The molecular structure of lecithin dihydrate.

Abstract:

:Lecithin is a major structural component of biological membranes. Because of their amphipathic nature, lecithin and related phospholipids tend to aggregate as bilayer structures in which the hydrophilic head groups are orientated towards the surface and the hydrophobic hydrocarbon chains towards the interior. A detailed knowledge of the three-dimensional structure of lecithins will aid in the understanding of their role in membrane structure and function, but is still lacking. To this end we have now crystallised and solved the molecular structure of 1,2-dimyristoyl-sn-glycero-3-phosphorylcholine (DMPC), a lecithin species in the naturally occurring configuration. This compound crystallises from a water-containing solution, with two water molecules (5% w/w) of hydration.

journal_name

Nature

journal_title

Nature

authors

Pearson RH,Pascher I

doi

10.1038/281499a0

subject

Has Abstract

pub_date

1979-10-11 00:00:00

pages

499-501

issue

5731

eissn

0028-0836

issn

1476-4687

journal_volume

281

pub_type

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