SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex.

abstract：:Surgical, pharmacological and genetic lesion studies have revealed distinct anatomical sites involved with different forms of learning. Studies of patients with localized brain damage and work in rodent model systems, for example, have shown that the hippocampal formation participates in acquisition of declarative tas...

journal_title：Nature

authors： Dubnau J,Grady L,Kitamoto T,Tully T

更新日期：2001-05-24 00:00:00

abstract：:A series of findings over the past decade has begun to identify the brain circuitry and neurotransmitters that regulate our daily cycles of sleep and wakefulness. The latter depends on a network of cell groups that activate the thalamus and the cerebral cortex. A key switch in the hypothalamus shuts off this arousal s...

journal_title：Nature

authors： Saper CB,Scammell TE,Lu J

更新日期：2005-10-27 00:00:00

abstract：:Criteria for 'green buildings' need to make energy performance a priority--as do universities. ...

journal_title：Nature

authors：

更新日期：2009-09-10 00:00:00

abstract：:Type-A γ-aminobutyric (GABAA) receptors are ligand-gated chloride channels with a very rich pharmacology. Some of their modulators, including benzodiazepines and general anaesthetics, are among the most successful drugs in clinical use and are common substances of abuse. Without reliable structural data, the mechanist...

journal_title：Nature

authors： Masiulis S,Desai R,Uchański T,Serna Martin I,Laverty D,Karia D,Malinauskas T,Zivanov J,Pardon E,Kotecha A,Steyaert J,Miller KW,Aricescu AR

更新日期：2019-01-01 00:00:00

abstract：:Aquaporin (AQP) water-channel proteins are freely permeated by water but not by ions or charged solutes. Although mammalian aquaporins were believed to be located in plasma membranes, rat AQP6 is restricted to intracellular vesicles in renal epithelia. Here we show that AQP6 is functionally distinct from other known a...

journal_title：Nature

authors： Yasui M,Hazama A,Kwon TH,Nielsen S,Guggino WB,Agre P

更新日期：1999-11-11 00:00:00

abstract：:A short exposure of primary cultures of mouse mammary tumour cells to glucocorticoids results in at least a three-fold stimulation of mammary tumour virus (MTV) production. Specific interaction of glucocorticoids with the cytoplasmic and nuclear receptors can also be demonstrated. The biological potency of various ste...

journal_title：Nature

authors： Shyamala G,Dickson C

更新日期：1976-07-08 00:00:00

abstract：:In metazoans, the Ras-Raf-MEK (mitogen-activated protein-kinase kinase)-ERK (extracellular signal-regulated kinase) signalling pathway relays extracellular stimuli to elicit changes in cellular function and gene expression. Aberrant activation of this pathway through oncogenic mutations is responsible for a large prop...

journal_title：Nature

authors： Brennan DF,Dar AC,Hertz NT,Chao WC,Burlingame AL,Shokat KM,Barford D

更新日期：2011-04-21 00:00:00

abstract：:Cells subjected to a heat shock, or a variety of other stresses increase the synthesis of a set of proteins, known as heat shock proteins. This response is apparently universal, occurring in the entire range from bacterial to mammalian cells. In Escherichia coli heat shock protein synthesis transiently increases follo...

journal_title：Nature

authors： Straus DB,Walter WA,Gross CA

更新日期：1987-09-24 00:00:00

abstract：:Lyman-alpha emitters are thought to be young, low-mass galaxies with ages of approximately 10(8) yr (refs 1, 2). An overdensity of them in one region of the sky (the SSA 22 field) traces out a filamentary structure in the early Universe at a redshift of z approximately 3.1 (equivalent to 15 per cent of the age of the ...

journal_title：Nature

authors： Tamura Y,Kohno K,Nakanishi K,Hatsukade B,Iono D,Wilson GW,Yun MS,Takata T,Matsuda Y,Tosaki T,Ezawa H,Perera TA,Scott KS,Austermann JE,Hughes DH,Aretxaga I,Chung A,Oshima T,Yamaguchi N,Tanaka K,Kawabe R

更新日期：2009-05-07 00:00:00

abstract：:During puberty, the mouse mammary gland develops into a highly branched epithelial network. Owing to the absence of exclusive stem cell markers, the location, multiplicity, dynamics and fate of mammary stem cells (MaSCs), which drive branching morphogenesis, are unknown. Here we show that morphogenesis is driven by pr...

journal_title：Nature

authors： Scheele CL,Hannezo E,Muraro MJ,Zomer A,Langedijk NS,van Oudenaarden A,Simons BD,van Rheenen J

更新日期：2017-02-16 00:00:00

abstract：:The generation of a local chromatin topology conducive to transcription is a key step in gene regulation. The yeast SWI/SNF complex is the founding member of a family of ATP-dependent remodelling activities capable of altering chromatin structure both in vitro and in vivo. Despite its importance, the pathway by which ...

journal_title：Nature

authors： Whitehouse I,Flaus A,Cairns BR,White MF,Workman JL,Owen-Hughes T

更新日期：1999-08-19 00:00:00

abstract：:DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization, followed by passive loss that reaches a minimum at the blastocyst stage. However, this model is based on limited data, and so far no base-resoluti...

journal_title：Nature

authors： Smith ZD,Chan MM,Mikkelsen TS,Gu H,Gnirke A,Regev A,Meissner A

更新日期：2012-03-28 00:00:00

abstract：:The observation that a few species in ecological communities are exceptionally abundant, whereas most are rare, prompted the development of species abundance models. Nevertheless, despite the large literature on the commonness and rarity of species inspired by these pioneering studies, some widespread empirical patter...

journal_title：Nature

authors： Magurran AE,Henderson PA

更新日期：2003-04-17 00:00:00

abstract：:The factors driving glacial changes in ocean overturning circulation are not well understood. On the basis of a comparison of 20 climate variables over the past four glacial cycles, the SPECMAP project proposed that summer insolation at high northern latitudes (that is, Milankovitch forcing) drives the same sequence o...

journal_title：Nature

authors： Lisiecki LE,Raymo ME,Curry WB

更新日期：2008-11-06 00:00:00

abstract：:Surface gravity is a basic stellar property, but it is difficult to measure accurately, with typical uncertainties of 25 to 50 per cent if measured spectroscopically and 90 to 150 per cent if measured photometrically. Asteroseismology measures gravity with an uncertainty of about 2 per cent but is restricted to relati...

journal_title：Nature

authors： Bastien FA,Stassun KG,Basri G,Pepper J

更新日期：2013-08-22 00:00:00

abstract：:Cell-cell interactions are thought to play a crucial part in determining the developmental fate of vertebrate cells and regulating their subsequent differentiation. In the peripheral nervous system, for example, signals from neuronal axons determine whether or not some Schwann cells wrap their plasma membrane concentr...

journal_title：Nature

authors： Mudge AW

更新日期：1984-05-24 00:00:00

abstract：:The alpha beta T-cell receptors (TCRs) react with complex ligands composed of peptides bound to major histocompatibility complex (MHC) proteins. In the absence of foreign antigens the peptides bound to MHC molecules come from the proteins of the host itself. Interactions between TCRs and these self-peptide-MHC ligands...

journal_title：Nature

authors： Kozono H,White J,Clements J,Marrack P,Kappler J

更新日期：1994-05-12 00:00:00

abstract：:Many extensions of the Standard Model of particle physics explain the dominance of matter over antimatter in our Universe by neutrinos being their own antiparticles. This would imply the existence of neutrinoless double-β decay, which is an extremely rare lepton-number-violating radioactive decay process whose detecti...

journal_title：Nature

authors： GERDA Collaboration.

更新日期：2017-04-05 00:00:00

abstract：:The factors shaping cometary nuclei are still largely unknown, but could be the result of concurrent effects of evolutionary and primordial processes. The peculiar bilobed shape of comet 67P/Churyumov-Gerasimenko may be the result of the fusion of two objects that were once separate or the result of a localized excava...

journal_title：Nature

authors： Massironi M,Simioni E,Marzari F,Cremonese G,Giacomini L,Pajola M,Jorda L,Naletto G,Lowry S,El-Maarry MR,Preusker F,Scholten F,Sierks H,Barbieri C,Lamy P,Rodrigo R,Koschny D,Rickman H,Keller HU,A'Hearn MF,Agarwal J

更新日期：2015-10-15 00:00:00

abstract：:The complexity of ecosystems can cause subtle and chaotic responses to changes in external forcing. Although ecosystems may not normally behave chaotically, sensitivity to external influences associated with nonlinearity can lead to amplification of climatic signals. Strong correlations between an El Niño index and ra...

journal_title：Nature

authors： Taylor AH,Allen JI,Clark PA

更新日期：2002-04-11 00:00:00

abstract：:Because it is so tall, the giraffe, Giraffa camelopardalis, provides an important animal model for investigating adaptive mechanisms to orthostatic (gravitational) pressure changes. Previous physiological studies of the giraffe have concentrated on arterial blood pressures in the heart and neck. Briefly, these investi...

journal_title：Nature

authors： Hargens AR,Millard RW,Pettersson K,Johansen K

更新日期：1987-09-03 00:00:00

abstract：:The vomeronasal organ (VNO) is a chemoreceptive organ that is thought to transduce pheromones into electrical responses that regulate sexual, hormonal and reproductive function in mammals. The characteristics of pheromone signal detection by vomeronasal neurons remain unclear. Here we use a mouse VNO slice preparation...

journal_title：Nature

authors： Leinders-Zufall T,Lane AP,Puche AC,Ma W,Novotny MV,Shipley MT,Zufall F

更新日期：2000-06-15 00:00:00

abstract：:Q beta replicase, in the absence of added template, will synthesize RNA autocatalytically. A variety of small RNa species, termed '6S RNAs' are generated. As this reaction purportedly occurs in the absence of template, it has been termed 'de novo' RNA synthesis. The question of whether Q beta replicase can polymerize ...

journal_title：Nature

authors： Hill D,Blumenthal T

更新日期：1983-01-27 00:00:00

abstract：:Observations of cometary nuclei have revealed a very limited amount of surface water ice, which is insufficient to explain the observed water outgassing. This was clearly demonstrated on comet 9P/Tempel 1, where the dust jets (driven by volatiles) were only partially correlated with the exposed ice regions. The observ...

journal_title：Nature

authors： De Sanctis MC,Capaccioni F,Ciarniello M,Filacchione G,Formisano M,Mottola S,Raponi A,Tosi F,Bockelée-Morvan D,Erard S,Leyrat C,Schmitt B,Ammannito E,Arnold G,Barucci MA,Combi M,Capria MT,Cerroni P,Ip WH,Kuehrt E,M

更新日期：2015-09-24 00:00:00

abstract：:Asexual reproduction by free-living invertebrate larvae is a rare and enigmatic phenomenon and, although it is known to occur in sea stars and brittle stars, it has not been detected in other echinoderms despite more than a century of intensive study. Here we describe spontaneous larval cloning in three species from t...

journal_title：Nature

authors： Eaves AA,Palmer AR

更新日期：2003-09-11 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:The nucleosome subunit of chromatin consists of DNA folded around a histone core as a 1.8-turn left-handed solenoid. The crystal structure of the nucleosome core particle revealed that it has a dyad symmetry axis and that the minor helix groove faces outwards from the protein core. Richmond et al. noticed that the pat...

journal_title：Nature

authors： Hogan ME,Rooney TF,Austin RH

更新日期：1987-08-06 00:00:00

abstract：:Although the influence of electrical activity on neural development has been studied extensively, experiments have only recently focused on the role of activity in the development of the mammalian central nervous system (CNS). Using tetrodotoxin (TTX) to abolish sodium-mediated action potentials, studies on the visual...

journal_title：Nature

authors： Kalil RE,Dubin MW,Scott G,Stark LA

更新日期：1986-09-11 00:00:00

abstract：:The single endogenous DBA/2J ectropic provirus segregated concordantly with the dilute (d) coat colour mutation on chromosome 9 in 53/53 DBA/2J-derived recombinant inbred mouse strains and all seven inbred and mutant strains tested that carry the d allele. Analysis of DNA from a spontaneous DBA/2J d revertant (d+2J) s...

journal_title：Nature

authors： Jenkins NA,Copeland NG,Taylor BA,Lee BK

更新日期：1981-10-01 00:00:00

abstract：:More than twenty types of retinal ganglion cells conduct visual information from the eye to the rest of the brain. Each retinal ganglion cell type tessellates the retina in a regular mosaic, so that every point in visual space is processed for visual primitives such as contrast and motion. This information flows to tw...

journal_title：Nature

authors： Feinberg EH,Meister M

更新日期：2015-03-12 00:00:00