Abstract:
:Analysis of a series of mutants of an Escherichia coli alanine transfer RNA shows that substitution of a single G-U base pair in the acceptor helix eliminates aminoacylation with alanine in vivo and in vitro. Introduction of that base pair into the analogous position of a cysteine and a phenylalanine transfer RNA confers upon each the ability to be aminoacylated with alanine. Thus, as little as a single base pair can direct an amino acid to a specific transfer RNA.
journal_name
Naturejournal_title
Natureauthors
Hou YM,Schimmel Pdoi
10.1038/333140a0subject
Has Abstractpub_date
1988-05-12 00:00:00pages
140-5issue
6169eissn
0028-0836issn
1476-4687journal_volume
333pub_type
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