Solar eclipses of Phobos and Deimos observed from the surface of Mars.

abstract：:Molecular noise is a natural phenomenon that is inherent to all biological systems1,2. How stochastic processes give rise to the robust outcomes that support tissue homeostasis remains unclear. Here we use single-molecule RNA fluorescent in situ hybridization (smFISH) on mouse stem cells derived from haematopoietic ti...

journal_title：Nature

authors： Wheat JC,Sella Y,Willcockson M,Skoultchi AI,Bergman A,Singer RH,Steidl U

更新日期：2020-07-01 00:00:00

abstract：:Although directed migration is a feature of both individual cells and cell groups, guided migration has been studied most extensively for single cells in simple environments. Collective guidance of cell groups remains poorly understood, despite its relevance for development and metastasis. Neural crest cells and neuro...

journal_title：Nature

authors： Bianco A,Poukkula M,Cliffe A,Mathieu J,Luque CM,Fulga TA,Rørth P

更新日期：2007-07-19 00:00:00

abstract：:Helium-neon lasers emitting at 632.8 nm can influence the phytochrome controlled growth and development of plants more than a quarter of a mile away. It may therefore be possible to control the growth of crops using lasers to activate the phytochrome system. ...

journal_title：Nature

authors： Paleg LG,Aspinall D

更新日期：1970-12-05 00:00:00

abstract：:The crystal structure of human H-Ras complexed with the Ras guanine-nucleotide-exchange-factor region of the Son of sevenless (Sos) protein has been determined at 2.8 A resolution. The normally tight interaction of nucleotides with Ras is disrupted by Sos in two ways. First, the insertion into Ras of an alpha-helix fr...

journal_title：Nature

authors： Boriack-Sjodin PA,Margarit SM,Bar-Sagi D,Kuriyan J

更新日期：1998-07-23 00:00:00

abstract：:El Niño events are characterized by surface warming of the tropical Pacific Ocean and weakening of equatorial trade winds that occur every few years. Such conditions are accompanied by changes in atmospheric and oceanic circulation, affecting global climate, marine and terrestrial ecosystems, fisheries and human activ...

journal_title：Nature

authors： Timmermann A,An SI,Kug JS,Jin FF,Cai W,Capotondi A,Cobb KM,Lengaigne M,McPhaden MJ,Stuecker MF,Stein K,Wittenberg AT,Yun KS,Bayr T,Chen HC,Chikamoto Y,Dewitte B,Dommenget D,Grothe P,Guilyardi E,Ham YG,Hayashi M

更新日期：2018-07-01 00:00:00

abstract：:Topological states of matter are characterized by topological invariants, which are physical quantities whose values are quantized and do not depend on the details of the system (such as its shape, size and impurities). Of these quantities, the easiest to probe is the electrical Hall conductance, and fractional values...

journal_title：Nature

authors： Banerjee M,Heiblum M,Umansky V,Feldman DE,Oreg Y,Stern A

更新日期：2018-07-01 00:00:00

abstract：:Nonrandom chromosome rearrangements, observed in a variety of human and animal tumours, are associated in some cases with enhanced expression or deregulation of cellular oncogenes. Recently, it was shown that normal, diploid rodent cells are neoplastically transformed following transfection with two cooperating oncoge...

journal_title：Nature

authors： Oshimura M,Gilmer TM,Barrett JC

更新日期：1985-08-15 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:Over the last twenty years, there has been rapid growth of a new approach to understanding the evolution of organismic form. This evolutionary developmental biology, or 'evo-devo', is focused on the developmental genetic machinery that lies behind embryological phenotypes, which were all that could be studied in the p...

journal_title：Nature

authors： Arthur W

更新日期：2002-02-14 00:00:00

abstract：:Surface gravity is a basic stellar property, but it is difficult to measure accurately, with typical uncertainties of 25 to 50 per cent if measured spectroscopically and 90 to 150 per cent if measured photometrically. Asteroseismology measures gravity with an uncertainty of about 2 per cent but is restricted to relati...

journal_title：Nature

authors： Bastien FA,Stassun KG,Basri G,Pepper J

更新日期：2013-08-22 00:00:00

abstract：:Polycomb group proteins have an essential role in the epigenetic maintenance of repressive chromatin states. The gene-silencing activity of the Polycomb repressive complex 2 (PRC2) depends on its ability to trimethylate lysine 27 of histone H3 (H3K27) by the catalytic SET domain of the EZH2 subunit, and at least two o...

journal_title：Nature

authors： Margueron R,Justin N,Ohno K,Sharpe ML,Son J,Drury WJ 3rd,Voigt P,Martin SR,Taylor WR,De Marco V,Pirrotta V,Reinberg D,Gamblin SJ

更新日期：2009-10-08 00:00:00

abstract：:Humans have engaged in endurance running for millions of years, but the modern running shoe was not invented until the 1970s. For most of human evolutionary history, runners were either barefoot or wore minimal footwear such as sandals or moccasins with smaller heels and little cushioning relative to modern running sh...

journal_title：Nature

authors： Lieberman DE,Venkadesan M,Werbel WA,Daoud AI,D'Andrea S,Davis IS,Mang'eni RO,Pitsiladis Y

更新日期：2010-01-28 00:00:00

abstract：:Recent theory on sexual selection suggests that females in species without paternal care choose mates by their secondary sexual characters because these indicate genotypic quality which will be transmitted to the offspring. These ideas are not yet empirically supported as data quantifying the relationship between fema...

journal_title：Nature

authors： von Schantz T,Göransson G,Andersson G,Fröberg I,Grahn M,Helgée A,Wittzell H

更新日期：1989-01-12 00:00:00

abstract：:The assessment of changes in tropical cyclone activity within the context of anthropogenically influenced climate change has been limited by the short temporal resolution of the instrumental tropical cyclone record (less than 50 years). Furthermore, controversy exists regarding the robustness of the observational reco...

journal_title：Nature

authors： Haig J,Nott J,Reichart GJ

更新日期：2014-01-30 00:00:00

abstract：:Distrust in scientific expertise1-14 is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks2-4, as happened for measles in 20195,6. Homemade remedies7,8 and falsehoods are being shared widely on the Internet, as well as dismi...

journal_title：Nature

authors： Johnson NF,Velásquez N,Restrepo NJ,Leahy R,Gabriel N,El Oud S,Zheng M,Manrique P,Wuchty S,Lupu Y

更新日期：2020-06-01 00:00:00

abstract：:The diverse functions of RNA, which include enzymatic activities, regulatory roles in transcription and translation, are made possible by tertiary structure. Computer algorithms can predict the secondary structure of an RNA molecule using free-energy parameters for base pairing and stacking, loops and bulges. However,...

journal_title：Nature

authors： Puglisi JD,Wyatt JR,Tinoco I Jr

更新日期：1988-01-21 00:00:00

abstract：:It is generally thought that interspecific (lateral) transfer of genes is so extensive among bacteria that it is difficult, and perhaps impossible, to determine their phylogenetic relationships. Ambler and coworkers reflect this in their suggestion that the relationships seen among cytochrome c sequences of the Rhodos...

journal_title：Nature

authors： Woese CR,Gibson J,Fox GE

更新日期：1980-01-10 00:00:00

abstract：:We often face alternatives that we are free to choose between. Planning movements to select an alternative involves several areas in frontal and parietal cortex that are anatomically connected into long-range circuits. These areas must coordinate their activity to select a common movement goal, but how neural circuits...

journal_title：Nature

authors： Pesaran B,Nelson MJ,Andersen RA

更新日期：2008-05-15 00:00:00

abstract：:Haematopoiesis, the process of mature blood and immune cell production, is functionally organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent progenitor cells sitting at the very top. Multiple models have been proposed as to what the earliest lineage choices are in these primitive haem...

journal_title：Nature

authors： Rodriguez-Fraticelli AE,Wolock SL,Weinreb CS,Panero R,Patel SH,Jankovic M,Sun J,Calogero RA,Klein AM,Camargo FD

更新日期：2018-01-11 00:00:00

abstract：:Systems of colour vision are normally identical in all members of a species, but a single design may not be adequate for species living in a diverse range of light environments. Here we show that in the mantis shrimp Haptosquilla trispinosa, which occupies a range of depths in the ocean, long-wavelength colour recepto...

journal_title：Nature

authors： Cronin TW,Caldwell RL,Marshall J

更新日期：2001-05-31 00:00:00

abstract：:Gene targeting in embryonic stem cells has become the principal technology for manipulation of the mouse genome, offering unrivalled accuracy in allele design and access to conditional mutagenesis. To bring these advantages to the wider research community, large-scale mouse knockout programmes are producing a permanen...

journal_title：Nature

authors： Skarnes WC,Rosen B,West AP,Koutsourakis M,Bushell W,Iyer V,Mujica AO,Thomas M,Harrow J,Cox T,Jackson D,Severin J,Biggs P,Fu J,Nefedov M,de Jong PJ,Stewart AF,Bradley A

更新日期：2011-06-15 00:00:00

abstract：:Toxoplasma gondii, an obligate intracellular parasite of the phylum Apicomplexa, can cause severe disease in humans with an immature or suppressed immune system. The outcome of Toxoplasma infection is highly dependent on the strain type, as are many of its in vitro growth properties. Here we use genetic crosses betwee...

journal_title：Nature

authors： Saeij JP,Coller S,Boyle JP,Jerome ME,White MW,Boothroyd JC

更新日期：2007-01-18 00:00:00

abstract：:The manner in which phase transformations occur in solids determines important structural and physical properties of many materials. The main problem in characterizing the kinetic processes that occur during phase transformations is the difficulty of observing directly, in real time, the growth of one phase at the exp...

journal_title：Nature

authors： Hannon JB,Hibino H,Bartelt NC,Swartzentruber BS,Ogino T,Kellogg GL

更新日期：2000-06-01 00:00:00

abstract：:The motility of the gastrointestinal tract consists of local, non-propulsive mixing (pendular or segmental) and propulsive (peristaltic) movements. It is generally considered that mixing movements are produced by intrinsic pacemakers which generate rhythmic contractions, and peristalsis by intrinsic excitatory and inh...

journal_title：Nature

authors： Stevens RJ,Publicover NG,Smith TK

更新日期：1999-05-06 00:00:00

abstract：:Synaptic plasticity dependent on N-methyl-D-aspartate (NMDA) receptors is thought to underlie certain types of learning and memory. In support of this, both hippocampal long-term potentiation and spatial learning in a watermaze are impaired by blocking NMDA receptors with a selective antagonist D(-)-2-amino-5-phosphon...

journal_title：Nature

authors： Bannerman DM,Good MA,Butcher SP,Ramsay M,Morris RG

更新日期：1995-11-09 00:00:00

abstract：:In response to adenosine 5'-diphosphate, the P2Y1 receptor (P2Y1R) facilitates platelet aggregation, and thus serves as an important antithrombotic drug target. Here we report the crystal structures of the human P2Y1R in complex with a nucleotide antagonist MRS2500 at 2.7 Å resolution, and with a non-nucleotide antago...

journal_title：Nature

authors： Zhang D,Gao ZG,Zhang K,Kiselev E,Crane S,Wang J,Paoletta S,Yi C,Ma L,Zhang W,Han GW,Liu H,Cherezov V,Katritch V,Jiang H,Stevens RC,Jacobson KA,Zhao Q,Wu B

更新日期：2015-04-16 00:00:00

abstract：:Four-residue beta-turns and larger loop structures represent a significant fraction of globular protein surfaces and play an important role in determining the conformation and specificity of enzyme active sites and antibody-combining sites. Turns are an attractive starting point to develop protein design methods, as t...

journal_title：Nature

authors： Hynes TR,Kautz RA,Goodman MA,Gill JF,Fox RO

更新日期：1989-05-04 00:00:00

abstract：:The nicotinic acetylcholine receptor (AChR) from the electroplax of the ray Torpedo californica is composed of five subunits present in a molar stoichiometry of alpha 2 beta gamma delta (refs 1-3) and contains both the binding site for the neurotransmitter and the cation gating unit (reviewed in refs 4-6). We have rec...

journal_title：Nature

authors： Noda M,Takahashi H,Tanabe T,Toyosato M,Kikyotani S,Furutani Y,Hirose T,Takashima H,Inayama S,Miyata T,Numa S

更新日期：1983-04-07 00:00:00

abstract：:Medulloblastoma, the most common malignant paediatric brain tumour, arises in the cerebellum and disseminates through the cerebrospinal fluid in the leptomeningeal space to coat the brain and spinal cord. Dissemination, a marker of poor prognosis, is found in up to 40% of children at diagnosis and in most children at ...

journal_title：Nature

authors： Wu X,Northcott PA,Dubuc A,Dupuy AJ,Shih DJ,Witt H,Croul S,Bouffet E,Fults DW,Eberhart CG,Garzia L,Van Meter T,Zagzag D,Jabado N,Schwartzentruber J,Majewski J,Scheetz TE,Pfister SM,Korshunov A,Li XN,Scherer SW,Ch

更新日期：2012-02-15 00:00:00