Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein.

abstract：:Neutrophils activated by the formyl peptide f-Met-Leu-Phe transiently accumulate a small subset of highly polar inositol lipids. A similar family of lipids also appear in many other cells in response to a range of growth factors and activated oncogenes, and are presumed to be the direct or indirect products of 3-phosp...

journal_title：Nature

authors： Stephens LR,Hughes KT,Irvine RF

更新日期：1991-05-02 00:00:00

abstract：:The crab Xenograpsus testudinatus lives at enormously high densities around the sulphur-rich hydrothermal vents found in shallow waters off Taiwan, even though this acidic environment is low in nutrients. Here we show that these crabs swarm out of their crevices at slack water and feed on the vast numbers of zooplankt...

journal_title：Nature

authors： Jeng MS,Ng NK,Ng PK

更新日期：2004-12-23 00:00:00

abstract：:Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as prevalent as cancer in industrialized nations. Most blindness in AMD results from invasion of the retina by choroidal neovascularisation (CNV). Here we show that the eosinophil/mast cell chemokine receptor CCR3 is specifically expres...

journal_title：Nature

authors： Takeda A,Baffi JZ,Kleinman ME,Cho WG,Nozaki M,Yamada K,Kaneko H,Albuquerque RJ,Dridi S,Saito K,Raisler BJ,Budd SJ,Geisen P,Munitz A,Ambati BK,Green MG,Ishibashi T,Wright JD,Humbles AA,Gerard CJ,Ogura Y,Pan Y,S

更新日期：2009-07-09 00:00:00

abstract：:The type I interferon response protects cells against invading viral pathogens. The cellular factors that mediate this defence are the products of interferon-stimulated genes (ISGs). Although hundreds of ISGs have been identified since their discovery more than 25 years ago, only a few have been characterized with res...

journal_title：Nature

authors： Schoggins JW,Wilson SJ,Panis M,Murphy MY,Jones CT,Bieniasz P,Rice CM

更新日期：2011-04-28 00:00:00

abstract：:Periodic somite segmentation in vertebrate embryos is controlled by the 'segmentation clock', which consists of numerous cellular oscillators. Although the properties of a single oscillator, driven by a hairy negative-feedback loop, have been investigated, the system-level properties of the segmentation clock remain l...

journal_title：Nature

authors： Horikawa K,Ishimatsu K,Yoshimoto E,Kondo S,Takeda H

更新日期：2006-06-08 00:00:00

abstract：:The signal recognition particle (SRP) consists of one RNA and six protein subunits. The N-terminal domain of the 54K subunit contains a putative GTP-binding site, whereas the C-terminal domain binds signal sequences and SRP RNA. Binding of SRP to the signal sequence as it emerges from the ribosome creates a cytosolic ...

journal_title：Nature

authors： Miller JD,Wilhelm H,Gierasch L,Gilmore R,Walter P

更新日期：1993-11-25 00:00:00

abstract：:It has been suggested that the initiation step in mouse skin carcinogenesis involves an alteration in epidermal-differentiation, as mouse basal keratinocytes exposed to initiators resist the arrest of cell growth that is normally associated with the induction of terminal differentiation by calcium ions. The growth of ...

journal_title：Nature

authors： Yuspa SH,Kilkenny AE,Stanley J,Lichti U

更新日期：1985-04-04 00:00:00

abstract：:The current need for novel antibiotics is especially acute for drug-resistant Gram-negative pathogens1,2. These microorganisms have a highly restrictive permeability barrier, which limits the penetration of most compounds3,4. As a result, the last class of antibiotics that acted against Gram-negative bacteria was deve...

journal_title：Nature

authors： Imai Y,Meyer KJ,Iinishi A,Favre-Godal Q,Green R,Manuse S,Caboni M,Mori M,Niles S,Ghiglieri M,Honrao C,Ma X,Guo JJ,Makriyannis A,Linares-Otoya L,Böhringer N,Wuisan ZG,Kaur H,Wu R,Mateus A,Typas A,Savitski MM,Es

更新日期：2019-12-01 00:00:00

abstract：:The human AIDS viruses human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) represent cross-species (zoonotic) infections. Although the primate reservoir of HIV-2 has been clearly identified as the sooty mangabey (Cercocebus atys), the origin of HIV-1 remains uncertain. Viruses related to HIV-1 have been iso...

journal_title：Nature

authors： Gao F,Bailes E,Robertson DL,Chen Y,Rodenburg CM,Michael SF,Cummins LB,Arthur LO,Peeters M,Shaw GM,Sharp PM,Hahn BH

更新日期：1999-02-04 00:00:00

abstract：:Liver cirrhosis is a major cause of death worldwide and is characterized by extensive fibrosis. There are currently no effective antifibrotic therapies available. To obtain a better understanding of the cellular and molecular mechanisms involved in disease pathogenesis and enable the discovery of therapeutic targets, ...

journal_title：Nature

authors： Ramachandran P,Dobie R,Wilson-Kanamori JR,Dora EF,Henderson BEP,Luu NT,Portman JR,Matchett KP,Brice M,Marwick JA,Taylor RS,Efremova M,Vento-Tormo R,Carragher NO,Kendall TJ,Fallowfield JA,Harrison EM,Mole DJ,Wigmore SJ

更新日期：2019-11-01 00:00:00

abstract：:A variety of microbial communities and their genes (the microbiome) exist throughout the human body, with fundamental roles in human health and disease. The National Institutes of Health (NIH)-funded Human Microbiome Project Consortium has established a population-scale framework to develop metagenomic protocols, resu...

journal_title：Nature

authors： Human Microbiome Project Consortium.

更新日期：2012-06-13 00:00:00

abstract：:Neural mechanisms that mediate the ability to make value-guided decisions have received substantial attention in humans and animals1-6. Experiments in animals typically involve long training periods. By contrast, choices in the real world often need to be made between new options spontaneously. It is therefore possibl...

journal_title：Nature

authors： Bongioanni A,Folloni D,Verhagen L,Sallet J,Klein-Flügge MC,Rushworth MFS

更新日期：2021-01-06 00:00:00

abstract：:The ability to pattern surfaces on a microscopic length scale is of importance for technological applications such as the fabrication of microelectronic circuits and digital storage media. Devices fabricated entirely from polymers are now available, opening up the possibility of adapting polymer processing technologie...

journal_title：Nature

authors： Higgins AM,Jones RA

更新日期：2000-03-30 00:00:00

abstract：:The emergence and outgrowth of a population of tumour cells resistant to multiple drugs is a major problem in the chemotherapeutic treatment of cancer. We have used highly drug-resistant cell lines developed in vitro to study the molecular basis of multidrug resistance. In these cell lines high levels of resistance ar...

journal_title：Nature

authors： Gros P,Ben Neriah YB,Croop JM,Housman DE

更新日期：1986-10-23 00:00:00

abstract：:The first open meeting to discuss the growing issue of commercialism in academic research was convened by the New York Bar Association's patent committee. Participants included Steven Muller, president of Johns Hopkins University, Joshua Lederberg, president of Rockefeller University, and A. Thomas Bartlett, presiden...

journal_title：Nature

authors： Stein MD

更新日期：1982-04-29 00:00:00

abstract：:A powerful way to discover key genes with causal roles in oncogenesis is to identify genomic regions that undergo frequent alteration in human cancers. Here we present high-resolution analyses of somatic copy-number alterations (SCNAs) from 3,131 cancer specimens, belonging largely to 26 histological types. We identif...

journal_title：Nature

authors： Beroukhim R,Mermel CH,Porter D,Wei G,Raychaudhuri S,Donovan J,Barretina J,Boehm JS,Dobson J,Urashima M,Mc Henry KT,Pinchback RM,Ligon AH,Cho YJ,Haery L,Greulich H,Reich M,Winckler W,Lawrence MS,Weir BA,Tanaka KE,

更新日期：2010-02-18 00:00:00

abstract：:During lymphocyte development, cellular proliferation and positive and negative selection events ensure the production of T and B lymphocytes bearing highly diverse, but self-tolerant, repertoires of antigen receptors. These processes are initiated when engagement of growth-factor receptors, or the T and B lymphocyte ...

journal_title：Nature

authors： Fischer KD,Zmuldzinas A,Gardner S,Barbacid M,Bernstein A,Guidos C

更新日期：1995-03-30 00:00:00

abstract：:Jets of highly energized plasma with relativistic velocities are associated with black holes ranging in mass from a few times that of the Sun to the billion-solar-mass black holes at the centres of galaxies. A popular but unconfirmed hypothesis to explain how the plasma is energized is the 'internal shock model', in w...

journal_title：Nature

authors： Meyer ET,Georganopoulos M,Sparks WB,Perlman E,van der Marel RP,Anderson J,Sohn ST,Biretta J,Norman C,Chiaberge M

更新日期：2015-05-28 00:00:00

abstract：:The interneuronal messenger nitric oxide (NO) may play a central role in the processing of olfactory information. Several circuit elements in the mammalian olfactory bulb contain NO synthase or its functional equivalent, NADPH diaphorase. The effects of NO on cellular excitability or circuit dynamics in the olfactory ...

journal_title：Nature

authors： Gelperin A

更新日期：1994-05-05 00:00:00

abstract：:The TGF-beta/activin/BMP cytokine family signals through serine/threonine kinase receptors, but how the receptors transduce the signal is unknown. The Mad (Mothers against decapentaplegic) gene from Drosophila and the related Sma genes from Caenorhabditis elegans have been genetically implicated in signalling by membe...

journal_title：Nature

authors： Liu F,Hata A,Baker JC,Doody J,Cárcamo J,Harland RM,Massagué J

更新日期：1996-06-13 00:00:00

abstract：:Materials showing simultaneous ferroelectric and magnetic ordering are attracting a great deal of interest because of their unusual physics and potential applications. Hemberger et al. have reported relaxor-like dielectric properties and colossal magnetocapacitance (in excess of 500%) for the cubic spinel compound CdC...

journal_title：Nature

authors： Catalan G,Scott JF

更新日期：2007-08-23 00:00:00

abstract：:Ultrathin ferroelectric materials could potentially enable low-power perovskite ferroelectric tetragonality logic and nonvolatile memories1,2. As ferroelectric materials are made thinner, however, the ferroelectricity is usually suppressed. Size effects in ferroelectrics have been thoroughly investigated in perovskite...

journal_title：Nature

authors： Cheema SS,Kwon D,Shanker N,Dos Reis R,Hsu SL,Xiao J,Zhang H,Wagner R,Datar A,McCarter MR,Serrao CR,Yadav AK,Karbasian G,Hsu CH,Tan AJ,Wang LC,Thakare V,Zhang X,Mehta A,Karapetrova E,Chopdekar RV,Shafer P,Arenh

更新日期：2020-04-01 00:00:00

abstract：:Intracellular responses recorded in vitro from the cochleas of anaesthetized mammals have shown that the mechanoreceptive inner and outer hair cells are sharply tuned, accounting for many of the properties of the afferent fibres in the auditory nerve. However, in vivo it has not been possible to measure directly the e...

journal_title：Nature

authors： Russell IJ,Richardson GP,Cody AR

更新日期：1986-05-29 00:00:00

abstract：:Electronic devices have advanced from their heavy, bulky origins to become smart, mobile appliances. Nevertheless, they remain rigid, which precludes their intimate integration into everyday life. Flexible, textile and stretchable electronics are emerging research areas and may yield mainstream technologies. Rollable ...

journal_title：Nature

authors： Kaltenbrunner M,Sekitani T,Reeder J,Yokota T,Kuribara K,Tokuhara T,Drack M,Schwödiauer R,Graz I,Bauer-Gogonea S,Bauer S,Someya T

更新日期：2013-07-25 00:00:00

abstract：:The UK Farm-Scale Evaluations (FSE) compared the effects on biodiversity of management of genetically modified herbicide-tolerant (GMHT) spring-sown crops with conventional crop management. The FSE reported larger weed abundance under GMHT management for fodder maize, one of three crops studied. Increased seed product...

journal_title：Nature

authors： Perry JN,Firbank LG,Champion GT,Clark SJ,Heard MS,May MJ,Hawes C,Squire GR,Rothery P,Woiwod IP,Pidgeon JD

更新日期：2004-03-18 00:00:00

abstract：:Yeasts, which have been a component of the human diet for at least 7,000 years, possess an elaborate cell wall α-mannan. The influence of yeast mannan on the ecology of the human microbiota is unknown. Here we show that yeast α-mannan is a viable food source for the Gram-negative bacterium Bacteroides thetaiotaomicron...

journal_title：Nature

authors： Cuskin F,Lowe EC,Temple MJ,Zhu Y,Cameron E,Pudlo NA,Porter NT,Urs K,Thompson AJ,Cartmell A,Rogowski A,Hamilton BS,Chen R,Tolbert TJ,Piens K,Bracke D,Vervecken W,Hakki Z,Speciale G,Munōz-Munōz JL,Day A,Peña MJ,

更新日期：2015-01-08 00:00:00

abstract：:In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and cancer are responsible for most deaths. These ailments have complex causes involving genetic, environmental and nutritional factors. There is evidence that a group of closely related nuclear receptors, called peroxisome proliferato...

journal_title：Nature

authors： Kersten S,Desvergne B,Wahli W

更新日期：2000-05-25 00:00:00

abstract：:Arbuscular mycorrhizal fungi (AMF) are ancient asexually reproducing organisms that form symbioses with the majority of plant species, improving plant nutrition and promoting plant diversity. Little is known about the evolution or organization of the genomes of any eukaryotic symbiont or ancient asexual organism. Dire...

journal_title：Nature

authors： Hijri M,Sanders IR

更新日期：2005-01-13 00:00:00

abstract：:In several well-characterized site-specific recombination systems it has been shown that, for efficient recombination, the two recombining sites must have identical DNA sequences across the region between the staggered points of exchange. The precise DNA sequence of this overlap region, however, appears to be of littl...

journal_title：Nature

authors： Falvey E,Hatfull GF,Grindley ND

更新日期：1988-04-28 00:00:00

abstract：:A large number of high-accuracy vector measurements of the Earth's magnetic field have recently become available from the satellite Oersted, complementing previous vector data from the satellite Magsat, which operated in 1979/80. These data can be used to infer the morphology of the magnetic field at the surface of th...

journal_title：Nature

authors： Jackson A

更新日期：2003-08-14 00:00:00