Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.

abstract：:DNA-binding repressor proteins mediate regulation of yeast genes by cell type (Mcm1/alpha 2 and a1/alpha 2), glucose (Mig1) and oxygen (Rox1) (refs 1-4 respectively). An unusual feature of all these regulatory pathways is that transcriptional repression requires two physically associated proteins that do not bind DNA ...

journal_title：Nature

authors： Tzamarias D,Struhl K

更新日期：1994-06-30 00:00:00

abstract：: ...

journal_title：Nature

authors： Gewin V

更新日期：2019-02-01 00:00:00

abstract：:The single endogenous DBA/2J ectropic provirus segregated concordantly with the dilute (d) coat colour mutation on chromosome 9 in 53/53 DBA/2J-derived recombinant inbred mouse strains and all seven inbred and mutant strains tested that carry the d allele. Analysis of DNA from a spontaneous DBA/2J d revertant (d+2J) s...

journal_title：Nature

authors： Jenkins NA,Copeland NG,Taylor BA,Lee BK

更新日期：1981-10-01 00:00:00

abstract：:Greek speakers say "omicronupsilonrho", Germans "schwanz" and the French "queue" to describe what English speakers call a 'tail', but all of these languages use a related form of 'two' to describe the number after one. Among more than 100 Indo-European languages and dialects, the words for some meanings (such as 'tail...

journal_title：Nature

authors： Pagel M,Atkinson QD,Meade A

更新日期：2007-10-11 00:00:00

abstract：:The evolution of animal personalities is a topic of primary importance in behavioural ecology. An intriguing empirical fact is the consistency of animal responses to repeated stresses or threats. Wolf et al. propose an evolutionary model to explain the emergence of consistent personalities. They show that a population...

journal_title：Nature

authors： Massol F,Crochet PA

更新日期：2008-02-28 00:00:00

abstract：:ELLIPTICAL galaxies acting as gravitational lenses occasionally produce spectacular images-Einstein rings-of distant objects. Giant arcs(1) and radio rings(2) have been observed. A wide variety of image morphologies is possible, the generation of which is qualitatively understood in terms of large magnifications at ca...

journal_title：Nature

authors： Langston GI,Conner SR,Lehar J,Burke BF,Weiler KW

更新日期：1990-03-01 00:00:00

abstract：:Spontaneous mutations are the source of genetic variation required for evolutionary change, and are therefore important for many aspects of evolutionary biology. For example, the divergence between taxa at neutrally evolving sites in the genome is proportional to the per nucleotide mutation rate, u (ref. 1), and this ...

journal_title：Nature

authors： Haag-Liautard C,Dorris M,Maside X,Macaskill S,Halligan DL,Houle D,Charlesworth B,Keightley PD

更新日期：2007-01-04 00:00:00

abstract：:It has been established that many eukaryotic mRNAs contain poly(adenylic acid) tracts at their 3'-termini. The polyadenylation of mRNA occurs post-transcriptionally in the nucleus as a rapid, initial addition of 100-200 adenylate residues to the pre-mRNA (ref. 1). Subsequently, a slower chain extension (6-8 bases) of ...

journal_title：Nature

authors： Rose KM,Bell LE,Jacob ST

更新日期：1977-05-12 00:00:00

abstract：:Resolving current concerns about the role of biodiversity on ecosystems calls for understanding the separate roles of changes in species numbers and of composition. Recent work shows that primary productivity often, but not always, saturates with species richness within single trophic levels. However, any interpretati...

journal_title：Nature

authors： Downing AL,Leibold MA

更新日期：2002-04-25 00:00:00

abstract：:Mechanical stimuli can modify the energy landscape of chemical reactions and enable reaction pathways, offering a synthetic strategy that complements conventional chemistry. These mechanochemical mechanisms have been studied extensively in one-dimensional polymers under tensile stress using ring-opening and reorganiza...

journal_title：Nature

authors： Yan H,Yang F,Pan D,Lin Y,Hohman JN,Solis-Ibarra D,Li FH,Dahl JEP,Carlson RMK,Tkachenko BA,Fokin AA,Schreiner PR,Galli G,Mao WL,Shen ZX,Melosh NA

更新日期：2018-02-21 00:00:00

abstract：:Data collected at approximately 60 Global Positioning System (GPS) sites in southeast Asia show the crustal deformation caused by the 26 December 2004 Sumatra-Andaman earthquake at an unprecedented large scale. Small but significant co-seismic jumps are clearly detected more than 3,000 km from the earthquake epicentre...

journal_title：Nature

authors： Vigny C,Simons WJ,Abu S,Bamphenyu R,Satirapod C,Choosakul N,Subarya C,Socquet A,Omar K,Abidin HZ,Ambrosius BA

更新日期：2005-07-14 00:00:00

abstract：:The architecture of trabecular bone, the porous bone found in the spine and at articulating joints, provides the requirements for optimal load transfer, by pairing suitable strength and stiffness to minimal weight according to rules of mathematical design. But, as it is unlikely that the architecture is fully pre-prog...

journal_title：Nature

authors： Huiskes R,Ruimerman R,van Lenthe GH,Janssen JD

更新日期：2000-06-08 00:00:00

abstract：:Autism spectrum disorder (ASD) is a group of conditions characterized by impaired social interaction and communication, and restricted and repetitive behaviours. ASD is a highly heritable disorder involving various genetic determinants. Shank2 (also known as ProSAP1) is a multi-domain scaffolding protein and signallin...

journal_title：Nature

authors： Won H,Lee HR,Gee HY,Mah W,Kim JI,Lee J,Ha S,Chung C,Jung ES,Cho YS,Park SG,Lee JS,Lee K,Kim D,Bae YC,Kaang BK,Lee MG,Kim E

更新日期：2012-06-13 00:00:00

abstract：:The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. Here we report the sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy, along with transcriptomes of development and stress response and the proteom...

journal_title：Nature

authors： Zhang G,Fang X,Guo X,Li L,Luo R,Xu F,Yang P,Zhang L,Wang X,Qi H,Xiong Z,Que H,Xie Y,Holland PW,Paps J,Zhu Y,Wu F,Chen Y,Wang J,Peng C,Meng J,Yang L,Liu J,Wen B,Zhang N,Huang Z,Zhu Q,Feng Y,Mount A

更新日期：2012-10-04 00:00:00

abstract：:Although vascular endothelial growth factor (VEGF) induces angiogenesis, it also disrupts vascular barrier function in diseased tissues. Accordingly, VEGF expression in cancer and ischaemic disease has unexpected pathophysiological consequences. By uncoupling endothelial cell-cell junctions VEGF causes vascular permea...

journal_title：Nature

authors： Weis SM,Cheresh DA

更新日期：2005-09-22 00:00:00

abstract：:The maternal gene bicoid (bcd) determines pattern in the anterior half of the Drosophila embryo. It is reported here that the injection of bcd mutant embryos with messenger RNAs that encode proteins consisting of heterologous acidic transcriptional activating sequences fused to the DNA-binding portion of the bcd gene ...

journal_title：Nature

authors： Driever W,Ma J,Nüsslein-Volhard C,Ptashne M

更新日期：1989-11-09 00:00:00

abstract：:ATP is the dominant energy source in animals for mechanical and electrical work (for example, muscle contraction or neuronal firing). For chemical work, there is an equally important role for NADPH, which powers redox defence and reductive biosynthesis. The most direct route to produce NADPH from glucose is the oxidat...

journal_title：Nature

authors： Fan J,Ye J,Kamphorst JJ,Shlomi T,Thompson CB,Rabinowitz JD

更新日期：2014-06-12 00:00:00

abstract：:Homologous recombination is a molecular process that has multiple important roles in DNA metabolism, both for DNA repair and genetic variation in all forms of life. Generally, homologous recombination involves the exchange of genetic information between two identical or nearly identical DNA molecules; however, homolog...

journal_title：Nature

authors： Keskin H,Shen Y,Huang F,Patel M,Yang T,Ashley K,Mazin AV,Storici F

更新日期：2014-11-20 00:00:00

abstract：:In photoreceptors, a latency of many milliseconds elapses between the absorption of a light quantum and the occurrence of the late receptor potential, even for strong light stimuli. Surprisingly, this is much longer than the time necessary for conductance changes such as occur in membranes of neurones or muscles, medi...

journal_title：Nature

authors： Hamdorf K,Kirschfeld K

更新日期：1980-02-28 00:00:00

abstract：:Adenylyl cyclase is the prototypical second messenger generator. Nearly all of the eight cloned adenylyl cyclases are regulated by one or other arm of the phospholipase C pathway. Functional and ultrastructural investigations have shown that adenylyl cyclases are intimately associated with sites of calcium ion entry i...

journal_title：Nature

authors： Cooper DM,Mons N,Karpen JW

更新日期：1995-03-30 00:00:00

abstract：:Inositol 1,4,5-trisphosphate (InsP3) can initiate calcium release into the cytoplasm in a variety of cells. From experiments using permeabilized cells, membrane vesicles, and patch-clamp techniques, it has been suggested that InsP3 acts by directly opening calcium channels. Here, we show that InsP3 induced openings of...

journal_title：Nature

authors： Ehrlich BE,Watras J

更新日期：1988-12-08 00:00:00

abstract：:In this Article, owing to an error during the production process, in Fig. 1a, the dark blue and light blue wedges were incorrectly labelled as 'G•C → T•A' and 'G•C → A•T', instead of 'C•G → T•A' and 'C•G → A•T', respectively. Fig. 1 has been corrected online. ...

journal_title：Nature

authors： Gaudelli NM,Komor AC,Rees HA,Packer MS,Badran AH,Bryson DI,Liu DR

更新日期：2018-07-01 00:00:00

abstract：:Government policies currently commit us to surface warming of three to four degrees Celsius above pre-industrial levels by 2100, which will lead to enhanced ice-sheet melt. Ice-sheet discharge was not explicitly included in Coupled Model Intercomparison Project phase 5, so effects on climate from this melt are not cur...

journal_title：Nature

authors： Golledge NR,Keller ED,Gomez N,Naughten KA,Bernales J,Trusel LD,Edwards TL

更新日期：2019-02-01 00:00:00

abstract：:Monocular lid suture during the sensitive period early in the life of a kitten disrupts normal development of inputs from the two eyes to the visual cortex, causing a decrease in the fraction of cortical cells responding to the deprived eye. Such an ocular dominance shift has been assumed to depend on patterned visual...

journal_title：Nature

authors： Chapman B,Jacobson MD,Reiter HO,Stryker MP

更新日期：1986-11-13 00:00:00

abstract：:Mating and egg laying are tightly cooordinated events in the reproductive life of all oviparous females. Oviposition is typically rare in virgin females but is initiated after copulation. Here we identify the neural circuitry that links egg laying to mating status in Drosophila melanogaster. Activation of female-speci...

journal_title：Nature

authors： Wang F,Wang K,Forknall N,Patrick C,Yang T,Parekh R,Bock D,Dickson BJ

更新日期：2020-03-01 00:00:00

abstract：:Critical issues in the cognitive neuroscience of language are whether there are multiple systems for the representation of meaning, perhaps organized by processing system (such as vision or language), and whether further subsystems are distinguishable within these larger ones. We describe here a patient (K.R.) with ce...

journal_title：Nature

authors： Hart J Jr,Gordon B

更新日期：1992-09-03 00:00:00

abstract：:Electrons in a single sheet of graphene behave quite differently from those in traditional two-dimensional electron systems. Like massless relativistic particles, they have linear dispersion and chiral eigenstates. Furthermore, two sets of electrons centred at different points in reciprocal space ('valleys') have this...

journal_title：Nature

authors： Song YJ,Otte AF,Kuk Y,Hu Y,Torrance DB,First PN,de Heer WA,Min H,Adam S,Stiles MD,MacDonald AH,Stroscio JA

更新日期：2010-09-09 00:00:00

abstract：:The mechanical environment crucially influences many cell functions. However, it remains largely mysterious how mechanical stimuli are transmitted into biochemical signals. Src is known to regulate the integrin-cytoskeleton interaction, which is essential for the transduction of mechanical stimuli. Using fluorescent r...

journal_title：Nature

authors： Wang Y,Botvinick EL,Zhao Y,Berns MW,Usami S,Tsien RY,Chien S

更新日期：2005-04-21 00:00:00

abstract：:High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein. In the cell nucleus it acts as an architectural chromatin-binding factor that bends DNA and promotes protein assembly on specific DNA targets. Outside the cell, it binds with high affinity to RAGE (the receptor for advanced glycatio...

journal_title：Nature

authors： Scaffidi P,Misteli T,Bianchi ME

更新日期：2002-07-11 00:00:00

abstract：:Transmembrane channels and pores have key roles in fundamental biological processes1 and in biotechnological applications such as DNA nanopore sequencing2-4, resulting in considerable interest in the design of pore-containing proteins. Synthetic amphiphilic peptides have been found to form ion channels5,6, and there h...

journal_title：Nature

authors： Xu C,Lu P,Gamal El-Din TM,Pei XY,Johnson MC,Uyeda A,Bick MJ,Xu Q,Jiang D,Bai H,Reggiano G,Hsia Y,Brunette TJ,Dou J,Ma D,Lynch EM,Boyken SE,Huang PS,Stewart L,DiMaio F,Kollman JM,Luisi BF,Matsuura T,Catterall

更新日期：2020-09-01 00:00:00