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NATURE文献大全abstract::Zika virus (ZIKV) remained obscure until the recent explosive outbreaks in French Polynesia (2013-2014) and South America (2015-2016). Phylogenetic studies have shown that ZIKV has evolved into African and Asian lineages. The Asian lineage of ZIKV was responsible for the recent epidemics in the Americas. However, the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature22365
更新日期:2017-05-25 00:00:00
abstract::Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide1. The only available vaccine, BCG (Bacillus Calmette-Guérin), is given intradermally and has variable efficacy against pulmonary tuberculosis, the major cause of mortality and disease transmission1,2. Here we show that intravenous ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1817-8
更新日期:2020-01-01 00:00:00
abstract::Many voltage-dependent K+ channels open when the membrane is depolarized and then rapidly close by a process called inactivation. Neurons use inactivating K+ channels to modulate their firing frequency. In Shaker-type K+ channels, the inactivation gate, which is responsible for the closing of the channel, is formed by...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35079500
更新日期:2001-06-07 00:00:00
abstract::The Wnt family of secreted glycoproteins mediate cell cell interactions during cell growth and differentiation in both embryos and adults. Canonical Wnt signalling by way of the beta-catenin pathway is transduced by two receptor families. Frizzled proteins and lipoprotein-receptor-related proteins 5 and 6 (LRP5/6) bin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature756
更新日期:2002-06-06 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/d41586-018-07046-0
更新日期:2018-10-01 00:00:00
abstract::Improvement in the clinical outcome of lung cancer is likely to be achieved by identification of the molecular events that underlie its pathogenesis. Here we show that a small inversion within chromosome 2p results in the formation of a fusion gene comprising portions of the echinoderm microtubule-associated protein-l...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05945
更新日期:2007-08-02 00:00:00
abstract::53BP1 governs a specialized, context-specific branch of the classical non-homologous end joining DNA double-strand break repair pathway. Mice lacking 53bp1 (also known as Trp53bp1) are immunodeficient owing to a complete loss of immunoglobulin class-switch recombination1,2, and reduced fidelity of long-range V(D)J rec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0362-1
更新日期:2018-08-01 00:00:00
abstract::The Borrmann effect-a dramatic increase in transparency to X-ray beams-is observed when X-rays satisfying Bragg's law diffract through a perfect crystal. The minimization of absorption seen in the Borrmann effect has been explained by noting that the electric field of the X-ray beam approaches zero amplitude at the cr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07099
更新日期:2008-07-10 00:00:00
abstract::Visual transduction in vertebrate photoreceptors is thought to involve a diffusible internal transmitter which links photon absorption in disk membranes to the conductance decrease in the plasma membrane of the outer segment. The desensitisation of the photoresponse which occurs during and after illumination may also ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/283085a0
更新日期:1980-01-03 00:00:00
abstract::That animals and humans can accomplish the same goal using different effectors and different goals using the same effectors attests to the remarkable flexibility of the central nervous system. This phenomenon has been termed 'motor equivalence', an example being the writing of a name with a pencil held between the toe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/33922
更新日期:1998-04-23 00:00:00
abstract::Molecular noise is a natural phenomenon that is inherent to all biological systems1,2. How stochastic processes give rise to the robust outcomes that support tissue homeostasis remains unclear. Here we use single-molecule RNA fluorescent in situ hybridization (smFISH) on mouse stem cells derived from haematopoietic ti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2432-4
更新日期:2020-07-01 00:00:00
abstract::Abiraterone blocks androgen synthesis and prolongs survival in patients with castration-resistant prostate cancer, which is otherwise driven by intratumoral androgen synthesis. Abiraterone is metabolized in patients to Δ(4)-abiraterone (D4A), which has even greater anti-tumour activity and is structurally similar to e...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature17954
更新日期:2016-05-26 00:00:00
abstract::Acetylcholine (ACh) released on vagal stimulation reduces the heart rate by increasing K+ conductance of pacemaker cells in the sinoatrial (S-A) node. Fluctuation analysis of ACh-activated currents in pacemaker tissue showed this to be due to opening of a separate class of K+ channels gated by muscarinic ACh receptors...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/303250a0
更新日期:1983-05-19 00:00:00
abstract::Regulation of ion transport by phosphorylation and G proteins occurs in several epithelial and non-epithelial cell plasma membranes1-5. It is not known whether transporters on intracellular membranes are target sites for second messengers. Here we present direct evidence that a chloride conductance in endocytic vesicl...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/348637a0
更新日期:1990-12-13 00:00:00
abstract::Contamination of ground waters with water-soluble aromatic hydrocarbons, common components of petroleum pollution, often produces anoxic conditions under which microbial degradation of the aromatics is slow. Oxygen is often added to contaminated ground water to stimulate biodegradation, but this can be technically dif...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/370128a0
更新日期:1994-07-14 00:00:00
abstract::DNA mismatch repair is critical for increasing replication fidelity in organisms ranging from bacteria to humans. MutS protein, a member of the ABC ATPase superfamily, recognizes mispaired and unpaired bases in duplex DNA and initiates mismatch repair. Mutations in human MutS genes cause a predisposition to hereditary...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35037509
更新日期:2000-10-12 00:00:00
abstract::The radio sky is relatively unexplored for transient signals, although the potential of radio-transient searches is high. This was demonstrated recently by the discovery of a previously unknown type of source, varying on timescales of minutes to hours. Here we report a search for radio sources that vary on much shorte...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04440
更新日期:2006-02-16 00:00:00
abstract::The Nuffield Council on Bioethics suggests that introgression of genetic material into related species in centres of crop biodiversity is an insufficient justification to bar the use of genetically modified crops in the developing world. They consider that a precautionary approach to forgo the possible benefits invoke...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03048
更新日期:2004-11-11 00:00:00
abstract::To artists, the face is a mirror of the soul. To biologists, the face reflects remarkable structural diversity--think of bulldogs and wolfhounds or galapagos finches. How do such variations in skeletal form arise? Do the same mechanisms control skeletogenesis elsewhere in the body? The answers lie in the molecular mac...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature01656
更新日期:2003-05-15 00:00:00
abstract::Oral administration of antigen is used to induce antigen-specific peripheral immune tolerance. As well as preventing systemic immune responses to ingested proteins, oral tolerance to autoantigens has also been used to suppress autoimmune diseases in animals and humans. Both active suppression and clonal anergy are sug...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/376177a0
更新日期:1995-07-13 00:00:00
abstract::The nematode Caenorhabditis elegans is an important model for studying the genetics of ageing, with over 50 life-extension mutations known so far. However, little is known about the pathobiology of ageing in this species, limiting attempts to connect genotype with senescent phenotype. Using ultrastructural analysis an...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01135
更新日期:2002-10-24 00:00:00
abstract::The biosynthesis of many of the complement proteins by cells of the monocyte-macrophage series has been established. Studies on these cells using radiolabelled amino acids demonstrated synthesis of precursor proteins (pro-complement), and the native complement protein similar in size to that found in the plasma. Howev...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/298389a0
更新日期:1982-07-22 00:00:00
abstract::Networks of interacting proteins orchestrate the responses of living cells to a variety of external stimuli, but how sensitive is the functioning of these protein networks to variations in their biochemical parameters? One possibility is that to achieve appropriate function, the reaction rate constants and enzyme conc...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/16483
更新日期:1999-01-14 00:00:00
abstract::The planet in the system HD209458 is the first one for which repeated transits across the stellar disk have been observed. Together with radial velocity measurements, this has led to a determination of the planet's radius and mass, confirming it to be a gas giant. But despite numerous searches for an atmospheric signa...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01448
更新日期:2003-03-13 00:00:00
abstract::L-glutamate, the neurotransmitter of the majority of excitatory synapses in the brain, acts on three classes of ionotropic receptors: NMDA (N-methyl-D-aspartate), AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) and kainate receptors. Little is known about the physiological role of kainate receptors be...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/33408
更新日期:1998-04-09 00:00:00
abstract::Mammals owe part of their evolutionary success to the harmonious exchanges of information, energy and immunity between females and their offspring. This functional reciprocity is vital for the survival and normal development of infants, and for the inclusive fitness of parents. It is best seen in the intense exchanges...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01739
更新日期:2003-07-03 00:00:00
abstract::Fluorine is the thirteenth most abundant element in the earth's crust, but fluoride concentrations in surface water are low and fluorinated metabolites are extremely rare. The fluoride ion is a potent nucleophile in its desolvated state, but is tightly hydrated in water and effectively inert. Low availability and a la...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02280
更新日期:2004-02-05 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,新闻
doi:10.1038/d41586-019-00393-6
更新日期:2019-02-01 00:00:00
abstract::The yeast [PSI+] element represents a new type of genetic inheritance, in which changes in phenotype are transmitted by a 'protein only' mechanism reminiscent of the 'protein-only' transmission of mammalian prion diseases. The underlying molecular mechanisms for both are poorly understood and it is not clear how simil...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/23048
更新日期:1999-08-05 00:00:00
abstract::It has been shown that Neanderthals contributed genetically to modern humans outside Africa 47,000-65,000 years ago. Here we analyse the genomes of a Neanderthal and a Denisovan from the Altai Mountains in Siberia together with the sequences of chromosome 21 of two Neanderthals from Spain and Croatia. We find that a p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16544
更新日期:2016-02-25 00:00:00