Abstract：
:Outbreaks of haemorrhagic fever caused by the Ebola virus are associated with high mortality rates that are a distinguishing feature of this human pathogen. The highest lethality is associated with the Zaire subtype, one of four strains identified to date. Its rapid progression allows little opportunity to develop natural immunity, and there is currently no effective anti-viral therapy. Therefore, vaccination offers a promising intervention to prevent infection and limit spread. Here we describe a highly effective vaccine strategy for Ebola virus infection in non-human primates. A combination of DNA immunization and boosting with adenoviral vectors that encode viral proteins generated cellular and humoral immunity in cynomolgus macaques. Challenge with a lethal dose of the highly pathogenic, wild-type, 1976 Mayinga strain of Ebola Zaire virus resulted in uniform infection in controls, who progressed to a moribund state and death in less than one week. In contrast, all vaccinated animals were asymptomatic for more than six months, with no detectable virus after the initial challenge. These findings demonstrate that it is possible to develop a preventive vaccine against Ebola virus infection in primates.
journal_name
Naturejournal_title
Natureauthors
Sullivan NJ,Sanchez A,Rollin PE,Yang ZY,Nabel GJdoi
10.1038/35046108keywords:
subject
Has Abstractpub_date
2000-11-30 00:00:00pages
605-9issue
6812eissn
0028-0836issn
1476-4687journal_volume
408pub_type
杂志文章相关文献
NATURE文献大全abstract：:The foundations of mammalian development lie in a cluster of embryonic epiblast stem cells. In response to extracellular matrix signalling, these cells undergo epithelialization and create an apical surface in contact with a cavity, a fundamental event for all subsequent development. Concomitantly, epiblast cells tran...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature24675
更新日期：2017-12-14 00:00:00
abstract：:Tumour-initiating cells capable of self-renewal and differentiation, which are responsible for tumour growth, have been identified in human haematological malignancies and solid cancers. If such minority populations are associated with tumour progression in human patients, specific targeting of tumour-initiating cells...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature06489
更新日期：2008-01-17 00:00:00
abstract：:The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a ligand-dependent transcription factor that is important in adipocyte differentiation and glucose homeostasis and which depends on interactions with co-activators, including steroid receptor co-activating factor-1 (SRC-1). Here we present the X-ray ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/25931
更新日期：1998-09-10 00:00:00
abstract：:During the evolution of the beta-globin family gene in vertebrates, different globin genes acquired different developmental patterns of expression. In mammals, specific 'embryonic' beta-like globins are synthesized in the earliest erythroid cells, which differentiate in the yolk sac of the embryo. In most mammals the ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/319685a0
更新日期：1986-02-20 00:00:00
abstract：:The neurotransmitter dopamine has been demonstrated by biochemical, histochemical and immunocytochemical techniques to be unevenly distributed in the mammalian central nervous system. DARPP-32 (dopamine- and cyclic-AMP-regulated phosphoprotein of molecular weight 32,000) is a neuronal phosphoprotein that displays a re...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/310503a0
更新日期：1984-08-09 00:00:00
abstract：:Quasicrystals are unique structures with long-range order but no periodicity. Their properties have intrigued scientists ever since their discovery and initial theoretical analysis. The lack of periodicity excludes the possibility of describing quasicrystal structures with well-established analytical tools, including ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature04722
更新日期：2006-04-27 00:00:00
abstract：:Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder which affects approximately 1 in 3,300 males, making it the most common of the neuromuscular dystrophies. The biochemical basis of the disease is unknown and as yet no effective treatment is available. A small number of females are also affected with ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/318672a0
更新日期：1985-12-19 00:00:00
abstract：:In sexually reproducing animals, a crucial step in zygote formation is the decondensation of the fertilizing sperm nucleus into a DNA replication-competent male pronucleus. Genome-wide nucleosome assembly on paternal DNA implies the replacement of sperm chromosomal proteins, such as protamines, by maternally provided ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature04059
更新日期：2005-10-27 00:00:00
abstract：:Three environmental groups have filed suit against the National Institutes of Health in an attempt to block an experiment approved in April by the NIH Recombinant DNA Advisory Committee. The experiment, designed by researchers at the University of California, Berkeley, to enhance the frost resistance of crops, would ...
journal_title：Nature
pub_type： 新闻
doi：10.1038/305262a0
更新日期：1983-09-22 00:00:00
abstract：:The key behavioural, physiological and anatomical components of a magnetite-based magnetic sense have been demonstrated in rainbow trout (Oncorhynchus mykiss). Candidate receptor cells located within a discrete sub-layer of the olfactory lamellae contained iron-rich crystals that were similar in size and shape to magn...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35018561
更新日期：2000-07-20 00:00:00
abstract：:Therapies for patients with cancer have changed gradually over the past decade, moving away from the administration of broadly acting cytotoxic drugs towards the use of more-specific therapies that are targeted to each tumour. To facilitate this shift, tests need to be developed to identify those individuals who requi...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/nature06915
更新日期：2008-04-03 00:00:00
abstract：:Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural feature, providing the physical basis for intercommunication during Ca(2+) signalling; yet, the molecular mechanisms controlling this interaction are unknown. Here we show that mitofusin 2, a mitochondrial dynamin-related protein ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07534
更新日期：2008-12-04 00:00:00
abstract：:The retinoblastoma tumour-suppressor protein Rb inhibits cell proliferation by repressing a subset of genes that are controlled by the E2F family of transcription factors and which are involved in progression from the G1 to the S phase of the cell cycle. Rb, which is recruited to target promoters by E2F1, represses tr...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35410
更新日期：1998-02-05 00:00:00
abstract：:RNA is involved in many biological functions, ranging from information storage and transfer to the catalysis of reactions involving both nucleic acids and proteins. Previous crystallographic studies on RNA oligomeric chains provide only averaged structures or information limited in resolution. The oligomer [U(U-A)6A]2...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/335375a0
更新日期：1988-09-22 00:00:00
abstract：:Interfacing a single photon with another quantum system is a key capability in modern quantum information science. It allows quantum states of matter, such as spin states of atoms, atomic ensembles or solids, to be prepared and manipulated by photon counting and, in particular, to be distributed over long distances. S...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature16536
更新日期：2016-02-18 00:00:00
abstract：:Gap junction channels are structurally distinct from other ion channels in that they comprise two hemichannels which interact head-to-head to form an aqueous channel between cells. Intercellular voltage differences together with increased intracellular concentrations of H+ and Ca2+ cause closure of these normally pate...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/365847a0
更新日期：1993-10-28 00:00:00
abstract：:Groundwater drawn daily from shallow alluvial sands by millions of wells over large areas of south and southeast Asia exposes an estimated population of over a hundred million people to toxic levels of arsenic. Holocene aquifers are the source of widespread arsenic poisoning across the region. In contrast, Pleistocene...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature12444
更新日期：2013-09-12 00:00:00
abstract：:Four-residue beta-turns and larger loop structures represent a significant fraction of globular protein surfaces and play an important role in determining the conformation and specificity of enzyme active sites and antibody-combining sites. Turns are an attractive starting point to develop protein design methods, as t...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/339073a0
更新日期：1989-05-04 00:00:00
abstract：:Millions of years before we began to manipulate the flow of light using synthetic structures, biological systems were using nanometre-scale architectures to produce striking optical effects. An astonishing variety of natural photonic structures exists: a species of Brittlestar uses photonic elements composed of calcit...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/nature01941
更新日期：2003-08-14 00:00:00
abstract：:Exoplanet detections have revolutionized astronomy, offering new insights into solar system architecture and planet demographics. While nearly 1,900 exoplanets have now been discovered and confirmed, none are still in the process of formation. Transition disks, protoplanetary disks with inner clearings best explained ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature15761
更新日期：2015-11-19 00:00:00
abstract：:The steel of Damascus blades, which were first encountered by the Crusaders when fighting against Muslims, had features not found in European steels--a characteristic wavy banding pattern known as damask, extraordinary mechanical properties, and an exceptionally sharp cutting edge. Here we use high-resolution transmis...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/444286a
更新日期：2006-11-16 00:00:00
abstract：:A variety of microbial communities and their genes (the microbiome) exist throughout the human body, with fundamental roles in human health and disease. The National Institutes of Health (NIH)-funded Human Microbiome Project Consortium has established a population-scale framework to develop metagenomic protocols, resu...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11209
更新日期：2012-06-13 00:00:00
abstract：:The carbothermal reduction of silica into silicon requires the use of temperatures well above the silicon melting point (> or =2,000 degrees C). Solid silicon has recently been generated directly from silica at much lower temperatures (< or =850 degrees C) via electrochemical reduction in molten salts. However, the si...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature05570
更新日期：2007-03-08 00:00:00
abstract：:Comprehensive protein protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function. Recently, large-scale approaches have predicted many new protein interactions in yeast. To measure their accuracy and potential as well as to identify biases, strengths and weak...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature750
更新日期：2002-05-23 00:00:00
abstract：:A detailed description of the interactions between an antibody and its epitope is necessary to allow an understanding of the way in which antibodies bind to antigenic surfaces presented by foreign molecules. Ideally this should be done by analysis of crystal structures of antibody-antigen complexes, but so far only tw...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/328731a0
更新日期：1987-08-20 00:00:00
abstract：:Dendritic cells (DCs) orchestrate a repertoire of immune responses that bring about resistance to infection and silencing or tolerance to self. In the settings of infection and cancer, microbes and tumours can exploit DCs to evade immunity, but DCs also can generate resistance, a capacity that is readily enhanced with...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/nature06175
更新日期：2007-09-27 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 评论,信件
doi：10.1038/d41586-019-00764-z
更新日期：2019-03-01 00:00:00
abstract：:Cancer-associated systemic inflammation is strongly linked to poor disease outcome in patients with cancer1,2. For most human epithelial tumour types, high systemic neutrophil-to-lymphocyte ratios are associated with poor overall survival3, and experimental studies have demonstrated a causal relationship between neutr...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-1450-6
更新日期：2019-08-01 00:00:00
abstract：:The editing of RNA in trypanosomatid mitochondria involves the insertion and occasional deletion of uridine residues within coding regions of maxicircle messenger RNA transcripts. The extent to which the transcripts of homologous genes undergo editing differs in different species. In some, entire genes are edited (pan...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/368345a0
更新日期：1994-03-24 00:00:00
abstract：:It is not yet clear whether humans are able to learn while they are sleeping. Here we show that full-term human newborns can be taught to discriminate between similar vowel sounds when they are fast asleep. It is possible that such sleep training soon after birth could find application in clinical or educational situa...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/415599b
更新日期：2002-02-07 00:00:00
