Abstract:
:Neutrophils activated by the formyl peptide f-Met-Leu-Phe transiently accumulate a small subset of highly polar inositol lipids. A similar family of lipids also appear in many other cells in response to a range of growth factors and activated oncogenes, and are presumed to be the direct or indirect products of 3-phosphatidylinositol kinase. The structures of these lipids are shown to be phosphatidylinositol 3-phosphate, phosphatidylinositol-(3,4)bisphosphate and phosphatidylinositol-(3,4,5)trisphosphate, and we present evidence that in intact neutrophils a phosphatidyl-inositol-(4,5)bisphosphate-3-kinase seems to be the focal point through which agonists stimulate the formation of 3-phosphorylated inositol lipids.
journal_name
Naturejournal_title
Natureauthors
Stephens LR,Hughes KT,Irvine RFdoi
10.1038/351033a0subject
Has Abstractpub_date
1991-05-02 00:00:00pages
33-9issue
6321eissn
0028-0836issn
1476-4687journal_volume
351pub_type
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