Abstract:
:Neural mechanisms that mediate the ability to make value-guided decisions have received substantial attention in humans and animals1-6. Experiments in animals typically involve long training periods. By contrast, choices in the real world often need to be made between new options spontaneously. It is therefore possible that the neural mechanisms targeted in animal studies differ from those required for new decisions, which are typical of human imaging studies. Here we show that the primate medial frontal cortex (MFC)7 is involved in making new inferential choices when the options have not been previously experienced. Macaques spontaneously inferred the values of new options via similarities with the component parts of previously encountered options. Functional magnetic resonance imaging (fMRI) suggested that this ability was mediated by the MFC, which is rarely investigated in monkeys3; MFC activity reflected different processes of comparison for unfamiliar and familiar options. Multidimensional representations of options in the MFC used a coding scheme resembling that of grid cells, which is well known in spatial navigation8,9, to integrate dimensions in this non-physical space10 during novel decision-making. By contrast, the orbitofrontal cortex held specific object-based value representations1,11. In addition, minimally invasive ultrasonic disruption12 of MFC, but not adjacent tissue, altered the estimation of novel choice values.
journal_name
Naturejournal_title
Natureauthors
Bongioanni A,Folloni D,Verhagen L,Sallet J,Klein-Flügge MC,Rushworth MFSdoi
10.1038/s41586-020-03115-5subject
Has Abstractpub_date
2021-01-06 00:00:00eissn
0028-0836issn
1476-4687pii
10.1038/s41586-020-03115-5pub_type
杂志文章相关文献
NATURE文献大全abstract::Very large collisions in the asteroid belt could lead temporarily to a substantial increase in the rate of impacts of meteorites on Earth. Orbital simulations predict that fragments from such events may arrive considerably faster than the typical transit times of meteorites falling today, because in some large impacts...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02736
更新日期:2004-07-15 00:00:00
abstract::A product encoded at the claret locus in Drosophila is needed for normal chromosome segregation in meiosis in females and in early mitotic divisions of the embryo. The predicted amino-acid sequence of the segregation protein was shown recently to be strikingly similar to Drosophila kinesin heavy chain. We have express...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347780a0
更新日期:1990-10-25 00:00:00
abstract::Cytotoxic T lymphocytes (CTLs) detect and destroy cells displaying class I molecules of the major histocompatibility complex (MHC) that present oligopeptides derived from aberrant self or foreign proteins. Most class I peptide ligands are created from proteins that are degraded by proteasomes and transported, by the t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02240
更新日期:2004-01-15 00:00:00
abstract::53BP1 governs a specialized, context-specific branch of the classical non-homologous end joining DNA double-strand break repair pathway. Mice lacking 53bp1 (also known as Trp53bp1) are immunodeficient owing to a complete loss of immunoglobulin class-switch recombination1,2, and reduced fidelity of long-range V(D)J rec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0362-1
更新日期:2018-08-01 00:00:00
abstract::The formation of precise connections between retina and lateral geniculate nucleus (LGN) involves the activity-dependent elimination of some synapses, with strengthening and retention of others. Here we show that the major histocompatibility complex (MHC) class I molecule H2-D(b) is necessary and sufficient for synaps...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13154
更新日期:2014-05-08 00:00:00
abstract::In the brain, hippocampal pyramidal cells use temporal as well as rate coding to signal spatial aspects of the animal's environment or behaviour. The temporal code takes the form of a phase relationship to the concurrent cycle of the hippocampal electroencephalogram theta rhythm. These two codes could each represent a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02058
更新日期:2003-10-23 00:00:00
abstract::Surgical sectioning of the corpus callosum in epileptic patients has provided a unique opportunity to study separately the competence and processing capacities of the two cerebral hemispheres, each of which is able to perceive, think, memorize and learn independently and essentially outside the realm of awareness of t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/305800a0
更新日期:1983-10-27 00:00:00
abstract::Glandular epithelia, including the mammary and prostate glands, are composed of basal cells (BCs) and luminal cells (LCs)1,2. Many glandular epithelia develop from multipotent basal stem cells (BSCs) that are replaced in adult life by distinct pools of unipotent stem cells1,3-8. However, adult unipotent BSCs can react...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2632-y
更新日期:2020-08-01 00:00:00
abstract::Breast cancer patients with the same stage of disease can have markedly different treatment responses and overall outcome. The strongest predictors for metastases (for example, lymph node status and histological grade) fail to classify accurately breast tumours according to their clinical behaviour. Chemotherapy or ho...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/415530a
更新日期:2002-01-31 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/551S40a
更新日期:2017-11-08 00:00:00
abstract::How left/right functional asymmetry is layered on top of an anatomically symmetrical nervous system is poorly understood. In the nematode Caenorhabditis elegans, two morphologically bilateral taste receptor neurons, ASE left (ASEL) and ASE right (ASER), display a left/right asymmetrical expression pattern of putative ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02255
更新日期:2003-12-18 00:00:00
abstract::For many pathogens the availability of genome sequence, permitting genome-dependent methods of research, can partially substitute for powerful forward genetic methods (genome-independent) that have advanced model organism research for decades. In 2002 the genome sequence of Plasmodium falciparum, the parasite causing ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature07361
更新日期:2008-10-09 00:00:00
abstract::The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft between a domain structurally homologous to small GTPases and a helical domain unique to heterotrimeric G proteins. The structure, when combined with biochemical and genetic stud...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/366654a0
更新日期:1993-12-16 00:00:00
abstract::The extreme resistance of bacterial endospores to heat may result from dehydration of the central protoplast brought about and maintained by osmotic activity of expanded electronegative peptidoglycan polymer, and positively charged counterions associated with it, in the surrounding cortex. The cortex may thus act as a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/258402a0
更新日期:1975-12-04 00:00:00
abstract::Adenosine is a potent modulator of transmitter release at a variety of synapses. The adenosine A1 receptor is assumed to reside in presynaptic terminals and to function as a negative autoreceptor. How adenosine reduces transmitter release is uncertain; it may reduce the calcium influx during nerve terminal depolarizat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/365256a0
更新日期:1993-09-16 00:00:00
abstract::An experiment by the Gates Foundation is food for thought for other research agencies. ...
journal_title:Nature
pub_type: 社论
doi:10.1038/4551150a
更新日期:2008-10-30 00:00:00
abstract::Recent work demonstrates that stochastic fluctuations in molecular populations have consequences for gene regulation. Previous experiments focused on noise sources or noise propagation through gene networks by measuring noise magnitudes. However, in theoretical analysis, we showed that noise frequency content is deter...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04194
更新日期:2006-02-02 00:00:00
abstract::The antidiuretic effect of arginine vasopressin (AVP) is mediated by renal-type (V2) receptors linked to adenylyl cyclase. We report here the cloning of the rat kidney V2 AVP receptor complementary DNA that encodes a 370-amino-acid protein with a transmembrane topography characteristic of G protein-coupled receptors, ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/357336a0
更新日期:1992-05-28 00:00:00
abstract::Pathogenic bacteria such as Escherichia coli assemble surface structures termed pili, or fimbriae, to mediate binding to host-cell receptors1. Type 1 pili are assembled via the conserved chaperone-usher pathway2-5. The outer-membrane usher FimD recruits pilus subunits bound by the chaperone FimC via the periplasmic N-...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0587-z
更新日期:2018-10-01 00:00:00
abstract::The gal operon of Escherichia coli is controlled by two independent promotors--one is activated and the other inhibited by cyclic AMP and cyclic AMP receptor protein. The two promotors are modulated, however, by the same operator locus and receptor protein. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/279492a0
更新日期:1979-06-07 00:00:00
abstract::Nature's high-performance polymer, spider silk, consists of specific proteins, spidroins, with repetitive segments flanked by conserved non-repetitive domains. Spidroins are stored as a highly concentrated fluid dope. On silk formation, intermolecular interactions between repeat regions are established that provide st...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08962
更新日期:2010-05-13 00:00:00
abstract::Defects in the architecture or integrity of the nuclear envelope are associated with a variety of human diseases1. Micronuclei, one common nuclear aberration, are an origin for chromothripsis2, a catastrophic mutational process that is commonly observed in cancer3-5. Chromothripsis occurs after micronuclei spontaneous...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0534-z
更新日期:2018-09-01 00:00:00
abstract::The main asteroid belt lies between the orbits of Mars and Jupiter, but the region is not uniformly filled with asteroids. There are gaps, known as the Kirkwood gaps, in distinct locations that are associated with orbital resonances with the giant planets; asteroids placed in these locations will follow chaotic orbits...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07778
更新日期:2009-02-26 00:00:00
abstract::Highly efficient neutron detectors are critical in many sectors, including national security1,2, medicine3, crystallography4 and astronomy5. The main neutron detection technologies currently used involve 3He-gas-filled proportional counters6 and light scintillators7 for thermalized neutrons. Semiconductors could provi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1886-8
更新日期:2020-01-01 00:00:00
abstract::Hyperpolarization-activated cation channels of the HCN gene family contribute to spontaneous rhythmic activity in both heart and brain. All four family members contain both a core transmembrane segment domain, homologous to the S1-S6 regions of voltage-gated K+ channels, and a carboxy-terminal 120 amino-acid cyclic nu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35081088
更新日期:2001-06-14 00:00:00
abstract::Paired-associate learning is often used to examine episodic memory in humans. Animal models include the recall of food-cache locations by scrub jays and sequential memory. Here we report a model in which rats encode, during successive sample trials, two paired associates (flavours of food and their spatial locations) ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01769
更新日期:2003-07-10 00:00:00
abstract::Inherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in 269 DNA samples fro...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04226
更新日期:2005-10-27 00:00:00
abstract::The alpha beta T-cell receptors (TCRs) react with complex ligands composed of peptides bound to major histocompatibility complex (MHC) proteins. In the absence of foreign antigens the peptides bound to MHC molecules come from the proteins of the host itself. Interactions between TCRs and these self-peptide-MHC ligands...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/369151a0
更新日期:1994-05-12 00:00:00
abstract::Mutation of the XRCC4 gene in mammalian cells prevents the formation of the signal and coding joints in the V(D)J recombination reaction, which is necessary for production of a functional immunoglobulin gene, and renders the cells highly sensitive to ionizing radiation. However, XRCC4 shares no sequence homology with ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/41358
更新日期:1997-07-31 00:00:00
abstract::Acetylcholine and dopamine are key neurotransmitters in the extrapyramidal motor system, where they are thought to lie in a 'functional balance' brought about by interactions between the terminals of the dopamine-containing nigrostriatal tract and the cholinergic interneurones of the striatum. The precise nature of th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/323625a0
更新日期:1986-10-16 00:00:00