Abstract：
:Germ cells must develop along distinct male or female paths to produce the sperm or eggs required for sexual reproduction. In both mouse and Drosophila, the sexual identity of germ cells is influenced by the sex of the surrounding somatic tissue (for example, refs 1, 2, reviewed in refs 3, 4); however, little is known about how the soma controls germline sex determination. Here we show that the janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway provides a sex-specific signal from the soma to the germ line in Drosophila embryonic gonads. The somatic gonad expresses a JAK/STAT ligand, unpaired (upd), in a male-specific manner, and activates the JAK/STAT pathway in male germ cells at the time of gonad formation. Furthermore, the JAK/STAT pathway is necessary for male-specific germ cell behaviour during early gonad development, and is sufficient to activate aspects of male germ cell behaviour in female germ cells. Our findings provide direct evidence that the JAK/STAT pathway mediates a key signal from the somatic gonad that regulates male germline sexual development.
journal_name
Naturejournal_title
Natureauthors
Wawersik M,Milutinovich A,Casper AL,Matunis E,Williams B,Van Doren Mdoi
10.1038/nature03849keywords:
subject
Has Abstractpub_date
2005-07-28 00:00:00pages
563-7issue
7050eissn
0028-0836issn
1476-4687pii
nature03849journal_volume
436pub_type
杂志文章相关文献
NATURE文献大全abstract：:Atlantic tropical cyclone activity, as measured by annual storm counts, reached anomalous levels over the past decade. The short nature of the historical record and potential issues with its reliability in earlier decades, however, has prompted an ongoing debate regarding the reality and significance of the recent ris...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08219
更新日期：2009-08-13 00:00:00
abstract：:Guanine-nucleotide-exchange factors (GEFs) promote the exchange of GDP for GTP in Ras GTPases, and thereby positively regulate their functions. Members of the Sec4/Ypt1/Rab branch of the Ras superfamily are essential for vesicular transport. A GEF for a subset of Rab proteins, termed mammalian suppressor of Sec4 (Mss4...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/376788a0
更新日期：1995-08-31 00:00:00
abstract：:Chronic administration of several chemical carcinogens to laboratory animals induces a variety of tumours which arise from specific cell populations within the liver. In the rat, diethylnitrosamine induces hepatocellular carcinomas, dimethylnitrosamine induces both angiosarcomas and hepatocellular carcinomas, vinyl ch...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/288185a0
更新日期：1980-11-13 00:00:00
abstract：:On the basis of their primary structure, the lysine-rich histones are a unified family of proteins. Each has an amino acid chain which falls into three distinct domains. Only the central domain (approximately 80 residues) is in a folded conformation. It is protected from trypsin digestion in chromatin and corresponds ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/288675a0
更新日期：1980-12-25 00:00:00
abstract：:Multiple sclerosis is thought to be an autoimmune disease of the central nervous system mediated by T cells specific for a myelin antigen. Myelin basic protein has been studied as a potential autoantigen in the disease because of its role as an encephalitogen in experimental autoimmune encephalomyelitis and post-viral...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/346183a0
更新日期：1990-07-12 00:00:00
abstract：:The recognition of foreign antigens by T lymphocytes is essential to most adaptive immune responses. It is driven by specific T-cell antigen receptors (TCRs) binding to antigenic peptide-major histocompatibility complex (pMHC) molecules on other cells. If productive, these interactions promote the formation of an immu...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08746
更新日期：2010-02-18 00:00:00
abstract：:Osteoclasts are multinucleated giant cells that resorb bone, ensuring development and continuous remodelling of the skeleton and the bone marrow haematopoietic niche. Defective osteoclast activity leads to osteopetrosis and bone marrow failure1-9, whereas excess activity can contribute to bone loss and osteoporosis10....
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-1105-7
更新日期：2019-04-01 00:00:00
abstract：:Archaeal and eukaryotic translation elongation factor 2 contain a unique post-translationally modified histidine residue called diphthamide, which is the target of diphtheria toxin. The biosynthesis of diphthamide was proposed to involve three steps, with the first being the formation of a C-C bond between the histidi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09138
更新日期：2010-06-17 00:00:00
abstract：:In the coming decades, a crucial challenge for humanity will be meeting future food demands without undermining further the integrity of the Earth's environmental systems. Agricultural systems are already major forces of global environmental degradation, but population growth and increasing consumption of calorie- and...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11420
更新日期：2012-10-11 00:00:00
abstract：:A 12 amino-acid synthetic peptide (NANP)3 comprising the immunodominant epitope of Plasmodium falciparum circumsporozoite protein was conjugated to tetanus toxoid (TT), adjuvanted with aluminium hydroxide, and administered intramuscularly in three doses at monthly intervals to 35 healthy males as a malaria vaccine. No...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/328257a0
更新日期：1987-07-16 00:00:00
abstract：:Molecular cloning and DNA sequencing have yielded considerable structural information about proenkephalin. All previously characterized intermediate peptides of the enkephalin pathways in bovine adrenal medulla have now been aligned into an unambiguous primary structure. Two basic amino acid residues serve as processi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/295206a0
更新日期：1982-01-21 00:00:00
abstract：:Positron emission tomography (PET) measurements of brain blood flow were used to monitor changes in the human primary and secondary somatosensory cortices during the period when somatosensory stimuli were expected. In anticipation of either focal or innocuous touching, or localized, painful shocks, blood flow decrease...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/373249a0
更新日期：1995-01-19 00:00:00
abstract：:Although drugs are intended to be selective, at least some bind to several physiological targets, explaining side effects and efficacy. Because many drug-target combinations exist, it would be useful to explore possible interactions computationally. Here we compared 3,665 US Food and Drug Administration (FDA)-approved...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08506
更新日期：2009-11-12 00:00:00
abstract：:Membrane remodelling plays an important role in cellular tasks such as endocytosis, vesiculation and protein sorting, and in the biogenesis of organelles such as the endoplasmic reticulum or the Golgi apparatus. It is well established that the remodelling process is aided by specialized proteins that can sense as well...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature05840
更新日期：2007-05-24 00:00:00
abstract：:Stimulation of transient increases in intracellular calcium (Cai2+) activates protein kinases, regulates transcription and influences motility and morphology. Developing neurons generate spontaneous Cai2+ transients, but their role in directing neuronal differentiation and the way in which they encode information are ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/375784a0
更新日期：1995-06-29 00:00:00
abstract：:Guard cells are located in the epidermis of plant leaves, and in pairs surround stomatal pores. These control both the influx of CO2 as a raw material for photosynthesis and water loss from plants through transpiration to the atmosphere. Guard cells have become a highly developed system for dissecting early signal tra...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/35066500
更新日期：2001-03-15 00:00:00
abstract：:The single endogenous DBA/2J ectropic provirus segregated concordantly with the dilute (d) coat colour mutation on chromosome 9 in 53/53 DBA/2J-derived recombinant inbred mouse strains and all seven inbred and mutant strains tested that carry the d allele. Analysis of DNA from a spontaneous DBA/2J d revertant (d+2J) s...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/293370a0
更新日期：1981-10-01 00:00:00
abstract：:During the past ten years, coupled quantum wells have emerged as a promising system for experiments on Bose condensation of excitons, with numerous theoretical and experimental studies aimed at the demonstration of this effect. One of the issues driving these studies is the possibility of long-range coherent transport...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature00940
更新日期：2002-08-15 00:00:00
abstract：:Cpdm (chronic proliferative dermatitis) mice develop chronic dermatitis and an immunodeficiency with increased serum IgM, symptoms that resemble those of patients with X-linked hyper-IgM syndrome and hypohydrotic ectodermal dysplasia (XHM-ED), which is caused by mutations in NEMO (NF-κB essential modulator; also known...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09815
更新日期：2011-03-31 00:00:00
abstract：:Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in different proteins, such as huntingtin in Huntington's disease and ataxin 3 in spinocerebellar ataxia type 3 (SCA3). Age at onset of disease decreases with increasing polyglutamine length in these proteins and the normal length also...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature22078
更新日期：2017-05-04 00:00:00
abstract：:Haploids and double haploids are important resources for studying recessive traits and have large impacts on crop breeding, but natural haploids are rare in animals. Mammalian haploids are restricted to germline cells and are occasionally found in tumours with massive chromosome loss. Recent success in establishing ha...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11435
更新日期：2012-10-18 00:00:00
abstract：:Mutations or amplification of the MET proto-oncogene are involved in the pathogenesis of several tumours, which rely on the constitutive engagement of this pathway for their growth and survival. However, MET is expressed not only by cancer cells but also by tumour-associated stromal cells, although its precise role in...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature14407
更新日期：2015-06-18 00:00:00
abstract：:Extracellular signalling by the purine nucleotide ATP has long been associated with sensory function. In the periphery, ATP mediates nociception, mechanosensitivity, thermal sensitivity and O2 chemosensitivity. These processes share a common mechanism that involves the release of ATP to excite afferent fibres via acti...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature03690
更新日期：2005-07-07 00:00:00
abstract：:The AP-1 family of transcription factors, which includes the proto-oncogene products c-Jun and c-Fos, controls the stimulation of cellular genes by growth factors and the expression of oncogenes, including src and ras. Transcriptional activation by c-Jun is regulated by a cell-type-specific inhibitor that represses th...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/352165a0
更新日期：1991-07-11 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41586-020-2691-0
更新日期：2020-09-01 00:00:00
abstract：:The peptide GsMTx4, isolated from the venom of the tarantula Grammostola spatulata, is a selective inhibitor of stretch-activated cation channels (SACs). The mechanism of inhibition remains unknown; but both GsMTx4 and its enantiomer, enGsMTx4, modify the gating of SACs, thus violating a trademark of the traditional l...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature02743
更新日期：2004-07-08 00:00:00
abstract：:Fermi-liquid theory (the standard model of metals) has been challenged by the discovery of anomalous properties in an increasingly large number of metals. The anomalies often occur near a quantum critical point--a continuous phase transition in the limit of absolute zero, typically between magnetically ordered and par...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature01968
更新日期：2003-10-09 00:00:00
abstract：:Deception is common in nature and humans are no exception. Modern societies have created institutions to control cheating, but many situations remain where only intrinsic honesty keeps people from cheating and violating rules. Psychological, sociological and economic theories suggest causal pathways to explain how the...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature17160
更新日期：2016-03-24 00:00:00
abstract：:The hypothesis that certain RNA molecules may be able to catalyse RNA replication is central to current theories of the early evolution of life. In support of this idea, we describe here an RNA that synthesizes RNA using the same reaction as that employed by protein enzymes that catalyse RNA polymerization. In the pre...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/382373a0
更新日期：1996-07-25 00:00:00
abstract：:Aquifex aeolicus was one of the earliest diverging, and is one of the most thermophilic, bacteria known. It can grow on hydrogen, oxygen, carbon dioxide, and mineral salts. The complex metabolic machinery needed for A. aeolicus to function as a chemolithoautotroph (an organism which uses an inorganic carbon source for...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/32831
更新日期：1998-03-26 00:00:00
