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Mechanosensitivity of mammalian auditory hair cells in vitro.

Abstract：

:Intracellular responses recorded in vitro from the cochleas of anaesthetized mammals have shown that the mechanoreceptive inner and outer hair cells are sharply tuned, accounting for many of the properties of the afferent fibres in the auditory nerve. However, in vivo it has not been possible to measure directly the excitatory mechanical input to these cells (the displacement of their mechanosensitive stereocilia) and thus to determine the relationship between the receptor potentials and displacement of their stereocilia. As a means of circumventing this technical difficulty, we have developed an organ culture of the mouse cochlea and here we describe the receptor potentials generated by the hair cells in response to direct displacement of their stereocilia.

journal_name

Nature

journal_title

Nature

authors

Russell IJ,Richardson GP,Cody AR

doi

10.1038/321517a0

subject

Has Abstract

pub_date

1986-05-29 00:00:00

pages

517-9

issue

6069

eissn

0028-0836

issn

1476-4687

journal_volume

321

pub_type

杂志文章

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