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NATURE文献大全abstract::Atmospheric carbon dioxide concentrations seem to have been several times modern levels during much of the Palaeozoic era (543-248 million years ago), but decreased during the Carboniferous period to concentrations similar to that of today. Given that carbon dioxide is a greenhouse gas, it has been proposed that surfa...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature06085
更新日期:2007-09-13 00:00:00
abstract::The theory of electric polarization in crystals defines the dipole moment of an insulator in terms of a Berry phase (geometric phase) associated with its electronic ground state. This concept not only solves the long-standing puzzle of how to calculate dipole moments in crystals, but also explains topological band str...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25777
更新日期:2018-03-14 00:00:00
abstract::Villin is an actin-binding protein of relative molecular mass (Mr) 95,000 found in the core bundle of microfilaments in brush border microvilli from intestine. In physiological calcium concentrations (less than 1 microM), villin crosslinks actin filaments into bundles. However, in free calcium concentrations (greater ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/315248a0
更新日期:1985-05-16 00:00:00
abstract::A long-standing problem in managing the behaviour of a collection of solid grains concerns the nature of the grain packing, a property that is typically controlled by how the grains are poured or shaken. Here we show that a systematic and controllable increase in granular packing can be induced by simply raising and t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/442257a
更新日期:2006-07-20 00:00:00
abstract::During serial structure analysis of cobaloxime derivatives, aimed at interpreting the catalytic capability of the asymmetric hydrogenation, we have found that the crystal of R-alpha-cyanoethyl (S-alpha-methylbenzylamine)-cobaloxime changes its unit cell dimensions by X-ray exposure without degradation of a single crys...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/267142a0
更新日期:1977-05-12 00:00:00
abstract::Although the first ten million years of whale evolution are documented by a remarkable series of fossil skeletons, the link to the ancestor of cetaceans has been missing. It was known that whales are related to even-toed ungulates (artiodactyls), but until now no artiodactyls were morphologically close to early whales...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06343
更新日期:2007-12-20 00:00:00
abstract::DNA winds about itself in a right-handed or left-handed fashion at several structural levels. The double helix is generally right-handed and is given a (+) sign by convention, whereas supercoiling of the helix axis is always (-) in the cell. The winding in higher -order forms such as knots and catenanes is unknown, an...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/304559a0
更新日期:1983-08-11 00:00:00
abstract::Grid cells provide a neural representation of space, by discharging when an animal traverses through the vertices of a periodic hexagonal grid spanning the environment. Although grid cells have been characterized in detail in rats, the fundamental question of what neural dynamics give rise to the grid structure remain...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10583
更新日期:2011-11-02 00:00:00
abstract::Recent studies have suggested that actomyosin threads may provide a useful model for studying the properties of contractile systems. The development of highly sensitive positional feedback transducers has enabled the properties of these threads to be measured reproducibly. Potential applications include such systems a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/287338a0
更新日期:1980-09-25 00:00:00
abstract::The reciprocal chromosome translocation, t(8;14), involving the heavy chain locus on chromosome 14 and the c-myc oncogene on chromosome 8 is a characteristic of the B-cell malignancies Burkitt's lymphoma and acute lymphoblastic leukaemia (ALL). We have cloned and sequenced the t(8; 14) breakpoints of an African Burkit...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/324158a0
更新日期:1986-11-13 00:00:00
abstract::Self-reproduction is central to biological life for long-term sustainability and evolutionary adaptation. Although these traits would also be desirable in many engineered systems, the principles of self-reproduction have not been exploited in machine design. Here we create simple machines that act as autonomous modula...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/435163a
更新日期:2005-05-12 00:00:00
abstract::Spatially extended dynamical systems exhibit complex behaviour in both space and time--spatiotemporal chaos. Analysis of dynamical quantities (such as fractal dimensions and Lyapunov exponents) has provided insights into low-dimensional systems; but it has proven more difficult to understand spatiotemporal chaos in hi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35008013
更新日期:2000-04-13 00:00:00
abstract::The mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a receptor in many of their T cells for the male (H-Y) antigen in the context of class I H-2Db MHC antigens. Autospecific T cells are deleted in male mice. The deletion affects only transgene-expressing cells with a relatively hig...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/333742a0
更新日期:1988-06-23 00:00:00
abstract::The tumour-suppressor gene p53 is frequently mutated in human cancers and is important in the cellular response to DNA damage. Although the p53 family members p63 and p73 are structurally related to p53, they have not been directly linked to tumour suppression, although they have been implicated in apoptosis. Given th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/416560a
更新日期:2002-04-04 00:00:00
abstract::The tumour microenvironment may contribute to tumorigenesis owing to mechanical forces such as fibrotic stiffness or mechanical pressure caused by the expansion of hyper-proliferative cells. Here we explore the contribution of the mechanical pressure exerted by tumour growth onto non-tumorous adjacent epithelium. In t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14329
更新日期:2015-07-02 00:00:00
abstract::There are major impediments to finding improved DEET alternatives because the receptors causing olfactory repellency are unknown, and new chemicals require exorbitant costs to determine safety for human use. Here we identify DEET-sensitive neurons in a pit-like structure in the Drosophila melanogaster antenna called t...
journal_title:Nature
pub_type: 杂志文章,收录出版
doi:10.1038/nature12594
更新日期:2013-10-24 00:00:00
abstract::An increasing body of evidence points to mitochondrial dysfunction as a contributor to the molecular pathogenesis of neurodegenerative diseases such as Parkinson's disease. Recent studies of the Parkinson's disease associated genes PINK1 (ref. 2) and parkin (PARK2, ref. 3) indicate that they may act in a quality contr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12748
更新日期:2013-12-12 00:00:00
abstract::The ras proto-oncogene, found in all eukaryotes so far examined, encode s a protein with guanine nucleotide-binding and GTPase activity. Gene disruption experiments in yeast indicate that ras is essential for cell growth. Anit-sense mutagenesis approaches suggest that this is also true for Dictyostelium. Most mutation...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/323340a0
更新日期:1986-09-25 00:00:00
abstract::Germinal centres are specialized structures wherein B lymphocytes undergo clonal expansion, class switch recombination, antibody gene diversification and affinity maturation. Three to four antigen-specific B cells colonize a follicle to establish a germinal centre and become rapidly dividing germinal-centre centroblas...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05573
更新日期:2007-03-01 00:00:00
abstract::The radio sky is relatively unexplored for transient signals, although the potential of radio-transient searches is high. This was demonstrated recently by the discovery of a previously unknown type of source, varying on timescales of minutes to hours. Here we report a search for radio sources that vary on much shorte...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04440
更新日期:2006-02-16 00:00:00
abstract::Models and simulations of the epoch of reionization predict that spectra of the 21-centimetre transition of atomic hydrogen will show a clear fluctuation peak, at a redshift and scale, respectively, that mark the central stage of reionization and the characteristic size of ionized bubbles. This is based on the assumpt...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12999
更新日期:2014-02-13 00:00:00
abstract::Osmotic pressures are generated by differences in chemical potential of a solution across a membrane. But whether osmosis can have a significant effect on the pressure of fluids in geological environments has been controversial, because the membrane properties of geological media are poorly understood. 'Anomalous' pre...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35003174
更新日期:2000-01-13 00:00:00
abstract::A fundamental challenge to our understanding of biodiversity is to explain why some groups of species undergo adaptive radiations, diversifying extensively into many and varied species, whereas others do not. Both extrinsic environmental factors (for example, resource availability, climate) and intrinsic lineage-speci...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11144
更新日期:2012-07-19 00:00:00
abstract::In this Letter, in Fig. 3c and f the Saccharomyces cerevisiae and Escherichia coli networks were subject to both weight loss and node deletion, a combination of two types of perturbation, as opposed to weight loss only (as the labelling incorrectly indicated). The collapse in Fig. 3h was also obtained from this combin...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1091-9
更新日期:2019-04-01 00:00:00
abstract::Interleukin (IL)-2 is a pleiotropic cytokine that is necessary to prevent chronic inflammation in the gastrointestinal tract1-4. The protective effects of IL-2 involve the generation, maintenance and function of regulatory T (Treg) cells4-8, and the use of low doses of IL-2 has emerged as a potential therapeutic strat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1082-x
更新日期:2019-04-01 00:00:00
abstract::Transmembrane sodium-ion gradients provide energy that can be harnessed by 'secondary transporters' to drive the translocation of solute molecules into a cell. Decades of study have shown that such sodium-coupled transporters are involved in many physiological processes, making them targets for the treatment of numero...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature08143
更新日期:2009-05-21 00:00:00
abstract::Mitogen-activated protein kinases, MAP kinases or ERKs (extracellular signal-regulated kinases) are rapidly stimulated by growth-promoting factors acting on a variety of cell-surface receptors. In turn, ERKs phosphorylate and regulate key intracellular enzymes and transcription factors involved in the control of cellu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/369418a0
更新日期:1994-06-02 00:00:00
abstract::Chronic electrical stimulation of the auditory nerve in patients with profound sensori-neural deafness is becoming increasingly routine. Therefore, it is important to understand more about the long-term consequences of this procedure. Hitherto, structural studies in animals after electrocochlear stimulation have conce...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/320065a0
更新日期:1986-03-06 00:00:00
abstract::Haematopoiesis is a developmental cascade that generates all blood cell lineages in health and disease. This process relies on quiescent haematopoietic stem cells capable of differentiating, self renewing and expanding upon physiological demand. However, the mechanisms that regulate haematopoietic stem cell homeostasi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13498
更新日期:2014-10-02 00:00:00
abstract::Refractoriness to induction chemotherapy and relapse after achievement of remission are the main obstacles to cure in acute myeloid leukaemia (AML). After standard induction chemotherapy, patients are assigned to different post-remission strategies on the basis of cytogenetic and molecular abnormalities that broadly d...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature20598
更新日期:2016-12-15 00:00:00