Abstract:
:Disruption of the normal regulation of cell-cycle progression and division lies at the heart of the events leading to cancer. Complex networks of regulatory factors, the tumour microenvironment and stress signals, such as those resulting from damaged DNA, dictate whether cancer cells proliferate or die. Recent progress in understanding the molecular changes that underlie cancer development offer the prospect of specifically targeting malfunctioning molecules and pathways to achieve more effective and rational cancer therapy.
journal_name
Naturejournal_title
Natureauthors
Sawyers Cdoi
10.1038/nature03095keywords:
subject
Has Abstractpub_date
2004-11-18 00:00:00pages
294-7issue
7015eissn
0028-0836issn
1476-4687pii
nature03095journal_volume
432pub_type
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