Abstract:
:Organocatalysis-catalysis mediated by small chiral organic molecules-is a powerful technology for enantioselective synthesis, and has extensive applications in traditional ionic, two-electron-pair reactivity domains. Recently, organocatalysis has been successfully combined with photochemical reactivity to unlock previously inaccessible reaction pathways, thereby creating new synthetic opportunities. Here we describe the historical context, scientific reasoning and landmark discoveries that were essential in expanding the functions of organocatalysis to include one-electron-mediated chemistry and excited-state reactivity.
journal_name
Naturejournal_title
Natureauthors
Silvi M,Melchiorre Pdoi
10.1038/nature25175subject
Has Abstractpub_date
2018-01-31 00:00:00pages
41-49issue
7690eissn
0028-0836issn
1476-4687pii
nature25175journal_volume
554pub_type
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