Abstract:
:TPA (12-O-tetradecanoyl-phorbol-13-acetate) reversibly inhibits the binding of (125)I-labelled epidermal growth factor (EGF) to treated mouse and human cells, but does not affect the binding of various other ligands to their membrane receptors. It alters the affinity of the receptors for EGF without changing the total number of available receptors per cell. Those phorbol esters which stimulate cell growth in culture and have tumour-promoting activity in vivo alter the EGF-receptor affinity, while the biologically inactive derivatives fail to change the affinity of EGF for its receptors.
journal_name
Naturejournal_title
Natureauthors
Shoyab M,De Larco JE,Todaro GJdoi
10.1038/279387a0keywords:
subject
Has Abstractpub_date
1979-05-31 00:00:00pages
387-91issue
5712eissn
0028-0836issn
1476-4687pii
279387a0journal_volume
279pub_type
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