Abstract:
:Thrombin is a coagulation protease that activates platelets, leukocytes, endothelial and mesenchymal cells at sites of vascular injury, acting partly through an unusual proteolytically activated G-protein-coupled receptor. Knockout of the gene encoding this receptor provided definitive evidence for a second thrombin receptor in mouse platelets and for tissue-specific roles for different thrombin receptors. We now report the cloning and characterization of a new human thrombin receptor, designated protease-activated receptor 3 (PAR3). PAR3 can mediate thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues, including human bone marrow and mouse megakaryocytes, making it a candidate for the sought-after second platelet thrombin receptor. PAR3 provides a new tool for understanding thrombin signalling and a possible target for therapeutics designed selectively to block thrombotic, inflammatory and proliferative responses to thrombin.
journal_name
Naturejournal_title
Natureauthors
Ishihara H,Connolly AJ,Zeng D,Kahn ML,Zheng YW,Timmons C,Tram T,Coughlin SRdoi
10.1038/386502a0subject
Has Abstractpub_date
1997-04-03 00:00:00pages
502-6issue
6624eissn
0028-0836issn
1476-4687journal_volume
386pub_type
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