Abstract：
:In lung diseases such as asthma, expiratory flow becomes limited, airways can collapse and the vital exchange of gases is compromised. Here we model the inflation of collapsed regions of the lung during inspiration in terms of avalanches propagating through a bifurcating network of airways, and find that the accompanying cascade of dynamic pressure instabilities -- avalanche 'shocks' -- manifests as negative elastic resistance of the lung. Our analysis of this apparent thermodynamic paradox provides a better understanding of aeration in the deep regions of the lung, which may find application in medical conditions in which gas exchange is impaired.
journal_name
Naturejournal_title
Natureauthors
Alencar AM,Arold SP,Buldyrev SV,Majumdar A,Stamenović D,Stanley HE,Suki Bdoi
10.1038/417809bkeywords:
subject
Has Abstractpub_date
2002-06-20 00:00:00pages
809-11issue
6891eissn
0028-0836issn
1476-4687pii
417809bjournal_volume
417pub_type
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