相关文献
NATURE文献大全abstract::In Fig. 1b of this Article, a U was inadvertently inserted after G15 in the D loop. The original Article has not been corrected. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41586-018-0760-4
更新日期:2018-12-01 00:00:00
abstract::The making and breaking of atomic bonds are essential processes in chemical reactions. Although the ultrafast dynamics of bond breaking have been studied intensively using time-resolved techniques, it is very difficult to study the structural dynamics of bond making, mainly because of its bimolecular nature. It is esp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14163
更新日期:2015-02-19 00:00:00
abstract::We have followed individual ribosomes as they translate single messenger RNA hairpins tethered by the ends to optical tweezers. Here we reveal that translation occurs through successive translocation--and-pause cycles. The distribution of pause lengths, with a median of 2.8 s, indicates that at least two rate-determin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06716
更新日期:2008-04-03 00:00:00
abstract::Classical novae are the most common astrophysical thermonuclear explosions, occurring on the surfaces of white dwarf stars accreting gas from companions in binary star systems. Novae typically expel about 10(-4) solar masses of material at velocities exceeding 1,000 kilometres per second. However, the mechanism of mas...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13773
更新日期:2014-10-16 00:00:00
abstract::Signal sequences target proteins for secretion from cells or for integration into cell membranes. As nascent proteins emerge from the ribosome, signal sequences are recognized by the signal recognition particle (SRP), which subsequently associates with its receptor (SR). In this complex, the SRP and SR stimulate each ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02250
更新日期:2004-01-15 00:00:00
abstract::Nerve growth factor (NGF) is involved in a variety of processes involving signalling, such as cell differentiation and survival, growth cessation and apoptosis of neurons. These events are mediated by NGF as a result of binding to its two cell-surface receptors, TrkA and p75. TrkA is a receptor with tyrosine kinase ac...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/43705
更新日期:1999-09-09 00:00:00
abstract::Differentiation of bone marrow derived precursors into mature T cells takes place in the thymus. During differentiation, T cells develop the receptor repertoire which allows them to recognize antigen in the context of self major histocompatibility complex (MHC) molecules. Mature T helper cells (mostly CD4+ CD8-) recog...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/333180a0
更新日期:1988-05-12 00:00:00
abstract::In addition to coordinating immune and inflammatory responses, NF-kappaB/Rel transcription factors control cell survival. Normally, NF-kappaB dimers are sequestered in the cytoplasm by binding to inhibitory IkappaB proteins, and can be activated rapidly by signals that induce the sequential phosphorylation and proteol...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35104560
更新日期:2001-11-15 00:00:00
abstract::Proximal spinal muscular atrophies represent the second most common fatal, autosomal recessive disorder after cystic fibrosis. The childhood form is classically subdivided into three groups: acute Werdnig-Hoffmann (type I), intermediate Werdnig-Hoffmann disease (type II) and Kugelberg-Welander disease (type III). Thes...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/344767a0
更新日期:1990-04-19 00:00:00
abstract::Glycine is an important inhibitory transmitter in the brainstem and spinal cord. In the trigeminal subnucleus caudalis (medullary dorsal horn) and in the spinal dorsal horn (the relaying centres for processing pain and sensory information), glycine inhibits the glutamate-evoked depolarization and depresses firing of n...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/348242a0
更新日期:1990-11-15 00:00:00
abstract::Highly correlated electronic systems--such as transition-metal oxides that are doped Mott insulators--are complex systems which exhibit puzzling phenomena, including high-temperature superconductivity and colossal magnetoresistivity. Recent studies suggest that in such systems collective electronic phenomena are impor...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35021018
更新日期:2000-08-17 00:00:00
abstract::Mutations in the p53 tumour-suppressor gene are the most frequently observed genetic lesions in human cancers. To investigate the role of the p53 gene in mammalian development and tumorigenesis, a null mutation was introduced into the gene by homologous recombination in murine embryonic stem cells. Mice homozygous for...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/356215a0
更新日期:1992-03-19 00:00:00
abstract::Pluto's tenuous nitrogen atmosphere was first detected by the imprint left on the light curve of a star that was occulted by the planet in 1985 (ref. 1), and studied more extensively during a second occultation event in 1988 (refs 2-6). These events are, however, quite rare and Pluto's atmosphere remains poorly unders...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01766
更新日期:2003-07-10 00:00:00
abstract::Understanding the physical mechanisms behind the generation of ocean waves by wind has been a longstanding challenge. Previous studies have assumed that ocean waves induce fluctuations in velocity and pressure of the overlying air that are synchronized with the waves, and numerical models have supported this assumptio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01382
更新日期:2003-03-06 00:00:00
abstract::Synapse assembly requires trans-synaptic signals between the pre- and postsynapse, but our understanding of the essential organizational molecules involved in this process remains incomplete. Teneurin proteins are conserved, epidermal growth factor (EGF)-repeat-containing transmembrane proteins with large extracellula...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10923
更新日期:2012-03-18 00:00:00
abstract::In the chick embryo hindbrain, morphological segmentation into rhombomeres is matched by metameric patterns of early neuronal differentiation and axonogenesis. Boundaries between rhombomeres coincide with boundaries of expression of murine regulatory genes. By clonal analysis using intracellular marking, we show here ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/344431a0
更新日期:1990-03-29 00:00:00
abstract::Observations of galaxies and primordial radiation suggest that the Universe is made mostly of non-luminous dark matter1,2. Several new types of fundamental particle have been proposed as candidates for dark matter3, such as weakly interacting massive particles (WIMPs)4,5. These particles would be expected to interact ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0739-1
更新日期:2018-12-01 00:00:00
abstract::Experimental and simulation studies show that small monomeric proteins fold in one kinetic step, which entails overcoming the free-energy barrier between the unfolded and the native protein through a transition state. Two models of transition state formation have been proposed: a 'nonspecific' one in which it depends ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/379096a0
更新日期:1996-01-04 00:00:00
abstract::Galactic cosmic rays (CRs) are widely believed to be accelerated by shock waves associated with the expansion of supernova ejecta into the interstellar medium. A key issue in this long-standing conjecture is a theoretical prediction that the interstellar magnetic field can be substantially amplified at the shock of a ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06210
更新日期:2007-10-04 00:00:00
abstract::Eukaryotic ribosomes consist of a small 40S and a large 60S subunit that are assembled in a highly coordinated manner. More than 200 factors ensure correct modification, processing and folding of ribosomal RNA and the timely incorporation of ribosomal proteins1,2. Small subunit maturation ends in the cytosol, when the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2929-x
更新日期:2020-11-01 00:00:00
abstract::Many animals rely on an internal heading representation when navigating in varied environments1-10. How this representation is linked to the sensory cues that define different surroundings is unclear. In the fly brain, heading is represented by 'compass' neurons that innervate a ring-shaped structure known as the elli...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1767-1
更新日期:2019-12-01 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,新闻
doi:10.1038/d41586-018-07224-0
更新日期:2018-11-01 00:00:00
abstract::Many planktonic organisms produce 'resting' stages when the environmental conditions deteriorate. Like seeds, resting stages can survive unfavourable conditions. The crustacean Daphnia normally reproduces by means of parthenogenetically produced normal, not resting, eggs-but occasionally switches to bisexual reproduct...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/414899a
更新日期:2001-12-20 00:00:00
abstract::Conifers have dominated forests for more than 200 million years and are of huge ecological and economic importance. Here we present the draft assembly of the 20-gigabase genome of Norway spruce (Picea abies), the first available for any gymnosperm. The number of well-supported genes (28,354) is similar to the >100 tim...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12211
更新日期:2013-05-30 00:00:00
abstract::Acyclovir (9-[2-hydroxyethoxymethyl]guanine or ACV) is a nucleoside analogue with considerable potential for the treatment of herpes simplex virus (HSV) infections in man. Two virus-coded enzymes are important in the mechanism of action of this drug: thymidine kinase (TK) which initiates its activation by converting i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/289081a0
更新日期:1981-01-01 00:00:00
abstract::Humans and cats can localize a sound source accurately if its spectrum is fairly broad and flat, as is typical of most natural sounds. However, if sounds are filtered to reduce the width of the spectrum, they result in illusions of sources that are very different from the actual locations, particularly in the up/down ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/21424
更新日期:1999-06-17 00:00:00
abstract::Granular superconductivity occurs when microscopic superconducting grains are separated by non-superconducting regions; Josephson tunnelling between the grains establishes the macroscopic superconducting state. Although crystals of the copper oxide high-transition-temperature (high-Tc) superconductors are not granular...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/415412a
更新日期:2002-01-24 00:00:00
abstract::Drosophila mutants transformed with a chimaeric gene that expresses the ocellar visual pigment in the major class of photoreceptor cells of the retina were used to investigate the properties of this minor pigment. The photoreceptor cells in which this opsin was misexpressed showed new spectral characteristics and phys...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/333737a0
更新日期:1988-06-23 00:00:00
abstract::The crab Xenograpsus testudinatus lives at enormously high densities around the sulphur-rich hydrothermal vents found in shallow waters off Taiwan, even though this acidic environment is low in nutrients. Here we show that these crabs swarm out of their crevices at slack water and feed on the vast numbers of zooplankt...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/432969a
更新日期:2004-12-23 00:00:00
abstract::IgE and its receptors are believed to have evolved as a mechanism to protect mammals against parasites. But other and intrinsically innocuous antigens can subvert this system to provoke an allergic response. For human populations in industrialized countries, allergy and asthma now represent a far greater threat than p...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/366421a0
更新日期:1993-12-02 00:00:00