Aggression by polyembryonic wasp soldiers correlates with kinship but not resource competition.

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains recalcitrant to all forms of cancer treatment and carries a five-year survival rate of only 8%1. Inhibition of oncogenic KRAS (hereafter KRAS*), the earliest lesion in disease development that is present in more than 90% of PDACs, and its signalling surrogates has yielde...

journal_title：Nature

authors： Yao W,Rose JL,Wang W,Seth S,Jiang H,Taguchi A,Liu J,Yan L,Kapoor A,Hou P,Chen Z,Wang Q,Nezi L,Xu Z,Yao J,Hu B,Pettazzoni PF,Ho IL,Feng N,Ramamoorthy V,Jiang S,Deng P,Ma GJ,Den P,Tan Z,Zhang SX,Wang H,

更新日期：2019-04-01 00:00:00

abstract：:Insulin binding to its receptor leads to negatively cooperative interactions among the receptor sites. Studies with 29 insulin analogues (animal insulins and proinsulin, insulin-like growth factor and chemically modified insulins) which vary 1,000-fold in their affinity for the receptor and in their biological potency...

journal_title：Nature

authors： De Meyts P,Van Obberghen E,Roth J

更新日期：1978-06-15 00:00:00

abstract：:The double helix of DNA epitomizes this molecule's ability to self-assemble in aqueous solutions into a complex chiral structure using hydrogen bonding and hydrophobic interactions. Non-covalently interacting molecules in organic solvents are used to design systems that similarly form controlled architectures. Periphe...

journal_title：Nature

authors： Hirschberg JH,Brunsveld L,Ramzi A,Vekemans JA,Sijbesma RP,Meijer EW

更新日期：2000-09-14 00:00:00

abstract：:Phosphorylation of membrane components is thought to be an important process in membrane function. Phosphorylated proteins and a special class of phospholipids, the (poly)phosphoinositides (poly PI), are implicated in the regulation of membrane permeability and synaptic transmission in neurones. For many years, protei...

journal_title：Nature

authors： Jolles J,Zwiers H,van Dongen CJ,Schotman P,Wirtz KW,Gispen WH

更新日期：1980-08-07 00:00:00

abstract：:Many eukaryotic cellular and viral proteins have a covalently attached myristoyl group at the amino terminus. One such protein is recoverin, a calcium sensor in retinal rod cells, which controls the lifetime of photoexcited rhodopsin by inhibiting rhodopsin kinase. Recoverin has a relative molecular mass of 23,000 (M[...

journal_title：Nature

authors： Ames JB,Ishima R,Tanaka T,Gordon JI,Stryer L,Ikura M

更新日期：1997-09-11 00:00:00

abstract：:The widely occurring tetradecapeptide somatostatin (SRIF-14) has been variously implicated as a neurotransmitter, a neurohormone, a cybernin (local regulatory factor) and a hormone. In the first isolation of SRIF-14 from hypothalamic extracts and subsequent extracts of other tissues, peptides of higher molecular weigh...

journal_title：Nature

authors： Mandarino L,Stenner D,Blanchard W,Nissen S,Gerich J,Ling N,Brazeau P,Bohlen P,Esch F,Guillemin R

更新日期：1981-05-07 00:00:00

abstract：:Electrophoretic studies suggest that bacterial populations consist of a number of independent clones and that genetic recombination is rare in nature. But DNA sequencing reveals that individual bacterial genes have a mosaic structure that could have arisen only by recombination. How can these observations be reconcile...

journal_title：Nature

authors： Smith JM,Dowson CG,Spratt BG

更新日期：1991-01-03 00:00:00

abstract：:Spontaneous type 1 diabetes occurs when the autoimmune destruction of pancreatic beta-islet cells prevents production of the hormone insulin. This causes an inability to regulate glucose metabolism, which results in dangerously raised blood glucose concentrations. It is generally accepted that thymus-derived lymphocyt...

journal_title：Nature

authors： Wilson DB

更新日期：2005-11-24 00:00:00

abstract：:An experiment by the Gates Foundation is food for thought for other research agencies. ...

journal_title：Nature

authors：

更新日期：2008-10-30 00:00:00

abstract：:Mammalian sex chromosomes share a small terminal region of homologous DNA sequences, which pair and recombine during male meiosis. Alleles in this region can be exchanged between X and Y chromosomes and are therefore inherited as if autosomal. Genes from this so-called pseudoautosomal region (PAR) are present in two d...

journal_title：Nature

authors： Gough NM,Gearing DP,Nicola NA,Baker E,Pritchard M,Callen DF,Sutherland GR

更新日期：1990-06-21 00:00:00

abstract：:Although individuals age and die with time, an animal species can continue indefinitely, because of its immortal germ-cell lineage. How the germline avoids transmitting damage from one generation to the next remains a fundamental question in biology. Here we identify a lysosomal switch that enhances germline proteosta...

journal_title：Nature

authors： Bohnert KA,Kenyon C

更新日期：2017-11-30 00:00:00

abstract：:Haemoglobin is the prototype of an allosteric protein in which cooperative behaviour depends on interaction between unlike subunits. Here we present haematological and biochemical evidence that electrostatic interactions are an important determinant of haemoglobin assembly. Individuals heterozygous for positively char...

journal_title：Nature

authors： Bunn HF,McDonald MJ

更新日期：1983-12-01 00:00:00

abstract：:The embryos and larvae of stalked crinoids, which are considered the most basal group of extant echinoderms, have not previously been described. In contrast, much is known about the development of the more accessible stalkless crinoids (feather stars), which are phylogenetically derived from stalked forms. Here we des...

journal_title：Nature

authors： Nakano H,Hibino T,Oji T,Hara Y,Amemiya S

更新日期：2003-01-09 00:00:00

abstract：:Metformin is considered to be one of the most effective therapeutics for treating type 2 diabetes because it specifically reduces hepatic gluconeogenesis without increasing insulin secretion, inducing weight gain or posing a risk of hypoglycaemia. For over half a century, this agent has been prescribed to patients wit...

journal_title：Nature

authors： Madiraju AK,Erion DM,Rahimi Y,Zhang XM,Braddock DT,Albright RA,Prigaro BJ,Wood JL,Bhanot S,MacDonald MJ,Jurczak MJ,Camporez JP,Lee HY,Cline GW,Samuel VT,Kibbey RG,Shulman GI

更新日期：2014-06-26 00:00:00

abstract：:The import of nuclear proteins proceeds through the nuclear pore complex and requires nuclear localization signals (NLSs), energy and soluble factors, namely importin-alpha (M(r) 60K), importin-beta (90K) and Ran. Importin-alpha is primarily responsible for NLS recognition and is a member of a protein family that incl...

journal_title：Nature

authors： Görlich D,Vogel F,Mills AD,Hartmann E,Laskey RA

更新日期：1995-09-21 00:00:00

abstract：:Synapsin I is a neuron-specific phosphoprotein localized to the cytoplasmic surface of synaptic vesicles. This phosphoprotein is a major substrate for cyclic AMP-dependent and calcium/calmodulin-dependent protein kinases. Its state of phosphorylation can be altered both in vivo and in vitro by a variety of physiologic...

journal_title：Nature

authors： Bähler M,Greengard P

更新日期：1987-04-16 00:00:00

abstract：:Satellite observations have transformed our understanding of the Antarctic cryosphere. The continent holds the vast majority of Earth's fresh water, and blankets swathes of the Southern Hemisphere in ice. Reductions in the thickness and extent of floating ice shelves have disturbed inland ice, triggering retreat, acce...

journal_title：Nature

authors： Shepherd A,Fricker HA,Farrell SL

更新日期：2018-06-01 00:00:00

abstract：:Glandular epithelia, including the mammary and prostate glands, are composed of basal cells (BCs) and luminal cells (LCs)1,2. Many glandular epithelia develop from multipotent basal stem cells (BSCs) that are replaced in adult life by distinct pools of unipotent stem cells1,3-8. However, adult unipotent BSCs can react...

journal_title：Nature

authors： Centonze A,Lin S,Tika E,Sifrim A,Fioramonti M,Malfait M,Song Y,Wuidart A,Van Herck J,Dannau A,Bouvencourt G,Dubois C,Dedoncker N,Sahay A,de Maertelaer V,Siebel CW,Van Keymeulen A,Voet T,Blanpain C

更新日期：2020-08-01 00:00:00

abstract：:Viable tumour-derived epithelial cells (circulating tumour cells or CTCs) have been identified in peripheral blood from cancer patients and are probably the origin of intractable metastatic disease. Although extremely rare, CTCs represent a potential alternative to invasive biopsies as a source of tumour tissue for th...

journal_title：Nature

authors： Nagrath S,Sequist LV,Maheswaran S,Bell DW,Irimia D,Ulkus L,Smith MR,Kwak EL,Digumarthy S,Muzikansky A,Ryan P,Balis UJ,Tompkins RG,Haber DA,Toner M

更新日期：2007-12-20 00:00:00

abstract：:Subduction zones produce the largest earthquakes. Over the past two decades, space geodesy has revolutionized our view of crustal deformation between consecutive earthquakes. The short time span of modern measurements necessitates comparative studies of subduction zones that are at different stages of the deformation ...

journal_title：Nature

authors： Wang K,Hu Y,He J

更新日期：2012-04-18 00:00:00

abstract：:A major factor in the progression to heart failure in humans is the inability of the adult heart to repair itself after injury. We recently demonstrated that the early postnatal mammalian heart is capable of regeneration following injury through proliferation of preexisting cardiomyocytes1,2 and that Meis1, a three am...

journal_title：Nature

authors： Nguyen NUN,Canseco DC,Xiao F,Nakada Y,Li S,Lam NT,Muralidhar SA,Savla JJ,Hill JA,Le V,Zidan KA,El-Feky HW,Wang Z,Ahmed MS,Hubbi ME,Menendez-Montes I,Moon J,Ali SR,Le V,Villalobos E,Mohamed MS,Elhelaly WM,Thet

更新日期：2020-06-01 00:00:00

abstract：:The limited ranges of the wild progenitors of many of the primary European domestic species point to their origins further east in Anatolia or the fertile crescent. The wild ox (Bos primigenius), however, ranged widely and it is unknown whether it was domesticated within Europe as one feature of a local contribution t...

journal_title：Nature

authors： Troy CS,MacHugh DE,Bailey JF,Magee DA,Loftus RT,Cunningham P,Chamberlain AT,Sykes BC,Bradley DG

更新日期：2001-04-26 00:00:00

abstract：:The Colorado plateau is a large, tectonically intact, physiographic province in the southwestern North American Cordillera that stands at ∼1,800-2,000 m elevation and has long been thought to be in isostatic equilibrium. The origin of these high elevations is unclear because unlike the surrounding provinces, which hav...

journal_title：Nature

authors： Levander A,Schmandt B,Miller MS,Liu K,Karlstrom KE,Crow RS,Lee CT,Humphreys ED

更新日期：2011-04-28 00:00:00

abstract：:The success of cisplatin in cancer chemotherapy derives from its ability to crosslink DNA and alter the structure. Most cisplatin-DNA adducts are intrastrand d(GpG) and d(ApG) crosslinks, which unwind and bend the duplex to facilitate the binding of proteins that contain one or more high-mobility group (HMG) domains. ...

journal_title：Nature

authors： Takahara PM,Rosenzweig AC,Frederick CA,Lippard SJ

更新日期：1995-10-19 00:00:00

abstract：:Kinetoplastid RNA editing alters mitochondrial RNA transcripts by addition and deletion of uridine residues, producing open reading frames that may be twice as long as the original RNA. Although the COIII gene encoding cytochrome c oxidase subunit III in Trypanosoma brucei is edited along its entire length, the presum...

journal_title：Nature

authors： Landweber LF,Gilbert W

更新日期：1993-05-13 00:00:00

abstract：:The protein coding sequences of most eukaryotic messenger RNA precursors (pre-mRNAs) are interrupted by non-coding sequences called introns. Pre-mRNA splicing is the process by which introns are removed and the protein coding elements assembled into mature mRNAs. Alternative pre-mRNA splicing selectively joins differe...

journal_title：Nature

authors： Maniatis T,Tasic B

更新日期：2002-07-11 00:00:00

abstract：:Change history: In Fig. 1c of this Letter, the two graphs were duplicates. The right panel of Fig. 1c has been corrected online. ...

journal_title：Nature

authors： Lai B,Gao W,Cui K,Xie W,Tang Q,Jin W,Hu G,Ni B,Zhao K

更新日期：2018-12-01 00:00:00

abstract：:Many biomolecules are characterized by surfaces containing extended nonpolar regions, and the aggregation and subsequent removal of such surfaces from water is believed to play a critical role in the biomolecular assembly in cells. A better understanding of the hydrophobic hydration of biomolecules may therefore yield...

journal_title：Nature

authors： Cheng YK,Rossky PJ

更新日期：1998-04-16 00:00:00

abstract：:Much of our knowledge of galaxies comes from analysing the radiation emitted by their stars, which depends on the present number of each type of star in the galaxy. The present number depends on the stellar initial mass function (IMF), which describes the distribution of stellar masses when the population formed, and ...

journal_title：Nature

authors： Cappellari M,McDermid RM,Alatalo K,Blitz L,Bois M,Bournaud F,Bureau M,Crocker AF,Davies RL,Davis TA,de Zeeuw PT,Duc PA,Emsellem E,Khochfar S,Krajnović D,Kuntschner H,Lablanche PY,Morganti R,Naab T,Oosterloo T,Sarz

更新日期：2012-04-25 00:00:00

abstract：:A new process, antigenization of antibodies, consisting of the expression of oligopeptides in the hypervariable loops of an antibody molecule is described. The potential applications of antigenized antibodies are discussed. ...

journal_title：Nature

authors： Zanetti M

更新日期：1992-01-30 00:00:00