Simple RNA enzymes with new and highly specific endoribonuclease activities.

abstract：:Cytotoxic T cells lyse only those virus infected target cells in vitro which express, in addition to the viral antigen(s), those K or D region products of the major histocompatibility complex (MHC) which were present during anti-viral sensitisation in vivo. This 'associative recognition' by cytotoxic T cells could ref...

journal_title：Nature

authors： Koszinowski U,Gething MJ,Waterfield M

更新日期：1977-05-12 00:00:00

abstract：:Humans are able to classify novel items correctly by category; some other animals have also been shown to do this. During category learning, humans group perceptual stimuli by abstracting qualities from similarity relationships of their physical properties. Forming categories is fundamental to cognition and can be ind...

journal_title：Nature

authors： Ohl FW,Scheich H,Freeman WJ

更新日期：2001-08-16 00:00:00

abstract：:Autism spectrum disorder (ASD) is an early-onset developmental disorder characterized by deficits in communication and social interaction and restrictive or repetitive behaviours1,2. Family studies demonstrate that ASD has a substantial genetic basis with contributions both from inherited and de novo variants3,4. It h...

journal_title：Nature

authors： Mitra I,Huang B,Mousavi N,Ma N,Lamkin M,Yanicky R,Shleizer-Burko S,Lohmueller KE,Gymrek M

更新日期：2021-01-01 00:00:00

abstract：:Cooperative binding, whereby an initial binding event facilitates the uptake of additional substrate molecules, is common in biological systems such as haemoglobin. It was recently shown that porous solids that exhibit cooperative binding have substantial energetic benefits over traditional adsorbents, but few guideli...

journal_title：Nature

authors： Reed DA,Keitz BK,Oktawiec J,Mason JA,Runčevski T,Xiao DJ,Darago LE,Crocellà V,Bordiga S,Long JR

更新日期：2017-10-05 00:00:00

abstract：:Since the first aeroplane flight more than 100 years ago, aeroplanes have been propelled using moving surfaces such as propellers and turbines. Most have been powered by fossil-fuel combustion. Electroaerodynamics, in which electrical forces accelerate ions in a fluid1,2, has been proposed as an alternative method of ...

journal_title：Nature

authors： Xu H,He Y,Strobel KL,Gilmore CK,Kelley SP,Hennick CC,Sebastian T,Woolston MR,Perreault DJ,Barrett SRH

更新日期：2018-11-01 00:00:00

abstract：:The importance of the dopaminergic system in brain function has been emphasized by its association with neurological and psychiatric disorders such as Parkinson's disease and schizophrenia. On the basis of their biochemical and pharmacological characteristics, dopamine receptors are classified into D1 and D2 subtypes....

journal_title：Nature

authors： Zhou QY,Grandy DK,Thambi L,Kushner JA,Van Tol HH,Cone R,Pribnow D,Salon J,Bunzow JR,Civelli O

更新日期：1990-09-06 00:00:00

abstract：:Ice sheets are currently ignored in global methane budgets1,2. Although ice sheets have been proposed to contain large reserves of methane that may contribute to a rise in atmospheric methane concentration if released during periods of rapid ice retreat3,4, no data exist on the current methane footprint of ice sheets....

journal_title：Nature

authors： Lamarche-Gagnon G,Wadham JL,Sherwood Lollar B,Arndt S,Fietzek P,Beaton AD,Tedstone AJ,Telling J,Bagshaw EA,Hawkings JR,Kohler TJ,Zarsky JD,Mowlem MC,Anesio AM,Stibal M

更新日期：2019-01-01 00:00:00

abstract：:DNA replication in eukaryotes is strictly regulated by several mechanisms. A central step in this replication is the assembly of the heterohexameric minichromosome maintenance (MCM2-7) helicase complex at replication origins during G1 phase as an inactive double hexamer. Here, using cryo-electron microscopy, we report...

journal_title：Nature

authors： Li N,Zhai Y,Zhang Y,Li W,Yang M,Lei J,Tye BK,Gao N

更新日期：2015-08-13 00:00:00

abstract：:On 12 May 2008, the devastating magnitude 7.9 (Wenchuan) earthquake struck the eastern edge of the Tibetan plateau, collapsing buildings and killing thousands in major cities aligned along the western Sichuan basin in China. After such a large-magnitude earthquake, rearrangement of stresses in the crust commonly leads...

journal_title：Nature

authors： Parsons T,Ji C,Kirby E

更新日期：2008-07-24 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains recalcitrant to all forms of cancer treatment and carries a five-year survival rate of only 8%1. Inhibition of oncogenic KRAS (hereafter KRAS*), the earliest lesion in disease development that is present in more than 90% of PDACs, and its signalling surrogates has yielde...

journal_title：Nature

authors： Yao W,Rose JL,Wang W,Seth S,Jiang H,Taguchi A,Liu J,Yan L,Kapoor A,Hou P,Chen Z,Wang Q,Nezi L,Xu Z,Yao J,Hu B,Pettazzoni PF,Ho IL,Feng N,Ramamoorthy V,Jiang S,Deng P,Ma GJ,Den P,Tan Z,Zhang SX,Wang H,

更新日期：2019-04-01 00:00:00

abstract：:Eukaryotes and archaea use a protease called the proteasome that has an integral role in maintaining cellular function through the selective degradation of proteins. Proteolysis occurs in a barrel-shaped 20S core particle, which in Thermoplasma acidophilum is built from four stacked homoheptameric rings of subunits, α...

journal_title：Nature

authors： Ruschak AM,Religa TL,Breuer S,Witt S,Kay LE

更新日期：2010-10-14 00:00:00

abstract：:The current picture of galaxy evolution advocates co-evolution of galaxies and their nuclear massive black holes, through accretion and galactic merging. Pairs of quasars, each with a massive black hole at the centre of its galaxy, have separations of 6,000 to 300,000 light years (refs 2 and 3; 1 parsec = 3.26 light y...

journal_title：Nature

authors： Fabbiano G,Wang J,Elvis M,Risaliti G

更新日期：2011-08-31 00:00:00

abstract：:Achieving site selectivity in carbon-hydrogen (C-H) functionalization reactions is a long-standing challenge in organic chemistry. The small differences in intrinsic reactivity of C-H bonds in any given organic molecule can lead to the activation of undesired C-H bonds by a non-selective catalyst. One solution to this...

journal_title：Nature

authors： Tang RY,Li G,Yu JQ

更新日期：2014-03-13 00:00:00

abstract：:Water has many kinetic and thermodynamic properties that exhibit an anomalous dependence on temperature, in particular in the supercooled phase. These anomalies have long been interpreted in terms of underlying structural causes, and their experimental characterization points to the existence of a singularity at a tem...

journal_title：Nature

authors： Torre R,Bartolini P,Righini R

更新日期：2004-03-18 00:00:00

abstract：:When integral membrane proteins are visualized in detergents or other artificial systems, an important layer of information is lost regarding lipid interactions and their effects on protein structure. This is especially relevant to proteins for which lipids have both structural and regulatory roles. Here we demonstrat...

journal_title：Nature

authors： Gao Y,Cao E,Julius D,Cheng Y

更新日期：2016-06-16 00:00:00

abstract：:Membrane remodelling plays an important role in cellular tasks such as endocytosis, vesiculation and protein sorting, and in the biogenesis of organelles such as the endoplasmic reticulum or the Golgi apparatus. It is well established that the remodelling process is aided by specialized proteins that can sense as well...

journal_title：Nature

authors： Reynwar BJ,Illya G,Harmandaris VA,Müller MM,Kremer K,Deserno M

更新日期：2007-05-24 00:00:00

abstract：:A non-discriminatory base analogue, or universal base, would be an invaluable component of oligonucleotide probes and primers for solving the design problems that arise as a result of the degeneracy of the genetic code, or when only fragmentary peptide sequence data are available. We have designed an alternative to pr...

journal_title：Nature

authors： Nichols R,Andrews PC,Zhang P,Bergstrom DE

更新日期：1994-06-09 00:00:00

abstract：:Apoptosis is a highly regulated process that is crucial for normal development and homeostasis of multicellular organisms. The p35 protein from baculoviruses effectively prevents apoptosis by its broad-spectrum caspase inhibition. Here we report the crystal structure of p35 in complex with human caspase-8 at 3.0 A res...

journal_title：Nature

authors： Xu G,Cirilli M,Huang Y,Rich RL,Myszka DG,Wu H

更新日期：2001-03-22 00:00:00

abstract：:Streptococcus pneumoniae, the pneumococcus, is the most common cause of sepsis and meningitis. Multiple-antibiotic-resistant strains are widespread, and vancomycin is the antibiotic of last resort. Emergence of vancomycin resistance in this community-acquired bacterium would be catastrophic. Antibiotic tolerance, the ...

journal_title：Nature

authors： Novak R,Henriques B,Charpentier E,Normark S,Tuomanen E

更新日期：1999-06-10 00:00:00

abstract：:The heat-shock protein Hsp90 supports diverse but specific signal transducers and lies at the interface of several developmental pathways. We report here that when Drosophila Hsp90 is mutant or pharmacologically impaired, phenotypic variation affecting nearly any adult structure is produced, with specific variants dep...

journal_title：Nature

authors： Rutherford SL,Lindquist S

更新日期：1998-11-26 00:00:00

abstract：:DNA mismatch repair is critical for increasing replication fidelity in organisms ranging from bacteria to humans. MutS protein, a member of the ABC ATPase superfamily, recognizes mispaired and unpaired bases in duplex DNA and initiates mismatch repair. Mutations in human MutS genes cause a predisposition to hereditary...

journal_title：Nature

authors： Obmolova G,Ban C,Hsieh P,Yang W

更新日期：2000-10-12 00:00:00

abstract：:The formation of a primordial crust is a critical step in the evolution of terrestrial planets but the timing of this process is poorly understood. The mineral zircon is a powerful tool for constraining crust formation because it can be accurately dated with the uranium-to-lead (U-Pb) isotopic decay system and is resi...

journal_title：Nature

authors： Bouvier LC,Costa MM,Connelly JN,Jensen NK,Wielandt D,Storey M,Nemchin AA,Whitehouse MJ,Snape JF,Bellucci JJ,Moynier F,Agranier A,Gueguen B,Schönbächler M,Bizzarro M

更新日期：2018-06-01 00:00:00

abstract：:The mammalian central nervous system (CNS) contains a remarkable array of neural cells, each with a complex pattern of connections that together generate perceptions and higher brain functions. Here we describe a large-scale screen to create an atlas of CNS gene expression at the cellular level, and to provide a libra...

journal_title：Nature

authors： Gong S,Zheng C,Doughty ML,Losos K,Didkovsky N,Schambra UB,Nowak NJ,Joyner A,Leblanc G,Hatten ME,Heintz N

更新日期：2003-10-30 00:00:00

abstract：:Highly correlated electronic systems--such as transition-metal oxides that are doped Mott insulators--are complex systems which exhibit puzzling phenomena, including high-temperature superconductivity and colossal magnetoresistivity. Recent studies suggest that in such systems collective electronic phenomena are impor...

journal_title：Nature

authors： Yoo YK,Duewer F,Yang H,Yi D,Li JW,Xiang XD

更新日期：2000-08-17 00:00:00

abstract：:Cell-cell interactions are thought to play a crucial part in determining the developmental fate of vertebrate cells and regulating their subsequent differentiation. In the peripheral nervous system, for example, signals from neuronal axons determine whether or not some Schwann cells wrap their plasma membrane concentr...

journal_title：Nature

authors： Mudge AW

更新日期：1984-05-24 00:00:00

abstract：:The structure of an N-terminal fragment of CD4 has been determined to 2.4 A resolution. It has two tightly abutting domains connected by a continuous beta strand. Both have the immunoglobulin fold, but domain 2 has a truncated beta barrel and a non-standard disulphide bond. The binding sites for monoclonal antibodies,...

journal_title：Nature

authors： Wang JH,Yan YW,Garrett TP,Liu JH,Rodgers DW,Garlick RL,Tarr GE,Husain Y,Reinherz EL,Harrison SC

更新日期：1990-11-29 00:00:00

abstract：:Real-time investigations of the rearrangement of bonds during chemical transformations require femtosecond temporal resolution, so that the atomic vibrations within the reacting molecules can be observed. Following the development of lasers capable of emitting ultrashort laser flashes on this timescale, chemical react...

journal_title：Nature

authors： Kobayashi T,Saito T,Ohtani H

更新日期：2001-11-29 00:00:00

abstract：:Exploiters (parasites and predators) are thought to play a significant role in diversification, and ultimately speciation, of their hosts or prey. Exploiters may drive sympatric (within-population) diversification if there are a variety of exploiter-resistance strategies or fitness costs associated with exploiter resi...

journal_title：Nature

authors： Buckling A,Rainey PB

更新日期：2002-12-05 00:00:00

abstract：:The heterotrimeric G proteins mediate a variety of cellular processes by coupling transmembrane receptors to different effector molecules, including adenylyl cyclases and inositol-phospholipid-specific phospholipase C (PLC)1-3. Activation of adenylyl cyclases results in the production of cyclic AMP and activation of c...

journal_title：Nature

authors： Liu M,Simon MI

更新日期：1996-07-04 00:00:00

abstract：:DEAD-box RNA helicases are vital for the regulation of various aspects of the RNA life cycle, but the molecular underpinnings of their involvement, particularly in mammalian cells, remain poorly understood. Here we show that the DEAD-box RNA helicase DDX21 can sense the transcriptional status of both RNA polymerase (P...

journal_title：Nature

authors： Calo E,Flynn RA,Martin L,Spitale RC,Chang HY,Wysocka J

更新日期：2015-02-12 00:00:00