Following translation by single ribosomes one codon at a time.

abstract：:Mature cortical pyramidal neurons receive excitatory inputs onto small protrusions emanating from their dendrites called spines. Spines undergo activity-dependent remodelling, stabilization and pruning during development, and similar structural changes can be triggered by learning and changes in sensory experiences. H...

journal_title：Nature

authors： Kwon HB,Sabatini BL

更新日期：2011-06-02 00:00:00

abstract：:Concentrations of dissolved oxygen in the ocean seem to correlate well with climate instabilities over the past 100,000 years. For example, the concentration of dissolved oxygen in Pacific intermediate waters was considerably higher during Pleistocene glacial periods than it is today. This has been inferred from the p...

journal_title：Nature

authors： Stott LD,Berelson W,Douglas R,Gorsline D

更新日期：2000-09-21 00:00:00

abstract：:Current ideas about the dependence of neurons on target-derived growth factors were formulated on the basis of experiments involving neurons with projections to the periphery. Nerve growth factor (NGF) and recently identified members of the NGF family of neuronal growth factors, known as neurotrophins, are thought to ...

journal_title：Nature

authors： Yan Q,Elliott J,Snider WD

更新日期：1992-12-24 00:00:00

abstract：:The hot streak-loosely defined as 'winning begets more winnings'-highlights a specific period during which an individual's performance is substantially better than his or her typical performance. Although hot streaks have been widely debated in sports1,2, gambling3-5 and financial markets6,7 over the past several deca...

journal_title：Nature

authors： Liu L,Wang Y,Sinatra R,Giles CL,Song C,Wang D

更新日期：2018-07-01 00:00:00

abstract：:Observations from cultured cells, animal models and patients raise the possibility that the dependency of tumours on the therapeutic drugs to which they have acquired resistance represents a vulnerability with potential applications in cancer treatment. However, for this drug addiction trait to become of clinical inte...

journal_title：Nature

authors： Kong X,Kuilman T,Shahrabi A,Boshuizen J,Kemper K,Song JY,Niessen HWM,Rozeman EA,Geukes Foppen MH,Blank CU,Peeper DS

更新日期：2017-10-12 00:00:00

abstract：:The biosynthesis of many of the complement proteins by cells of the monocyte-macrophage series has been established. Studies on these cells using radiolabelled amino acids demonstrated synthesis of precursor proteins (pro-complement), and the native complement protein similar in size to that found in the plasma. Howev...

journal_title：Nature

authors： Ooi YM,Ooi BS

更新日期：1982-07-22 00:00:00

abstract：:A short exposure of primary cultures of mouse mammary tumour cells to glucocorticoids results in at least a three-fold stimulation of mammary tumour virus (MTV) production. Specific interaction of glucocorticoids with the cytoplasmic and nuclear receptors can also be demonstrated. The biological potency of various ste...

journal_title：Nature

authors： Shyamala G,Dickson C

更新日期：1976-07-08 00:00:00

abstract：:Metallothioneins are small cysteine-rich proteins that bind heavy metals such as zinc, cadmium, copper and mercury. Recent interest in these proteins has focused on the part they play in zinc metabolism and heavy metal detoxification. Our interest in metallothionein genes stems largely from the observations that these...

journal_title：Nature

authors： Glanville N,Durnam DM,Palmiter RD

更新日期：1981-07-16 00:00:00

abstract：:One of the main unanswered questions in solar physics is why the Sun's outer atmosphere is hotter than its surface. Theory predicts abundant production of high-frequency (10-50 mHz) acoustic waves in subsurface layers of the Sun, and such waves are believed by many to constitute the dominant heating mechanism of the c...

journal_title：Nature

authors： Fossum A,Carlsson M

更新日期：2005-06-16 00:00:00

abstract：:Various mechanisms have been proposed for beta-adrenergically mediated relaxation of smooth muscle. All theories suggest the involvement of cyclic AMP as a second messenger: beta-agonists stimulate adenylate cyclase which converts ATP to cyclic AMP and protein kinase, activated by cyclic AMP, is then thought to cataly...

journal_title：Nature

authors： Mueller E,van Breemen C

更新日期：1979-10-25 00:00:00

abstract：:The single endogenous DBA/2J ectropic provirus segregated concordantly with the dilute (d) coat colour mutation on chromosome 9 in 53/53 DBA/2J-derived recombinant inbred mouse strains and all seven inbred and mutant strains tested that carry the d allele. Analysis of DNA from a spontaneous DBA/2J d revertant (d+2J) s...

journal_title：Nature

authors： Jenkins NA,Copeland NG,Taylor BA,Lee BK

更新日期：1981-10-01 00:00:00

abstract：:How diverse cell fates and complex forms emerge and feed back to each other to sculpt functional organs remains unclear. In the developing heart, the myocardium transitions from a simple epithelium to an intricate tissue that consists of distinct layers: the outer compact and inner trabecular layers. Defects in this p...

journal_title：Nature

authors： Priya R,Allanki S,Gentile A,Mansingh S,Uribe V,Maischein HM,Stainier DYR

更新日期：2020-12-01 00:00:00

abstract：:Change history: In this Letter, the bottom blot in Fig. 2g (for 'IB: Myc') was missing. This has been corrected online. ...

journal_title：Nature

authors： Su T,Izawa T,Thoms M,Yamashita Y,Cheng J,Berninghausen O,Hartl FU,Inada T,Neupert W,Beckmann R

更新日期：2019-07-01 00:00:00

abstract：:Members of the Hedgehog family of secreted proteins control a number of important inductive interactions in the development of both vertebrates and Drosophila, but little is known about the ways in which their signalling activities are transduced. In Drosophila, hedgehog is one of the segment-polarity genes, mutations...

journal_title：Nature

authors： van den Heuvel M,Ingham PW

更新日期：1996-08-08 00:00:00

abstract：:Quantum computers are expected to outperform conventional computers in several important applications, from molecular simulation to search algorithms, once they can be scaled up to large numbers-typically millions-of quantum bits (qubits)1-3. For most solid-state qubit technologies-for example, those using superconduc...

journal_title：Nature

authors： Yang CH,Leon RCC,Hwang JCC,Saraiva A,Tanttu T,Huang W,Camirand Lemyre J,Chan KW,Tan KY,Hudson FE,Itoh KM,Morello A,Pioro-Ladrière M,Laucht A,Dzurak AS

更新日期：2020-04-01 00:00:00

abstract：:The nucleotide sequence of the RNA polymerase binding site at a promotor on fd RF DNA has been determined in comparison with the starting sequence of RNA initiated at this promoter. The RNA polymerase binding site contained the startpoint of transcription in the centre and a region with twofold symmetry in the non-tra...

journal_title：Nature

authors： Sugimoto K,Okamoto T,Sugisaki H,Takanami M

更新日期：1975-02-06 00:00:00

abstract：:The success of cisplatin in cancer chemotherapy derives from its ability to crosslink DNA and alter the structure. Most cisplatin-DNA adducts are intrastrand d(GpG) and d(ApG) crosslinks, which unwind and bend the duplex to facilitate the binding of proteins that contain one or more high-mobility group (HMG) domains. ...

journal_title：Nature

authors： Takahara PM,Rosenzweig AC,Frederick CA,Lippard SJ

更新日期：1995-10-19 00:00:00

abstract：:The manner in which phase transformations occur in solids determines important structural and physical properties of many materials. The main problem in characterizing the kinetic processes that occur during phase transformations is the difficulty of observing directly, in real time, the growth of one phase at the exp...

journal_title：Nature

authors： Hannon JB,Hibino H,Bartelt NC,Swartzentruber BS,Ogino T,Kellogg GL

更新日期：2000-06-01 00:00:00

abstract：:In Xenopus the c-mos proto-oncogene product (Mos) is essential for the initiation of oocyte maturation, for the progression from meiosis I to meiosis II and for the second meiotic metaphase arrest, acting as an essential component of the cytostatic factor CSF. Its function in mouse oocytes is unclear, however, as is t...

journal_title：Nature

authors： Hashimoto N,Watanabe N,Furuta Y,Tamemoto H,Sagata N,Yokoyama M,Okazaki K,Nagayoshi M,Takeda N,Ikawa Y

更新日期：1994-07-07 00:00:00

abstract：:Analysis of a series of mutants of an Escherichia coli alanine transfer RNA shows that substitution of a single G-U base pair in the acceptor helix eliminates aminoacylation with alanine in vivo and in vitro. Introduction of that base pair into the analogous position of a cysteine and a phenylalanine transfer RNA conf...

journal_title：Nature

authors： Hou YM,Schimmel P

更新日期：1988-05-12 00:00:00

abstract：:Protein modification by the conjugation of ubiquitin moieties--ubiquitination--plays a major part in many biological processes, including cell cycle and apoptosis. The enzymes that mediate ubiquitin-conjugation have been well-studied, but much less is known about the ubiquitin-specific proteases that mediate de-ubiqui...

journal_title：Nature

authors： Brummelkamp TR,Nijman SM,Dirac AM,Bernards R

更新日期：2003-08-14 00:00:00

abstract：:A set of restriction fragments cloned into phage lambda vectors has allowed us to locate a site necessary for full rpoBC expression. We find that these genes for the two large subunits of RNA polymerase and the genes, rplL and rplJ, for two ribosomal proteins, form a single operon. ...

journal_title：Nature

authors： Linn T,Scaife J

更新日期：1978-11-02 00:00:00

abstract：:Miocene hominoid material is very scarce and has previously only been reported as cranial fragments in the Old World. Here we describe a new specimen of Ouranopithecus macedoniensis, which consists of the right part of the face of an adult male with a portion of the frontal bone, a portion of the left part of the face...

journal_title：Nature

authors： de Bonis L,Bouvrain G,Geraads D,Koufos G

更新日期：1990-06-21 00:00:00

abstract：:A congressional investigation alleges that some researchers have failed to report all the drug-company money that they have received--and that universities may have been too slow to police them. ...

journal_title：Nature

authors：

更新日期：2008-10-16 00:00:00

abstract：:In Drosophila melanogaster, the rRNA genes (rDNA) are clustered at single sites on two non-homologous chromosomes, the X and Y. Examination of the structure of X and Y rDNAs with restriction endonucleases reveals that the X rDNA contains repeating units not present in the Y. Such observations, as well as genetic evide...

journal_title：Nature

authors： Tartof KD,Dawid IG

更新日期：1976-09-02 00:00:00

abstract：:The development of photolabile caged neurotransmitters has made possible the study of the split-second kinetics of receptor-ligand interactions. An instrument has now been developed for activating the neurotransmitter and measuring the neuron's response. ...

journal_title：Nature

authors： Marque JJ

更新日期：1989-02-09 00:00:00

abstract：:Observations of cometary nuclei have revealed a very limited amount of surface water ice, which is insufficient to explain the observed water outgassing. This was clearly demonstrated on comet 9P/Tempel 1, where the dust jets (driven by volatiles) were only partially correlated with the exposed ice regions. The observ...

journal_title：Nature

authors： De Sanctis MC,Capaccioni F,Ciarniello M,Filacchione G,Formisano M,Mottola S,Raponi A,Tosi F,Bockelée-Morvan D,Erard S,Leyrat C,Schmitt B,Ammannito E,Arnold G,Barucci MA,Combi M,Capria MT,Cerroni P,Ip WH,Kuehrt E,M

更新日期：2015-09-24 00:00:00

abstract：:The discovery of a repeating fast radio burst (FRB) source1,2, FRB 121102, eliminated models involving cataclysmic events for this source. No other repeating FRB has hitherto been detected despite many recent discoveries and follow-ups3-5, suggesting that repeaters may be rare in the FRB population. Here we report the...

journal_title：Nature

authors： CHIME\/FRB Collaboration.

更新日期：2019-02-01 00:00:00

abstract：:The microscopic origin of superconductivity in the high-transition-temperature (high-T(c)) copper oxides remains the subject of active inquiry; several of their electronic characteristics are well established as universal to all the known materials, forming the experimental foundation that all theories must address. T...

journal_title：Nature

authors： Schaak RE,Klimczuk T,Foo ML,Cava RJ

更新日期：2003-07-31 00:00:00

abstract：:Tumour-initiating cells capable of self-renewal and differentiation, which are responsible for tumour growth, have been identified in human haematological malignancies and solid cancers. If such minority populations are associated with tumour progression in human patients, specific targeting of tumour-initiating cells...

journal_title：Nature

authors： Schatton T,Murphy GF,Frank NY,Yamaura K,Waaga-Gasser AM,Gasser M,Zhan Q,Jordan S,Duncan LM,Weishaupt C,Fuhlbrigge RC,Kupper TS,Sayegh MH,Frank MH

更新日期：2008-01-17 00:00:00