Milestone meetings.








Gewin V





2018-12-01 00:00:00
















  • Sequence organization and genomic complexity of primate theta 1 globin gene, a novel alpha-globin-like gene.

    abstract::The alpha-like and beta-like globin genes have provided a paradigm for the study of molecular evolution and regulation of multigene families in eukaryotes. The human alpha-globin gene cluster, which is on chromosome 16 (ref. 1), consists of six genes arranged in the order 5'-zeta(embryonic)-psi zeta-psi alpha 2-psi al...


    pub_type: 杂志文章


    authors: Marks J,Shaw JP,Shen CK

    更新日期:1986-06-19 00:00:00

  • The changing face of HIV in China.

    abstract::HIV has advanced from high-risk groups such as intravenous drug users to some in the general population, according to comprehensive new data from the south of China. What needs to be done to halt its spread? ...


    pub_type: 杂志文章


    authors: Lu L,Jia M,Ma Y,Yang L,Chen Z,Ho DD,Jiang Y,Zhang L

    更新日期:2008-10-02 00:00:00

  • Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines.

    abstract::The ability to excise (repair) UV-induced pyrimidine dimers in Escherichia coli is not related to its ability to remove N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced O6-methylguanine (O6-MeG) from DNA. It was therefore surprising that certain xeroderma pigmentosum cell lines, deficient in dimer excision, were al...


    pub_type: 杂志文章


    authors: Sklar R,Strauss B

    更新日期:1981-01-29 00:00:00

  • Reversing a model of Parkinson's disease with in situ converted nigral neurons.

    abstract::Parkinson's disease is characterized by loss of dopamine neurons in the substantia nigra1. Similar to other major neurodegenerative disorders, there are no disease-modifying treatments for Parkinson's disease. While most treatment strategies aim to prevent neuronal loss or protect vulnerable neuronal circuits, a poten...


    pub_type: 杂志文章


    authors: Qian H,Kang X,Hu J,Zhang D,Liang Z,Meng F,Zhang X,Xue Y,Maimon R,Dowdy SF,Devaraj NK,Zhou Z,Mobley WC,Cleveland DW,Fu XD

    更新日期:2020-06-01 00:00:00

  • Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2.

    abstract::Interleukin (IL)-2 is a pleiotropic cytokine that is necessary to prevent chronic inflammation in the gastrointestinal tract1-4. The protective effects of IL-2 involve the generation, maintenance and function of regulatory T (Treg) cells4-8, and the use of low doses of IL-2 has emerged as a potential therapeutic strat...


    pub_type: 杂志文章


    authors: Zhou L,Chu C,Teng F,Bessman NJ,Goc J,Santosa EK,Putzel GG,Kabata H,Kelsen JR,Baldassano RN,Shah MA,Sockolow RE,Vivier E,Eberl G,Smith KA,Sonnenberg GF

    更新日期:2019-04-01 00:00:00

  • A high-resolution map of the three-dimensional chromatin interactome in human cells.

    abstract::A large number of cis-regulatory sequences have been annotated in the human genome, but defining their target genes remains a challenge. One strategy is to identify the long-range looping interactions at these elements with the use of chromosome conformation capture (3C)-based techniques. However, previous studies lac...


    pub_type: 杂志文章


    authors: Jin F,Li Y,Dixon JR,Selvaraj S,Ye Z,Lee AY,Yen CA,Schmitt AD,Espinoza CA,Ren B

    更新日期:2013-11-14 00:00:00

  • Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis.

    abstract::Osteoclasts are the only somatic cells with bone-resorbing capacity and, as such, they have a critical role not only in normal bone homeostasis (called 'bone remodelling') but also in the pathogenesis of bone destructive disorders such as rheumatoid arthritis and osteoporosis. A major focus of research in the field ha...


    pub_type: 杂志文章


    authors: Ishii M,Egen JG,Klauschen F,Meier-Schellersheim M,Saeki Y,Vacher J,Proia RL,Germain RN

    更新日期:2009-03-26 00:00:00

  • A negatively powered lens in the chameleon.

    abstract::Chameleons are arboral lizards that spot their prey visually and catch it by highly precise shots with their long sticky tongue. They scan their environment by large-amplitude independent saccadic eye movements; once an insect is detected, the head axis is aligned towards the target ('head tracking', both eyes come fo...


    pub_type: 杂志文章


    authors: Ott M,Schaeffel F

    更新日期:1995-02-23 00:00:00

  • The reaction mechanism of the internal thioester in the human complement component C4.

    abstract::A key step in the elimination of pathogens from the body is the covalent binding of complement proteins C3 and C4 to their surfaces. Proteolytic activation of these proteins results in a conformational change, and an internal thioester is exposed which reacts with amino or hydroxyl groups on the target surface to form...


    pub_type: 杂志文章


    authors: Dodds AW,Ren XD,Willis AC,Law SK

    更新日期:1996-01-11 00:00:00

  • A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity.

    abstract::Positive selection allows thymocytes that recognize an individual's own major histocompatibility complex (self-MHC) molecules to survive and differentiate, whereas negative selection removes overtly self-reactive thymocytes. Although both forms of thymic selection are mediated by the alphabeta T-cell receptor (TCR) an...


    pub_type: 杂志文章


    authors: Werlen G,Hausmann B,Palmer E

    更新日期:2000-07-27 00:00:00

  • The nucleotide sequence of an RNA polymerase binding site on bacteriophage fd DNA.

    abstract::The nucleotide sequence of the RNA polymerase binding site at a promotor on fd RF DNA has been determined in comparison with the starting sequence of RNA initiated at this promoter. The RNA polymerase binding site contained the startpoint of transcription in the centre and a region with twofold symmetry in the non-tra...


    pub_type: 杂志文章


    authors: Sugimoto K,Okamoto T,Sugisaki H,Takanami M

    更新日期:1975-02-06 00:00:00

  • Very mild muscular dystrophy associated with the deletion of 46% of dystrophin.

    abstract::Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), a much milder form of the disease where the age of onset can sometimes be as late as the third or fourth decade of life, are caused by mutations in the same X-linked gene, a 14 kilobase (kb) transcript which is spread over more than 2 megabases of ...


    pub_type: 杂志文章


    authors: England SB,Nicholson LV,Johnson MA,Forrest SM,Love DR,Zubrzycka-Gaarn EE,Bulman DE,Harris JB,Davies KE

    更新日期:1990-01-11 00:00:00

  • The spring in the arch of the human foot.

    abstract::Large mammals, including humans, save much of the energy needed for running by means of elastic structures in their legs and feet. Kinetic and potential energy removed from the body in the first half of the stance phase is stored briefly as elastic strain energy and then returned in the second half by elastic recoil. ...


    pub_type: 杂志文章


    authors: Ker RF,Bennett MB,Bibby SR,Kester RC,Alexander RM

    更新日期:1987-01-08 00:00:00

  • ovo/svb integrates Wingless and DER pathways to control epidermis differentiation.

    abstract::In Drosophila, as in mammals, epidermal differentiation is controlled by signalling cascades that include Wnt proteins and the ovo/shavenbaby (svb) family of zinc-finger transcription factors. Ovo/svb is a complex gene with two genetic functions corresponding to separate control regions: ovo is required for female ger...


    pub_type: 杂志文章


    authors: Payre F,Vincent A,Carreno S

    更新日期:1999-07-15 00:00:00

  • The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.

    abstract::Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids1,2. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into non-toxic lipid alcohols3,4. Ferroptosis has previously been implica...


    pub_type: 杂志文章


    authors: Bersuker K,Hendricks JM,Li Z,Magtanong L,Ford B,Tang PH,Roberts MA,Tong B,Maimone TJ,Zoncu R,Bassik MC,Nomura DK,Dixon SJ,Olzmann JA

    更新日期:2019-11-01 00:00:00

  • Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology.

    abstract::WAVE1--the Wiskott-Aldrich syndrome protein (WASP)--family verprolin homologous protein 1--is a key regulator of actin-dependent morphological processes in mammals, through its ability to activate the actin-related protein (Arp2/3) complex. Here we show that WAVE1 is phosphorylated at multiple sites by cyclin-dependen...


    pub_type: 杂志文章


    authors: Kim Y,Sung JY,Ceglia I,Lee KW,Ahn JH,Halford JM,Kim AM,Kwak SP,Park JB,Ho Ryu S,Schenck A,Bardoni B,Scott JD,Nairn AC,Greengard P

    更新日期:2006-08-17 00:00:00

  • Intracellular ATP directly blocks K+ channels in pancreatic B-cells.

    abstract::It is known that glucose-induced depolarization of pancreatic B-cells is due to reduced membrane K+-permeability and is coupled to an increase in the rate of glycolysis, but there has been no direct evidence linking specific metabolic processes or products to the closing of membrane K+ channels. During patch-clamp stu...


    pub_type: 杂志文章


    authors: Cook DL,Hales CN

    更新日期:1984-09-20 00:00:00

  • An artificial landscape-scale fishery in the Bolivian Amazon.

    abstract::Historical ecologists working in the Neotropics argue that the present natural environment is an historical product of human intentionality and ingenuity, a creation that is imposed, built, managed and maintained by the collective multigenerational knowledge and experience of Native Americans. In the past 12,000 years...


    pub_type: 历史文章,杂志文章


    authors: Erickson CL

    更新日期:2000-11-09 00:00:00

  • Perovskite oxides for visible-light-absorbing ferroelectric and photovoltaic materials.

    abstract::Ferroelectrics have recently attracted attention as a candidate class of materials for use in photovoltaic devices, and for the coupling of light absorption with other functional properties. In these materials, the strong inversion symmetry breaking that is due to spontaneous electric polarization promotes the desirab...


    pub_type: 杂志文章


    authors: Grinberg I,West DV,Torres M,Gou G,Stein DM,Wu L,Chen G,Gallo EM,Akbashev AR,Davies PK,Spanier JE,Rappe AM

    更新日期:2013-11-28 00:00:00

  • Half-metallic graphene nanoribbons.

    abstract::Electrical current can be completely spin polarized in a class of materials known as half-metals, as a result of the coexistence of metallic nature for electrons with one spin orientation and insulating nature for electrons with the other. Such asymmetric electronic states for the different spins have been predicted f...


    pub_type: 杂志文章


    authors: Son YW,Cohen ML,Louie SG

    更新日期:2006-11-16 00:00:00

  • RNA editing as a source of genetic variation.

    abstract::Kinetoplastid RNA editing alters mitochondrial RNA transcripts by addition and deletion of uridine residues, producing open reading frames that may be twice as long as the original RNA. Although the COIII gene encoding cytochrome c oxidase subunit III in Trypanosoma brucei is edited along its entire length, the presum...


    pub_type: 杂志文章


    authors: Landweber LF,Gilbert W

    更新日期:1993-05-13 00:00:00

  • Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.

    abstract::Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated not only with loss-of-function mutations of tumour suppressor genes, but also with gain-of-function mutations of proto-oncogenes. Here we show unique gain-of-function mutations of the C-CBL (...


    pub_type: 杂志文章


    authors: Sanada M,Suzuki T,Shih LY,Otsu M,Kato M,Yamazaki S,Tamura A,Honda H,Sakata-Yanagimoto M,Kumano K,Oda H,Yamagata T,Takita J,Gotoh N,Nakazaki K,Kawamata N,Onodera M,Nobuyoshi M,Hayashi Y,Harada H,Kurokawa M,Chiba

    更新日期:2009-08-13 00:00:00

  • Publisher Correction: Butterfly effect and a self-modulating El Niño response to global warming.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...


    pub_type: 已发布勘误


    authors: Cai W,Ng B,Geng T,Wu L,Santoso A,McPhaden MJ

    更新日期:2020-12-01 00:00:00

  • Neurons derived from radial glial cells establish radial units in neocortex.

    abstract::The neocortex of the adult brain consists of neurons and glia that are generated by precursor cells of the embryonic ventricular zone. In general, glia are generated after neurons during development, but radial glia are an exception to this rule. Radial glia are generated before neurogenesis and guide neuronal migrati...


    pub_type: 杂志文章


    authors: Noctor SC,Flint AC,Weissman TA,Dammerman RS,Kriegstein AR

    更新日期:2001-02-08 00:00:00

  • A spin transition mechanism for cooperative adsorption in metal-organic frameworks.

    abstract::Cooperative binding, whereby an initial binding event facilitates the uptake of additional substrate molecules, is common in biological systems such as haemoglobin. It was recently shown that porous solids that exhibit cooperative binding have substantial energetic benefits over traditional adsorbents, but few guideli...


    pub_type: 杂志文章


    authors: Reed DA,Keitz BK,Oktawiec J,Mason JA,Runčevski T,Xiao DJ,Darago LE,Crocellà V,Bordiga S,Long JR

    更新日期:2017-10-05 00:00:00

  • The impacts of climate change on water resources and agriculture in China.

    abstract::China is the world's most populous country and a major emitter of greenhouse gases. Consequently, much research has focused on China's influence on climate change but somewhat less has been written about the impact of climate change on China. China experienced explosive economic growth in recent decades, but with only...


    pub_type: 杂志文章


    authors: Piao S,Ciais P,Huang Y,Shen Z,Peng S,Li J,Zhou L,Liu H,Ma Y,Ding Y,Friedlingstein P,Liu C,Tan K,Yu Y,Zhang T,Fang J

    更新日期:2010-09-02 00:00:00

  • T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection.

    abstract::The clinical course of autoimmune and infectious disease varies greatly, even between individuals with the same condition. An understanding of the molecular basis for this heterogeneity could lead to significant improvements in both monitoring and treatment. During chronic infection the process of T-cell exhaustion in...


    pub_type: 杂志文章


    authors: McKinney EF,Lee JC,Jayne DR,Lyons PA,Smith KG

    更新日期:2015-07-30 00:00:00

  • No evidence for globally coherent warm and cold periods over the preindustrial Common Era.

    abstract::Earth's climate history is often understood by breaking it down into constituent climatic epochs1. Over the Common Era (the past 2,000 years) these epochs, such as the Little Ice Age2-4, have been characterized as having occurred at the same time across extensive spatial scales5. Although the rapid global warming seen...


    pub_type: 历史文章,杂志文章


    authors: Neukom R,Steiger N,Gómez-Navarro JJ,Wang J,Werner JP

    更新日期:2019-07-01 00:00:00

  • Blocking FSH induces thermogenic adipose tissue and reduces body fat.

    abstract::Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) increases bone mass in mice. Here, we report that this antibody sharply reduces adipose tissue in wild-type mice, phenocopying genetic hap...


    pub_type: 杂志文章


    authors: Liu P,Ji Y,Yuen T,Rendina-Ruedy E,DeMambro VE,Dhawan S,Abu-Amer W,Izadmehr S,Zhou B,Shin AC,Latif R,Thangeswaran P,Gupta A,Li J,Shnayder V,Robinson ST,Yu YE,Zhang X,Yang F,Lu P,Zhou Y,Zhu LL,Oberlin DJ,Davie

    更新日期:2017-06-01 00:00:00

  • TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105.

    abstract::The transcription factor NF-kappaB is composed of homodimeric and heterodimeric complexes of Rel/NF-kappaB-family polypeptides, which include Rel-A, c-Rel, Rel-B, NF-kappaB/p50 and NF-kappaB2/p52 . The NF-kappaB1 gene encodes a larger precursor protein, p105, from which p50 is produced constitutively by proteasome-med...


    pub_type: 杂志文章


    authors: Belich MP,Salmerón A,Johnston LH,Ley SC

    更新日期:1999-01-28 00:00:00