen-bonded to residue i + ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/359653a0

    authors: Miick SM,Martinez GV,Fiori WR,Todd AP,Millhauser GL

    更新日期:1992-10-15 00:00:00

  • A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage.

    abstract::Although individuals age and die with time, an animal species can continue indefinitely, because of its immortal germ-cell lineage. How the germline avoids transmitting damage from one generation to the next remains a fundamental question in biology. Here we identify a lysosomal switch that enhances germline proteosta...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature24620

    authors: Bohnert KA,Kenyon C

    更新日期:2017-11-30 00:00:00

  • Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction.

    abstract::A serine/threonine kinase, named protein kinase B (PKB) for its sequence homology to both protein kinase A and C, has previously been isolated. PKB, which is identical to the kinase Rac, was later found to be the cellular homologue of the transforming v-Akt. Here we show that PKB is activated by stimuli such as insuli...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/376599a0

    authors: Burgering BM,Coffer PJ

    更新日期:1995-08-17 00:00:00

  • Clathrin light chains and secretory vesicle binding proteins are distinct.

    abstract::Recently, several groups have initiated studies on cytosolic proteins that bind to isolated secretory vesicle membranes in the presence of Ca2+ in order to identify proteins that may regulate exocytosis. Two major chromaffin granule binding proteins, of molecular weights 32,000 (32K) and 34,000 (34K), were reported to...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/308208a0

    authors: Creutz CE,Harrison JR

    更新日期:1984-03-08 00:00:00

  • CpG methylation is maintained in human cancer cells lacking DNMT1.

    abstract::Hypermethylation is associated with the silencing of tumour susceptibility genes in several forms of cancer; however, the mechanisms responsible for this aberrant methylation are poorly understood. The prototypic DNA methyltransferase, DNMT1, has been widely assumed to be responsible for most of the methylation of the...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35010000

    authors: Rhee I,Jair KW,Yen RW,Lengauer C,Herman JG,Kinzler KW,Vogelstein B,Baylin SB,Schuebel KE

    更新日期:2000-04-27 00:00:00

  • Activation of a C. elegans Antennapedia homologue in migrating cells controls their direction of migration.

    abstract::Anterior-posterior patterning in insects, vertebrates and nematodes involves members of conserved Antennapedia-class homeobox gene clusters (HOM-C) that are thought to give specific body regions their identities. The effects of these genes on region-specific body structures have been described extensively, particularl...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/355255a0

    authors: Salser SJ,Kenyon C

    更新日期:1992-01-16 00:00:00

  • Isolation and expression of a complementary DNA that confers multidrug resistance.

    abstract::The emergence and outgrowth of a population of tumour cells resistant to multiple drugs is a major problem in the chemotherapeutic treatment of cancer. We have used highly drug-resistant cell lines developed in vitro to study the molecular basis of multidrug resistance. In these cell lines high levels of resistance ar...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/323728a0

    authors: Gros P,Ben Neriah YB,Croop JM,Housman DE

    更新日期:1986-10-23 00:00:00

  • Publisher Correction: Principles of nucleosome organization revealed by single-cell micrococcal nuclease sequencing.

    abstract::Change history: In Fig. 1c of this Letter, the two graphs were duplicates. The right panel of Fig. 1c has been corrected online. ...

    journal_title:Nature

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/s41586-018-0690-1

    authors: Lai B,Gao W,Cui K,Xie W,Tang Q,Jin W,Hu G,Ni B,Zhao K

    更新日期:2018-12-01 00:00:00

  • Materials chemistry: a synthetic enamel for rapid tooth repair.

    abstract::The conventional treatment of dental caries involves mechanical removal of the affected part and filling of the hole with a resin or metal alloy. But this method is not ideal for tiny early lesions because a disproportionate amount of healthy tooth must be removed to make the alloy or resin stick. Here we describe a d...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/433819a

    authors: Yamagishi K,Onuma K,Suzuki T,Okada F,Tagami J,Otsuki M,Senawangse P

    更新日期:2005-02-24 00:00:00

  • Symbolic arithmetic knowledge without instruction.

    abstract::Symbolic arithmetic is fundamental to science, technology and economics, but its acquisition by children typically requires years of effort, instruction and drill. When adults perform mental arithmetic, they activate nonsymbolic, approximate number representations, and their performance suffers if this nonsymbolic sys...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature05850

    authors: Gilmore CK,McCarthy SE,Spelke ES

    更新日期:2007-05-31 00:00:00

  • California's methane super-emitters.

    abstract::Methane is a powerful greenhouse gas and is targeted for emissions mitigation by the US state of California and other jurisdictions worldwide1,2. Unique opportunities for mitigation are presented by point-source emitters-surface features or infrastructure components that are typically less than 10 metres in diameter a...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-019-1720-3

    authors: Duren RM,Thorpe AK,Foster KT,Rafiq T,Hopkins FM,Yadav V,Bue BD,Thompson DR,Conley S,Colombi NK,Frankenberg C,McCubbin IB,Eastwood ML,Falk M,Herner JD,Croes BE,Green RO,Miller CE

    更新日期:2019-11-01 00:00:00