Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin.

abstract：:The recent discoveries of RNA interference and related RNA silencing pathways have revolutionized our understanding of gene regulation. RNA interference has been used as a research tool to control the expression of specific genes in numerous experimental organisms and has potential as a therapeutic strategy to reduce ...

journal_title：Nature

authors： Mello CC,Conte D Jr

更新日期：2004-09-16 00:00:00

abstract：:Most species live in species-rich food webs; yet, for a century, most mathematical models for population dynamics have included only one or two species. We ask whether such models are relevant to the real world. Two-species population models of an interacting consumer and resource collapse to one-species dynamics when...

journal_title：Nature

authors： Murdoch WW,Kendall BE,Nisbet RM,Briggs CJ,McCauley E,Bolser R

更新日期：2002-05-30 00:00:00

abstract：:Metamaterials are artificial optical media composed of sub-wavelength metallic and dielectric building blocks that feature optical phenomena not present in naturally occurring materials. Although they can serve as the basis for unique optical devices that mould the flow of light in unconventional ways, three-dimension...

journal_title：Nature

authors： High AA,Devlin RC,Dibos A,Polking M,Wild DS,Perczel J,de Leon NP,Lukin MD,Park H

更新日期：2015-06-11 00:00:00

abstract：:Certain bacteria promote the formation of ice in super-cooled water by means of ice nucleators which contain a unique protein associated with the cell membrane. Ice nucleators in general are believed to act by mimicking the structure of an ice crystal surface, thus imposing an ice-like arrangement on the water molecul...

journal_title：Nature

authors： Parody-Morreale A,Murphy KP,Di Cera E,Fall R,DeVries AL,Gill SJ

更新日期：1988-06-23 00:00:00

abstract：:Retinoid X receptor (RXR) plays a central role in the regulation of many intracellular receptor signalling pathways and can mediate ligand-dependent transcription, acting as a homodimer or as a heterodimer. Here we identify an antagonist towards RXR homodimers which also functions as an agonist when RXR is paired as a...

journal_title：Nature

authors： Lala DS,Mukherjee R,Schulman IG,Koch SS,Dardashti LJ,Nadzan AM,Croston GE,Evans RM,Heyman RA

更新日期：1996-10-03 00:00:00

abstract：:Biological dinitrogen fixation provides the largest input of nitrogen to the oceans, therefore exerting important control on the ocean's nitrogen inventory and primary productivity. Nitrogen-isotope data from ocean sediments suggest that the marine-nitrogen inventory has been balanced for the past 3,000 years (ref. 4)...

journal_title：Nature

authors： Großkopf T,Mohr W,Baustian T,Schunck H,Gill D,Kuypers MM,Lavik G,Schmitz RA,Wallace DW,LaRoche J

更新日期：2012-08-16 00:00:00

abstract：:Since the original work on Bose-Einstein condensation1,2, the use of quantum degenerate gases of atoms has enabled the quantum emulation of important systems in condensed matter and nuclear physics, as well as the study of many-body states that have no analogue in other fields of physics3. Ultracold molecules in the m...

journal_title：Nature

authors： Son H,Park JJ,Ketterle W,Jamison AO

更新日期：2020-04-01 00:00:00

abstract：:When an intense laser pulse is focused into a gas, the light-atom interaction that occurs as atoms are ionized results in an extremely nonlinear optical process--the generation of high harmonics of the driving laser frequency. Harmonics that extend up to orders of about 300 have been reported, some corresponding to ph...

journal_title：Nature

authors： Bartels R,Backus S,Zeek E,Misoguti L,Vdovin G,Christov IP,Murnane MM,Kapteyn HC

更新日期：2000-07-13 00:00:00

abstract：:Global patterns of species richness and their structuring forces have fascinated biologists since Darwin and provide critical context for contemporary studies in ecology, evolution and conservation. Anthropogenic impacts and the need for systematic conservation planning have further motivated the analysis of diversity...

journal_title：Nature

authors： Tittensor DP,Mora C,Jetz W,Lotze HK,Ricard D,Berghe EV,Worm B

更新日期：2010-08-26 00:00:00

abstract：:Recent observations have revealed streams of gas and stars in the halo of the Milky Way that are the debris from interactions between our Galaxy and some of its dwarf companion galaxies; the Sagittarius dwarf galaxy and the Magellanic clouds. Analysis of the material has shown that much of the halo is made up of canni...

journal_title：Nature

authors： Ibata R,Irwin M,Lewis G,Ferguson AM,Tanvir N

更新日期：2001-07-05 00:00:00

abstract：:Many eukaryotic cellular and viral proteins have a covalently attached myristoyl group at the amino terminus. One such protein is recoverin, a calcium sensor in retinal rod cells, which controls the lifetime of photoexcited rhodopsin by inhibiting rhodopsin kinase. Recoverin has a relative molecular mass of 23,000 (M[...

journal_title：Nature

authors： Ames JB,Ishima R,Tanaka T,Gordon JI,Stryer L,Ikura M

更新日期：1997-09-11 00:00:00

abstract：:Plasmodium falciparum infected erythrocytes containing mature trophozoites and schizonts sequester along venular endothelium and are not in the peripheral circulation of patients with malaria. Knobs appear on infected erythrocytes and are the points of attachment to endothelium. Sequestration may protect the parasite ...

journal_title：Nature

authors： Roberts DD,Sherwood JA,Spitalnik SL,Panton LJ,Howard RJ,Dixit VM,Frazier WA,Miller LH,Ginsburg V

更新日期：1985-11-07 00:00:00

abstract：:The expression of immunodeficiency in patients with specific purine enzyme defects indicates a crucial role of the purine salvage pathway in the acquisition and expression of normal immune function. One current hypothesis links the failure of normal lymphocyte development in these diseases to the accumulation of deoxy...

journal_title：Nature

authors： Dosch HM,Mansour A,Cohen A,Shore A,Gelfand EW

更新日期：1980-06-12 00:00:00

abstract：:An unusual feature of the cerebellar cortex is that its output neurons, Purkinje cells, release GABA (γ-aminobutyric acid). Their high intrinsic firing rates (50 Hz) and extensive convergence predict that their target neurons in the cerebellar nuclei would be largely inhibited unless Purkinje cells pause their spiking...

journal_title：Nature

authors： Person AL,Raman IM

更新日期：2011-12-25 00:00:00

abstract：:Large, actively swimming suspension feeders evolved several times in Earth's history, arising independently from groups as diverse as sharks, rays and stem teleost fishes, and in mysticete whales. However, animals occupying this niche have not been identified from the early Palaeozoic era. Anomalocarids, a group of st...

journal_title：Nature

authors： Vinther J,Stein M,Longrich NR,Harper DA

更新日期：2014-03-27 00:00:00

abstract：:Membrane-enclosed organelles, a defining characteristic of eukaryotic cells, are lost during differentiation of specific cell types such as reticulocytes (an intermediate in differentiation of erythrocytes), central fibre cells of the eye lens, and keratinocytes. The degradation of these organelles must be tightly reg...

journal_title：Nature

authors： van Leyen K,Duvoisin RM,Engelhardt H,Wiedmann M

更新日期：1998-09-24 00:00:00

abstract：:Interactions of CD4 with the class II major histocompatibility complex (MHC) are crucial during thymic ontogeny and subsequently for helper and cytotoxic functions of CD4+CD8- T lymphocytes. CD4 is the receptor for the T-lymphotropic human immunodeficiency virus and binds its envelope glycoprotein, gp120. The residues...

journal_title：Nature

authors： Clayton LK,Sieh M,Pious DA,Reinherz EL

更新日期：1989-06-15 00:00:00

abstract：:Pressure is mounting to relax the regulations on importation of chimpanzees for research. Such a policy is unnecessary and would deepen the plight of an already endangered species. ...

journal_title：Nature

authors： Prince AM,Moor-Jankowski J,Eichberg JW,Schellekens H,Mauler RF,Girard M,Goodall J

更新日期：1988-06-09 00:00:00

abstract：:Adsorption-based phenomena are important in gas separations, such as the treatment of greenhouse-gas and toxic-gas pollutants, and in water-adsorption-based heat pumps for solar cooling systems. The ability to tune the pore size, shape and functionality of crystalline porous coordination polymers--or metal-organic fra...

journal_title：Nature

authors： Krause S,Bon V,Senkovska I,Stoeck U,Wallacher D,Többens DM,Zander S,Pillai RS,Maurin G,Coudert FX,Kaskel S

更新日期：2016-04-21 00:00:00

abstract：:The regular occurrence of a peak due to an unidentified substance (X) in the gas chromatographic traces obtained from phenolic extracts of urine from human pregnant and non-pregnant females has been reported. The biphasic excretion of X with maxima in the luteal phase of the ovulatory cycle and relatively high levels ...

journal_title：Nature

authors： Stitch SR,Toumba JK,Groen MB,Funke CW,Leemhuis J,Vink J,Woods GF

更新日期：1980-10-23 00:00:00

abstract：:This corrects the article DOI: 10.1038/nature21725. ...

journal_title：Nature

authors： Ndeh D,Rogowski A,Cartmell A,Luis AS,Baslé A,Gray J,Venditto I,Briggs J,Zhang X,Labourel A,Terrapon N,Buffetto F,Nepogodiev S,Xiao Y,Field RA,Zhu Y,O'Neill MA,Urbanowicz BR,York WS,Davies GJ,Abbott DW,Ralet MC,

更新日期：2017-08-31 00:00:00

abstract：:It has been known for some 50 years that birds use photoreceptors in or near the hypothalamus to mediate the photoperiodic responses that control seasonal breeding. So far, however, attempts to identify the photopigment by determining an action spectrum have failed. The problems stem from the selective filtering of li...

journal_title：Nature

authors： Foster RG,Follett BK,Lythgoe JN

更新日期：1985-01-03 00:00:00

abstract：:The products of the classical human major histocompatibility complex (MHC) class I genes (HLA-A, -B, -C) are highly polymorphic molecules that bind peptides and present them to T lymphocytes. The non-polymorphic, non-classical MHC class I gene products (HLA-E, -F, -G) are not restricting elements for the majority of T...

journal_title：Nature

authors： Watkins DI,Chen ZW,Hughes AL,Evans MG,Tedder TF,Letvin NL

更新日期：1990-07-05 00:00:00

abstract：:Despite the introduction of antiproliferative drug-eluting stents, coronary heart disease remains the leading cause of death in the United States. In-stent restenosis and bypass graft failure are characterized by excessive smooth muscle cell (SMC) proliferation and concomitant myointima formation with luminal oblitera...

journal_title：Nature

authors： Deuse T,Hua X,Wang D,Maegdefessel L,Heeren J,Scheja L,Bolaños JP,Rakovic A,Spin JM,Stubbendorff M,Ikeno F,Länger F,Zeller T,Schulte-Uentrop L,Stoehr A,Itagaki R,Haddad F,Eschenhagen T,Blankenberg S,Kiefmann R,Reic

更新日期：2014-05-29 00:00:00

abstract：:The maternal gene bicoid (bcd) determines pattern in the anterior half of the Drosophila embryo. It is reported here that the injection of bcd mutant embryos with messenger RNAs that encode proteins consisting of heterologous acidic transcriptional activating sequences fused to the DNA-binding portion of the bcd gene ...

journal_title：Nature

authors： Driever W,Ma J,Nüsslein-Volhard C,Ptashne M

更新日期：1989-11-09 00:00:00

abstract：:Lung diseases such as chronic obstructive pulmonary disease and pulmonary fibrosis involve the progressive and inexorable destruction of oxygen exchange surfaces and airways, and have emerged as a leading cause of death worldwide. Mitigating therapies, aside from impractical organ transplantation, remain limited and t...

journal_title：Nature

authors： Zuo W,Zhang T,Wu DZ,Guan SP,Liew AA,Yamamoto Y,Wang X,Lim SJ,Vincent M,Lessard M,Crum CP,Xian W,McKeon F

更新日期：2015-01-29 00:00:00

abstract：:One of the most exciting events in recent years in molecular biology was the discovery of the left-handed Z form of the DNA double helix. Originally found in linear self-complementary d(GC)x . d(GC)x polymers and oligomers in non-physiological conditions (a rather high salt concentration), it was recently shown to be ...

journal_title：Nature

authors： Frank-Kamenetskii MD,Vologodskii AV

更新日期：1984-02-02 00:00:00

abstract：:Behavioural experiences activate the FOS transcription factor in sparse populations of neurons that are critical for encoding and recalling specific events1-3. However, there is limited understanding of the mechanisms by which experience drives circuit reorganization to establish a network of Fos-activated cells. It i...

journal_title：Nature

authors： Yap EL,Pettit NL,Davis CP,Nagy MA,Harmin DA,Golden E,Dagliyan O,Lin C,Rudolph S,Sharma N,Griffith EC,Harvey CD,Greenberg ME

更新日期：2020-12-09 00:00:00

abstract：:Soybean (Glycine max (L.) Merr.) is an important crop that provides a sustainable source of protein and oil worldwide. Soybean cyst nematode (Heterodera glycines Ichinohe) is a microscopic roundworm that feeds on the roots of soybean and is a major constraint to soybean production. This nematode causes more than US$1 ...

journal_title：Nature

authors： Liu S,Kandoth PK,Warren SD,Yeckel G,Heinz R,Alden J,Yang C,Jamai A,El-Mellouki T,Juvale PS,Hill J,Baum TJ,Cianzio S,Whitham SA,Korkin D,Mitchum MG,Meksem K

更新日期：2012-12-13 00:00:00

abstract：:On being heated, ice melts into liquid water. Although in practice this process tends to be heterogeneous, it can occur homogeneously inside bulk ice. The thermally induced homogeneous melting of solids is fairly well understood, and involves the formation and growth of melting nuclei. But in the case of water, resili...

journal_title：Nature

authors： Mochizuki K,Matsumoto M,Ohmine I

更新日期：2013-06-20 00:00:00