Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus.

abstract：:Since at least the last common ancestor of all life on Earth, genetic information has been stored in a four-letter alphabet that is propagated and retrieved by the formation of two base pairs. The central goal of synthetic biology is to create new life forms and functions, and the most general route to this goal is th...

journal_title：Nature

authors： Zhang Y,Ptacin JL,Fischer EC,Aerni HR,Caffaro CE,San Jose K,Feldman AW,Turner CR,Romesberg FE

更新日期：2017-11-29 00:00:00

abstract：:The taxonomy of a parasite can be an important guide to its pathogenic characteristics. A wide range of anatomical, biochemical and behavioural tests is now being developed to define different strains and subspecies of the main tropical parasites. ...

journal_title：Nature

authors： Godfrey DG

更新日期：1978-06-22 00:00:00

abstract：:Aluminium adjuvants, typically referred to as 'alum', are the most commonly used adjuvants in human and animal vaccines worldwide, yet the mechanism underlying the stimulation of the immune system by alum remains unknown. Toll-like receptors are critical in sensing infections and are therefore common targets of variou...

journal_title：Nature

authors： Eisenbarth SC,Colegio OR,O'Connor W,Sutterwala FS,Flavell RA

更新日期：2008-06-19 00:00:00

abstract：:Assembly of multi-component supramolecular machines is fundamental to biology, yet in most cases, assembly pathways and their control are poorly understood. An example is the type III secretion machine, which mediates the transfer of bacterial virulence proteins into host cells. A central component of this nanomachine...

journal_title：Nature

authors： Marlovits TC,Kubori T,Lara-Tejero M,Thomas D,Unger VM,Galán JE

更新日期：2006-06-01 00:00:00

abstract：:Explaining the large-scale diversity of soil organisms that drive biogeochemical processes-and their responses to environmental change-is critical. However, identifying consistent drivers of belowground diversity and abundance for some soil organisms at large spatial scales remains problematic. Here we investigate a m...

journal_title：Nature

authors： van der Linde S,Suz LM,Orme CDL,Cox F,Andreae H,Asi E,Atkinson B,Benham S,Carroll C,Cools N,De Vos B,Dietrich HP,Eichhorn J,Gehrmann J,Grebenc T,Gweon HS,Hansen K,Jacob F,Kristöfel F,Lech P,Manninger M,Martin J

更新日期：2018-06-01 00:00:00

abstract：:Although individuals age and die with time, an animal species can continue indefinitely, because of its immortal germ-cell lineage. How the germline avoids transmitting damage from one generation to the next remains a fundamental question in biology. Here we identify a lysosomal switch that enhances germline proteosta...

journal_title：Nature

authors： Bohnert KA,Kenyon C

更新日期：2017-11-30 00:00:00

abstract：:Sex and recombination are widespread, but explaining these phenomena has been one of the most difficult problems in evolutionary biology. Recombination is advantageous when different individuals in a population carry different advantageous alleles. By bringing together advantageous alleles onto the same chromosome, re...

journal_title：Nature

authors： Keightley PD,Otto SP

更新日期：2006-09-07 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a widely expressed neuropeptide that has a major role in sensory neurotransmission. The CGRP receptor is a heterodimer of the calcitonin receptor-like receptor (CLR) class B G-protein-coupled receptor and a type 1 transmembrane domain protein, receptor activity-modifying prote...

journal_title：Nature

authors： Liang YL,Khoshouei M,Deganutti G,Glukhova A,Koole C,Peat TS,Radjainia M,Plitzko JM,Baumeister W,Miller LJ,Hay DL,Christopoulos A,Reynolds CA,Wootten D,Sexton PM

更新日期：2018-09-01 00:00:00

abstract：:Measles virus is an aerosol-transmitted virus that affects more than 10 million children each year and accounts for approximately 120,000 deaths. Although it was long believed to replicate in the respiratory epithelium before disseminating, it was recently shown to infect initially macrophages and dendritic cells of t...

journal_title：Nature

authors： Mühlebach MD,Mateo M,Sinn PL,Prüfer S,Uhlig KM,Leonard VH,Navaratnarajah CK,Frenzke M,Wong XX,Sawatsky B,Ramachandran S,McCray PB Jr,Cichutek K,von Messling V,Lopez M,Cattaneo R

更新日期：2011-11-02 00:00:00

abstract：:Recent studies have suggested a critical role of specific gene loss in several embryonic tumours and certain adult cancers. In retinoblastoma, hemizygosity or homozygosity of a recessive mutant allele results in the loss of normal gene product, and this seems to cause the manifestation of the disorder. Familial polypo...

journal_title：Nature

authors： Okamoto M,Sasaki M,Sugio K,Sato C,Iwama T,Ikeuchi T,Tonomura A,Sasazuki T,Miyaki M

更新日期：1988-01-21 00:00:00

abstract：:Pyroptosis is a form of cell death that is critical for immunity. It can be induced by the canonical caspase-1 inflammasomes or by activation of caspase-4, -5 and -11 by cytosolic lipopolysaccharide. The caspases cleave gasdermin D (GSDMD) in its middle linker to release autoinhibition on its gasdermin-N domain, which...

journal_title：Nature

authors： Wang Y,Gao W,Shi X,Ding J,Liu W,He H,Wang K,Shao F

更新日期：2017-07-06 00:00:00

abstract：:Analysis of changes in viral load after initiation of treatment with potent antiretroviral agents has provided substantial insight into the dynamics of human immunodeficiency virus type 1 (HIV-1). The concentration of HIV-1 in plasma drops by approximately 99% in the first two weeks of treatment owing to the rapid eli...

journal_title：Nature

authors： Perelson AS,Essunger P,Cao Y,Vesanen M,Hurley A,Saksela K,Markowitz M,Ho DD

更新日期：1997-05-08 00:00:00

abstract：:AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission throughout the central nervous system. Gated by the neurotransmitter glutamate, AMPA receptors are critical for synaptic strength, and dysregulation of AMPA receptor-mediated si...

journal_title：Nature

authors： Twomey EC,Yelshanskaya MV,Grassucci RA,Frank J,Sobolevsky AI

更新日期：2017-09-07 00:00:00

abstract：:In 1994, two independent groups extracted DNA from several Pleistocene epoch mammoths and noted differences among individual specimens. Subsequently, DNA sequences have been published for a number of extinct species. However, such ancient DNA is often fragmented and damaged, and studies to date have typically focused ...

journal_title：Nature

authors： Miller W,Drautz DI,Ratan A,Pusey B,Qi J,Lesk AM,Tomsho LP,Packard MD,Zhao F,Sher A,Tikhonov A,Raney B,Patterson N,Lindblad-Toh K,Lander ES,Knight JR,Irzyk GP,Fredrikson KM,Harkins TT,Sheridan S,Pringle T,Schuste

更新日期：2008-11-20 00:00:00

abstract：:Mesenchymal cells contribute to the 'stroma' of most normal and malignant tissues, with specific mesenchymal cells participating in the regulatory niches of stem cells. By examining how mesenchymal osteolineage cells modulate haematopoiesis, here we show that deletion of Dicer1 specifically in mouse osteoprogenitors, ...

journal_title：Nature

authors： Raaijmakers MH,Mukherjee S,Guo S,Zhang S,Kobayashi T,Schoonmaker JA,Ebert BL,Al-Shahrour F,Hasserjian RP,Scadden EO,Aung Z,Matza M,Merkenschlager M,Lin C,Rommens JM,Scadden DT

更新日期：2010-04-08 00:00:00

abstract：:Fluids and melts liberated from subducting oceanic crust recycle lithophile elements back into the mantle wedge, facilitate melting and ultimately lead to prolific subduction-zone arc volcanism. The nature and composition of the mobile phases generated in the subducting slab at high pressures have, however, remained l...

journal_title：Nature

authors： Kessel R,Schmidt MW,Ulmer P,Pettke T

更新日期：2005-09-29 00:00:00

abstract：:The 3-A structure of DNA-binding protein II, which exhibits histone-like properties in bacteria, has been determined. The molecule is dimeric and appears to bind to the phosphate backbone of DNA through two symmetry-related arms. A mechanism by which the protein induces DNA supercoiling is proposed. ...

journal_title：Nature

authors： Tanaka I,Appelt K,Dijk J,White SW,Wilson KS

更新日期：1984-08-02 00:00:00

abstract：:The actions of many peptide growth factors include both stimulation and inhibition of cell proliferation, as well as effects unrelated to the control of cell growth. One peptide can have both stimulatory and inhibitory activity in a single cell, depending on the context of the other signal molecules present. ...

journal_title：Nature

authors： Sporn MB,Roberts AB

更新日期：1988-03-17 00:00:00

abstract：:Microsomes prepared from rabbit or pig aortas transformed endoperoxides (PGG2 or PGH2) to an unstable substance (PGX) that inhibited human platelet aggregation. PGX was 30 times more potent in this respect than prostaglandin E1. PGX contracted some gastrointestinal smooth muscle and relaxed certain isolated blood vess...

journal_title：Nature

authors： Moncada S,Gryglewski R,Bunting S,Vane JR

更新日期：1976-10-21 00:00:00

abstract：:Successful expression of genes transferred into distantly related species in which genetic functions have been maintained through evolution has been reported previously. In the case of the silkmoth Bombyx mori and the fruitfly Drosophila melanogaster, both of which produce chorions (eggshells), Bombyx chorion genes ar...

journal_title：Nature

authors： Bello B,Couble P

更新日期：1990-08-02 00:00:00

abstract：:Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin mu or kappa enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leukaemogenic at severa...

journal_title：Nature

authors： Adams JM,Harris AW,Pinkert CA,Corcoran LM,Alexander WS,Cory S,Palmiter RD,Brinster RL

更新日期：1985-12-12 00:00:00

abstract：:Only 17% of 111 reef-building coral genera and none of the 18 coral families with reef-builders are considered endemic to the Atlantic, whereas the corresponding percentages for the Indo-west Pacific are 76% and 39%. These figures depend on the assumption that genera and families spanning the two provinces belong to t...

journal_title：Nature

authors： Fukami H,Budd AF,Paulay G,Solé-Cava A,Allen Chen C,Iwao K,Knowlton N

更新日期：2004-02-26 00:00:00

abstract：:Recent studies have suggested that bone marrow cells possess a broad differentiation potential, being able to form new liver cells, cardiomyocytes and neurons. Several groups have attributed this apparent plasticity to 'transdifferentiation'. Others, however, have suggested that cell fusion could explain these results...

journal_title：Nature

authors： Alvarez-Dolado M,Pardal R,Garcia-Verdugo JM,Fike JR,Lee HO,Pfeffer K,Lois C,Morrison SJ,Alvarez-Buylla A

更新日期：2003-10-30 00:00:00

abstract：:The Southern Ocean is very important for the potential sequestration of carbon dioxide in the oceans and is expected to be vulnerable to changes in carbon export forced by anthropogenic climate warming. Annual phytoplankton blooms in seasonal ice zones are highly productive and are thought to contribute significantly ...

journal_title：Nature

authors： DiTullio GR,Grebmeier JM,Arrigo KR,Lizotte MP,Robinson DH,Leventer A,Barry JP,VanWoert ML,Dunbar RB

更新日期：2000-04-06 00:00:00

abstract：: ...

journal_title：Nature

authors： Hills R,Kulkarni G,Meerburg PD,Puchwein E

更新日期：2018-12-01 00:00:00

abstract：:It is thought that immunity depends on naive CD4 T cells that proliferate in response to microbial antigens, differentiate into memory cells that produce anti-microbial lymphokines, and migrate to sites of infection. Here we use immunohistology to enumerate individual naive CD4 T cells, specific for a model antigen, i...

journal_title：Nature

authors： Reinhardt RL,Khoruts A,Merica R,Zell T,Jenkins MK

更新日期：2001-03-01 00:00:00

abstract：:One of the earliest computational principles attributed to the cerebellum was the measurement of time. This idea was originally suggested on anatomical grounds, and was taken up again to explain some of the deficits in cerebellar patients. The contribution of the cerebellum to eye movements, in contrast, has tradition...

journal_title：Nature

authors： Thier P,Dicke PW,Haas R,Barash S

更新日期：2000-05-04 00:00:00

abstract：:Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis, is a major cause of morbidity and mortality worldwide. Efforts to control it are hampered by difficulties with diagnosis, prevention and treatment. Most people infected with M. tuberculosis remain asymptomatic, termed latent TB, with a 10% lifetim...

journal_title：Nature

authors： Berry MP,Graham CM,McNab FW,Xu Z,Bloch SA,Oni T,Wilkinson KA,Banchereau R,Skinner J,Wilkinson RJ,Quinn C,Blankenship D,Dhawan R,Cush JJ,Mejias A,Ramilo O,Kon OM,Pascual V,Banchereau J,Chaussabel D,O'Garra A

更新日期：2010-08-19 00:00:00

abstract：:The presence of homoeo box sequences in the genomes of vertebrates has suggested that these metazoans possess the equivalent of the homoeotic genes that have a key role in regulating the development of the fruitfly Drosophila melanogaster. We report here that a novel murine homoeo box-containing gene is expressed in e...

journal_title：Nature

authors： Colberg-Poley AM,Voss SD,Chowdhury K,Gruss P

更新日期：1985-04-25 00:00:00

abstract：:Unmethylated CpG dinucleotides are more frequent in the genomes of bacteria and viruses than of vertebrates. We report here that bacterial DNA and synthetic oligodeoxynucleotides containing unmethylated CpG dinucleotides induce murine B cells to proliferate and secrete immunoglobulin in vitro and in vivo. This activat...

journal_title：Nature

authors： Krieg AM,Yi AK,Matson S,Waldschmidt TJ,Bishop GA,Teasdale R,Koretzky GA,Klinman DM

更新日期：1995-04-06 00:00:00