Amyloid plaques, neurofibrillary tangles and neuronal loss in brains of transgenic mice overexpressing a C-terminal fragment of human amyloid precursor protein.

abstract：:The coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with more than 780,000 deaths worldwide (as of 20 August 2020). To develop antiviral interventions quickly, drugs used for the treatment of unrelated diseases are curre...

journal_title：Nature

authors： Hoffmann M,Mösbauer K,Hofmann-Winkler H,Kaul A,Kleine-Weber H,Krüger N,Gassen NC,Müller MA,Drosten C,Pöhlmann S

更新日期：2020-09-01 00:00:00

abstract：:The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mev...

journal_title：Nature

authors： Goldstein JL,Brown MS

更新日期：1990-02-01 00:00:00

abstract：:Large low-velocity seismic anomalies have been detected in the Earth's lower mantle beneath Africa and the Pacific Ocean that are not easily explained by temperature variations alone. The African anomaly has been interpreted to be a northwest-southeast-trending structure with a sharp-edged linear, ridge-like morpholog...

journal_title：Nature

authors： McNamara AK,Zhong S

更新日期：2005-10-20 00:00:00

abstract：:Collagen fibrils have been extensively studied by electron microscopy, but only scant evidence has yet been obtained about their transverse structure. A transverse pediodicity of about 40 or 80 A might be expected if the microfibril model (until recently the common preference) is correct, but little direct evidence fo...

journal_title：Nature

authors： Squire JM,Freundlich A

更新日期：1980-11-27 00:00:00

abstract：:The radio sky is relatively unexplored for transient signals, although the potential of radio-transient searches is high. This was demonstrated recently by the discovery of a previously unknown type of source, varying on timescales of minutes to hours. Here we report a search for radio sources that vary on much shorte...

journal_title：Nature

authors： McLaughlin MA,Lyne AG,Lorimer DR,Kramer M,Faulkner AJ,Manchester RN,Cordes JM,Camilo F,Possenti A,Stairs IH,Hobbs G,D'Amico N,Burgay M,O'Brien JT

更新日期：2006-02-16 00:00:00

abstract：:Helium-neon lasers emitting at 632.8 nm can influence the phytochrome controlled growth and development of plants more than a quarter of a mile away. It may therefore be possible to control the growth of crops using lasers to activate the phytochrome system. ...

journal_title：Nature

authors： Paleg LG,Aspinall D

更新日期：1970-12-05 00:00:00

abstract：:When a force deforms an elastic object, practical experience suggests that the resulting displacement will be in the same direction as the force. This property is known as positive stiffness. Less familiar is the concept of negative stiffness, where the deforming force and the resulting displacement are in opposite di...

journal_title：Nature

authors： Lakes RS,Lee T,Bersie A,Wang YC

更新日期：2001-03-29 00:00:00

abstract：:Jets of highly energized plasma with relativistic velocities are associated with black holes ranging in mass from a few times that of the Sun to the billion-solar-mass black holes at the centres of galaxies. A popular but unconfirmed hypothesis to explain how the plasma is energized is the 'internal shock model', in w...

journal_title：Nature

authors： Meyer ET,Georganopoulos M,Sparks WB,Perlman E,van der Marel RP,Anderson J,Sohn ST,Biretta J,Norman C,Chiaberge M

更新日期：2015-05-28 00:00:00

abstract：:In bacteria, archaea, fungi and plants the Trk, Ktr and HKT ion transporters are key components of osmotic regulation, pH homeostasis and resistance to drought and high salinity. These ion transporters are functionally diverse: they can function as Na(+) or K(+) channels and possibly as cation/K(+) symporters. They ar...

journal_title：Nature

authors： Vieira-Pires RS,Szollosi A,Morais-Cabral JH

更新日期：2013-04-18 00:00:00

abstract：:The nucleus of mammalian cells displays a distinct spatial segregation of active euchromatic and inactive heterochromatic regions of the genome1,2. In conventional nuclei, microscopy shows that euchromatin is localized in the nuclear interior and heterochromatin at the nuclear periphery1,2. Genome-wide chromosome conf...

journal_title：Nature

authors： Falk M,Feodorova Y,Naumova N,Imakaev M,Lajoie BR,Leonhardt H,Joffe B,Dekker J,Fudenberg G,Solovei I,Mirny LA

更新日期：2019-06-01 00:00:00

abstract：:The evolution of animal personalities is a topic of primary importance in behavioural ecology. An intriguing empirical fact is the consistency of animal responses to repeated stresses or threats. Wolf et al. propose an evolutionary model to explain the emergence of consistent personalities. They show that a population...

journal_title：Nature

authors： Massol F,Crochet PA

更新日期：2008-02-28 00:00:00

abstract：:Pro-inflammatory cytokines activate the transcription factor NF-kappaB by stimulating the activity of a protein kinase that phosphorylates IkappaB, an inhibitor of NF-kappaB, at sites that trigger its ubiquitination and degradation. This results in the nuclear translocation of freed NF-kappaB dimers and the activation...

journal_title：Nature

authors： Rothwarf DM,Zandi E,Natoli G,Karin M

更新日期：1998-09-17 00:00:00

abstract：:To mediate its survival and virulence, the malaria parasite Plasmodium falciparum exports hundreds of proteins into the host erythrocyte. To enter the host cell, exported proteins must cross the parasitophorous vacuolar membrane (PVM) within which the parasite resides, but the mechanism remains unclear. A putative Pla...

journal_title：Nature

authors： Beck JR,Muralidharan V,Oksman A,Goldberg DE

更新日期：2014-07-31 00:00:00

abstract：:Expansion of anthropogenic noise and night lighting across our planet1,2 is of increasing conservation concern3-6. Despite growing knowledge of physiological and behavioural responses to these stimuli from single-species and local-scale studies, whether these pollutants affect fitness is less clear, as is how and why ...

journal_title：Nature

authors： Senzaki M,Barber JR,Phillips JN,Carter NH,Cooper CB,Ditmer MA,Fristrup KM,McClure CJW,Mennitt DJ,Tyrrell LP,Vukomanovic J,Wilson AA,Francis CD

更新日期：2020-11-01 00:00:00

abstract：:Dopamine D2 receptors (D2Rs) are densely expressed in the striatum and have been linked to neuropsychiatric disorders such as schizophrenia1,2. High-affinity binding of dopamine suggests that D2Rs detect transient reductions in dopamine concentration (the dopamine dip) during punishment learning3-5. However, the natur...

journal_title：Nature

authors： Iino Y,Sawada T,Yamaguchi K,Tajiri M,Ishii S,Kasai H,Yagishita S

更新日期：2020-03-01 00:00:00

abstract：:Adult newts regenerate functional limbs after amputation. This process normally depends on the trophic influence of nerves on the regenerating limbs, particularly in the early stages before differentiation of the regeneration blastema, when it stimulates growth by maintaining high rates of macromolecular synthesis. Th...

journal_title：Nature

authors： Rathbone MP,Petri J,Choo AF,Logan DM,Carlone RL,Foret JE

更新日期：1980-01-24 00:00:00

abstract：:The distal lung contains terminal bronchioles and alveoli that facilitate gas exchange. Three-dimensional in vitro human distal lung culture systems would strongly facilitate the investigation of pathologies such as interstitial lung disease, cancer and coronavirus disease 2019 (COVID-19) pneumonia caused by severe ac...

journal_title：Nature

authors： Salahudeen AA,Choi SS,Rustagi A,Zhu J,van Unen V,de la O SM,Flynn RA,Margalef-Català M,Santos AJM,Ju J,Batish A,Usui T,Zheng GXY,Edwards CE,Wagar LE,Luca V,Anchang B,Nagendran M,Nguyen K,Hart DJ,Terry JM,Belgrad

更新日期：2020-12-01 00:00:00

abstract：:The mushroom bodies in the protocerebrum are believed to be the structures of the insect brain most closely associated with higher-order sensory integration and learning. Drosophila melanogaster mutants with olfactory learning deficits have anatomically abnormal mushroom bodies or altered patterns of gene expression i...

journal_title：Nature

authors： Withers GS,Fahrbach SE,Robinson GE

更新日期：1993-07-15 00:00:00

abstract：:Climate strongly affects the production of sediment from mountain catchments as well as its transport and deposition within adjacent sedimentary basins. However, identifying climatic influences on basin stratigraphy is complicated by nonlinearities, feedback loops, lag times, buffering and convergence among processes ...

journal_title：Nature

authors： Foreman BZ,Heller PL,Clementz MT

更新日期：2012-11-01 00:00:00

abstract：:Analysis of changes in viral load after initiation of treatment with potent antiretroviral agents has provided substantial insight into the dynamics of human immunodeficiency virus type 1 (HIV-1). The concentration of HIV-1 in plasma drops by approximately 99% in the first two weeks of treatment owing to the rapid eli...

journal_title：Nature

authors： Perelson AS,Essunger P,Cao Y,Vesanen M,Hurley A,Saksela K,Markowitz M,Ho DD

更新日期：1997-05-08 00:00:00

abstract：:Nuclear pore complexes reside in the nuclear envelope of eukaryotic cells and mediate the nucleocytoplasmic exchange of macromolecules. Traffic is regulated by mobile transport receptors that target their cargo to the central translocation channel, where phenylalanine-glycine-rich repeats serve as binding sites. The s...

journal_title：Nature

authors： Beck M,Lucić V,Förster F,Baumeister W,Medalia O

更新日期：2007-10-04 00:00:00

abstract：:Separation of eukaryotic sister chromatids during the cell cycle is timed by the spindle assembly checkpoint (SAC) and ultimately triggered when separase cleaves cohesion-mediating cohesin1-3. Silencing of the SAC during metaphase activates the ubiquitin ligase APC/C (anaphase-promoting complex, also known as the cycl...

journal_title：Nature

authors： Hellmuth S,Gómez-H L,Pendás AM,Stemmann O

更新日期：2020-04-01 00:00:00

abstract：:The generation and selection of somatic antibody mutants are key elements of acquired immunity, essential for the affinity maturation of antibody responses dependent on T cells. The mutants are generated through a mechanism that introduces point mutations at high rate into rearranged variable (V) region genes in the c...

journal_title：Nature

authors： Jacob J,Kelsoe G,Rajewsky K,Weiss U

更新日期：1991-12-05 00:00:00

abstract：:Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by extensive genomic rearrangements and an oscillating pattern of DNA copy number levels, all curiously restricted to one or a few chromosomes. The mechanism for chromot...

journal_title：Nature

authors： Zhang CZ,Spektor A,Cornils H,Francis JM,Jackson EK,Liu S,Meyerson M,Pellman D

更新日期：2015-06-11 00:00:00

abstract：:Fusion of myeloma cells and B lymphocytes to form hybridomas which produce monoclonal antibodies has been a major advance, but the poor efficiency and randomness of viral or polyethylene glycol fusion techniques generally gives poor yields of specific, high affinity antibodies. High voltage electrical fields with diel...

journal_title：Nature

authors： Lo MM,Tsong TY,Conrad MK,Strittmatter SM,Hester LD,Snyder SH

更新日期：1984-08-30 00:00:00

abstract：:Humans and cats can localize a sound source accurately if its spectrum is fairly broad and flat, as is typical of most natural sounds. However, if sounds are filtered to reduce the width of the spectrum, they result in illusions of sources that are very different from the actual locations, particularly in the up/down ...

journal_title：Nature

authors： Xu L,Furukawa S,Middlebrooks JC

更新日期：1999-06-17 00:00:00

abstract：:Muscarinic receptors of cardiac pacemaker and atrial cells are linked to a potassium channel (IK.ACh) by a pertussis toxin-sensitive GTP-binding protein. The dissociation of G-proteins leads to the generation of two potential transducing elements, alpha-GTP and beta gamma. IK.ACh is activated by G-protein alpha- and b...

journal_title：Nature

authors： Kim D,Lewis DL,Graziadei L,Neer EJ,Bar-Sagi D,Clapham DE

更新日期：1989-02-09 00:00:00

abstract：:The resemblance of the orbitally filtered isotope signal from the past 340 kyr in Antarctic ice cores to Northern Hemisphere summer insolation intensity has been used to suggest that the northern hemisphere may drive orbital-scale global climate changes. A recent Letter by Laepple et al. suggests that, contrary to thi...

journal_title：Nature

authors： Sime LC,Wolff EW

更新日期：2011-11-09 00:00:00

abstract：:Genetic studies, using floral homeotic mutants, have led to the ABC model of flower development. This model proposes that the combinatorial action of three sets of genes, the A, B and C function genes, specify the four floral organs (sepals, petals, stamens and carpels) in the concentric floral whorls. However, attemp...

journal_title：Nature

authors： Honma T,Goto K

更新日期：2001-01-25 00:00:00

abstract：:Pollinators are declining worldwide and this has raised concerns for a parallel decline in the essential pollination service they provide to both crops and wild plants. Anthropogenic drivers linked to this decline include habitat changes, intensive agriculture, pesticides, invasive alien species, spread of pathogens a...

journal_title：Nature

authors： Knop E,Zoller L,Ryser R,Gerpe C,Hörler M,Fontaine C

更新日期：2017-08-10 00:00:00