Evolution of distinct developmental functions of three Drosophila genes by acquisition of different cis-regulatory regions.

abstract：:The human gene for the hepatic enzyme phenylalanine hydroxylase has been cloned and used to analyse the phenylalanine hydroxylase locus in the human genome. The detection of polymorphisms in this locus by several restriction enzymes has allowed feasibility studies of prenatal diagnosis of classical phenylketonuria and...

journal_title：Nature

authors： Woo SL,Lidsky AS,Güttler F,Chandra T,Robson KJ

更新日期：1983-11-10 00:00:00

abstract：:Mechanical milling is an effective technique for the preparation of fine metallic and ceramic powders and can also be used to drive a wide range of chemical reactions. Milling devices include planetary machines, attritors and vibrational mills; products include amorphous, nanocrystalline and quasicrystalline materials...

journal_title：Nature

authors： Calka A,Wexler D

更新日期：2002-09-12 00:00:00

abstract：:The largest products of magmatic activity on Earth, the great bodies of granite and their corresponding large eruptions, have a dual nature: homogeneity at the large scale and spatial and temporal heterogeneity at the small scale. This duality calls for a mechanism that selectively removes the large-scale heterogeneit...

journal_title：Nature

authors： Burgisser A,Bergantz GW

更新日期：2011-03-10 00:00:00

abstract：:Polycomb and trithorax group (PcG and trxG) proteins maintain silent and active transcriptional states, respectively, throughout development. In Drosophila, PcG and trxG proteins associate with DNA regions named Polycomb and trithorax response elements (PRE and TRE), but the mechanisms of recruitment are unknown. We p...

journal_title：Nature

authors： Déjardin J,Rappailles A,Cuvier O,Grimaud C,Decoville M,Locker D,Cavalli G

更新日期：2005-03-24 00:00:00

abstract：:In many cell types, receptor-mediated Ca2+ release from internal stores is followed by Ca2+ influx across the plasma membrane. The sustained entry of Ca2+ is thought to result partly from the depletion of intracellular Ca2+ pools. Most investigations have characterized Ca2+ influx indirectly by measuring Ca(2+)-activa...

journal_title：Nature

authors： Hoth M,Penner R

更新日期：1992-01-23 00:00:00

abstract：:Analysis of a series of mutants of an Escherichia coli alanine transfer RNA shows that substitution of a single G-U base pair in the acceptor helix eliminates aminoacylation with alanine in vivo and in vitro. Introduction of that base pair into the analogous position of a cysteine and a phenylalanine transfer RNA conf...

journal_title：Nature

authors： Hou YM,Schimmel P

更新日期：1988-05-12 00:00:00

abstract：:Is the big-bang hot, warm or cold? And are galactic masses determined by the interplay of gravitational and strong interactions in the very early universe? ...

journal_title：Nature

authors： Harrison ER

更新日期：1970-10-17 00:00:00

abstract：:Classical novae are the most common astrophysical thermonuclear explosions, occurring on the surfaces of white dwarf stars accreting gas from companions in binary star systems. Novae typically expel about 10(-4) solar masses of material at velocities exceeding 1,000 kilometres per second. However, the mechanism of mas...

journal_title：Nature

authors： Chomiuk L,Linford JD,Yang J,O'Brien TJ,Paragi Z,Mioduszewski AJ,Beswick RJ,Cheung CC,Mukai K,Nelson T,Ribeiro VA,Rupen MP,Sokoloski JL,Weston J,Zheng Y,Bode MF,Eyres S,Roy N,Taylor GB

更新日期：2014-10-16 00:00:00

abstract：:The inhibitory activity associated with myelin is a major obstacle for successful axon regeneration in the adult mammalian central nervous system (CNS). In addition to myelin-associated glycoprotein (MAG) and Nogo-A, available evidence suggests the existence of additional inhibitors in CNS myelin. We show here that a ...

journal_title：Nature

authors： Wang KC,Koprivica V,Kim JA,Sivasankaran R,Guo Y,Neve RL,He Z

更新日期：2002-06-27 00:00:00

abstract：:Individuals with congenital or acquired prolongation of the QT interval, or long QT syndrome (LQTS), are at risk of life-threatening ventricular arrhythmia. LQTS is commonly genetic in origin but can also be caused or exacerbated by environmental factors. A missense mutation in the L-type calcium channel Ca(V)1.2 lead...

journal_title：Nature

authors： Yazawa M,Hsueh B,Jia X,Pasca AM,Bernstein JA,Hallmayer J,Dolmetsch RE

更新日期：2011-03-10 00:00:00

abstract：:The M13 coat protein spans the Escherichia coli plasma membrane with its amino-terminus facing the periplasm. It is made as a precursor--the procoat--with a typical leader peptide. Mutations which destroy the basic character of the carboxy-terminal domain of procoat, a domain which is oriented towards the cytoplasm, b...

journal_title：Nature

authors： Kuhn A,Wickner W,Kreil G

更新日期：1986-07-24 00:00:00

abstract：:In addition to coordinating immune and inflammatory responses, NF-kappaB/Rel transcription factors control cell survival. Normally, NF-kappaB dimers are sequestered in the cytoplasm by binding to inhibitory IkappaB proteins, and can be activated rapidly by signals that induce the sequential phosphorylation and proteol...

journal_title：Nature

authors： De Smaele E,Zazzeroni F,Papa S,Nguyen DU,Jin R,Jones J,Cong R,Franzoso G

更新日期：2001-11-15 00:00:00

abstract：:The Tasmanian devil, a large carnivorous Australian marsupial, is under threat from a widespread fatal disease in which a malignant oral-facial tumour obstructs the animal's ability to feed. Here we show that the chromosomes in these tumours have undergone a complex rearrangement that is identical for every animal stu...

journal_title：Nature

authors： Pearse AM,Swift K

更新日期：2006-02-02 00:00:00

abstract：:Homeostasis is a biological principle for regulation of essential physiological parameters within a set range. Behavioural responses due to deviation from homeostasis are critical for survival, but motivational processes engaged by physiological need states are incompletely understood. We examined motivational charact...

journal_title：Nature

authors： Betley JN,Xu S,Cao ZFH,Gong R,Magnus CJ,Yu Y,Sternson SM

更新日期：2015-05-14 00:00:00

abstract：:Animal behaviour arises from computations in neuronal circuits, but our understanding of these computations has been frustrated by the lack of detailed synaptic connection maps, or connectomes. For example, despite intensive investigations over half a century, the neuronal implementation of local motion detection in t...

journal_title：Nature

authors： Takemura SY,Bharioke A,Lu Z,Nern A,Vitaladevuni S,Rivlin PK,Katz WT,Olbris DJ,Plaza SM,Winston P,Zhao T,Horne JA,Fetter RD,Takemura S,Blazek K,Chang LA,Ogundeyi O,Saunders MA,Shapiro V,Sigmund C,Rubin GM,Scheffe

更新日期：2013-08-08 00:00:00

abstract：:Cancers emerge from an ongoing Darwinian evolutionary process, often leading to multiple competing subclones within a single primary tumour. This evolutionary process culminates in the formation of metastases, which is the cause of 90% of cancer-related deaths. However, despite its clinical importance, little is known...

journal_title：Nature

authors： Gundem G,Van Loo P,Kremeyer B,Alexandrov LB,Tubio JMC,Papaemmanuil E,Brewer DS,Kallio HML,Högnäs G,Annala M,Kivinummi K,Goody V,Latimer C,O'Meara S,Dawson KJ,Isaacs W,Emmert-Buck MR,Nykter M,Foster C,Kote-Jarai Z,

更新日期：2015-04-16 00:00:00

abstract：:First-order difference equations arise in many contexts in the biological, economic and social sciences. Such equations, even though simple and deterministic, can exhibit a surprising array of dynamical behaviour, from stable points, to a bifurcating hiearchy of stable cycles, to apparently random fluctuations. There ...

journal_title：Nature

authors： May RM

更新日期：1976-06-10 00:00:00

abstract：:Vaccines against a variety of infectious diseases represent one of the great triumphs of medicine. The immune correlates of protection induced by most current vaccines seem to be mediated by long-lived humoral immune responses. By contrast, there are no currently available vaccines that are uniformly effective for dis...

journal_title：Nature

authors： Seder RA,Hill AV

更新日期：2000-08-17 00:00:00

abstract：:The enzyme complex nitrogenase, which reduces N2 to NH+4, involves two redox proteins, both irreversibly damaged by O2 (ref. 1). Enzyme activity therefore requires anaerobic conditions, a source of reductant and a large amount of ATP (approximately 16 ATPs per N2). In both aerobic and facultative anaerobic N2-fixing b...

journal_title：Nature

authors： Hill S,Kennedy C,Kavanagh E,Goldberg RB,Hanau R

更新日期：1981-04-02 00:00:00

abstract：:Amino-acid radicals play key roles in many enzymatic reactions. Catalysis often involves transfer of a radical character within the protein, as in class I ribonucleotide reductase where radical transfer occurs over 35 A, from a tyrosyl radical to a cysteine. It is currently debated whether this kind of long-range tran...

journal_title：Nature

authors： Aubert C,Vos MH,Mathis P,Eker AP,Brettel K

更新日期：2000-06-01 00:00:00

abstract：:The process of DNA recognition by the activated form of the restriction endonuclease from E. coli K involves three enzyme-DNA complexes which can be differentiated experimentally. These are: an initial complex formed at a nonspecific site; a recognition complex involving the host specificity site; and a cleavage compl...

journal_title：Nature

authors： Yuan R,Bickle TA,Ebbers W,Brack C

更新日期：1975-08-14 00:00:00

abstract：:Insulin stimulates the transport of glucose into fat and muscle cells. Although the precise molecular mechanisms involved in this process remain uncertain, insulin initiates its actions by binding to its tyrosine kinase receptor, leading to the phosphorylation of intracellular substrates. One such substrate is the Cbl...

journal_title：Nature

authors： Baumann CA,Ribon V,Kanzaki M,Thurmond DC,Mora S,Shigematsu S,Bickel PE,Pessin JE,Saltiel AR

更新日期：2000-09-14 00:00:00

abstract：:The yeast nuclear protein Yra1p is an essential export factor for mRNA. Yra1p interacts directly with the mRNA transport factor Mex67p/Mtr2p, which is associated with the nuclear pore. Here, we report a genetic interaction between YRA1 and SUB2, the gene for a DEAD box helicase involved in splicing. Mutation of SUB2 a...

journal_title：Nature

authors： Strässer K,Hurt E

更新日期：2001-10-11 00:00:00

abstract：:At birth the trans-placental nutrient supply is suddenly interrupted, and neonates face severe starvation until supply can be restored through milk nutrients. Here, we show that neonates adapt to this adverse circumstance by inducing autophagy. Autophagy is the primary means for the degradation of cytoplasmic constitu...

journal_title：Nature

authors： Kuma A,Hatano M,Matsui M,Yamamoto A,Nakaya H,Yoshimori T,Ohsumi Y,Tokuhisa T,Mizushima N

更新日期：2004-12-23 00:00:00

abstract：: ...

journal_title：Nature

authors： Gewin V

更新日期：2018-10-01 00:00:00

abstract：:It is generally accepted that the oscillatory beating characteristic of sperm flagella is the result of an ATP-induced sliding between the doublet microtubules of the flagellar axoneme, with these longitudinal forces being converted into a lateral bending moment by resistive components of the structure that limit the ...

journal_title：Nature

authors： Gibbons IR,Shingyoji C,Murakami A,Takahashi K

更新日期：1987-01-22 00:00:00

abstract：:Cell-identity switches, in which terminally differentiated cells are converted into different cell types when stressed, represent a widespread regenerative strategy in animals, yet they are poorly documented in mammals. In mice, some glucagon-producing pancreatic α-cells and somatostatin-producing δ-cells become insul...

journal_title：Nature

authors： Furuyama K,Chera S,van Gurp L,Oropeza D,Ghila L,Damond N,Vethe H,Paulo JA,Joosten AM,Berney T,Bosco D,Dorrell C,Grompe M,Ræder H,Roep BO,Thorel F,Herrera PL

更新日期：2019-03-01 00:00:00

abstract：:Spin dynamics in antiferromagnets has much shorter timescales than in ferromagnets, offering attractive properties for potential applications in ultrafast devices1-3. However, spin-current generation via antiferromagnetic resonance and simultaneous electrical detection by the inverse spin Hall effect in heavy metals h...

journal_title：Nature

authors： Li J,Wilson CB,Cheng R,Lohmann M,Kavand M,Yuan W,Aldosary M,Agladze N,Wei P,Sherwin MS,Shi J

更新日期：2020-02-01 00:00:00

abstract：:White dwarfs represent the endpoint of stellar evolution for stars with initial masses between approximately 0.07 and 8-10, where is the mass of the Sun (more massive stars end their life as either black holes or neutron stars). The theory of stellar evolution predicts that the majority of white dwarfs have a core mad...

journal_title：Nature

authors： Dufour P,Liebert J,Fontaine G,Behara N

更新日期：2007-11-22 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00