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NATURE文献大全abstract::Chameleons are arboral lizards that spot their prey visually and catch it by highly precise shots with their long sticky tongue. They scan their environment by large-amplitude independent saccadic eye movements; once an insect is detected, the head axis is aligned towards the target ('head tracking', both eyes come fo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/373692a0
更新日期:1995-02-23 00:00:00
abstract::The RIG-like helicase (RLH) family of intracellular receptors detect viral nucleic acid and signal through the mitochondrial antiviral signalling adaptor MAVS (also known as Cardif, VISA and IPS-1) during a viral infection. MAVS activation leads to the rapid production of antiviral cytokines, including type 1 interfer...
journal_title:Nature
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abstract::alpha-Neurotoxins bind to cholinergic receptor, block transmission, and induce sprouting of retinal terminals in the toad tectum. New connections retain an orderliness that suggests a selective affinity between presynaptic terminals. The results suggest that postsynaptic cells exert a control, associated with receptor...
journal_title:Nature
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abstract::The interplay between magnetic fields and interacting particles can lead to exotic phases of matter that exhibit topological order and high degrees of spatial entanglement. Although these phases were discovered in a solid-state setting, recent innovations in systems of ultracold neutral atoms-uncharged atoms that do n...
journal_title:Nature
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更新日期:2017-06-21 00:00:00
abstract::The age of dense interstellar cloud cores, where stars and planets form, is a crucial parameter in star formation and difficult to measure. Some models predict rapid collapse, whereas others predict timescales of more than one million years (ref. 3). One possible approach to determining the age is through chemical cha...
journal_title:Nature
pub_type: 杂志文章
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abstract::It is not yet clear whether humans are able to learn while they are sleeping. Here we show that full-term human newborns can be taught to discriminate between similar vowel sounds when they are fast asleep. It is possible that such sleep training soon after birth could find application in clinical or educational situa...
journal_title:Nature
pub_type: 杂志文章
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更新日期:2002-02-07 00:00:00
abstract::Abscisic acid (ABA) is a ubiquitous hormone that regulates plant growth, development and responses to environmental stresses. Its action is mediated by the PYR/PYL/RCAR family of START proteins, but it remains unclear how these receptors bind ABA and, in turn, how hormone binding leads to inhibition of the downstream ...
journal_title:Nature
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abstract::Erythroid differentiation entails the biogenesis of a membrane skeleton, a network of proteins underlying and interacting with the plasma membrane, whose major constituent is the heterodimeric protein spectrin, composed of two structurally similar but distinct subunits, alpha (relative molecular mass (Mr) 240,000) and...
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abstract::The identification of novel metabolites and the characterization of their biological functions are major challenges in biology. X-ray crystallography can reveal unanticipated ligands that persist through purification and crystallization. These adventitious protein-ligand complexes provide insights into new activities,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12180
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abstract::The annotated genomes of organisms define a 'blueprint' of their possible gene products. Post-genome analyses attempt to confirm and modify the annotation and impose a sense of the spatial, temporal and developmental usage of genetic information by the organism. Here we describe a large-scale, high-accuracy (average d...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01111
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abstract::Endothelial cells adopt tissue-specific characteristics to instruct organ development and regeneration1,2. This adaptability is lost in cultured adult endothelial cells, which do not vascularize tissues in an organotypic manner. Here, we show that transient reactivation of the embryonic-restricted ETS variant transcri...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2712-z
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abstract::Support-free high-speed countercurrent liquid chromatography provides a rich domain of applications, some beyond reach of conventional liquid chromatography. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326419a0
更新日期:1987-03-26 00:00:00
abstract::Quantum computers are expected to outperform conventional computers in several important applications, from molecular simulation to search algorithms, once they can be scaled up to large numbers-typically millions-of quantum bits (qubits)1-3. For most solid-state qubit technologies-for example, those using superconduc...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2171-6
更新日期:2020-04-01 00:00:00
abstract::During the evolution of sea urchins, a transfer RNA gene lost its tRNA function and became part of a protein-coding gene. This functional loss of a tRNA with specificity for one group of leucine codons (CUN, where N is any base) was accompanied by the gain of a new tRNA with that specificity. The new tRNA gene for CUN...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/329853a0
更新日期:1987-10-29 00:00:00
abstract::Some plasmid DNAs, when maintained in wild-type Escherichia coli strains, form high levels of oligomeric species while others remain primarily monomers. One explanation of this observation is that the plasmids that do not form circular oligomers lack a DNA sequence necessary for the formation or maintenance of circula...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/303256a0
更新日期:1983-05-19 00:00:00
abstract::When simian virus 40 (SV40) infects host cells, the viral genes are expressed in two phases. Early in infection, the virus genome is transcribed and translated to yield two related proteins, 'large T' and 'small t' antigens. Later the rate of synthesis of the early messenger RNA falls and the viral genes coding for th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/289810a0
更新日期:1981-02-26 00:00:00
abstract::We have shown previously that chemically skinned fibre bundles from scallop muscle can be desensitized to the action of calcium by the removal of the regulatory light chains of myosin and that sensitivity can be restored by the re-addition of scallop light chains. We have now confirmed these results and extended our o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/286626a0
更新日期:1980-08-07 00:00:00
abstract::Molecular noise is a natural phenomenon that is inherent to all biological systems1,2. How stochastic processes give rise to the robust outcomes that support tissue homeostasis remains unclear. Here we use single-molecule RNA fluorescent in situ hybridization (smFISH) on mouse stem cells derived from haematopoietic ti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2432-4
更新日期:2020-07-01 00:00:00
abstract::The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure. Linkage studies in crosses between the stroke-prone spontaneous...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/353521a0
更新日期:1991-10-10 00:00:00
abstract::Complement-mediated inflammation exacerbates the tissue injury of ischaemic necrosis in heart attacks and strokes, the most common causes of death in developed countries. Large infarct size increases immediate morbidity and mortality and, in survivors of the acute event, larger non-functional scars adversely affect lo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04672
更新日期:2006-04-27 00:00:00
abstract::T cells recognize foreign proteins as peptides bound to self molecules encoded by the major histocompatibility complex (MHC). The kinetics of interaction between purified class II MHC molecules and peptides is unusual, in that the rate of association is very slow, but once formed, the complexes are extremely stable. T...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/342800a0
更新日期:1989-12-14 00:00:00
abstract::The quantum-level interplay between geometry, topology and correlation is at the forefront of fundamental physics1-15. Kagome magnets are predicted to support intrinsic Chern quantum phases owing to their unusual lattice geometry and breaking of time-reversal symmetry14,15. However, quantum materials hosting ideal spi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2482-7
更新日期:2020-07-01 00:00:00
abstract::The amino-terminal region of the common corticotropin/beta-lipotrophin (beta-LPH) precursor has been identified in the AtT-20 mouse tumor cells as a glycopeptide with an apparent molecular weight of 16,000 (the '16K fragment'). A third melanotropin core sequence or gamma-MSH similar to that found in ACTH and beta-LPH ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/291156a0
更新日期:1981-05-14 00:00:00
abstract::Practice, with feedback, is a fundamental variable that influences the aquisition of motor skills: with it, everyone improves, but some improve more than others. This simple fact has led to frequent debate over the relative importance of genetic and environmental influences on motor learning. In principle these factor...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/384356a0
更新日期:1996-11-28 00:00:00
abstract::About one-third of human breast cancers require hormones for their continued growth and endocrine ablation or anti-hormone therapy can cause regression of these tumours. As a consequence, ovariectomy in premenopausal women or administration of an anti-oestrogen (tamoxifen) in postmenopausal women represent major optio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/313231a0
更新日期:1985-01-17 00:00:00
abstract::Microcrystals of the lipoprotein-phosphoprotein complex which are found in the oocytes of Xenopus laevis were examined using electron microscopy. Analysis of Fourier transforms of the images of the (010) and (001) projections showed the space group to be P2(1)22(1). Ten projections were combined to produce a map of th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/272028a0
更新日期:1978-03-02 00:00:00
abstract::Interleukin-2 (IL-2) has a key role in the antigen-specific clonal growth of T lymphocytes, by virtue of its interaction with a specific cell-surface receptor (IL-2R). The growth signal seems to be delivered by IL-2 bound to the high-affinity, but not the low-affinity, receptor. Genes encoding IL-2 and its receptor (t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/318467a0
更新日期:1985-12-05 00:00:00
abstract::The canonical Wnt/β-catenin signalling pathway governs diverse developmental, homeostatic and pathological processes. Palmitoylated Wnt ligands engage cell-surface frizzled (FZD) receptors and LRP5 and LRP6 co-receptors, enabling β-catenin nuclear translocation and TCF/LEF-dependent gene transactivation. Mutations in ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature22313
更新日期:2017-05-11 00:00:00
abstract::The alternative non-homologous end-joining (NHEJ) machinery facilitates several genomic rearrangements, some of which can lead to cellular transformation. This error-prone repair pathway is triggered upon telomere de-protection to promote the formation of deleterious chromosome end-to-end fusions. Using next-generatio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14157
更新日期:2015-02-12 00:00:00
abstract::The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a ligand-dependent transcription factor that is important in adipocyte differentiation and glucose homeostasis and which depends on interactions with co-activators, including steroid receptor co-activating factor-1 (SRC-1). Here we present the X-ray ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/25931
更新日期:1998-09-10 00:00:00