Abstract:
:The cloning of mammals from differentiated donor cells has refuted the old dogma that development is an irreversible process. It has demonstrated that the oocyte can reprogramme an adult nucleus into an embryonic state that can direct development of a new organism. The prospect of deriving patient-specific embryonic stem cells by nuclear transfer underscores the potential use of this technology in regenerative medicine. The future challenge will be to study alternatives to nuclear transfer in order to recapitulate reprogramming in a Petri dish without the use of oocytes.
journal_name
Naturejournal_title
Natureauthors
Hochedlinger K,Jaenisch Rdoi
10.1038/nature04955subject
Has Abstractpub_date
2006-06-29 00:00:00pages
1061-7issue
7097eissn
0028-0836issn
1476-4687pii
nature04955journal_volume
441pub_type
杂志文章,评审相关文献
NATURE文献大全abstract::Understanding brain circuits begins with an appreciation of their component parts - the cells. Although GABAergic interneurons are a minority population within the brain, they are crucial for the control of inhibition. Determining the diversity of these interneurons has been a central goal of neurobiologists, but this...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature12983
更新日期:2014-01-16 00:00:00
abstract::The maternal messenger RNA An3 was originally identified localized to the animal hemisphere of Xenopus laevis oocytes, eggs and early embryos. Xenopus embryos depend on mRNA and protein present in the egg before fertilization (maternal molecules) to provide the information needed for early development. Localization of...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/349717a0
更新日期:1991-02-21 00:00:00
abstract::The Kondo effect--a many-body phenomenon in condensed-matter physics involving the interaction between a localized spin and free electrons--was discovered in metals containing small amounts of magnetic impurities, although it is now recognized to be of fundamental importance in a wide class of correlated electron syst...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35015509
更新日期:2000-06-15 00:00:00
abstract::Spontaneous symmetry breaking plays a key role in our understanding of nature. In relativistic quantum field theory, a broken continuous symmetry leads to the emergence of two types of fundamental excitation: massless Nambu-Goldstone modes and a massive 'Higgs' amplitude mode. An excitation of Higgs type is of crucial...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11255
更新日期:2012-07-25 00:00:00
abstract::Neurons in the visual cortex typically respond selectively to the orientation, and velocity and direction of movement, of moving-bar stimuli. These responses are generally thought to provide information about the orientation and position of lines and edges in the visual field. Some cells are also endstopped, that is s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/329438a0
更新日期:1987-10-01 00:00:00
abstract::To cause diseases in plants, pathogenic microorganisms have evolved mechanisms to deliver proteins directly into plant cells, where they suppress plant defences and facilitate tissue invasion. How plant pathogenic fungi, which cause many of the world's most serious plant diseases, deliver proteins during plant infecti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04567
更新日期:2006-03-23 00:00:00
abstract::CYCLINS are proteins synthesized during each cell cycle and abruptly destroyed in each mitosis. Cyclins have been implicated in the induction of mitosis and are associated with the serine-threonine protein kinase p34cdc2 as components of mitosis promoting factor (MPF). On the basis of conserved sequence motifs cyclins...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/346760a0
更新日期:1990-08-23 00:00:00
abstract::Large-scale chromosome structure and spatial nuclear arrangement have been linked to control of gene expression and DNA replication and repair. Genomic techniques based on chromosome conformation capture (3C) assess contacts for millions of loci simultaneously, but do so by averaging chromosome conformations from mill...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12593
更新日期:2013-10-03 00:00:00
abstract::Metastasis is a major cause of death in cancer patients and involves a multistep process including detachment of cancer cells from a primary cancer, invasion of surrounding tissue, spread through circulation, re-invasion and proliferation in distant organs. KiSS-1 is a human metastasis suppressor gene, that suppresses...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35079135
更新日期:2001-05-31 00:00:00
abstract::Abyssal-hill-bounding faults that pervade the oceanic crust are the most common tectonic feature on the surface of the Earth. The recognition that these faults form at plate spreading centres came with the plate tectonic revolution. Recent observations reveal a large range of fault sizes and orientations; numerical mo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03358
更新日期:2005-04-07 00:00:00
abstract::The cyanobacterium Prochlorococcus is the dominant oxygenic phototroph in the tropical and subtropical regions of the world's oceans. It can grow at a range of depths over which light intensities can vary by up to 4 orders of magnitude. This broad depth distribution has been hypothesized to stem from the coexistence o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/30965
更新日期:1998-06-04 00:00:00
abstract::The factors determining disease severity in malaria are complex and include host polymorphisms, acquired immunity and parasite virulence. Studies in Africa have shown that severe malaria is associated with the ability of erythrocytes infected with the parasite Plasmodium falciparum to bind uninfected erythrocytes and ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/40888
更新日期:1997-07-17 00:00:00
abstract::The first nerve cells to appear in the limb buds of embryonic grasshoppers are a pair which lie at the distal tip and project axons along the length of the limb to the central nervous system (CNS). The stereotyped route navigated by these 'pioneer' axons is followed by other neurones and eventually becomes that of a m...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/304062a0
更新日期:1983-07-07 00:00:00
abstract::Glycosaminoglycans such as heparan sulphate and chondroitin sulphate are extracellular sugar chains involved in intercellular signalling. Disruptions of genes encoding enzymes that mediate glycosaminoglycan biosynthesis have severe consequences in Drosophila and mice. Mutations in the Drosophila gene sugarless, which ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01635
更新日期:2003-05-22 00:00:00
abstract::The hypothesis that certain RNA molecules may be able to catalyse RNA replication is central to current theories of the early evolution of life. In support of this idea, we describe here an RNA that synthesizes RNA using the same reaction as that employed by protein enzymes that catalyse RNA polymerization. In the pre...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/382373a0
更新日期:1996-07-25 00:00:00
abstract::Mast cells are primary effectors in allergic reactions, and may have important roles in disease by secreting histamine and various inflammatory and immunomodulatory substances. Although they are classically activated by immunoglobulin (Ig)E antibodies, a unique property of mast cells is their antibody-independent resp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14022
更新日期:2015-03-12 00:00:00
abstract::Homogeneous nucleation and subsequent cluster growth leads to the formation of new aerosol particles in the atmosphere. The nucleation of sulfuric acid and organic vapours is thought to be responsible for the formation of new particles over continents, whereas iodine oxide vapours have been implicated in particle form...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature19314
更新日期:2016-09-22 00:00:00
abstract::Change history: In Fig. 1b and c of this Letter, the inset times in the DIC and GFP microscopy images should be in minutes ('min') instead of seconds ('s'). This has not been corrected online. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1327-8
更新日期:2019-07-01 00:00:00
abstract::Diatoms are one of the most ecologically successful classes of photosynthetic marine eukaryotes in the contemporary oceans. Over the past 30 million years, they have helped to moderate Earth's climate by absorbing carbon dioxide from the atmosphere, sequestering it via the biological carbon pump and ultimately burying...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14599
更新日期:2015-08-20 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07589-2
更新日期:2018-12-01 00:00:00
abstract::Coordinated cell migration is essential in many fundamental biological processes including embryonic development, organogenesis, wound healing and the immune response. During organogenesis, groups of cells are directed to specific locations within the embryo. Here we show that the zebrafish miles apart (mil) mutation ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35018092
更新日期:2000-07-13 00:00:00
abstract::Kalka is one of about 14 major layered mafic-ultramafic intrusions forming the Giles Complex in central Australia1. The stratigraphical section of the Kalka Intrusion passes from a basal pyroxenite zone (450 + m) through norite and olivine gabbro zones (3,500 m) to an uppermost anorthosite zone (800 + m)2. Further res...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/294155a0
更新日期:1981-11-12 00:00:00
abstract::When a spatially uniform temperature change is imposed on a solid with more than one phase, or on a polycrystal of a single, non-cubic phase (showing anisotropic expansion-contraction), the resulting thermal strain is inhomogeneous (non-affine). Thermal cycling induces internal stresses, leading to structural and prop...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14674
更新日期:2015-08-13 00:00:00
abstract::The erosion of mountain belts controls their topographic and structural evolution and is the main source of sediment delivered to the oceans. Mountain erosion rates have been estimated from current relief and precipitation, but a more complete evaluation of the controls on erosion rates requires detailed measurements ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02150
更新日期:2003-12-11 00:00:00
abstract::Primordial germ cells (PGCs) are first identifiable as a population of about eight alkaline phosphatase-positive cells in the 7.0 days postcoitum mouse embryo. During the next 6 days of development they proliferate to give rise to the 25,000 cells that will establish the meiotic population. Steel factor is required fo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/359550a0
更新日期:1992-10-08 00:00:00
abstract::In the brain, hippocampal pyramidal cells use temporal as well as rate coding to signal spatial aspects of the animal's environment or behaviour. The temporal code takes the form of a phase relationship to the concurrent cycle of the hippocampal electroencephalogram theta rhythm. These two codes could each represent a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02058
更新日期:2003-10-23 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/551S40a
更新日期:2017-11-08 00:00:00
abstract::Reported widespread declines of wild and managed insect pollinators have serious consequences for global ecosystem services and agricultural production. Bees contribute approximately 80% of insect pollination, so it is important to understand and mitigate the causes of current declines in bee populations . Recent stud...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11585
更新日期:2012-11-01 00:00:00
abstract::Non-impulsive seismic radiation or 'tremor' has long been observed at volcanoes and more recently around subduction zones. Although the number of observations of non-volcanic tremor is steadily increasing, the causative mechanism remains unclear. Some have attributed non-volcanic tremor to the movement of fluids, whil...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06017
更新日期:2007-08-02 00:00:00
abstract::Although it has been proposed that the activation of T lymphocytes is mediated by an early rise in cytosolic calcium concentration, it has not been possible to mimic antigen- or mitogen-induced mouse lymphocyte activation by calcium ionophores that bypass receptor-mediated processes. There is now evidence from other s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/313318a0
更新日期:1985-01-24 00:00:00