Author Correction: Diffusible repression of cytokinin signalling produces endodermal symmetry and passage cells.

abstract：:Inorganic nanoparticles exhibit size-dependent properties that are of interest for applications ranging from biosensing and catalysis to optics and data storage. They are readily available in a wide variety of discrete compositions and sizes. Shape-selective synthesis strategies now also yield shapes other than nanosp...

journal_title：Nature

authors： Jin R,Cao YC,Hao E,Métraux GS,Schatz GC,Mirkin CA

更新日期：2003-10-02 00:00:00

abstract：:ATP is the dominant energy source in animals for mechanical and electrical work (for example, muscle contraction or neuronal firing). For chemical work, there is an equally important role for NADPH, which powers redox defence and reductive biosynthesis. The most direct route to produce NADPH from glucose is the oxidat...

journal_title：Nature

authors： Fan J,Ye J,Kamphorst JJ,Shlomi T,Thompson CB,Rabinowitz JD

更新日期：2014-06-12 00:00:00

abstract：:Coordinated cell migration is essential in many fundamental biological processes including embryonic development, organogenesis, wound healing and the immune response. During organogenesis, groups of cells are directed to specific locations within the embryo. Here we show that the zebrafish miles apart (mil) mutation ...

journal_title：Nature

authors： Kupperman E,An S,Osborne N,Waldron S,Stainier DY

更新日期：2000-07-13 00:00:00

abstract：:That animals and humans can accomplish the same goal using different effectors and different goals using the same effectors attests to the remarkable flexibility of the central nervous system. This phenomenon has been termed 'motor equivalence', an example being the writing of a name with a pencil held between the toe...

journal_title：Nature

authors： Kelso JA,Fuchs A,Lancaster R,Holroyd T,Cheyne D,Weinberg H

更新日期：1998-04-23 00:00:00

abstract：:RecBCD is a multi-functional enzyme complex that processes DNA ends resulting from a double-strand break. RecBCD is a bipolar helicase that splits the duplex into its component strands and digests them until encountering a recombinational hotspot (Chi site). The nuclease activity is then attenuated and RecBCD loads Re...

journal_title：Nature

authors： Singleton MR,Dillingham MS,Gaudier M,Kowalczykowski SC,Wigley DB

更新日期：2004-11-11 00:00:00

abstract：:Major histocompatibility complex (MHC) class II molecules are highly polymorphic cell-surface glycoproteins that present antigenic peptides to CD4+ T lymphocytes. The normal assembly of class II molecules with cognate peptides for antigen presentation requires an accessory function provided by a gene mapping to the cl...

journal_title：Nature

authors： Fling SP,Arp B,Pious D

更新日期：1994-04-07 00:00:00

abstract：:CD4 and CD8 antigens are simultaneously expressed on most of the cortical thymocytes, that weakly express the T-cell antigen receptor(TCR)/CD3 complex. Mature peripheral T cells, however, strongly express the TCR complex and are positive for either CD4 or CD8. Nevertheless, a small percentage of peripheral CD3+ T cell...

journal_title：Nature

authors： Paliard X,Malefijt RW,de Vries JE,Spits H

更新日期：1988-10-13 00:00:00

abstract：:Interest in mapping the global distribution of malaria is motivated by a need to define populations at risk for appropriate resource allocation and to provide a robust framework for evaluating its global economic impact. Comparison of older and more recent malaria maps shows how the disease has been geographically res...

journal_title：Nature

authors： Snow RW,Guerra CA,Noor AM,Myint HY,Hay SI

更新日期：2005-03-10 00:00:00

abstract：:Biochemical and structural studies have shown that the initiation of RNA polymerase II transcription proceeds in the following stages: assembly of the polymerase with general transcription factors and promoter DNA in a 'closed' preinitiation complex (PIC); unwinding of about 15 base pairs of the promoter DNA to form a...

journal_title：Nature

authors： Fazal FM,Meng CA,Murakami K,Kornberg RD,Block SM

更新日期：2015-09-10 00:00:00

abstract：:Ice sheets are currently ignored in global methane budgets1,2. Although ice sheets have been proposed to contain large reserves of methane that may contribute to a rise in atmospheric methane concentration if released during periods of rapid ice retreat3,4, no data exist on the current methane footprint of ice sheets....

journal_title：Nature

authors： Lamarche-Gagnon G,Wadham JL,Sherwood Lollar B,Arndt S,Fietzek P,Beaton AD,Tedstone AJ,Telling J,Bagshaw EA,Hawkings JR,Kohler TJ,Zarsky JD,Mowlem MC,Anesio AM,Stibal M

更新日期：2019-01-01 00:00:00

abstract：:The normal cellular form of prion protein (PrPC) is a precursor to the pathogenic protease-resistant forms (PrPSc) believed to cause scrapie, bovine spongiform encephalopathy (BSE) and Creutzfeldt-Jakob disease. Its amino terminus contains the octapeptide PHGGGWGQ, which is repeated four times and is among the best-pr...

journal_title：Nature

authors： Brown DR,Qin K,Herms JW,Madlung A,Manson J,Strome R,Fraser PE,Kruck T,von Bohlen A,Schulz-Schaeffer W,Giese A,Westaway D,Kretzschmar H

更新日期：1997-12-18 00:00:00

abstract：:Intensive fisheries have reduced fish biodiversity and abundance in aquatic ecosystems worldwide1-3. 'No-take' marine reserves have become a cornerstone of marine ecosystem-based fisheries management4-6, and their benefits for adjacent fisheries are maximized when reserve design fosters synergies among nearby reserves...

journal_title：Nature

authors： Koning AA,Perales KM,Fluet-Chouinard E,McIntyre PB

更新日期：2020-12-01 00:00:00

abstract：:A continuous array of overlapping clones covering the entire human chromosome 21q was constructed from human yeast artificial chromosome libraries using sequence-tagged sites as landmarks specifically detected by polymerase chain reaction. The yeast artificial chromosome contiguous unit starts with pericentromeric and...

journal_title：Nature

authors： Chumakov I,Rigault P,Guillou S,Ougen P,Billaut A,Guasconi G,Gervy P,LeGall I,Soularue P,Grinas L

更新日期：1992-10-01 00:00:00

abstract：:TPA (12-O-tetradecanoyl-phorbol-13-acetate) reversibly inhibits the binding of (125)I-labelled epidermal growth factor (EGF) to treated mouse and human cells, but does not affect the binding of various other ligands to their membrane receptors. It alters the affinity of the receptors for EGF without changing the total...

journal_title：Nature

authors： Shoyab M,De Larco JE,Todaro GJ

更新日期：1979-05-31 00:00:00

abstract：:Understanding the capacity of natural populations to adapt to their local environment is a central topic in evolutionary biology. Phenotypic differences between populations may have a genetic basis, but showing that they reflect different adaptive optima requires the quantification of both gene flow and selection. Goo...

journal_title：Nature

authors： Postma E,van Noordwijk AJ

更新日期：2005-01-06 00:00:00

abstract：:Genetic studies, using floral homeotic mutants, have led to the ABC model of flower development. This model proposes that the combinatorial action of three sets of genes, the A, B and C function genes, specify the four floral organs (sepals, petals, stamens and carpels) in the concentric floral whorls. However, attemp...

journal_title：Nature

authors： Honma T,Goto K

更新日期：2001-01-25 00:00:00

abstract：:Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases. Sirtuin activating compounds (STACs) can promote the survival of human cells and extend the replicative lifespan of ...

journal_title：Nature

authors： Wood JG,Rogina B,Lavu S,Howitz K,Helfand SL,Tatar M,Sinclair D

更新日期：2004-08-05 00:00:00

abstract：:In vast areas of the ocean, the scarcity of iron controls the growth and productivity of phytoplankton. Although most dissolved iron in the marine environment is complexed with organic molecules, picomolar amounts of labile inorganic iron species (labile iron) are maintained within the euphotic zone and serve as an im...

journal_title：Nature

authors： McQuaid JB,Kustka AB,Oborník M,Horák A,McCrow JP,Karas BJ,Zheng H,Kindeberg T,Andersson AJ,Barbeau KA,Allen AE

更新日期：2018-03-22 00:00:00

abstract：:The dry valleys of southern Victoria Land in Antarctica contain several closed basins in which perennially ice-covered lakes are found. One of the most unusual features of these lakes is the occurrence of high O2 concentrations in the water column; values ranging from slightly more than saturation to more than four t...

journal_title：Nature

authors： Wharton RA Jr,McKay CP,Mancinelli RL,Simmons GM Jr

更新日期：1987-01-22 00:00:00

abstract：:Very large collisions in the asteroid belt could lead temporarily to a substantial increase in the rate of impacts of meteorites on Earth. Orbital simulations predict that fragments from such events may arrive considerably faster than the typical transit times of meteorites falling today, because in some large impacts...

journal_title：Nature

authors： Heck PR,Schmitz B,Baur H,Halliday AN,Wieler R

更新日期：2004-07-15 00:00:00

abstract：:Considerable evidence points to a role for G1 cyclin-dependent kinase (CDK) in allowing the accumulation of E2F transcription factor activity and induction of the S phase of the cell cycle. Numerous experiments have also demonstrated a critical role for both Myc and Ras activities in allowing cell-cycle progression. H...

journal_title：Nature

authors： Leone G,DeGregori J,Sears R,Jakoi L,Nevins JR

更新日期：1997-05-22 00:00:00

abstract：:Recognition of an avirulent pathogen triggers the rapid production of the reactive oxygen intermediates superoxide (O2-) and hydrogen peroxide (H2O2). This oxidative burst drives crosslinking of the cell wall, induces several plant genes involved in cellular protection and defence, and is necessary for the initiation ...

journal_title：Nature

authors： Delledonne M,Xia Y,Dixon RA,Lamb C

更新日期：1998-08-06 00:00:00

abstract：:The factors determining disease severity in malaria are complex and include host polymorphisms, acquired immunity and parasite virulence. Studies in Africa have shown that severe malaria is associated with the ability of erythrocytes infected with the parasite Plasmodium falciparum to bind uninfected erythrocytes and ...

journal_title：Nature

authors： Rowe JA,Moulds JM,Newbold CI,Miller LH

更新日期：1997-07-17 00:00:00

abstract：:Activated T lymphocytes differentiate into effector cells tailored to meet disparate challenges to host integrity. For example, type 1 and type 2 helper (T(H)1 and T(H)2) cells secrete cytokines that enhance cell-mediated and humoral immunity, respectively. The chemokine monocyte chemoattractant protein-1 (MCP-1) can ...

journal_title：Nature

authors： Gu L,Tseng S,Horner RM,Tam C,Loda M,Rollins BJ

更新日期：2000-03-23 00:00:00

abstract：:Neutralizing antibody function provides a foundation for the efficacy of vaccines and therapies1-3. Here, using a robust in vitro Ebola virus (EBOV) pseudo-particle infection assay and a well-defined set of solid-phase assays, we describe a wide spectrum of antibody responses in a cohort of healthy survivors of the Si...

journal_title：Nature

authors： Adaken C,Scott JT,Sharma R,Gopal R,Dicks S,Niazi S,Ijaz S,Edwards T,Smith CC,Cole CP,Kamara P,Kargbo O,Doughty HA,van Griensven J,Horby PW,Gevao SM,Sahr F,Ebola-CP Consortium.,Dimelow RJ,Tedder RS,Semple MG,Paxt

更新日期：2021-01-27 00:00:00

abstract：:Hypermethylation of the promoters of tumour suppressor genes represses transcription of these genes, conferring growth advantages to cancer cells. How these changes arise is poorly understood. Here we show that the activity of oxygen-dependent ten-eleven translocation (TET) enzymes is reduced by tumour hypoxia in huma...

journal_title：Nature

authors： Thienpont B,Steinbacher J,Zhao H,D'Anna F,Kuchnio A,Ploumakis A,Ghesquière B,Van Dyck L,Boeckx B,Schoonjans L,Hermans E,Amant F,Kristensen VN,Peng Koh K,Mazzone M,Coleman M,Carell T,Carmeliet P,Lambrechts D

更新日期：2016-09-01 00:00:00

abstract：:Humans have engaged in endurance running for millions of years, but the modern running shoe was not invented until the 1970s. For most of human evolutionary history, runners were either barefoot or wore minimal footwear such as sandals or moccasins with smaller heels and little cushioning relative to modern running sh...

journal_title：Nature

authors： Lieberman DE,Venkadesan M,Werbel WA,Daoud AI,D'Andrea S,Davis IS,Mang'eni RO,Pitsiladis Y

更新日期：2010-01-28 00:00:00

abstract：:Mutations of the presenilin-1 gene are a major cause of familial early-onset Alzheimer's disease. Presenilin-1 can associate with members of the catenin family of signalling proteins, but the significance of this association is unknown. Here we show that presenilin-1 forms a complex with beta-catenin in vivo that incr...

journal_title：Nature

authors： Zhang Z,Hartmann H,Do VM,Abramowski D,Sturchler-Pierrat C,Staufenbiel M,Sommer B,van de Wetering M,Clevers H,Saftig P,De Strooper B,He X,Yankner BA

更新日期：1998-10-15 00:00:00

abstract：:Establishment and maintenance of proper architecture is essential for endoplasmic reticulum (ER) function. Homotypic membrane fusion is required for ER biogenesis and maintenance, and has been shown to depend on GTP hydrolysis. Here we demonstrate that Drosophila Atlastin--the fly homologue of the mammalian GTPase atl...

journal_title：Nature

authors： Orso G,Pendin D,Liu S,Tosetto J,Moss TJ,Faust JE,Micaroni M,Egorova A,Martinuzzi A,McNew JA,Daga A

更新日期：2009-08-20 00:00:00

abstract：:The heat-shock protein Hsp90 supports diverse but specific signal transducers and lies at the interface of several developmental pathways. We report here that when Drosophila Hsp90 is mutant or pharmacologically impaired, phenotypic variation affecting nearly any adult structure is produced, with specific variants dep...

journal_title：Nature

authors： Rutherford SL,Lindquist S

更新日期：1998-11-26 00:00:00