Building a better lymphoma vaccine.

abstract：:MANY ferromanganese minerals have been found in marine manganese deposits. There have been terminological and intrinsic problems in accurately defining the constituents of manganese nodules(1), but 10-A manganite and delta-MnO(2) which are often compared with todorokite and birnessite seem to be the only major constit...

journal_title：Nature

authors： Usui A

更新日期：1979-05-31 00:00:00

abstract：:The tumour microenvironment may contribute to tumorigenesis owing to mechanical forces such as fibrotic stiffness or mechanical pressure caused by the expansion of hyper-proliferative cells. Here we explore the contribution of the mechanical pressure exerted by tumour growth onto non-tumorous adjacent epithelium. In t...

journal_title：Nature

authors： Fernández-Sánchez ME,Barbier S,Whitehead J,Béalle G,Michel A,Latorre-Ossa H,Rey C,Fouassier L,Claperon A,Brullé L,Girard E,Servant N,Rio-Frio T,Marie H,Lesieur S,Housset C,Gennisson JL,Tanter M,Ménager C,Fre S,Rob

更新日期：2015-07-02 00:00:00

abstract：:The polarized architecture of epithelial cells depends on the highly stereotypic distribution of cellular junctions and other membrane-associated protein complexes. In epithelial cells of the Drosophila embryo, three distinct domains subdivide the lateral plasma membrane. The most apical one comprises the subapical co...

journal_title：Nature

authors： Bachmann A,Schneider M,Theilenberg E,Grawe F,Knust E

更新日期：2001-12-06 00:00:00

abstract：:Three environmental groups have filed suit against the National Institutes of Health in an attempt to block an experiment approved in April by the NIH Recombinant DNA Advisory Committee. The experiment, designed by researchers at the University of California, Berkeley, to enhance the frost resistance of crops, would ...

journal_title：Nature

authors： David P

更新日期：1983-09-22 00:00:00

abstract：:Transient receptor potential (TRP) channels are sensors for a wide range of cellular and environmental signals, but elucidating how these channels respond to physical and chemical stimuli has been hampered by a lack of detailed structural information. Here we exploit advances in electron cryo-microscopy to determine t...

journal_title：Nature

authors： Liao M,Cao E,Julius D,Cheng Y

更新日期：2013-12-05 00:00:00

abstract：:There seems a real prospect that one of the infectious scourges of the past half century will not persist much beyond the present century, but polio will be only the second infection of human beings to be eradicated. Many more remain. ...

journal_title：Nature

authors：

更新日期：1995-04-20 00:00:00

abstract：:Despite the continued increase in atmospheric greenhouse gas concentrations, the annual-mean global temperature has not risen in the twenty-first century, challenging the prevailing view that anthropogenic forcing causes climate warming. Various mechanisms have been proposed for this hiatus in global warming, but thei...

journal_title：Nature

authors： Kosaka Y,Xie SP

更新日期：2013-09-19 00:00:00

abstract：: ...

journal_title：Nature

authors： Pappalardo JL,Hafler DA

更新日期：2019-02-01 00:00:00

abstract：:Recent studies have demonstrated that monkeys and humans can use signals from the brain to guide computer cursors. Brain-computer interfaces (BCIs) may one day assist patients suffering from neurological injury or disease, but relatively low system performance remains a major obstacle. In fact, the speed and accuracy ...

journal_title：Nature

authors： Santhanam G,Ryu SI,Yu BM,Afshar A,Shenoy KV

更新日期：2006-07-13 00:00:00

abstract：:Certain mast cell products, including the tetrapeptides Ala-Gly-Ser-Glu (Ala4) and Val-Gly-Ser-Glu (Val4) of the eosinophil chemotactic factor of anaphylaxis (ECF-A) and histamine, are preferentially chemotactic for eosinophils in vitro. Amino acid substitutions or modifications of the ECF-A tetrapeptides may substant...

journal_title：Nature

authors： Capron M,Capron A,Goetzl EJ,Austen KF

更新日期：1981-01-01 00:00:00

abstract：:The wavefunction is the complex distribution used to completely describe a quantum system, and is central to quantum theory. But despite its fundamental role, it is typically introduced as an abstract element of the theory with no explicit definition. Rather, physicists come to a working understanding of the wavefunct...

journal_title：Nature

authors： Lundeen JS,Sutherland B,Patel A,Stewart C,Bamber C

更新日期：2011-06-08 00:00:00

abstract：:How long does it take a random walker to reach a given target point? This quantity, known as a first-passage time (FPT), has led to a growing number of theoretical investigations over the past decade. The importance of FPTs originates from the crucial role played by first encounter properties in various real situation...

journal_title：Nature

authors： Condamin S,Bénichou O,Tejedor V,Voituriez R,Klafter J

更新日期：2007-11-01 00:00:00

abstract：:Outbreaks of haemorrhagic fever caused by the Ebola virus are associated with high mortality rates that are a distinguishing feature of this human pathogen. The highest lethality is associated with the Zaire subtype, one of four strains identified to date. Its rapid progression allows little opportunity to develop nat...

journal_title：Nature

authors： Sullivan NJ,Sanchez A,Rollin PE,Yang ZY,Nabel GJ

更新日期：2000-11-30 00:00:00

abstract：:One hundred years ago Albert Einstein introduced the concept of the photon. Although in the early years after 1905 the evidence for the quantum nature of light was not compelling, modern experiments--especially those using photon pairs--have beautifully confirmed its corpuscular character. Research on the quantum prop...

journal_title：Nature

authors： Zeilinger A,Weihs G,Jennewein T,Aspelmeyer M

更新日期：2005-01-20 00:00:00

abstract：:The evolutionary theory of ageing explains why ageing occurs, giving valuable insight into the mechanisms underlying the complex cellular and molecular changes that contribute to senescence. Such understanding also helps to clarify how the genome shapes the ageing process, thereby aiding the study of the genetic facto...

journal_title：Nature

authors： Kirkwood TB,Austad SN

更新日期：2000-11-09 00:00:00

abstract：:Spacecraft observations show that the presence of lightning activity is not confined to the terrestrial atmosphere, but is also found in the atmospheres of Venus, Jupiter and Saturn. Lightning activity may also occur in Titan's thick atmosphere. Calculations show that lightning produces a significant fraction of the...

journal_title：Nature

authors： Borucki WJ,McKay CP

更新日期：1987-08-06 00:00:00

abstract：:A hallmark of RNA silencing is a class of approximately 22-nucleotide RNAs that are processed from double-stranded RNA precursors by Dicer. Accurate processing by Dicer is crucial for the functionality of microRNAs (miRNAs). The current model posits that Dicer selects cleavage sites by measuring a set distance from th...

journal_title：Nature

authors： Park JE,Heo I,Tian Y,Simanshu DK,Chang H,Jee D,Patel DJ,Kim VN

更新日期：2011-07-13 00:00:00

abstract：:The human nose is often considered something of a luxury, but in the rest of the animal world, from bacteria to mammals, detecting chemicals in the environment has been critical to the successful organism. An indication of the importance of olfactory systems is the significant proportion - as much as 4% - of the genom...

journal_title：Nature

authors： Firestein S

更新日期：2001-09-13 00:00:00

abstract：:The amplitude and frequency of laser light can be routinely measured and controlled on a femtosecond (10(-15) s) timescale. However, in pulses comprising just a few wave cycles, the amplitude envelope and carrier frequency are not sufficient to characterize and control laser radiation, because evolution of the light f...

journal_title：Nature

authors： Baltuska A,Udem T,Uiberacker M,Hentschel M,Goulielmakis E,Gohle Ch,Holzwarth R,Yakovlev VS,Scrinzi A,Hänsch TW,Krausz F

更新日期：2003-02-06 00:00:00

abstract：:RNA ligases have essential roles in many cellular processes in eukaryotes, archaea and bacteria, including in RNA repair and stress-induced splicing of messenger RNA. In archaea and eukaryotes, RNA ligases also have a role in transfer RNA splicing to generate functional tRNAs required for protein synthesis. We recentl...

journal_title：Nature

authors： Popow J,Jurkin J,Schleiffer A,Martinez J

更新日期：2014-07-03 00:00:00

abstract：:For more than three-quarters of a century it has been assumed that basal metabolic rate increases as body mass raised to some power p. However, there is no broad consensus regarding the value of p: whereas many studies have asserted that p is 3/4 (refs 1-4; 'Kleiber's law'), some have argued that it is 2/3 (refs 5-7),...

journal_title：Nature

authors： Kolokotrones T,Van Savage,Deeds EJ,Fontana W

更新日期：2010-04-01 00:00:00

abstract：:Seismological observations have revealed the existence of low-velocity and high-attenuation zones above the discontinuity at 410 km depth, at the base of the Earth's upper mantle. It has been suggested that a small amount of melt could be responsible for such anomalies. The density of silicate melt under dry condition...

journal_title：Nature

authors： Sakamaki T,Suzuki A,Ohtani E

更新日期：2006-01-12 00:00:00

abstract：:The fruit, which mediates the maturation and dispersal of seeds, is a complex structure unique to flowering plants. Seed dispersal in plants such as Arabidopsis occurs by a process called fruit dehiscence, or pod shatter. Few studies have focused on identifying genes that regulate this process, in spite of the agronom...

journal_title：Nature

authors： Liljegren SJ,Ditta GS,Eshed Y,Savidge B,Bowman JL,Yanofsky MF

更新日期：2000-04-13 00:00:00

abstract：:Stevens-Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and Stevens-Johnson syndrome induced...

journal_title：Nature

authors： Chung WH,Hung SI,Hong HS,Hsih MS,Yang LC,Ho HC,Wu JY,Chen YT

更新日期：2004-04-01 00:00:00

abstract：:Many biomolecules are characterized by surfaces containing extended nonpolar regions, and the aggregation and subsequent removal of such surfaces from water is believed to play a critical role in the biomolecular assembly in cells. A better understanding of the hydrophobic hydration of biomolecules may therefore yield...

journal_title：Nature

authors： Cheng YK,Rossky PJ

更新日期：1998-04-16 00:00:00

abstract：:Epidermal growth factor (EGF) and transforming growth factor type I (TGF) are polypeptides of 53 and 50 amino acid residues, respectively. Both bind to EGF receptor, a 1,200-residue transmembranous glycoprotein, leading to phosphorylation of the receptor, enhancement of its tyrosine-specific kinase activity and ultima...

journal_title：Nature

authors： Brown JP,Twardzik DR,Marquardt H,Todaro GJ

更新日期：1985-02-07 00:00:00

abstract：:Tobacco smoking causes lung cancer1-3, a process that is driven by more than 60 carcinogens in cigarette smoke that directly damage and mutate DNA4,5. The profound effects of tobacco on the genome of lung cancer cells are well-documented6-10, but equivalent data for normal bronchial cells are lacking. Here we sequence...

journal_title：Nature

authors： Yoshida K,Gowers KHC,Lee-Six H,Chandrasekharan DP,Coorens T,Maughan EF,Beal K,Menzies A,Millar FR,Anderson E,Clarke SE,Pennycuick A,Thakrar RM,Butler CR,Kakiuchi N,Hirano T,Hynds RE,Stratton MR,Martincorena I,Janes

更新日期：2020-02-01 00:00:00

abstract：:Scrapie and related animal and human disorders are neurodegenerative diseases characterized by the formation of a modified, partly proteinase-resistant protein (PrP) of the host, which tends to aggregate as amyloid fibrils and accumulate in the brain of infected individuals. There is a general consensus that the patho...

journal_title：Nature

authors： Xi YG,Ingrosso L,Ladogana A,Masullo C,Pocchiari M

更新日期：1992-04-16 00:00:00

abstract：:The small martian satellites Phobos and Deimos orbit in synchronous rotation with inclinations of only 0.01 degrees and 0.92 degrees , respectively, relative to the planet's equatorial plane. Thus, an observer at near-equatorial latitudes on Mars could occasionally observe solar eclipses by these satellites (see ref. ...

journal_title：Nature

authors： Bell JF 3rd,Lemmon MT,Duxbury TC,Hubbard MY,Wolff MJ,Squyres SW,Craig L,Ludwinski JM

更新日期：2005-07-07 00:00:00

abstract：:Humans differ from other primates in their significantly lengthened growth period. The persistence of a fetal pattern of brain growth after birth is another important feature of human development. Here we present the results of an analysis of the 1.8-million-year-old Mojokerto child (Perning 1, Java), the only well pr...

journal_title：Nature

authors： Coqueugniot H,Hublin JJ,Veillon F,Houët F,Jacob T

更新日期：2004-09-16 00:00:00